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The map label for this gene is yrhP [H]

Identifier: 59712063

GI number: 59712063

Start: 1611567

End: 1612196

Strand: Reverse

Name: yrhP [H]

Synonym: VF_1456

Alternate gene names: 59712063

Gene position: 1612196-1611567 (Counterclockwise)

Preceding gene: 59712067

Following gene: 172087712

Centisome position: 55.64

GC content: 39.52

Gene sequence:

>630_bases
ATGATAATGGATTTTTGGGCATTTTTTATTGCCATATTGCTGTTAACAATGACACCTGGTTTAGATACGGCGTTAGTTAT
TCGTAATACAACACGTGGTGGTTGGAAAGATGGTATAACTTGCAGTCTTGGTATTTGTTGTGGGCTATTTGTTCATGCAA
CTATGTCAGCGGTTGGTTTGTCTGTGGTATTGGTGAGTTCGGCTGAGTTGTTTACCGTAGTGAAAACCATTGGTGCGATT
TATCTTATTTGGCTTGGTGTGCAATCCATAAGAAGTACTTTTAGTCACTCACAAGCCATAGACACGAGCAGCAATAAAAG
CCTTGAAGCGCCGTCATTAAAAGTGTCGTTTAAAGAAGGGTTTTTATCTAATATCTTGAACCCAAAAACCGCAGTATTTT
ATTTGGCATTATTACCGCAATTTATTAACCCTGAGTACAGCGCGTTTGCTCAATCATTATTGATGGCGAGTATTCATTTT
GTTATTGCGATGATATGGCAGGGTGGCGTTGCTTTGTTGGTGGAAAAAGCCAAGCAGTTAATGTCTAGCTCTGTGGTTAA
AAATAGAATTGAAAGGGTGACAGGGGCGGTACTTGTGATGCTTGGTGTGAACTTACTTGTTTCTAAATAG

Upstream 100 bases:

>100_bases
GGGGTGGTAATCAATAGAATTAATACTCTAGGTTGGGAATTTGATAGCTTTTTTAAACGGATTGTTATAAAACGAGATAA
AAGTAAAAAATGGATATTTT

Downstream 100 bases:

>100_bases
TTTGTTTTTAAAGTGTCAAGCTTGATATAAAAGATGAATGAAACAGTGCCATGCCTATTATTGAATACGCATGGCACTTT
TGTTTAGCTGTCTTTTGATC

Product: homoserine/homoserine lactone efflux protein

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MIMDFWAFFIAILLLTMTPGLDTALVIRNTTRGGWKDGITCSLGICCGLFVHATMSAVGLSVVLVSSAELFTVVKTIGAI
YLIWLGVQSIRSTFSHSQAIDTSSNKSLEAPSLKVSFKEGFLSNILNPKTAVFYLALLPQFINPEYSAFAQSLLMASIHF
VIAMIWQGGVALLVEKAKQLMSSSVVKNRIERVTGAVLVMLGVNLLVSK

Sequences:

>Translated_209_residues
MIMDFWAFFIAILLLTMTPGLDTALVIRNTTRGGWKDGITCSLGICCGLFVHATMSAVGLSVVLVSSAELFTVVKTIGAI
YLIWLGVQSIRSTFSHSQAIDTSSNKSLEAPSLKVSFKEGFLSNILNPKTAVFYLALLPQFINPEYSAFAQSLLMASIHF
VIAMIWQGGVALLVEKAKQLMSSSVVKNRIERVTGAVLVMLGVNLLVSK
>Mature_209_residues
MIMDFWAFFIAILLLTMTPGLDTALVIRNTTRGGWKDGITCSLGICCGLFVHATMSAVGLSVVLVSSAELFTVVKTIGAI
YLIWLGVQSIRSTFSHSQAIDTSSNKSLEAPSLKVSFKEGFLSNILNPKTAVFYLALLPQFINPEYSAFAQSLLMASIHF
VIAMIWQGGVALLVEKAKQLMSSSVVKNRIERVTGAVLVMLGVNLLVSK

Specific function: Conducts The Efflux Of Homoserine And Homoserine Lactone. [C]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=203, Percent_Identity=27.5862068965517, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1788099, Length=162, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI48994978, Length=193, Percent_Identity=26.4248704663212, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786522, Length=181, Percent_Identity=24.3093922651934, Blast_Score=67, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 22622; Mature: 22622

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMDFWAFFIAILLLTMTPGLDTALVIRNTTRGGWKDGITCSLGICCGLFVHATMSAVGL
CCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SVVLVSSAELFTVVKTIGAIYLIWLGVQSIRSTFSHSQAIDTSSNKSLEAPSLKVSFKEG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHH
FLSNILNPKTAVFYLALLPQFINPEYSAFAQSLLMASIHFVIAMIWQGGVALLVEKAKQL
HHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MSSSVVKNRIERVTGAVLVMLGVNLLVSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIMDFWAFFIAILLLTMTPGLDTALVIRNTTRGGWKDGITCSLGICCGLFVHATMSAVGL
CCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SVVLVSSAELFTVVKTIGAIYLIWLGVQSIRSTFSHSQAIDTSSNKSLEAPSLKVSFKEG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHH
FLSNILNPKTAVFYLALLPQFINPEYSAFAQSLLMASIHFVIAMIWQGGVALLVEKAKQL
HHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MSSSVVKNRIERVTGAVLVMLGVNLLVSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9308178 [H]