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The map label for this gene is tolC [H]

Identifier: 59711769

GI number: 59711769

Start: 1288784

End: 1290064

Strand: Direct

Name: tolC [H]

Synonym: VF_1162

Alternate gene names: 59711769

Gene position: 1288784-1290064 (Clockwise)

Preceding gene: 59711768

Following gene: 59711770

Centisome position: 44.48

GC content: 37.39

Gene sequence:

>1281_bases
ATGCGTGATAAATTCTCAGAAAAGATGCTCTTCGTTTTTTGGGCTCTTATTGCTAGTGGCTTAAGTTCTATGAGTTATGC
GTTAACTATTGAAGATGCATGGCAAGCGACAAAGCAATATGATCCAGAGTATTTACGGTCGCAATTAGATGAAAAGATAA
GTGAAACTACAATACGATCAAGTAAAAGTGCTCTACTTCCGAGTGCTAGGATTACCGCAACTACGGCTTGGAATGAAAAT
AGTACTTATGGTATTGCTCTAGAGCAAATCATTTGGGACAGCAGTAAATGGTCAGAACTTGATAGTTCTCAAGCTTCATT
ATTGGCTTCTCAATTGAAAATAAAACAGAGTCATAATGAACTAGCTGGACGATTAATTAGTGCATATCTTGATCTTGCCC
AGTCTCAAGGGGAGCTTCGTTTAGCGCAGCAAAAGTTTGATGAAGGCAGAAAGATGTTACGTATCGTTGAGCTACGTTAC
AAGGCTGGGAAAATTAGATCTGTTGATTTGGAGGATATGCGTTCTAATCATCTTGACGAAGAAGCAAATATATTAGCGAA
TCGATTACAAGTTGAAGACAAGAAAGTTCGTTTGATTAAGCTAATTAGTATAGAACCCACCCAAGTTAATGAAATTAAGA
CCAATAACCTATCACAACCAAAATTGATTGTGAACAGTAAGCAAGAGTGGCTGAAATTAGCAAGTAATTATAGCCCTGAT
CTATTAATGGCAAAACAAAATATTCGAATTTCTGAATTGGAAACAGGAAAGGCCAAAACGGGTTATTACCCTACGATCAC
CGCCTCAGTAGGATACAGCGATAATACTCGCTCAGATAATACTCGTTCAGATAGTGGACTGAATGCGAGCTTAAATTTGA
GTTTACCGCTTGATTTAAATAGTTCAATAGGATCCAGTGTTGAGCGTGCTAAGTTAGAAGTTCTCCGTGCTAAACAAGAT
GTTCGAGCGGTAGAGATTGAAATAAAAAGTACTATTTCTAACCGTTTTAATCAGCTATCTTTGAATTGGCAACGAGTTGA
AATGGCAGAGAAACAAGTCGCGTCGAAGGAGCTAGTTTTAAAAAGTAAACAAGCCATTTATAAAGCTGGAATGGCAGAAG
CGTCTGATATTATTGAGGCGCATAATAGTTTGTTTGTTAGTAAAAGCTCTTTACAATCATTGCTTTATCAATATTGGAGG
GATCGTATTTCCTTACTTAAGTCTGTCGGTAGATTAGATGATGAAACTATAACCTTGATTTCACAGGCACTGCAATCATG
A

Upstream 100 bases:

>100_bases
GTGACGCTCGGCTTATCTGACGGAGTCATGGTAGAAGTACTTTCTGGGTTAGAAGAGGGTGAAGAGATTGTCGATATGAG
CATGATGATAGGTGAGCTAA

Downstream 100 bases:

>100_bases
TGGCGTTATTCTCTCAAACAATTCAAACTTTATTGGCTCATCGTTTGAGAGGTTTTTTGGCTATCCTAGCTATTGTATGG
GGAATTATTTCAGTTTTGGT

Product: outer membrane protein TolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MRDKFSEKMLFVFWALIASGLSSMSYALTIEDAWQATKQYDPEYLRSQLDEKISETTIRSSKSALLPSARITATTAWNEN
STYGIALEQIIWDSSKWSELDSSQASLLASQLKIKQSHNELAGRLISAYLDLAQSQGELRLAQQKFDEGRKMLRIVELRY
KAGKIRSVDLEDMRSNHLDEEANILANRLQVEDKKVRLIKLISIEPTQVNEIKTNNLSQPKLIVNSKQEWLKLASNYSPD
LLMAKQNIRISELETGKAKTGYYPTITASVGYSDNTRSDNTRSDSGLNASLNLSLPLDLNSSIGSSVERAKLEVLRAKQD
VRAVEIEIKSTISNRFNQLSLNWQRVEMAEKQVASKELVLKSKQAIYKAGMAEASDIIEAHNSLFVSKSSLQSLLYQYWR
DRISLLKSVGRLDDETITLISQALQS

Sequences:

>Translated_426_residues
MRDKFSEKMLFVFWALIASGLSSMSYALTIEDAWQATKQYDPEYLRSQLDEKISETTIRSSKSALLPSARITATTAWNEN
STYGIALEQIIWDSSKWSELDSSQASLLASQLKIKQSHNELAGRLISAYLDLAQSQGELRLAQQKFDEGRKMLRIVELRY
KAGKIRSVDLEDMRSNHLDEEANILANRLQVEDKKVRLIKLISIEPTQVNEIKTNNLSQPKLIVNSKQEWLKLASNYSPD
LLMAKQNIRISELETGKAKTGYYPTITASVGYSDNTRSDNTRSDSGLNASLNLSLPLDLNSSIGSSVERAKLEVLRAKQD
VRAVEIEIKSTISNRFNQLSLNWQRVEMAEKQVASKELVLKSKQAIYKAGMAEASDIIEAHNSLFVSKSSLQSLLYQYWR
DRISLLKSVGRLDDETITLISQALQS
>Mature_426_residues
MRDKFSEKMLFVFWALIASGLSSMSYALTIEDAWQATKQYDPEYLRSQLDEKISETTIRSSKSALLPSARITATTAWNEN
STYGIALEQIIWDSSKWSELDSSQASLLASQLKIKQSHNELAGRLISAYLDLAQSQGELRLAQQKFDEGRKMLRIVELRY
KAGKIRSVDLEDMRSNHLDEEANILANRLQVEDKKVRLIKLISIEPTQVNEIKTNNLSQPKLIVNSKQEWLKLASNYSPD
LLMAKQNIRISELETGKAKTGYYPTITASVGYSDNTRSDNTRSDSGLNASLNLSLPLDLNSSIGSSVERAKLEVLRAKQD
VRAVEIEIKSTISNRFNQLSLNWQRVEMAEKQVASKELVLKSKQAIYKAGMAEASDIIEAHNSLFVSKSSLQSLLYQYWR
DRISLLKSVGRLDDETITLISQALQS

Specific function: Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI87082199, Length=424, Percent_Identity=21.9339622641509, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 48081; Mature: 48081

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDKFSEKMLFVFWALIASGLSSMSYALTIEDAWQATKQYDPEYLRSQLDEKISETTIRS
CCCCHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
SKSALLPSARITATTAWNENSTYGIALEQIIWDSSKWSELDSSQASLLASQLKIKQSHNE
CHHHCCCCCCEEEEEECCCCCEEHEEHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
LAGRLISAYLDLAQSQGELRLAQQKFDEGRKMLRIVELRYKAGKIRSVDLEDMRSNHLDE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHCCCCH
EANILANRLQVEDKKVRLIKLISIEPTQVNEIKTNNLSQPKLIVNSKQEWLKLASNYSPD
HHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCC
LLMAKQNIRISELETGKAKTGYYPTITASVGYSDNTRSDNTRSDSGLNASLNLSLPLDLN
EEEEECCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCC
SSIGSSVERAKLEVLRAKQDVRAVEIEIKSTISNRFNQLSLNWQRVEMAEKQVASKELVL
CHHCCHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KSKQAIYKAGMAEASDIIEAHNSLFVSKSSLQSLLYQYWRDRISLLKSVGRLDDETITLI
HHHHHHHHHCCHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
SQALQS
HHHHCC
>Mature Secondary Structure
MRDKFSEKMLFVFWALIASGLSSMSYALTIEDAWQATKQYDPEYLRSQLDEKISETTIRS
CCCCHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
SKSALLPSARITATTAWNENSTYGIALEQIIWDSSKWSELDSSQASLLASQLKIKQSHNE
CHHHCCCCCCEEEEEECCCCCEEHEEHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
LAGRLISAYLDLAQSQGELRLAQQKFDEGRKMLRIVELRYKAGKIRSVDLEDMRSNHLDE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHCCCCH
EANILANRLQVEDKKVRLIKLISIEPTQVNEIKTNNLSQPKLIVNSKQEWLKLASNYSPD
HHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCC
LLMAKQNIRISELETGKAKTGYYPTITASVGYSDNTRSDNTRSDSGLNASLNLSLPLDLN
EEEEECCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCC
SSIGSSVERAKLEVLRAKQDVRAVEIEIKSTISNRFNQLSLNWQRVEMAEKQVASKELVL
CHHCCHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KSKQAIYKAGMAEASDIIEAHNSLFVSKSSLQSLLYQYWRDRISLLKSVGRLDDETITLI
HHHHHHHHHCCHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
SQALQS
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8801424 [H]