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The map label for this gene is gltT [H]

Identifier: 59711762

GI number: 59711762

Start: 1279591

End: 1280874

Strand: Reverse

Name: gltT [H]

Synonym: VF_1155

Alternate gene names: 59711762

Gene position: 1280874-1279591 (Counterclockwise)

Preceding gene: 59711766

Following gene: 59711761

Centisome position: 44.21

GC content: 39.72

Gene sequence:

>1284_bases
ATGAAAAAGTCACTTTCCAGTAAAATTTTTATAGGTTTATTCGCAGGCCTATTAATAGGTACTGCTATTCAATATATGTT
TAATGGCATTGCTTTTTTTGATTCAGTTATATTAGGAGCTGCCGAAGGCGTTGGTGGGATGTTTGTCTCTCTAATTAAAC
TTCTTGTTGTTCCTCTTGTTTATGTTTCGATAGTTTGTGGCATCGTTGAATTAAAAGACATTGCCTCTTTTGGTCGCCTT
GGTGGTAAAACTTTTGCTCTTTACCTTATTAACACCATCATTGCGATTGCTGCTGCATTAACAGTAGGTATGATATTTGC
GCCAGGCGCTGACGCAAATTTAGCAGGAACGATTGCTGCAGGTACGGTTGAATTAAAAGCAACAGAAACACCTGATATCT
TTTCTCTAATAACGAATATTGTACCAAGCAACCCTATTCAAGCGTTTGCAAGTGGCGATATGCTGCAAATCATCTTTATG
GCAATTCTAACTGGCCTAGCTATTCAGGCACTTGACCACCGTGGCGGCCCTGCAATTAAGACCTTTAAAGTTGCGAATGA
AATCATGATGAAGCTAATTAGCTTAGTAATGAGTCTTGCCCCTTATGGTGTTTTTGCGCTTATGATTCAATTAGGCGCTA
CTTTAGATGCAAATACACTAATGTCAGTGGCTGGCTATGTTGCTCTTGTTATCGCTATGCTTGTATTCTGGATTTTTGTT
TTCTACCCAATAATGGTAGGTCTAACTACAGGAATTTCTCCAAAAACATTTTTACGTGCAGTTCGTGAACAAATTCTATT
TTCACTATCAACAGCAAGTTCAAATGCAACTATCCCTGTAACGATGCGTACTCTTACAGAGAAACTGAACGTATCTAAAT
CAGTCGCAGGCTTTGGGGTTCCTTTAGGTGCAACAATGAACATGTCTGGCGTATCAATCTATATCGCACTTGCTGCTATC
TTTGTAGCAAATGCATTTGGACAACCGATTAATTCAGCTGACTTATTCACTCTTGGCTTTACCATCCTATTACTTTCTAT
TGGTGCTGGTGGTGTTCCTGGCGGTGGCGTTGTTATGGTTGGTGTTATCTTGCACCAATTAGGACTTCCACCAGAAGGAT
TAGCAATTGTTGCTGCCGTTGACCGTATTAACGATATGTTCTGTACTTCATCAAATGTGGTTGGTGATACCGCAGTAAAT
ACCATTGTTGCAAAATCAGAAGGCGAAATCGCAGAAACAGAAGTTGAAGATGGGGCGACATTCGCTCAAACAATGAGAAA
TTAA

Upstream 100 bases:

>100_bases
TATTAACAATATGTAAACATCCCGTTGAATTCTCAATCAATAGAGAAACGTTATAGAAATCACGTATTAGTGAACACAAT
ATCCGGAGTAAAGGAAAATT

Downstream 100 bases:

>100_bases
TTATAATTTAGTCACTTAAGTAACGATAATGGGAGAGCAATCACGGCTCTCCCTTTTTATTTATGAACAAAGCAATTATA
ATGAATCGCCTTTTTATTTA

Product: proton glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKKSLSSKIFIGLFAGLLIGTAIQYMFNGIAFFDSVILGAAEGVGGMFVSLIKLLVVPLVYVSIVCGIVELKDIASFGRL
GGKTFALYLINTIIAIAAALTVGMIFAPGADANLAGTIAAGTVELKATETPDIFSLITNIVPSNPIQAFASGDMLQIIFM
AILTGLAIQALDHRGGPAIKTFKVANEIMMKLISLVMSLAPYGVFALMIQLGATLDANTLMSVAGYVALVIAMLVFWIFV
FYPIMVGLTTGISPKTFLRAVREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGVPLGATMNMSGVSIYIALAAI
FVANAFGQPINSADLFTLGFTILLLSIGAGGVPGGGVVMVGVILHQLGLPPEGLAIVAAVDRINDMFCTSSNVVGDTAVN
TIVAKSEGEIAETEVEDGATFAQTMRN

Sequences:

>Translated_427_residues
MKKSLSSKIFIGLFAGLLIGTAIQYMFNGIAFFDSVILGAAEGVGGMFVSLIKLLVVPLVYVSIVCGIVELKDIASFGRL
GGKTFALYLINTIIAIAAALTVGMIFAPGADANLAGTIAAGTVELKATETPDIFSLITNIVPSNPIQAFASGDMLQIIFM
AILTGLAIQALDHRGGPAIKTFKVANEIMMKLISLVMSLAPYGVFALMIQLGATLDANTLMSVAGYVALVIAMLVFWIFV
FYPIMVGLTTGISPKTFLRAVREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGVPLGATMNMSGVSIYIALAAI
FVANAFGQPINSADLFTLGFTILLLSIGAGGVPGGGVVMVGVILHQLGLPPEGLAIVAAVDRINDMFCTSSNVVGDTAVN
TIVAKSEGEIAETEVEDGATFAQTMRN
>Mature_427_residues
MKKSLSSKIFIGLFAGLLIGTAIQYMFNGIAFFDSVILGAAEGVGGMFVSLIKLLVVPLVYVSIVCGIVELKDIASFGRL
GGKTFALYLINTIIAIAAALTVGMIFAPGADANLAGTIAAGTVELKATETPDIFSLITNIVPSNPIQAFASGDMLQIIFM
AILTGLAIQALDHRGGPAIKTFKVANEIMMKLISLVMSLAPYGVFALMIQLGATLDANTLMSVAGYVALVIAMLVFWIFV
FYPIMVGLTTGISPKTFLRAVREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGVPLGATMNMSGVSIYIALAAI
FVANAFGQPINSADLFTLGFTILLLSIGAGGVPGGGVVMVGVILHQLGLPPEGLAIVAAVDRINDMFCTSSNVVGDTAVN
TIVAKSEGEIAETEVEDGATFAQTMRN

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=408, Percent_Identity=28.4313725490196, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI21314632, Length=431, Percent_Identity=29.4663573085847, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI169790839, Length=435, Percent_Identity=27.1264367816092, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI194239697, Length=416, Percent_Identity=26.9230769230769, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4827012, Length=279, Percent_Identity=31.5412186379928, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI5032093, Length=396, Percent_Identity=29.7979797979798, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI66773030, Length=404, Percent_Identity=25.7425742574257, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI223468566, Length=275, Percent_Identity=29.4545454545455, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI223468564, Length=269, Percent_Identity=29.7397769516729, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI301601644, Length=168, Percent_Identity=35.7142857142857, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI262359914, Length=372, Percent_Identity=26.0752688172043, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1790514, Length=422, Percent_Identity=31.7535545023697, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1789947, Length=422, Percent_Identity=29.3838862559242, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1788024, Length=436, Percent_Identity=27.5229357798165, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1789473, Length=286, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71983106, Length=399, Percent_Identity=29.0726817042606, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71983099, Length=399, Percent_Identity=29.0726817042606, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17537407, Length=412, Percent_Identity=29.3689320388349, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71996953, Length=429, Percent_Identity=26.1072261072261, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17541374, Length=395, Percent_Identity=29.3670886075949, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193206654, Length=432, Percent_Identity=26.6203703703704, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193206505, Length=393, Percent_Identity=25.1908396946565, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24583025, Length=441, Percent_Identity=25.8503401360544, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17137668, Length=441, Percent_Identity=25.8503401360544, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24583023, Length=441, Percent_Identity=25.8503401360544, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360481, Length=303, Percent_Identity=26.0726072607261, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI281360483, Length=303, Percent_Identity=26.0726072607261, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17137666, Length=303, Percent_Identity=26.0726072607261, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44439; Mature: 44439

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSLSSKIFIGLFAGLLIGTAIQYMFNGIAFFDSVILGAAEGVGGMFVSLIKLLVVPLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YVSIVCGIVELKDIASFGRLGGKTFALYLINTIIAIAAALTVGMIFAPGADANLAGTIAA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
GTVELKATETPDIFSLITNIVPSNPIQAFASGDMLQIIFMAILTGLAIQALDHRGGPAIK
CEEEEEECCCCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
TFKVANEIMMKLISLVMSLAPYGVFALMIQLGATLDANTLMSVAGYVALVIAMLVFWIFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FYPIMVGLTTGISPKTFLRAVREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCHHHHHCCCC
PLGATMNMSGVSIYIALAAIFVANAFGQPINSADLFTLGFTILLLSIGAGGVPGGGVVMV
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
GVILHQLGLPPEGLAIVAAVDRINDMFCTSSNVVGDTAVNTIVAKSEGEIAETEVEDGAT
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEECCCCCHHHHHHHCCHH
FAQTMRN
HHHHHCC
>Mature Secondary Structure
MKKSLSSKIFIGLFAGLLIGTAIQYMFNGIAFFDSVILGAAEGVGGMFVSLIKLLVVPLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YVSIVCGIVELKDIASFGRLGGKTFALYLINTIIAIAAALTVGMIFAPGADANLAGTIAA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
GTVELKATETPDIFSLITNIVPSNPIQAFASGDMLQIIFMAILTGLAIQALDHRGGPAIK
CEEEEEECCCCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
TFKVANEIMMKLISLVMSLAPYGVFALMIQLGATLDANTLMSVAGYVALVIAMLVFWIFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FYPIMVGLTTGISPKTFLRAVREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCHHHHHCCCC
PLGATMNMSGVSIYIALAAIFVANAFGQPINSADLFTLGFTILLLSIGAGGVPGGGVVMV
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
GVILHQLGLPPEGLAIVAAVDRINDMFCTSSNVVGDTAVNTIVAKSEGEIAETEVEDGAT
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEECCCCCHHHHHHHCCHH
FAQTMRN
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]