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The map label for this gene is macA [H]

Identifier: 59711768

GI number: 59711768

Start: 1287634

End: 1288791

Strand: Direct

Name: macA [H]

Synonym: VF_1161

Alternate gene names: 59711768

Gene position: 1287634-1288791 (Clockwise)

Preceding gene: 59711767

Following gene: 59711769

Centisome position: 44.44

GC content: 36.27

Gene sequence:

>1158_bases
ATGAAATTGGCTATAAACAAATATTGGATTTATTTATTCTTATTTTCGTTTGTTGTTGTGAGTGTTGGGTATTATTTTGT
ACGAGTAGATTCACAACATAAAAAATTACCTTTTGTTGTTGCTTCTATTGGCTCTATAGAGAAAAAAGCAGTCGCTGTAG
GGCATATTGTTCCTGCCCACTCTATTTCAATTAAATCTCAAATTGATGGGATTGTTGGTGAGATTTATCACCAAGTTGGT
GAAGTGGTTGCGATAAACACTCCATTAATTAAAATCCGCCCAAATCCAACGCCAGCAAAGTTAATGTTAGCTAATACAGA
CTTAATGCAAAGTGAAGCAAAATTAGAGTTAGCGCAAAAAAAATTAGAGAATCTTAAACAGTTAGTTGAGCAAAATATAA
TACCTGAAAATTATGGAGGATATATTGAAGCTAAATCTGATGTGAAATCTAATAAGGCTAGTGTACAGCAAAAAAAACAG
AACCTAGATCTGATCCTTAGTGGCGAGTCATCTGCTGGTAATTCTAAATTGAATTCAACCATAGTTGCGCCAATTAATGG
AACTATATTGAATTTAAAAGTTGAAATTGGTGAACCAATTATATCTACAGCATCAAACCAAGCGGCAACTGTGATGATGT
CAATCGCAGATATGAGCGATATTATTTTCAAAGGCAGTGTCAGCGAACACGATGCGTCTCGATTAACCGTTGGAACTCCA
GCAACGGTTATTTTAGCCTCGTATCCAGATATTGTGGTGTCAGGGAAATTAAGGAAAGTTGCTGTGCAATCAGAAAAGTT
AAATTTGACCACAACCAATACTAGTACCAATAGTGTGAAAAGTTTTGATAATGGTTTTCAGGTTGAAGTCGATCAGATTC
AGTTTCCAAAGAACTTAACTATTCGCTCTGGTTTTTCAGCAACGGCTCAAATTATTCTTCAGCAATCCACTAATGTAATC
ATTATTCCAGAGCGTTCGTTACAATTTAAAGGAGGTGAAGCAGAAGTTTGGGTTATTGATGATAGCGAATATGGTTATTC
ATCTAGAGTTGTGACGCTCGGCTTATCTGACGGAGTCATGGTAGAAGTACTTTCTGGGTTAGAAGAGGGTGAAGAGATTG
TCGATATGAGCATGATGATAGGTGAGCTAAATGCGTGA

Upstream 100 bases:

>100_bases
TCATAAATTAGACTTAATTTCATTGATTGGTGTAAACACTATTGGTTCTAAATTACATATCTTTTGTCCATTAATTTTAG
TAAGGCCGTAGTAGATTATT

Downstream 100 bases:

>100_bases
TAAATTCTCAGAAAAGATGCTCTTCGTTTTTTGGGCTCTTATTGCTAGTGGCTTAAGTTCTATGAGTTATGCGTTAACTA
TTGAAGATGCATGGCAAGCG

Product: periplasmic component of efflux system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKLAINKYWIYLFLFSFVVVSVGYYFVRVDSQHKKLPFVVASIGSIEKKAVAVGHIVPAHSISIKSQIDGIVGEIYHQVG
EVVAINTPLIKIRPNPTPAKLMLANTDLMQSEAKLELAQKKLENLKQLVEQNIIPENYGGYIEAKSDVKSNKASVQQKKQ
NLDLILSGESSAGNSKLNSTIVAPINGTILNLKVEIGEPIISTASNQAATVMMSIADMSDIIFKGSVSEHDASRLTVGTP
ATVILASYPDIVVSGKLRKVAVQSEKLNLTTTNTSTNSVKSFDNGFQVEVDQIQFPKNLTIRSGFSATAQIILQQSTNVI
IIPERSLQFKGGEAEVWVIDDSEYGYSSRVVTLGLSDGVMVEVLSGLEEGEEIVDMSMMIGELNA

Sequences:

