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The map label for this gene is pyrD [H]

Identifier: 59711892

GI number: 59711892

Start: 1433805

End: 1434815

Strand: Direct

Name: pyrD [H]

Synonym: VF_1285

Alternate gene names: 59711892

Gene position: 1433805-1434815 (Clockwise)

Preceding gene: 59711891

Following gene: 59711893

Centisome position: 49.48

GC content: 39.17

Gene sequence:

>1011_bases
ATGTTATATCGCATCGCCAGAGCTGGCATTTTCAAACTTGATGCTGAAAAAGCACATGACCTAGCAATTCAAAATTTCAA
ACGCTTCAACGGCACTCCTCTTGATATCTTCTATCGTCAAAACCTTGCTTCTAAACCGGTAGAAGTGATGGGTATTAAAT
TCAAAAATCCTGTTGGCCTTGCTGCTGGCCTTGATAAAAACGGTGAATGTATTGAAGCATTTGGCGCTATGGGTTTTGGA
TTTGTAGAAGTCGGCACTGTAACACCTCGTCCTCAATCTGGTAATGATAAACCACGCTTGTTCCGTCTTATTGAAGCTGA
AGGTATTATCAACCGTATGGGATTTAATAACCTAGGCGTAGATAACCTTGTTGAGAACGTTAAGAAAGCAAAATACGATG
GCGTTATCGGCATTAACATTGGTAAAAACAAGGATACACCAATTGAAAAGGGCACGGAAGATTACCTAATCTGTATGGAA
AAGGTATATCAATATGCCGGTTATATCGCGGTGAATATTTCATCTCCAAATACTCCAGGACTTCGAACTCTTCAATATGG
TGAAGCGTTAGATGATCTCTTATCTCAATTAAAAGAGAAACAAAAAGAGTTAGCAGAGAAATACGGTAAGTATGTTCCTG
TTGCACTTAAGATCGCTCCGGATCTAGAAGACGATGAATTGACACAAATTGCTGAATCATTGATCAAATATAAAATTGAT
GGGGTGATTGCAACAAACACAACATTAGATCGTTCTATGGTTGAAGGCATGAAGCATGCTGAAGAGATGGGTGGCTTAAG
TGGTCGTCCTGTTCAAACACGTAGTACTGAAGTTGTTCGTCGCCTTAAAGAATTACTTGGCGATAATCTACCAATTATTG
GAGTAGGTGGTATTGACTCTTATGTAGCAGCAAAAGAGAAGATGGTTGCTGGTGCAGAGCTAGTTCAAGTCTATTCTGGC
TTTATTTATAAAGGTCCAGGTCTGGTTCGAGATATTGTTAACAATATTTAA

Upstream 100 bases:

>100_bases
CAATAATTAATTATGAATAAAGTACGATTAAGTTTGAATTGTGAATAAAATCAGTGAATAATGTCTCCCCGTTTATACGG
GACTTAATTTTGGAGTTACA

Downstream 100 bases:

>100_bases
GGTTAAAATTTCAACAGTAAGTTGATTACAAGTGATTTTAATAAAGGGGAGAATAATATTTTCCCCTTTTTTTATTGCTA
ACCTCTTGTAAAATTAACAG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLYRIARAGIFKLDAEKAHDLAIQNFKRFNGTPLDIFYRQNLASKPVEVMGIKFKNPVGLAAGLDKNGECIEAFGAMGFG
FVEVGTVTPRPQSGNDKPRLFRLIEAEGIINRMGFNNLGVDNLVENVKKAKYDGVIGINIGKNKDTPIEKGTEDYLICME
KVYQYAGYIAVNISSPNTPGLRTLQYGEALDDLLSQLKEKQKELAEKYGKYVPVALKIAPDLEDDELTQIAESLIKYKID
GVIATNTTLDRSMVEGMKHAEEMGGLSGRPVQTRSTEVVRRLKELLGDNLPIIGVGGIDSYVAAKEKMVAGAELVQVYSG
FIYKGPGLVRDIVNNI

