Click here to switch to the map view.

The map label for this gene is norM [H]

Identifier: 59711939

GI number: 59711939

Start: 1479603

End: 1480946

Strand: Reverse

Name: norM [H]

Synonym: VF_1332

Alternate gene names: 59711939

Gene position: 1480946-1479603 (Counterclockwise)

Preceding gene: 59711942

Following gene: 59711938

Centisome position: 51.11

GC content: 39.58

Gene sequence:

>1344_bases
ATGAAAAAAATTCTTACGCTCGCTTTTCCTCTCATTGTTTCTCAATTGATTTCTATGGCGTTAGTTCTTACTGATGTTTG
GATGATGTCACGATTAAGTGTTTCGGCATTAGCTGGTGGTGGCTTGGGGGCATCGGTTTACTTTTTTATTTTTATCGTAG
CAAGCAGCACGGTAGGTTGCGTCGCTAATTTGATTGCTATTGCTTATGGGCAACGATTGGCGAGACCTGAATTTGGGAAT
CAACAAATTAGACTTGCTATAAAGGGTGCGGTTTTATTATCTGTAATATTGAGTGTTATTTTATTATTTGCCTTTTCTTA
TGCTCCAAACGTGCTGCGTTTAGCGGGACAACCAGAAGAAATGATTTCATTGGCGATGGAATACGTTGATGCTTTAAAGT
GGGCAATGTTTCCGTCACTAATACTGTTGGTTTTACGTGGTTTAACAAGCGCATTGGGCAATGTTCGTTCTATTATGGTG
ATGTCCGTGATCACGGTTGTTCTTAATGTTCCTATTAGTTATGTACTTACTTTTCAGCTTGGTATGGGATTGTATGGGCT
AGGGTTAGGCACCGCTGTTGCTGCATTGATGGTGATGCTAGGTTATGGGCTTTGGGTCTTTAAACAACAAGAGTACAAAC
CGTTTGCTCCTTGGTTAAATCTAGAAGAGTACTCGATAAAGTTGATTACACCTCTATTAGTGATGGGATTACCCATTGCT
GTTGCAGCCTTATTGGAACACGGATTGATTTATGGTGGTACTTTAATGGCGGGTACCATTAGTATTGCCTCATTAGCTTT
GCACCAAATCCTATTACAATGTTTGAGCTTTACTTGGAACTTTAACTTTGGTTTCTCGCAAGCTGCTGCAATCTTAGTTG
GAAGAGATTTTGGTGCAAACAATGTGGATGGAATTAAGAAAACGTCACAACATAGTTTTGTACTGGTTACGGTAATGAGT
GTATTTATTGCTGCTGTCTTTATCATTTGGCCAGAGAGTATTGCGGATCTATTCCAGTTAGATAATGGTGAAAATAATAT
GTCAGCTTTACTTACCTCGGTAATCTGGGTTGTTGCTTTATGTTTTGTTGTTGACGCGTGGCAATTGTTGGCAATCAATT
TATTACGAGGAATGAAGATTGTCTCCTTACCTACCGTAATGACCGCGATTGGTTACTGGGTATGTGGCTTACCTGCTGCT
TGGTATTTAATGCCAATATTTGGATTAAGTGGCATATGGGCAGGGATTGGCATTGGTTTAGGAGTAACGGGCATTTTGTT
ATTAGTGCAGTTGTTGATATCGATTGCACGAGTGAAAACTCATTATCAGGAAATAGAGAATTAA

Upstream 100 bases:

>100_bases
CTCGCATGAGTTTTTGGAATGCCAGTCTGACGGATTAATTAATTGAATACTACTTTTTTAAACGATAACGTGATGTGAAA
TTATTTAATCTATCTTTTTT

Downstream 100 bases:

>100_bases
AGTTGCCGTATTTTAAAACACTTCACAAATCAGGCTAAAAATTCATGATATTTTTGTACGTATATTAAGTATTTCATAAA
AGGGATTTATGATGATTTAT

Product: sodium-driven multidrug efflux pump

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKKILTLAFPLIVSQLISMALVLTDVWMMSRLSVSALAGGGLGASVYFFIFIVASSTVGCVANLIAIAYGQRLARPEFGN
QQIRLAIKGAVLLSVILSVILLFAFSYAPNVLRLAGQPEEMISLAMEYVDALKWAMFPSLILLVLRGLTSALGNVRSIMV
MSVITVVLNVPISYVLTFQLGMGLYGLGLGTAVAALMVMLGYGLWVFKQQEYKPFAPWLNLEEYSIKLITPLLVMGLPIA
VAALLEHGLIYGGTLMAGTISIASLALHQILLQCLSFTWNFNFGFSQAAAILVGRDFGANNVDGIKKTSQHSFVLVTVMS
VFIAAVFIIWPESIADLFQLDNGENNMSALLTSVIWVVALCFVVDAWQLLAINLLRGMKIVSLPTVMTAIGYWVCGLPAA
WYLMPIFGLSGIWAGIGIGLGVTGILLLVQLLISIARVKTHYQEIEN

Sequences:

>Translated_447_residues
MKKILTLAFPLIVSQLISMALVLTDVWMMSRLSVSALAGGGLGASVYFFIFIVASSTVGCVANLIAIAYGQRLARPEFGN
QQIRLAIKGAVLLSVILSVILLFAFSYAPNVLRLAGQPEEMISLAMEYVDALKWAMFPSLILLVLRGLTSALGNVRSIMV
MSVITVVLNVPISYVLTFQLGMGLYGLGLGTAVAALMVMLGYGLWVFKQQEYKPFAPWLNLEEYSIKLITPLLVMGLPIA
VAALLEHGLIYGGTLMAGTISIASLALHQILLQCLSFTWNFNFGFSQAAAILVGRDFGANNVDGIKKTSQHSFVLVTVMS
VFIAAVFIIWPESIADLFQLDNGENNMSALLTSVIWVVALCFVVDAWQLLAINLLRGMKIVSLPTVMTAIGYWVCGLPAA
WYLMPIFGLSGIWAGIGIGLGVTGILLLVQLLISIARVKTHYQEIEN
>Mature_447_residues
MKKILTLAFPLIVSQLISMALVLTDVWMMSRLSVSALAGGGLGASVYFFIFIVASSTVGCVANLIAIAYGQRLARPEFGN
QQIRLAIKGAVLLSVILSVILLFAFSYAPNVLRLAGQPEEMISLAMEYVDALKWAMFPSLILLVLRGLTSALGNVRSIMV
MSVITVVLNVPISYVLTFQLGMGLYGLGLGTAVAALMVMLGYGLWVFKQQEYKPFAPWLNLEEYSIKLITPLLVMGLPIA
VAALLEHGLIYGGTLMAGTISIASLALHQILLQCLSFTWNFNFGFSQAAAILVGRDFGANNVDGIKKTSQHSFVLVTVMS
VFIAAVFIIWPESIADLFQLDNGENNMSALLTSVIWVVALCFVVDAWQLLAINLLRGMKIVSLPTVMTAIGYWVCGLPAA
WYLMPIFGLSGIWAGIGIGLGVTGILLLVQLLISIARVKTHYQEIEN

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=441, Percent_Identity=24.0362811791383, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48363; Mature: 48363

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILTLAFPLIVSQLISMALVLTDVWMMSRLSVSALAGGGLGASVYFFIFIVASSTVGC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHH
VANLIAIAYGQRLARPEFGNQQIRLAIKGAVLLSVILSVILLFAFSYAPNVLRLAGQPEE
HHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHH
MISLAMEYVDALKWAMFPSLILLVLRGLTSALGNVRSIMVMSVITVVLNVPISYVLTFQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
GMGLYGLGLGTAVAALMVMLGYGLWVFKQQEYKPFAPWLNLEEYSIKLITPLLVMGLPIA
HCCHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VAALLEHGLIYGGTLMAGTISIASLALHQILLQCLSFTWNFNFGFSQAAAILVGRDFGAN
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEECCCCCC
NVDGIKKTSQHSFVLVTVMSVFIAAVFIIWPESIADLFQLDNGENNMSALLTSVIWVVAL
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
CFVVDAWQLLAINLLRGMKIVSLPTVMTAIGYWVCGLPAAWYLMPIFGLSGIWAGIGIGL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVTGILLLVQLLISIARVKTHYQEIEN
HHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKILTLAFPLIVSQLISMALVLTDVWMMSRLSVSALAGGGLGASVYFFIFIVASSTVGC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHH
VANLIAIAYGQRLARPEFGNQQIRLAIKGAVLLSVILSVILLFAFSYAPNVLRLAGQPEE
HHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHH
MISLAMEYVDALKWAMFPSLILLVLRGLTSALGNVRSIMVMSVITVVLNVPISYVLTFQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
GMGLYGLGLGTAVAALMVMLGYGLWVFKQQEYKPFAPWLNLEEYSIKLITPLLVMGLPIA
HCCHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VAALLEHGLIYGGTLMAGTISIASLALHQILLQCLSFTWNFNFGFSQAAAILVGRDFGAN
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEECCCCCC
NVDGIKKTSQHSFVLVTVMSVFIAAVFIIWPESIADLFQLDNGENNMSALLTSVIWVVAL
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
CFVVDAWQLLAINLLRGMKIVSLPTVMTAIGYWVCGLPAAWYLMPIFGLSGIWAGIGIGL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVTGILLLVQLLISIARVKTHYQEIEN
HHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]