>Translated_385_residues
MKLAINKYWIYLFLFSFVVVSVGYYFVRVDSQHKKLPFVVASIGSIEKKAVAVGHIVPAHSISIKSQIDGIVGEIYHQVG
EVVAINTPLIKIRPNPTPAKLMLANTDLMQSEAKLELAQKKLENLKQLVEQNIIPENYGGYIEAKSDVKSNKASVQQKKQ
NLDLILSGESSAGNSKLNSTIVAPINGTILNLKVEIGEPIISTASNQAATVMMSIADMSDIIFKGSVSEHDASRLTVGTP
ATVILASYPDIVVSGKLRKVAVQSEKLNLTTTNTSTNSVKSFDNGFQVEVDQIQFPKNLTIRSGFSATAQIILQQSTNVI
IIPERSLQFKGGEAEVWVIDDSEYGYSSRVVTLGLSDGVMVEVLSGLEEGEEIVDMSMMIGELNA
>Mature_385_residues
MKLAINKYWIYLFLFSFVVVSVGYYFVRVDSQHKKLPFVVASIGSIEKKAVAVGHIVPAHSISIKSQIDGIVGEIYHQVG
EVVAINTPLIKIRPNPTPAKLMLANTDLMQSEAKLELAQKKLENLKQLVEQNIIPENYGGYIEAKSDVKSNKASVQQKKQ
NLDLILSGESSAGNSKLNSTIVAPINGTILNLKVEIGEPIISTASNQAATVMMSIADMSDIIFKGSVSEHDASRLTVGTP
ATVILASYPDIVVSGKLRKVAVQSEKLNLTTTNTSTNSVKSFDNGFQVEVDQIQFPKNLTIRSGFSATAQIILQQSTNVI
IIPERSLQFKGGEAEVWVIDDSEYGYSSRVVTLGLSDGVMVEVLSGLEEGEEIVDMSMMIGELNA

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=354, Percent_Identity=25.1412429378531, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87082036, Length=333, Percent_Identity=24.024024024024, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41806; Mature: 41806

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAINKYWIYLFLFSFVVVSVGYYFVRVDSQHKKLPFVVASIGSIEKKAVAVGHIVPAH
CEEEEHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEEECCCCCHHEEEEEEEECCC
SISIKSQIDGIVGEIYHQVGEVVAINTPLIKIRPNPTPAKLMLANTDLMQSEAKLELAQK
CEEHHHHHHHHHHHHHHHHCCEEEECCCEEEECCCCCCCEEEEECCHHHHHHHHHHHHHH
KLENLKQLVEQNIIPENYGGYIEAKSDVKSNKASVQQKKQNLDLILSGESSAGNSKLNST
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCE
IVAPINGTILNLKVEIGEPIISTASNQAATVMMSIADMSDIIFKGSVSEHDASRLTVGTP
EEEECCCEEEEEEEEECCCHHHCCCCCCEEEEEEHHCHHHHEEECCCCCCCCCEEEECCC
ATVILASYPDIVVSGKLRKVAVQSEKLNLTTTNTSTNSVKSFDNGFQVEVDQIQFPKNLT
CEEEEECCCCEEEECCEEEEEEECCEEEEEECCCCCCCHHHCCCCCEEEEEEEECCCCCE
IRSGFSATAQIILQQSTNVIIIPERSLQFKGGEAEVWVIDDSEYGYSSRVVTLGLSDGVM
EECCCCCEEEEEEECCCCEEEEECCCEEECCCCEEEEEEECCCCCCCCEEEEEECCCCHH
VEVLSGLEEGEEIVDMSMMIGELNA
HHHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLAINKYWIYLFLFSFVVVSVGYYFVRVDSQHKKLPFVVASIGSIEKKAVAVGHIVPAH
CEEEEHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEEECCCCCHHEEEEEEEECCC
SISIKSQIDGIVGEIYHQVGEVVAINTPLIKIRPNPTPAKLMLANTDLMQSEAKLELAQK
CEEHHHHHHHHHHHHHHHHCCEEEECCCEEEECCCCCCCEEEEECCHHHHHHHHHHHHHH
KLENLKQLVEQNIIPENYGGYIEAKSDVKSNKASVQQKKQNLDLILSGESSAGNSKLNST
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCE
IVAPINGTILNLKVEIGEPIISTASNQAATVMMSIADMSDIIFKGSVSEHDASRLTVGTP
EEEECCCEEEEEEEEECCCHHHCCCCCCEEEEEEHHCHHHHEEECCCCCCCCCEEEECCC
ATVILASYPDIVVSGKLRKVAVQSEKLNLTTTNTSTNSVKSFDNGFQVEVDQIQFPKNLT
CEEEEECCCCEEEECCEEEEEEECCEEEEEECCCCCCCHHHCCCCCEEEEEEEECCCCCE
IRSGFSATAQIILQQSTNVIIIPERSLQFKGGEAEVWVIDDSEYGYSSRVVTLGLSDGVM
EECCCCCEEEEEEECCCCEEEEECCCEEECCCCEEEEEEECCCCCCCCEEEEEECCCCHH
VEVLSGLEEGEEIVDMSMMIGELNA
HHHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]