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The map label for this gene is tyrP [H]

Identifier: 59711778

GI number: 59711778

Start: 1301038

End: 1302192

Strand: Direct

Name: tyrP [H]

Synonym: VF_1171

Alternate gene names: 59711778

Gene position: 1301038-1302192 (Clockwise)

Preceding gene: 59711777

Following gene: 59711779

Centisome position: 44.9

GC content: 37.58

Gene sequence:

>1155_bases
GTGAATTTAAAATTAATCGGAAGCTCACTTATTATTTCAGGTACTGCGCTAGGCGCTGGTATGCTGGCAATCCCAATGGT
ATTGGCTCAATTTGGCCTACTTTGGGGTACTGCTCTAATGTTGTTTATCTGTCTTGGAACAACATATGCCGCTTTATTGC
TGCTAGAAGCGAGTATTAATGTTGGTGGTGGTTTAGGTATGAACACCATCGCTCGTAAAAGTTTAGGTAAAAGTGGACAA
ATTATTACTAATGGTCTGCTTTATGCGCTTTTAATCTGCTTATTAATGGCTTACATCTTAGGTGCTGGTGATCTATTAAA
TAAGCTGTTGCGTGGTATTGGTGTTGAGTTGTCACTCATTCAAAGCCAGATTGCATTTACATTGGTTGCCGGCATTATTG
TTGCTTCGGGAACTGCAGTTATCGATAAATTAAACCGTGTTTTATTTGGCATTATGCTGCTGATGCTTGTTTTAACGCTT
GTATTTTTAGTTCCTGACATATCGTTTGAGAATATGACACAAGTGACGAATTCAAGTACGACCGATTTAGTTAAAACCAG
TGCAATTATTTTTACCAGTTTTGGTTTTATGGTTGTTATCCCATCATTAGTGTCTTACAACCATGACGCAACACCAAAGC
AACTGAGAAATATGGTTATTCTTGGTTCATTAATCCCATTAGTTTGTTACCTAGTATGGCTTTATGCTGTGGTTGGTAAT
TTAACGGCTGAACAACTGATTCATTTTACAAATGTCTCTGAGTTAATCTCTGTATTTAGTGCAGAACATGCATTTATTAG
TGTTGTGTTATCTGGTTTTACAGGTCTTGCTTTATTAACCTCATTCTTAGGTGTAGCAATGGCGCTTTTCACTCAAAACC
AAGATATGTTTAAACAGAACAAAGTAGTAACTTATGTTATTAGTTTTATTCTGCCACTGACTGGCGCTATTTATGCGGCT
GATCAATTCTTATCTGTTTTAAGCTACGCAGGGATCATCTTAGTTTTCTTAGCGGTCTTTGTACCTCTTGCAATGGTGGT
AAAACTAAGAAAATCAGAGAATGCCGAGAAAACATACATTGCGGAGGGTGGGGTAGCTATGCTGACTTTCTCTTTTGCTT
TTGGTGGTTTTCTTCTGATTTCACAAGTGATCTAA

Upstream 100 bases:

>100_bases
TAATTTCAACCGCGTTATCTTTGTGGGTAATTTCTTGCGCGTTGAATTTGACAAAAAATAAAACTAAAGCTCAAACTCGA
ATAAAAGTAAGGGAAACATT

Downstream 100 bases:

>100_bases
TGTTATAAGCTCTTATTTACGGTGTTGTCACATACTATGAATAAGAGCACATCATATCGACAATCTAATTACAGTGTTGA
TATAAATTTGTTTCAAAAAG

Product: tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNLKLIGSSLIISGTALGAGMLAIPMVLAQFGLLWGTALMLFICLGTTYAALLLLEASINVGGGLGMNTIARKSLGKSGQ
IITNGLLYALLICLLMAYILGAGDLLNKLLRGIGVELSLIQSQIAFTLVAGIIVASGTAVIDKLNRVLFGIMLLMLVLTL
VFLVPDISFENMTQVTNSSTTDLVKTSAIIFTSFGFMVVIPSLVSYNHDATPKQLRNMVILGSLIPLVCYLVWLYAVVGN
LTAEQLIHFTNVSELISVFSAEHAFISVVLSGFTGLALLTSFLGVAMALFTQNQDMFKQNKVVTYVISFILPLTGAIYAA
DQFLSVLSYAGIILVFLAVFVPLAMVVKLRKSENAEKTYIAEGGVAMLTFSFAFGGFLLISQVI