Sequences:

>Translated_336_residues
MLYRIARAGIFKLDAEKAHDLAIQNFKRFNGTPLDIFYRQNLASKPVEVMGIKFKNPVGLAAGLDKNGECIEAFGAMGFG
FVEVGTVTPRPQSGNDKPRLFRLIEAEGIINRMGFNNLGVDNLVENVKKAKYDGVIGINIGKNKDTPIEKGTEDYLICME
KVYQYAGYIAVNISSPNTPGLRTLQYGEALDDLLSQLKEKQKELAEKYGKYVPVALKIAPDLEDDELTQIAESLIKYKID
GVIATNTTLDRSMVEGMKHAEEMGGLSGRPVQTRSTEVVRRLKELLGDNLPIIGVGGIDSYVAAKEKMVAGAELVQVYSG
FIYKGPGLVRDIVNNI
>Mature_336_residues
MLYRIARAGIFKLDAEKAHDLAIQNFKRFNGTPLDIFYRQNLASKPVEVMGIKFKNPVGLAAGLDKNGECIEAFGAMGFG
FVEVGTVTPRPQSGNDKPRLFRLIEAEGIINRMGFNNLGVDNLVENVKKAKYDGVIGINIGKNKDTPIEKGTEDYLICME
KVYQYAGYIAVNISSPNTPGLRTLQYGEALDDLLSQLKEKQKELAEKYGKYVPVALKIAPDLEDDELTQIAESLIKYKID
GVIATNTTLDRSMVEGMKHAEEMGGLSGRPVQTRSTEVVRRLKELLGDNLPIIGVGGIDSYVAAKEKMVAGAELVQVYSG
FIYKGPGLVRDIVNNI

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=328, Percent_Identity=42.6829268292683, Blast_Score=227, Evalue=1e-59,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=68.1547619047619, Blast_Score=500, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17509475, Length=322, Percent_Identity=42.2360248447205, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI281361352, Length=329, Percent_Identity=42.8571428571429, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI17137316, Length=329, Percent_Identity=42.8571428571429, Blast_Score=248, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36925; Mature: 36925

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYRIARAGIFKLDAEKAHDLAIQNFKRFNGTPLDIFYRQNLASKPVEVMGIKFKNPVGL
CCEEECCCCEEEECHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCCCE
AAGLDKNGECIEAFGAMGFGFVEVGTVTPRPQSGNDKPRLFRLIEAEGIINRMGFNNLGV
EECCCCCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
DNLVENVKKAKYDGVIGINIGKNKDTPIEKGTEDYLICMEKVYQYAGYIAVNISSPNTPG
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCC
LRTLQYGEALDDLLSQLKEKQKELAEKYGKYVPVALKIAPDLEDDELTQIAESLIKYKID
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHC
GVIATNTTLDRSMVEGMKHAEEMGGLSGRPVQTRSTEVVRRLKELLGDNLPIIGVGGIDS
CEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHH
YVAAKEKMVAGAELVQVYSGFIYKGPGLVRDIVNNI
HHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHCC
>Mature Secondary Structure
MLYRIARAGIFKLDAEKAHDLAIQNFKRFNGTPLDIFYRQNLASKPVEVMGIKFKNPVGL
CCEEECCCCEEEECHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCCCE
AAGLDKNGECIEAFGAMGFGFVEVGTVTPRPQSGNDKPRLFRLIEAEGIINRMGFNNLGV
EECCCCCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
DNLVENVKKAKYDGVIGINIGKNKDTPIEKGTEDYLICMEKVYQYAGYIAVNISSPNTPG
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCC
LRTLQYGEALDDLLSQLKEKQKELAEKYGKYVPVALKIAPDLEDDELTQIAESLIKYKID
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHC
GVIATNTTLDRSMVEGMKHAEEMGGLSGRPVQTRSTEVVRRLKELLGDNLPIIGVGGIDS
CEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHH
YVAAKEKMVAGAELVQVYSGFIYKGPGLVRDIVNNI
HHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA