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The map label for this gene is thrC [H]

Identifier: 59712065

GI number: 59712065

Start: 1614411

End: 1615541

Strand: Direct

Name: thrC [H]

Synonym: VF_1458

Alternate gene names: 59712065

Gene position: 1614411-1615541 (Clockwise)

Preceding gene: 59712064

Following gene: 59712066

Centisome position: 55.72

GC content: 39.61

Gene sequence:

>1131_bases
ATGAAATACCTCTGTATGGCGTGTAATAAAGAATACGCACCGAAACCTGAACTCATTAAATGTGAATGTGGCTCCGCCCT
ATGGGTTAAACCTCAAACGTCATTTAGTAAAAAAGATCTCATAGAAAATGAATTCACACCTAGACGCTATTCTAGTGCTT
TCCCAGTAAAAAAAGACGATATCAATATCACTTTCAATGAAGCCATCACACCTCTTTGCCAAGCTGAAATATCAGGAACT
CCAATACTGGTTAAACTCGATTCGCTACAACCAACAGGCTCATTTAAAGACCGAGGTGCCTCTCTTGTAATCAATTACCT
TAACAACCATGGAATAACAAGCATTGCAGAAGACTCAAGCGGTAATGGAGGAAGTGCTTATGCCGGTTATGCCGCTAAAG
GAAACATGCAATGCAACATATTTGTGCCTGCTGGAACATCCAAAGGAAAGACAACACAAACCCGATTATACGGCGCTAAC
TGTATTGAAGTAGAAGGAACAAGAGAAGATGTTGCTCTAGCTGCAATAGAGAGCAGCGTCACTCATGGAAGTCATTATGT
TGGGCATAACTGGCATCCCCTATTTATCGAAGGCGTCAAATCCATCGCTTATGAAATATGGGAACAGTGTGGATATAAAG
CCCCTGATAATTTTGTTGTTCCCGCAGGAAATGGAAGTTTACTCGCTGGAGCATATATCGGTTTCTCTGAATTATTAAAA
GGCGGAGAAATAAGCAAACTCCCTCGCCTTTTTGGTATTCAAAGTGAAAGCATTCAGCCGTTTGTACAAACCTTTAACAA
TAAAGAAATCAACATTACTTCAGAAGATACCATTGCTGAGGGTATTAAGATTAAGCGTTCATCACGAATGAATGAGATCG
TTCAATTTGTAAAAGAAACGAATGGGAATTTTATTAGTGTTAATGAACAACAAATCCAATCAGCATTAAAAGAGATGGGA
GCACAAGGATACTTTATCGAACCAACATCAGCGACGGCATTTGCAGGAATCGCTCAGCTTATAAAAACGCAAGAAATCAA
ACCTGACGAGCTTACCGTTGGAGTCGTAACCGGAAATGGACTCAAAGCAACAAACTCAATTGAACATTTAATCAATGATA
TGAGAGGTTAA

Upstream 100 bases:

>100_bases
CCATTTGGGAATAGAACGAATACCGAGCTTTCCTTTATAAAATAAAAAAATCGCCCGTAGAATATTTCTTCTAATTCATC
AAACTTAGAAGTGACCATCC

Downstream 100 bases:

>100_bases
TAATGAAATATATTCAAACTAAAAACTCATTAAAAGCAGCAGGACATTACTCTCAAGCGATAGTACATAATGGGTTAATT
TACGTATCTGGCCAATTACC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKYLCMACNKEYAPKPELIKCECGSALWVKPQTSFSKKDLIENEFTPRRYSSAFPVKKDDINITFNEAITPLCQAEISGT
PILVKLDSLQPTGSFKDRGASLVINYLNNHGITSIAEDSSGNGGSAYAGYAAKGNMQCNIFVPAGTSKGKTTQTRLYGAN
CIEVEGTREDVALAAIESSVTHGSHYVGHNWHPLFIEGVKSIAYEIWEQCGYKAPDNFVVPAGNGSLLAGAYIGFSELLK
GGEISKLPRLFGIQSESIQPFVQTFNNKEINITSEDTIAEGIKIKRSSRMNEIVQFVKETNGNFISVNEQQIQSALKEMG
AQGYFIEPTSATAFAGIAQLIKTQEIKPDELTVGVVTGNGLKATNSIEHLINDMRG

Sequences:

>Translated_376_residues
MKYLCMACNKEYAPKPELIKCECGSALWVKPQTSFSKKDLIENEFTPRRYSSAFPVKKDDINITFNEAITPLCQAEISGT
PILVKLDSLQPTGSFKDRGASLVINYLNNHGITSIAEDSSGNGGSAYAGYAAKGNMQCNIFVPAGTSKGKTTQTRLYGAN
CIEVEGTREDVALAAIESSVTHGSHYVGHNWHPLFIEGVKSIAYEIWEQCGYKAPDNFVVPAGNGSLLAGAYIGFSELLK
GGEISKLPRLFGIQSESIQPFVQTFNNKEINITSEDTIAEGIKIKRSSRMNEIVQFVKETNGNFISVNEQQIQSALKEMG
AQGYFIEPTSATAFAGIAQLIKTQEIKPDELTVGVVTGNGLKATNSIEHLINDMRG
>Mature_376_residues
MKYLCMACNKEYAPKPELIKCECGSALWVKPQTSFSKKDLIENEFTPRRYSSAFPVKKDDINITFNEAITPLCQAEISGT
PILVKLDSLQPTGSFKDRGASLVINYLNNHGITSIAEDSSGNGGSAYAGYAAKGNMQCNIFVPAGTSKGKTTQTRLYGAN
CIEVEGTREDVALAAIESSVTHGSHYVGHNWHPLFIEGVKSIAYEIWEQCGYKAPDNFVVPAGNGSLLAGAYIGFSELLK
GGEISKLPRLFGIQSESIQPFVQTFNNKEINITSEDTIAEGIKIKRSSRMNEIVQFVKETNGNFISVNEQQIQSALKEMG
AQGYFIEPTSATAFAGIAQLIKTQEIKPDELTVGVVTGNGLKATNSIEHLINDMRG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=329, Percent_Identity=28.2674772036474, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790207, Length=295, Percent_Identity=26.7796610169492, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508781, Length=270, Percent_Identity=30.7407407407407, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 40873; Mature: 40873

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYLCMACNKEYAPKPELIKCECGSALWVKPQTSFSKKDLIENEFTPRRYSSAFPVKKDD
CCEEEEECCCCCCCCCCEEEEECCCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCC
INITFNEAITPLCQAEISGTPILVKLDSLQPTGSFKDRGASLVINYLNNHGITSIAEDSS
EEEEHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCEECCCCC
GNGGSAYAGYAAKGNMQCNIFVPAGTSKGKTTQTRLYGANCIEVEGTREDVALAAIESSV
CCCCCEEECEEECCCEEEEEEEECCCCCCCCEEEEEECCEEEEECCCCHHEEEEEHHHHH
THGSHYVGHNWHPLFIEGVKSIAYEIWEQCGYKAPDNFVVPAGNGSLLAGAYIGFSELLK
CCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEHHCCHHHHHC
GGEISKLPRLFGIQSESIQPFVQTFNNKEINITSEDTIAEGIKIKRSSRMNEIVQFVKET
CCCHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCHHHHHCEEEHHHHHHHHHHHHHHHC
NGNFISVNEQQIQSALKEMGAQGYFIEPTSATAFAGIAQLIKTQEIKPDELTVGVVTGNG
CCCEEEECHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCC
LKATNSIEHLINDMRG
CCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKYLCMACNKEYAPKPELIKCECGSALWVKPQTSFSKKDLIENEFTPRRYSSAFPVKKDD
CCEEEEECCCCCCCCCCEEEEECCCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCC
INITFNEAITPLCQAEISGTPILVKLDSLQPTGSFKDRGASLVINYLNNHGITSIAEDSS
EEEEHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCEECCCCC
GNGGSAYAGYAAKGNMQCNIFVPAGTSKGKTTQTRLYGANCIEVEGTREDVALAAIESSV
CCCCCEEECEEECCCEEEEEEEECCCCCCCCEEEEEECCEEEEECCCCHHEEEEEHHHHH
THGSHYVGHNWHPLFIEGVKSIAYEIWEQCGYKAPDNFVVPAGNGSLLAGAYIGFSELLK
CCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEHHCCHHHHHC
GGEISKLPRLFGIQSESIQPFVQTFNNKEINITSEDTIAEGIKIKRSSRMNEIVQFVKET
CCCHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCHHHHHCEEEHHHHHHHHHHHHHHHC
NGNFISVNEQQIQSALKEMGAQGYFIEPTSATAFAGIAQLIKTQEIKPDELTVGVVTGNG
CCCEEEECHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCC
LKATNSIEHLINDMRG
CCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]