Sequences:

>Translated_384_residues
MNLKLIGSSLIISGTALGAGMLAIPMVLAQFGLLWGTALMLFICLGTTYAALLLLEASINVGGGLGMNTIARKSLGKSGQ
IITNGLLYALLICLLMAYILGAGDLLNKLLRGIGVELSLIQSQIAFTLVAGIIVASGTAVIDKLNRVLFGIMLLMLVLTL
VFLVPDISFENMTQVTNSSTTDLVKTSAIIFTSFGFMVVIPSLVSYNHDATPKQLRNMVILGSLIPLVCYLVWLYAVVGN
LTAEQLIHFTNVSELISVFSAEHAFISVVLSGFTGLALLTSFLGVAMALFTQNQDMFKQNKVVTYVISFILPLTGAIYAA
DQFLSVLSYAGIILVFLAVFVPLAMVVKLRKSENAEKTYIAEGGVAMLTFSFAFGGFLLISQVI
>Mature_384_residues
MNLKLIGSSLIISGTALGAGMLAIPMVLAQFGLLWGTALMLFICLGTTYAALLLLEASINVGGGLGMNTIARKSLGKSGQ
IITNGLLYALLICLLMAYILGAGDLLNKLLRGIGVELSLIQSQIAFTLVAGIIVASGTAVIDKLNRVLFGIMLLMLVLTL
VFLVPDISFENMTQVTNSSTTDLVKTSAIIFTSFGFMVVIPSLVSYNHDATPKQLRNMVILGSLIPLVCYLVWLYAVVGN
LTAEQLIHFTNVSELISVFSAEHAFISVVLSGFTGLALLTSFLGVAMALFTQNQDMFKQNKVVTYVISFILPLTGAIYAA
DQFLSVLSYAGIILVFLAVFVPLAMVVKLRKSENAEKTYIAEGGVAMLTFSFAFGGFLLISQVI

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=391, Percent_Identity=35.5498721227622, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1789552, Length=370, Percent_Identity=24.8648648648649, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790145, Length=363, Percent_Identity=26.4462809917355, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 40994; Mature: 40994

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKLIGSSLIISGTALGAGMLAIPMVLAQFGLLWGTALMLFICLGTTYAALLLLEASIN
CCCEEECCHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VGGGLGMNTIARKSLGKSGQIITNGLLYALLICLLMAYILGAGDLLNKLLRGIGVELSLI
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHH
QSQIAFTLVAGIIVASGTAVIDKLNRVLFGIMLLMLVLTLVFLVPDISFENMTQVTNSST
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCH
TDLVKTSAIIFTSFGFMVVIPSLVSYNHDATPKQLRNMVILGSLIPLVCYLVWLYAVVGN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LTAEQLIHFTNVSELISVFSAEHAFISVVLSGFTGLALLTSFLGVAMALFTQNQDMFKQN
CHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
KVVTYVISFILPLTGAIYAADQFLSVLSYAGIILVFLAVFVPLAMVVKLRKSENAEKTYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
AEGGVAMLTFSFAFGGFLLISQVI
ECCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLKLIGSSLIISGTALGAGMLAIPMVLAQFGLLWGTALMLFICLGTTYAALLLLEASIN
CCCEEECCHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VGGGLGMNTIARKSLGKSGQIITNGLLYALLICLLMAYILGAGDLLNKLLRGIGVELSLI
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHH
QSQIAFTLVAGIIVASGTAVIDKLNRVLFGIMLLMLVLTLVFLVPDISFENMTQVTNSST
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCH
TDLVKTSAIIFTSFGFMVVIPSLVSYNHDATPKQLRNMVILGSLIPLVCYLVWLYAVVGN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LTAEQLIHFTNVSELISVFSAEHAFISVVLSGFTGLALLTSFLGVAMALFTQNQDMFKQN
CHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
KVVTYVISFILPLTGAIYAADQFLSVLSYAGIILVFLAVFVPLAMVVKLRKSENAEKTYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
AEGGVAMLTFSFAFGGFLLISQVI
ECCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]