Click here to switch to the map view.

The map label for this gene is mltC [H]

Identifier: 59711975

GI number: 59711975

Start: 1513477

End: 1514640

Strand: Reverse

Name: mltC [H]

Synonym: VF_1368

Alternate gene names: 59711975

Gene position: 1514640-1513477 (Counterclockwise)

Preceding gene: 59711976

Following gene: 59711974

Centisome position: 52.27

GC content: 36.68

Gene sequence:

>1164_bases
ATGAAAAACGTATTAATTCCTTTTATTATTTCTTTAGCGACAGTCTCTTGTACGCCTATTTTTGATGGCAATTTCCAAAG
ACCTAACTCGAATTCATGTAATTGCGAGAGTGACATTACTAACTCGAACAATAATACAACTTCAAAGCCAGATTCTTGGA
AACCTAGCACGTCAAAACCAAATCAAAGCATTGAAGAGCAGTTAGAAAATCTTGCTAATCATGTTCATAAAACATGGGGA
GATAAAGAGTTTCTAGAAGCGGGTAAGCATCGTTACGTTAAGTATTTGGATGGATATAGAACTCGCGCACATATCGATTT
TGATAAAGGCAAAATTTACGTTTCGACGATCTCTCAATACCAACCAAAAGAAACGTTGAAGAAAGCGATCATCGGCACCG
TATTAATGCCAGCAGACCCATCACATGTGGATTTATTTAGCGATAAATCGATTCCGTTGCGTGGACGTCCATTCTTACTT
GGCCAAATTAAAGACCAAGAGAATAAAGACATTGAATGGCCATGGCGAGCAGGGCGTTATGCTGATTACTTAATCGAAAA
TAAGCTACAAACTAAAACCATTAAAAATGGTAAAGCGTATTATGTTGAGATATCTATGGTTGATGACCATTTAGAGCAAC
GTGAATTTCAATATGCTGATTTAATAAAAAAAGCATCAAAAGAGTACGATATTTCAATCGACTTAATCTATGCAATTATT
CAGACAGAGAGCAGCTTTAACCCTTATGCTGTAAGCCATGCAGGCGCTTACGGTTTAATGCAAGTGATCCCAAAAACCGC
AGGAGCGGATGTTTTTAAATTAGTTAAGAATAAGCCGGGGATCCCAACAAAAGAGTACTTGTTTAACCCTGCGCATAATA
TCGATACTGGTACAGCGTATTTCTATATTTTAAAGAATCGTTATTTAAGAGACATCAAACATCCAACTAATAAGCATTAC
AGTATGATCTCGGCTTATAACGGGGGCTCAGGTGGCGTTTTCTCAACATTTGATCCAAGCCGAACTAAAGCCATTGATGA
GATAAATAGTTTGCAACCAAATCAGCTTTATTGGGCGTTAACAAACAAACATCCTAAGGCTGAAGCTCGTAGATATTTAG
AAAAAGTGCTTAAATTTCAAAAAGAATTTAATGAGAAAAGTTAG

Upstream 100 bases:

>100_bases
ATAAACAATGTGTAAAATACGCCTCCTTATTGGTAACACCTAATGTGTAATCTATCCCAGTGCATTGAAAAATCCATTCA
ATTCGCTATTTAGGACATCG

Downstream 100 bases:

>100_bases
ATAAATTTTATTGATTGATAGGTGCAATAAATTCCATTATACATTTGCAGAGTGCTTTGTTAGTGTGCGTTTTTTGCACT
TATTTGTGTTTATTGATTGT

Product: membrane-bound lytic murein transglycosylase C precursor

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKNVLIPFIISLATVSCTPIFDGNFQRPNSNSCNCESDITNSNNNTTSKPDSWKPSTSKPNQSIEEQLENLANHVHKTWG
DKEFLEAGKHRYVKYLDGYRTRAHIDFDKGKIYVSTISQYQPKETLKKAIIGTVLMPADPSHVDLFSDKSIPLRGRPFLL
GQIKDQENKDIEWPWRAGRYADYLIENKLQTKTIKNGKAYYVEISMVDDHLEQREFQYADLIKKASKEYDISIDLIYAII
QTESSFNPYAVSHAGAYGLMQVIPKTAGADVFKLVKNKPGIPTKEYLFNPAHNIDTGTAYFYILKNRYLRDIKHPTNKHY
SMISAYNGGSGGVFSTFDPSRTKAIDEINSLQPNQLYWALTNKHPKAEARRYLEKVLKFQKEFNEKS

Sequences:

>Translated_387_residues
MKNVLIPFIISLATVSCTPIFDGNFQRPNSNSCNCESDITNSNNNTTSKPDSWKPSTSKPNQSIEEQLENLANHVHKTWG
DKEFLEAGKHRYVKYLDGYRTRAHIDFDKGKIYVSTISQYQPKETLKKAIIGTVLMPADPSHVDLFSDKSIPLRGRPFLL
GQIKDQENKDIEWPWRAGRYADYLIENKLQTKTIKNGKAYYVEISMVDDHLEQREFQYADLIKKASKEYDISIDLIYAII
QTESSFNPYAVSHAGAYGLMQVIPKTAGADVFKLVKNKPGIPTKEYLFNPAHNIDTGTAYFYILKNRYLRDIKHPTNKHY
SMISAYNGGSGGVFSTFDPSRTKAIDEINSLQPNQLYWALTNKHPKAEARRYLEKVLKFQKEFNEKS
>Mature_387_residues
MKNVLIPFIISLATVSCTPIFDGNFQRPNSNSCNCESDITNSNNNTTSKPDSWKPSTSKPNQSIEEQLENLANHVHKTWG
DKEFLEAGKHRYVKYLDGYRTRAHIDFDKGKIYVSTISQYQPKETLKKAIIGTVLMPADPSHVDLFSDKSIPLRGRPFLL
GQIKDQENKDIEWPWRAGRYADYLIENKLQTKTIKNGKAYYVEISMVDDHLEQREFQYADLIKKASKEYDISIDLIYAII
QTESSFNPYAVSHAGAYGLMQVIPKTAGADVFKLVKNKPGIPTKEYLFNPAHNIDTGTAYFYILKNRYLRDIKHPTNKHY
SMISAYNGGSGGVFSTFDPSRTKAIDEINSLQPNQLYWALTNKHPKAEARRYLEKVLKFQKEFNEKS

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=343, Percent_Identity=44.3148688046647, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI87081855, Length=164, Percent_Identity=37.1951219512195, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87082441, Length=172, Percent_Identity=31.3953488372093, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 44302; Mature: 44302

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVLIPFIISLATVSCTPIFDGNFQRPNSNSCNCESDITNSNNNTTSKPDSWKPSTSKP
CCCCHHHHHHHHHHHEECEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NQSIEEQLENLANHVHKTWGDKEFLEAGKHRYVKYLDGYRTRAHIDFDKGKIYVSTISQY
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEHHCC
QPKETLKKAIIGTVLMPADPSHVDLFSDKSIPLRGRPFLLGQIKDQENKDIEWPWRAGRY
CCHHHHHHHHHHHEECCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCH
ADYLIENKLQTKTIKNGKAYYVEISMVDDHLEQREFQYADLIKKASKEYDISIDLIYAII
HHHHHHCCHHHHEECCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEEH
QTESSFNPYAVSHAGAYGLMQVIPKTAGADVFKLVKNKPGIPTKEYLFNPAHNIDTGTAY
HCCCCCCCEEEHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCEE
FYILKNRYLRDIKHPTNKHYSMISAYNGGSGGVFSTFDPSRTKAIDEINSLQPNQLYWAL
EEEHHHHHHHHHCCCCCCCEEEEEEEECCCCCEECCCCCHHHHHHHHHHCCCCCEEEEEE
TNKHPKAEARRYLEKVLKFQKEFNEKS
CCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNVLIPFIISLATVSCTPIFDGNFQRPNSNSCNCESDITNSNNNTTSKPDSWKPSTSKP
CCCCHHHHHHHHHHHEECEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NQSIEEQLENLANHVHKTWGDKEFLEAGKHRYVKYLDGYRTRAHIDFDKGKIYVSTISQY
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEHHCC
QPKETLKKAIIGTVLMPADPSHVDLFSDKSIPLRGRPFLLGQIKDQENKDIEWPWRAGRY
CCHHHHHHHHHHHEECCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCH
ADYLIENKLQTKTIKNGKAYYVEISMVDDHLEQREFQYADLIKKASKEYDISIDLIYAII
HHHHHHCCHHHHEECCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEEH
QTESSFNPYAVSHAGAYGLMQVIPKTAGADVFKLVKNKPGIPTKEYLFNPAHNIDTGTAY
HCCCCCCCEEEHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCEE
FYILKNRYLRDIKHPTNKHYSMISAYNGGSGGVFSTFDPSRTKAIDEINSLQPNQLYWAL
EEEHHHHHHHHHCCCCCCCEEEEEEEECCCCCEECCCCCHHHHHHHHHHCCCCCEEEEEE
TNKHPKAEARRYLEKVLKFQKEFNEKS
CCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA