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The map label for this gene is mtaD [H]

Identifier: 59711763

GI number: 59711763

Start: 1281304

End: 1282713

Strand: Direct

Name: mtaD [H]

Synonym: VF_1156

Alternate gene names: 59711763

Gene position: 1281304-1282713 (Clockwise)

Preceding gene: 59711760

Following gene: 59711764

Centisome position: 44.22

GC content: 39.36

Gene sequence:

>1410_bases
ATGTATTTACGAAAATCGCTAGTCGCTGCAGCCGTTGCAGCAAGCTCATTATTTTCTTTTTCTGCTGTTTCTGCACAACA
AGCAGACTTAATGATCACTGACGCAACAGTACTGACAATGAACGCTGCAAAAGACGTTTATGAAAATGGTGTTGTTGTGA
TTAAAGGCAATAAAATTTTAGCGGTAGGTACAGAGGAACTTGCTAAAAAATATTCAGCGAAAACCACATTAGATGTGGAT
GGCGATATTGTACTGCCAGGCTTAATTAATACCCATACGCATGCTTCAATGACGGTTTTCCGATCATTAGGTGATGACGT
TCCTGACCGTTTACACCGTTATATATTCCCTCTAGAAAAGAAATTAGTGTCACGTGATATGGTCCGTATTGGTGCTAATT
TGGGTAACGTTGAAATGGTAAAAGGTGGGGTGACCACTTATGCTGATATGTACTATTTTGAAGATGAAGTTGCAAAAACA
GTCGATAAGATTGGTATGCGTGCAATTTTAGGTGAGAGTGTTATTAAGTTCCCTGTTGCTGATGCAGCAAATGCCGACGA
GGGCATTCAATACGCCCTAAATTTTATCGAGGAATATAAAGATCACCCTCGTATTACACCAGCGTTTGCTCCTCATGCTC
CTTATACAAATACTACTGAAACACTGCAAAAAATTGCCAAGTTATCATTAGAGTTAGATGTTCCTGTTATGATTCATTTG
GCAGAATCTCATCGTGAAGAGGAGGTGATTGCCGAACGTTCTAATGGGATGTCTCCAGTCGAATATATGCACAGTATTGG
AGCGCTTAATAAGAACCTGATTGGCGCTCATATGATCTTAATTGATGACAAAGATATTGAGTTAGTAAAAGAAGCGGATA
TGGGTGTTGCTCACAATATGAGTGCAAACATTAAGTCTGCGAAAGGGGTATCACCAGCTCTGAAAATGTACGACGAGGAC
GTGCGTATTGGTTTAGGTACAGACGGTCCAATGTCAGGTAATACACTAAGCATTATTGATGAGTTTAACCAAGTAGCGAA
AGTTCATAAACTGGTGAATAAAGATCGTGCAGCAATGCCACCGTTAAAAGTCATTGATATGGCGACAATGGGTGCAGCAA
AAGCATTACATATGGAAGATAAGATAGGCTCGCTAGAAGTTGGGAAATTAGCAGATATCATTGTGGTAGATACCAAAGCA
CCAAATATGTTACCAGTTTACAACCCATATTCAGCGTTAGTTTACTCTGCTAACTCAGGGAATGTTCGCCATACAATTGT
GGATGGTGAAATTCTGATGAAAGATCGTGAACTATTAACGGTTAATGAAGATGAAATCCGTAAAGAACTGATTGAATTTA
CAAAGGTTGTTCGTAAAACTGTTATCGATAGCGGTGAAGTTGTTCAATAA

Upstream 100 bases:

>100_bases
GAAACTGTGATGTGTGCCATATCAATTAATCACAATGATCTTGATATAAAAGCAATAACGTATACCATTCCTGTCAATTT
TATTAATAACGAGTTGACCC

Downstream 100 bases:

>100_bases
TCTTTAATAAGAAAACGTTTGTTTAAAGCCAGTTGTTATTCAACTGGCTTTTTTGCTATTTGCGTAATGAAGTCTAAGAT
CAATATATACCAATCATGTA

Product: chlorohydrolase/deaminase family protein

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MYLRKSLVAAAVAASSLFSFSAVSAQQADLMITDATVLTMNAAKDVYENGVVVIKGNKILAVGTEELAKKYSAKTTLDVD
GDIVLPGLINTHTHASMTVFRSLGDDVPDRLHRYIFPLEKKLVSRDMVRIGANLGNVEMVKGGVTTYADMYYFEDEVAKT
VDKIGMRAILGESVIKFPVADAANADEGIQYALNFIEEYKDHPRITPAFAPHAPYTNTTETLQKIAKLSLELDVPVMIHL
AESHREEEVIAERSNGMSPVEYMHSIGALNKNLIGAHMILIDDKDIELVKEADMGVAHNMSANIKSAKGVSPALKMYDED
VRIGLGTDGPMSGNTLSIIDEFNQVAKVHKLVNKDRAAMPPLKVIDMATMGAAKALHMEDKIGSLEVGKLADIIVVDTKA
PNMLPVYNPYSALVYSANSGNVRHTIVDGEILMKDRELLTVNEDEIRKELIEFTKVVRKTVIDSGEVVQ

Sequences:

>Translated_469_residues
MYLRKSLVAAAVAASSLFSFSAVSAQQADLMITDATVLTMNAAKDVYENGVVVIKGNKILAVGTEELAKKYSAKTTLDVD
GDIVLPGLINTHTHASMTVFRSLGDDVPDRLHRYIFPLEKKLVSRDMVRIGANLGNVEMVKGGVTTYADMYYFEDEVAKT
VDKIGMRAILGESVIKFPVADAANADEGIQYALNFIEEYKDHPRITPAFAPHAPYTNTTETLQKIAKLSLELDVPVMIHL
AESHREEEVIAERSNGMSPVEYMHSIGALNKNLIGAHMILIDDKDIELVKEADMGVAHNMSANIKSAKGVSPALKMYDED
VRIGLGTDGPMSGNTLSIIDEFNQVAKVHKLVNKDRAAMPPLKVIDMATMGAAKALHMEDKIGSLEVGKLADIIVVDTKA
PNMLPVYNPYSALVYSANSGNVRHTIVDGEILMKDRELLTVNEDEIRKELIEFTKVVRKTVIDSGEVVQ
>Mature_469_residues
MYLRKSLVAAAVAASSLFSFSAVSAQQADLMITDATVLTMNAAKDVYENGVVVIKGNKILAVGTEELAKKYSAKTTLDVD
GDIVLPGLINTHTHASMTVFRSLGDDVPDRLHRYIFPLEKKLVSRDMVRIGANLGNVEMVKGGVTTYADMYYFEDEVAKT
VDKIGMRAILGESVIKFPVADAANADEGIQYALNFIEEYKDHPRITPAFAPHAPYTNTTETLQKIAKLSLELDVPVMIHL
AESHREEEVIAERSNGMSPVEYMHSIGALNKNLIGAHMILIDDKDIELVKEADMGVAHNMSANIKSAKGVSPALKMYDED
VRIGLGTDGPMSGNTLSIIDEFNQVAKVHKLVNKDRAAMPPLKVIDMATMGAAKALHMEDKIGSLEVGKLADIIVVDTKA
PNMLPVYNPYSALVYSANSGNVRHTIVDGEILMKDRELLTVNEDEIRKELIEFTKVVRKTVIDSGEVVQ

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=366, Percent_Identity=24.8633879781421, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1789249, Length=372, Percent_Identity=25, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17540282, Length=361, Percent_Identity=22.7146814404432, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319963, Length=336, Percent_Identity=24.702380952381, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24643849, Length=428, Percent_Identity=25.2336448598131, Blast_Score=101, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 51273; Mature: 51273

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLRKSLVAAAVAASSLFSFSAVSAQQADLMITDATVLTMNAAKDVYENGVVVIKGNKIL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECEEEEEEHHHHHHHHCCEEEEECCEEE
AVGTEELAKKYSAKTTLDVDGDIVLPGLINTHTHASMTVFRSLGDDVPDRLHRYIFPLEK
EECHHHHHHHHCCCEEEECCCCEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
KLVSRDMVRIGANLGNVEMVKGGVTTYADMYYFEDEVAKTVDKIGMRAILGESVIKFPVA
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DAANADEGIQYALNFIEEYKDHPRITPAFAPHAPYTNTTETLQKIAKLSLELDVPVMIHL
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEE
AESHREEEVIAERSNGMSPVEYMHSIGALNKNLIGAHMILIDDKDIELVKEADMGVAHNM
HHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHCCCCEECCC
SANIKSAKGVSPALKMYDEDVRIGLGTDGPMSGNTLSIIDEFNQVAKVHKLVNKDRAAMP
CCCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PLKVIDMATMGAAKALHMEDKIGSLEVGKLADIIVVDTKAPNMLPVYNPYSALVYSANSG
CHHHHHHHHHCHHHHEEHHCCCCCEECCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCC
NVRHTIVDGEILMKDRELLTVNEDEIRKELIEFTKVVRKTVIDSGEVVQ
CEEEEEECCEEEEECCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MYLRKSLVAAAVAASSLFSFSAVSAQQADLMITDATVLTMNAAKDVYENGVVVIKGNKIL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECEEEEEEHHHHHHHHCCEEEEECCEEE
AVGTEELAKKYSAKTTLDVDGDIVLPGLINTHTHASMTVFRSLGDDVPDRLHRYIFPLEK
EECHHHHHHHHCCCEEEECCCCEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
KLVSRDMVRIGANLGNVEMVKGGVTTYADMYYFEDEVAKTVDKIGMRAILGESVIKFPVA
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DAANADEGIQYALNFIEEYKDHPRITPAFAPHAPYTNTTETLQKIAKLSLELDVPVMIHL
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEE
AESHREEEVIAERSNGMSPVEYMHSIGALNKNLIGAHMILIDDKDIELVKEADMGVAHNM
HHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHCCCCEECCC
SANIKSAKGVSPALKMYDEDVRIGLGTDGPMSGNTLSIIDEFNQVAKVHKLVNKDRAAMP
CCCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PLKVIDMATMGAAKALHMEDKIGSLEVGKLADIIVVDTKAPNMLPVYNPYSALVYSANSG
CHHHHHHHHHCHHHHEEHHCCCCCEECCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCC
NVRHTIVDGEILMKDRELLTVNEDEIRKELIEFTKVVRKTVIDSGEVVQ
CEEEEEECCEEEEECCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA