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The map label for this gene is pgcA [H]

Identifier: 59711663

GI number: 59711663

Start: 1165494

End: 1167203

Strand: Direct

Name: pgcA [H]

Synonym: VF_1056

Alternate gene names: 59711663

Gene position: 1165494-1167203 (Clockwise)

Preceding gene: 59711661

Following gene: 59711666

Centisome position: 40.22

GC content: 40.88

Gene sequence:

>1710_bases
ATGATGCAAAAAGTAACAGAGTGGCTTATGCGAGATCCTGATCCTAAAACTCGTGAAGAGCTTCAGTGTTTGGTTGATAG
TCATAATACACAAGAACTAGAAGAGCGTTTTCATTCACGTTTACAATTTGGTACGGCTGGTTTACGAGGTAAAGTCGGCG
CAGGGCCAAATAGAATGAATCGTTTAGTGATTCAAGAAACCGCTACTGGGTTGGGACATTACCTTATTGACCAAGTGAAA
GATGCTAAGCAACGTGGTGTGGTTGTTGGTTACGATGGAAGAAATGATTCAAAGCAGTTTGCACATGATACCGCGAGTGT
TTTAACAGCGCTTGGTATCAAGGTATTTTTAACATCAAAAGTAGCAGCAACACCGATCGTTGCTTTTGGTATTAAACATT
TCAATGCGGCTGGTGCTGTGGTTGTTACAGCAAGTCATAACCCACCAGAATACAATGGCTTTAAAGTGTACTGGGAAAAT
GGGGCGCAGATTATTCCACCACATGATTCTGGTATTGCGCAAACTATCGATATTGCAGCAACAAAATCGATTGTAATGAT
GCCGTTAGATGAAGCCGAAGAAAAAGGGCTACTAGTTTGGTTAGAAGATGATTACTACCAAACTTATCGAAATACAATGA
ACAGCAATAAATTGCTTTCTAATCATACTGATCCATCAAGTATAACTATTGCTTATACCGCGATGCATGGCGTGGGTGCT
GATATGGCCGAAACGCTATTACGTGATGCAGGCTTTAACCATGTATTTAGTGTGGCAGAGCAAAGAGAGCCTGATGGTAA
TTTTCCAACAGTAAACTTCCCCAATCCTGAAGAGGCTGGCGCAATGGACATGGTGGAAGCATTAGCCGCTTCTGCTAATG
CTGATATTGCTTGTGCCAATGACCCTGATGCAGACCGATTTGCACTTGCTGCAAGAAAACCTGATGGTGGATATAAAATG
CTAACTGGTGACCAAGTAGGTACTTTATTTGGACATTATTTACTAACGCATACAGAAGCAAGCGGGAAACTGGTTGGTAA
TACGATTGTGTCATCAACGTTACTTAAAAAAATTGCAGAATCGATGGGAGCTGAATACTTCCAAACATTAACGGGTTTTA
AATGGTTAACGAATGTTGCTATGCAAAAAGAGACGAAGGAAAAACAATTTTTATTCGCTTACGAAGAAGCGCTTGGTTAT
ACCATTGGGAGTCAAGTTTGGGATAAAGATGGTTTATCTGCTTTAGTTGCCTTTGCACAATTAACGGCGGAATTGGCGAC
GCAAGGTAAGTGTGTATGGGATCAATTAGAAAGCATTTATCGTCAGCACGGAATTCATATTAATGCACAACGCAGTATTG
CTCTTAACCCTGATTCTCCAGCAATAGGTGAACACTTGCGTGCAAATCCACCAACACACATTGCAGGTGTGAAGATAGAT
GTTGTCGAAGATTTAAAAGCATCGTTACGTTATTTACCTGATGGAGCAACAGAATCGATCGATTTACCCGCGAGTGATGT
ACTTATTTATCATCTTGAGAATGGGGCTCGAATTATTGTGCGTCCATCAGGAACAGAGCCTAAGTTGAAGTGTTATTACG
AAGTAGTGGCAGATATCTCTGAAGGTGAAGATTATTTTGACAAACAAGTGCAAGCTCAAGCCGCGATGGATAATCTTATC
GCTGAGCATCAAAAAAGCTTAACATTTTAA

Upstream 100 bases:

>100_bases
AGTACTGGTTTTTTATGAGAGTTTAGCGATTGCGTTCTAGTAATTGATAATGTTTATCATTTAGAATCAATGGAAAGATA
ATGCTTAAGAGGTTGATATT

Downstream 100 bases:

>100_bases
CGTGAGATGAAATAAAAACGGCGAGGATAGAACCTCGCCGTTTTTTTATGCGGTGACAAAAGCACTTAACATCCATACGG
CCAGAATGATGAATATTCCG

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MMQKVTEWLMRDPDPKTREELQCLVDSHNTQELEERFHSRLQFGTAGLRGKVGAGPNRMNRLVIQETATGLGHYLIDQVK
DAKQRGVVVGYDGRNDSKQFAHDTASVLTALGIKVFLTSKVAATPIVAFGIKHFNAAGAVVVTASHNPPEYNGFKVYWEN
GAQIIPPHDSGIAQTIDIAATKSIVMMPLDEAEEKGLLVWLEDDYYQTYRNTMNSNKLLSNHTDPSSITIAYTAMHGVGA
DMAETLLRDAGFNHVFSVAEQREPDGNFPTVNFPNPEEAGAMDMVEALAASANADIACANDPDADRFALAARKPDGGYKM
LTGDQVGTLFGHYLLTHTEASGKLVGNTIVSSTLLKKIAESMGAEYFQTLTGFKWLTNVAMQKETKEKQFLFAYEEALGY
TIGSQVWDKDGLSALVAFAQLTAELATQGKCVWDQLESIYRQHGIHINAQRSIALNPDSPAIGEHLRANPPTHIAGVKID
VVEDLKASLRYLPDGATESIDLPASDVLIYHLENGARIIVRPSGTEPKLKCYYEVVADISEGEDYFDKQVQAQAAMDNLI
AEHQKSLTF

Sequences:

>Translated_569_residues
MMQKVTEWLMRDPDPKTREELQCLVDSHNTQELEERFHSRLQFGTAGLRGKVGAGPNRMNRLVIQETATGLGHYLIDQVK
DAKQRGVVVGYDGRNDSKQFAHDTASVLTALGIKVFLTSKVAATPIVAFGIKHFNAAGAVVVTASHNPPEYNGFKVYWEN
GAQIIPPHDSGIAQTIDIAATKSIVMMPLDEAEEKGLLVWLEDDYYQTYRNTMNSNKLLSNHTDPSSITIAYTAMHGVGA
DMAETLLRDAGFNHVFSVAEQREPDGNFPTVNFPNPEEAGAMDMVEALAASANADIACANDPDADRFALAARKPDGGYKM
LTGDQVGTLFGHYLLTHTEASGKLVGNTIVSSTLLKKIAESMGAEYFQTLTGFKWLTNVAMQKETKEKQFLFAYEEALGY
TIGSQVWDKDGLSALVAFAQLTAELATQGKCVWDQLESIYRQHGIHINAQRSIALNPDSPAIGEHLRANPPTHIAGVKID
VVEDLKASLRYLPDGATESIDLPASDVLIYHLENGARIIVRPSGTEPKLKCYYEVVADISEGEDYFDKQVQAQAAMDNLI
AEHQKSLTF
>Mature_569_residues
MMQKVTEWLMRDPDPKTREELQCLVDSHNTQELEERFHSRLQFGTAGLRGKVGAGPNRMNRLVIQETATGLGHYLIDQVK
DAKQRGVVVGYDGRNDSKQFAHDTASVLTALGIKVFLTSKVAATPIVAFGIKHFNAAGAVVVTASHNPPEYNGFKVYWEN
GAQIIPPHDSGIAQTIDIAATKSIVMMPLDEAEEKGLLVWLEDDYYQTYRNTMNSNKLLSNHTDPSSITIAYTAMHGVGA
DMAETLLRDAGFNHVFSVAEQREPDGNFPTVNFPNPEEAGAMDMVEALAASANADIACANDPDADRFALAARKPDGGYKM
LTGDQVGTLFGHYLLTHTEASGKLVGNTIVSSTLLKKIAESMGAEYFQTLTGFKWLTNVAMQKETKEKQFLFAYEEALGY
TIGSQVWDKDGLSALVAFAQLTAELATQGKCVWDQLESIYRQHGIHINAQRSIALNPDSPAIGEHLRANPPTHIAGVKID
VVEDLKASLRYLPDGATESIDLPASDVLIYHLENGARIIVRPSGTEPKLKCYYEVVADISEGEDYFDKQVQAQAAMDNLI
AEHQKSLTF

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=569, Percent_Identity=34.622144112478, Blast_Score=325, Evalue=8e-89,
Organism=Homo sapiens, GI31377548, Length=572, Percent_Identity=33.7412587412587, Blast_Score=301, Evalue=2e-81,
Organism=Escherichia coli, GI1789566, Length=498, Percent_Identity=22.289156626506, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71993870, Length=556, Percent_Identity=34.1726618705036, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI71993878, Length=317, Percent_Identity=35.0157728706625, Blast_Score=197, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323934, Length=589, Percent_Identity=34.634974533107, Blast_Score=296, Evalue=7e-81,
Organism=Drosophila melanogaster, GI20129809, Length=583, Percent_Identity=35.3344768439108, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24651977, Length=562, Percent_Identity=35.0533807829181, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24653722, Length=600, Percent_Identity=31, Blast_Score=256, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 62395; Mature: 62395

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQKVTEWLMRDPDPKTREELQCLVDSHNTQELEERFHSRLQFGTAGLRGKVGAGPNRMN
CCHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
RLVIQETATGLGHYLIDQVKDAKQRGVVVGYDGRNDSKQFAHDTASVLTALGIKVFLTSK
EEEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEECH
VAATPIVAFGIKHFNAAGAVVVTASHNPPEYNGFKVYWENGAQIIPPHDSGIAQTIDIAA
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEECCCEEECCCCCCCHHEEEHHC
TKSIVMMPLDEAEEKGLLVWLEDDYYQTYRNTMNSNKLLSNHTDPSSITIAYTAMHGVGA
CCCEEEEECCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEHHCCCH
DMAETLLRDAGFNHVFSVAEQREPDGNFPTVNFPNPEEAGAMDMVEALAASANADIACAN
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECC
DPDADRFALAARKPDGGYKMLTGDQVGTLFGHYLLTHTEASGKLVGNTIVSSTLLKKIAE
CCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHH
SMGAEYFQTLTGFKWLTNVAMQKETKEKQFLFAYEEALGYTIGSQVWDKDGLSALVAFAQ
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LTAELATQGKCVWDQLESIYRQHGIHINAQRSIALNPDSPAIGEHLRANPPTHIAGVKID
HHHHHHHCCCHHHHHHHHHHHHCCCEEECCCEEEECCCCCCHHHHHCCCCCCEEEEEEEH
VVEDLKASLRYLPDGATESIDLPASDVLIYHLENGARIIVRPSGTEPKLKCYYEVVADIS
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHH
EGEDYFDKQVQAQAAMDNLIAEHQKSLTF
CCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMQKVTEWLMRDPDPKTREELQCLVDSHNTQELEERFHSRLQFGTAGLRGKVGAGPNRMN
CCHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
RLVIQETATGLGHYLIDQVKDAKQRGVVVGYDGRNDSKQFAHDTASVLTALGIKVFLTSK
EEEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEECH
VAATPIVAFGIKHFNAAGAVVVTASHNPPEYNGFKVYWENGAQIIPPHDSGIAQTIDIAA
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEECCCEEECCCCCCCHHEEEHHC
TKSIVMMPLDEAEEKGLLVWLEDDYYQTYRNTMNSNKLLSNHTDPSSITIAYTAMHGVGA
CCCEEEEECCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEHHCCCH
DMAETLLRDAGFNHVFSVAEQREPDGNFPTVNFPNPEEAGAMDMVEALAASANADIACAN
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECC
DPDADRFALAARKPDGGYKMLTGDQVGTLFGHYLLTHTEASGKLVGNTIVSSTLLKKIAE
CCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHH
SMGAEYFQTLTGFKWLTNVAMQKETKEKQFLFAYEEALGYTIGSQVWDKDGLSALVAFAQ
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LTAELATQGKCVWDQLESIYRQHGIHINAQRSIALNPDSPAIGEHLRANPPTHIAGVKID
HHHHHHHCCCHHHHHHHHHHHHCCCEEECCCEEEECCCCCCHHHHHCCCCCCEEEEEEEH
VVEDLKASLRYLPDGATESIDLPASDVLIYHLENGARIIVRPSGTEPKLKCYYEVVADIS
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHH
EGEDYFDKQVQAQAAMDNLIAEHQKSLTF
CCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]