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The map label for this gene is tyrP-A [H]

Identifier: 59711779

GI number: 59711779

Start: 1302304

End: 1303470

Strand: Direct

Name: tyrP-A [H]

Synonym: VF_1172

Alternate gene names: 59711779

Gene position: 1302304-1303470 (Clockwise)

Preceding gene: 59711778

Following gene: 59711780

Centisome position: 44.95

GC content: 33.25

Gene sequence:

>1167_bases
ATGAATTTTAAATTATTTGGTAGTGCGTTAATTTTATCTGGTACAGCATTAGGCGCAGGGATGCTGGCTATCCCTATGGT
ATTGGCACAGTTTGGATTGTTTTATAGCACTCTACTAATGTTGATTATCTGTGCAGGAACAACATACGCAGCTTTGCTAT
TAACAGAAGCATGTTCAAAAACAGAATTAGCATTTGGGATTAATACTGTAGCAAATAAGACCATTGGTAAAGGTGGTCAA
CTTGTTACTAATGCTCTGTTCTATCTTTTATTATTTTGCATGTTAATTGCTTATATTTTAGGGGCAGCAGATTTAATTAA
ACGTATATTTTCTATGATGAATGTAGAAATGAGCATTGAATTTGCTCAGGTTGCATTCACCTTGTTTGCGAGTGCTTTTG
TTGTTTGTGGAACACAAATTATTGATAAGCTAAATCGACTGTTGTTTTTCTTTATGATTTCCATGTTGGTGTTGACTTTA
ATCATTCTAATTCCAGGTATGACAGTGGAAAATCTATCGCAAGTAACAAACCATGATAAAGGTATGCTATTTGATACCAG
CACGATTTTGTTTACTAGCTTTGCCTCTATGCCAGTAATTCCTTCGTTAGTTGCTTATAATAAGGAAGCGACAAAACAAC
AATTGCGAAATATGGTTATTCTAGGATCGATCATTCCATTGATCTGTTATTTAGTATGGCTATATGCGGTTGTTGGTAAC
TTAACAGCAAATGAAATTACGCATTTTTCTAATATCTCTGATTTGATTCAAACATTCAGTGCGAAGAATGAATATATTGA
AATTATTCTGTCGATTTTCACATCATTAGCATTATTGACTTCTTTCCTTGGTGTGGCGATGGCTTTATATAATCAAAATA
AAGATATGATTTCACATAATAAGATTGTGACATATGTGTGCACGTTTATTTTGCCTTTATTAGGTGCTGGTTTAGCGGCT
GATCAATTCTTATCTGTACTTGGTTATGCTGGTGTTATCTTGGTTTTCTTAGCTATTTTTATTCCATTAGCAATGGTTGT
AACGTTAAGAAAAAAAGAGACAGAGGAAGTGCATCAAAACCTTCATATTTATACAGCTGAAGGTGGTAAATTAGCTCTTG
GTTTAACTCTTTTATTTGGTTTATTGCTATTAATTAGCCAAATTTAA

Upstream 100 bases:

>100_bases
CTTATTTACGGTGTTGTCACATACTATGAATAAGAGCACATCATATCGACAATCTAATTACAGTGTTGATATAAATTTGT
TTCAAAAAGAATGATATACA

Downstream 100 bases:

>100_bases
TAGATATTATGATCTGACCTGATACAGTTAACGTAATAGTTAAAGAATATTTACTGTAGAAGGTCAGCATTATGAAATAC
TTAATTATTGCATTTTCTGC

Product: tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease 1 [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNFKLFGSALILSGTALGAGMLAIPMVLAQFGLFYSTLLMLIICAGTTYAALLLTEACSKTELAFGINTVANKTIGKGGQ
LVTNALFYLLLFCMLIAYILGAADLIKRIFSMMNVEMSIEFAQVAFTLFASAFVVCGTQIIDKLNRLLFFFMISMLVLTL
IILIPGMTVENLSQVTNHDKGMLFDTSTILFTSFASMPVIPSLVAYNKEATKQQLRNMVILGSIIPLICYLVWLYAVVGN
LTANEITHFSNISDLIQTFSAKNEYIEIILSIFTSLALLTSFLGVAMALYNQNKDMISHNKIVTYVCTFILPLLGAGLAA
DQFLSVLGYAGVILVFLAIFIPLAMVVTLRKKETEEVHQNLHIYTAEGGKLALGLTLLFGLLLLISQI

Sequences:

>Translated_388_residues
MNFKLFGSALILSGTALGAGMLAIPMVLAQFGLFYSTLLMLIICAGTTYAALLLTEACSKTELAFGINTVANKTIGKGGQ
LVTNALFYLLLFCMLIAYILGAADLIKRIFSMMNVEMSIEFAQVAFTLFASAFVVCGTQIIDKLNRLLFFFMISMLVLTL
IILIPGMTVENLSQVTNHDKGMLFDTSTILFTSFASMPVIPSLVAYNKEATKQQLRNMVILGSIIPLICYLVWLYAVVGN
LTANEITHFSNISDLIQTFSAKNEYIEIILSIFTSLALLTSFLGVAMALYNQNKDMISHNKIVTYVCTFILPLLGAGLAA
DQFLSVLGYAGVILVFLAIFIPLAMVVTLRKKETEEVHQNLHIYTAEGGKLALGLTLLFGLLLLISQI
>Mature_388_residues
MNFKLFGSALILSGTALGAGMLAIPMVLAQFGLFYSTLLMLIICAGTTYAALLLTEACSKTELAFGINTVANKTIGKGGQ
LVTNALFYLLLFCMLIAYILGAADLIKRIFSMMNVEMSIEFAQVAFTLFASAFVVCGTQIIDKLNRLLFFFMISMLVLTL
IILIPGMTVENLSQVTNHDKGMLFDTSTILFTSFASMPVIPSLVAYNKEATKQQLRNMVILGSIIPLICYLVWLYAVVGN
LTANEITHFSNISDLIQTFSAKNEYIEIILSIFTSLALLTSFLGVAMALYNQNKDMISHNKIVTYVCTFILPLLGAGLAA
DQFLSVLGYAGVILVFLAIFIPLAMVVTLRKKETEEVHQNLHIYTAEGGKLALGLTLLFGLLLLISQI

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=393, Percent_Identity=31.8066157760814, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1790145, Length=398, Percent_Identity=24.3718592964824, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789552, Length=375, Percent_Identity=22.9333333333333, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42368; Mature: 42368

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFKLFGSALILSGTALGAGMLAIPMVLAQFGLFYSTLLMLIICAGTTYAALLLTEACSK
CCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
TELAFGINTVANKTIGKGGQLVTNALFYLLLFCMLIAYILGAADLIKRIFSMMNVEMSIE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
FAQVAFTLFASAFVVCGTQIIDKLNRLLFFFMISMLVLTLIILIPGMTVENLSQVTNHDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
GMLFDTSTILFTSFASMPVIPSLVAYNKEATKQQLRNMVILGSIIPLICYLVWLYAVVGN
CCEEEHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LTANEITHFSNISDLIQTFSAKNEYIEIILSIFTSLALLTSFLGVAMALYNQNKDMISHN
CHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
KIVTYVCTFILPLLGAGLAADQFLSVLGYAGVILVFLAIFIPLAMVVTLRKKETEEVHQN
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LHIYTAEGGKLALGLTLLFGLLLLISQI
CEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFKLFGSALILSGTALGAGMLAIPMVLAQFGLFYSTLLMLIICAGTTYAALLLTEACSK
CCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
TELAFGINTVANKTIGKGGQLVTNALFYLLLFCMLIAYILGAADLIKRIFSMMNVEMSIE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
FAQVAFTLFASAFVVCGTQIIDKLNRLLFFFMISMLVLTLIILIPGMTVENLSQVTNHDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
GMLFDTSTILFTSFASMPVIPSLVAYNKEATKQQLRNMVILGSIIPLICYLVWLYAVVGN
CCEEEHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LTANEITHFSNISDLIQTFSAKNEYIEIILSIFTSLALLTSFLGVAMALYNQNKDMISHN
CHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
KIVTYVCTFILPLLGAGLAADQFLSVLGYAGVILVFLAIFIPLAMVVTLRKKETEEVHQN
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LHIYTAEGGKLALGLTLLFGLLLLISQI
CEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]