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The map label for this gene is gltP [H]

Identifier: 59711633

GI number: 59711633

Start: 1130148

End: 1131404

Strand: Reverse

Name: gltP [H]

Synonym: VF_1026

Alternate gene names: 59711633

Gene position: 1131404-1130148 (Counterclockwise)

Preceding gene: 59711634

Following gene: 59711632

Centisome position: 39.05

GC content: 41.05

Gene sequence:

>1257_bases
GTGTTAAACAAAAAAGGATTTATGAACAACATTGGGGTTCAAGTCGTTATAGCCATGATTATAGGCACCATGGTTGGGGC
AACAATGGGCGAATCCGCGTCCATGTTTGCTCCTCTTGGAACCATTTTTATTAATCTAATTAAAATGTTAGTTATACCAT
TAGTTGCTGTTGCTCTTATTTCGGGAGCTGCAGGATTAGGTAACAGCAGTAATGCAGGAAAAGTTGGTTTAAGTACACTA
GGTTATTTTGGTATAACATCGGCACTAGCTGTTGCCTTAGCGCTATTTATGGGTGAAATTTTTGAACCGGGAAAAGGGAT
TGATGTTTCAGGTGTAGAAGGAATGTTCTCTTCTGCCTATGCATCTAAAGGAGAACTACCTACTTTTTGGGCAACCATTA
CAGGCATGATCCCAACCAACGTTTTCCAATCCTTAAATGAAGCAAATATTCTACAAATACTTGTTTTCTGTCTATTCTTT
GGTATCGGCTTATCTAAATTAGAAAAAACACGTCGTGAACCAATGCTTAATGCGGTTAACGCAATTGTTGATGTGATGGT
TTGGATGATCAACAAAGTAATGATCATTGCTCCTATCGGTGTATTTGGTTTAATGGCAGAAGCCGTTGGTACGTTTGGCT
TTGGTGCACTAATGGTGGTATTTAAGCTATTCGTTGTCTACGTTGCTGCTATTGTTATCTTTGGCTTTGTAGCCTACCCA
CTGATGGTTGGGTTATTTACTAAAACCTCTGCAAAGCAATTCCTTGTTGCAATGAAAAAACCACAAGCTGTGGCACTTTC
AACAGCATCATCAATGGCAACACTACCAGTTACGATGGAAACCGTTGAGAAAGATTTAGGGGTTCGCAACTCTACCGCCT
CTTTTGTCTTACCGCTTGGTGCAACCATTAACATGTCAGGTAACGCAATTTACTACGGCCTAGTTGCTATCTTCTTTGCT
CAACTGTTCAATATCGACCTATCTATTGGCGCCTACATCGCTATCATTGTGACTTCAACTCTAGGTGCTGTTGGCCAAGC
TGGCGTTCCAGGTCCTTCTTTCTTAGTGGTCGCAGTTTTATTAGCGGCAGGCATCCCAATCGAAGGTTTACCACTCTTAT
TCGCACTAGATCGTATCTTCGATATGATCCGTACAGCCTTAAACATTACAGGTGATGCGGCGTGTGCAGTGATCGTTGAT
GCGATGGTTGAAGAAGAACACAAAAAAACAGTAAGAACAGAAAATCAAAATGCTTAG

Upstream 100 bases:

>100_bases
TTACGTGTAAAACGACACCCGAATTTTTAATAACAATACACATAATAAATAAGAGCTATTCACTAAATTTTCGTAAGAAC
ACAACATAGAGGTAGACAAA

Downstream 100 bases:

>100_bases
AAAAAGTTAACCTAAATAAGCCCAATTTAAATCAACAAGGCCAATTATTTCACATTGGCCTTTTTTTGATCATCGAACAT
AAAATGTAACAAGCAATTTT

Product: glutamate/aspartate:proton symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MLNKKGFMNNIGVQVVIAMIIGTMVGATMGESASMFAPLGTIFINLIKMLVIPLVAVALISGAAGLGNSSNAGKVGLSTL
GYFGITSALAVALALFMGEIFEPGKGIDVSGVEGMFSSAYASKGELPTFWATITGMIPTNVFQSLNEANILQILVFCLFF
GIGLSKLEKTRREPMLNAVNAIVDVMVWMINKVMIIAPIGVFGLMAEAVGTFGFGALMVVFKLFVVYVAAIVIFGFVAYP
LMVGLFTKTSAKQFLVAMKKPQAVALSTASSMATLPVTMETVEKDLGVRNSTASFVLPLGATINMSGNAIYYGLVAIFFA
QLFNIDLSIGAYIAIIVTSTLGAVGQAGVPGPSFLVVAVLLAAGIPIEGLPLLFALDRIFDMIRTALNITGDAACAVIVD
AMVEEEHKKTVRTENQNA

Sequences:

>Translated_418_residues
MLNKKGFMNNIGVQVVIAMIIGTMVGATMGESASMFAPLGTIFINLIKMLVIPLVAVALISGAAGLGNSSNAGKVGLSTL
GYFGITSALAVALALFMGEIFEPGKGIDVSGVEGMFSSAYASKGELPTFWATITGMIPTNVFQSLNEANILQILVFCLFF
GIGLSKLEKTRREPMLNAVNAIVDVMVWMINKVMIIAPIGVFGLMAEAVGTFGFGALMVVFKLFVVYVAAIVIFGFVAYP
LMVGLFTKTSAKQFLVAMKKPQAVALSTASSMATLPVTMETVEKDLGVRNSTASFVLPLGATINMSGNAIYYGLVAIFFA
QLFNIDLSIGAYIAIIVTSTLGAVGQAGVPGPSFLVVAVLLAAGIPIEGLPLLFALDRIFDMIRTALNITGDAACAVIVD
AMVEEEHKKTVRTENQNA
>Mature_418_residues
MLNKKGFMNNIGVQVVIAMIIGTMVGATMGESASMFAPLGTIFINLIKMLVIPLVAVALISGAAGLGNSSNAGKVGLSTL
GYFGITSALAVALALFMGEIFEPGKGIDVSGVEGMFSSAYASKGELPTFWATITGMIPTNVFQSLNEANILQILVFCLFF
GIGLSKLEKTRREPMLNAVNAIVDVMVWMINKVMIIAPIGVFGLMAEAVGTFGFGALMVVFKLFVVYVAAIVIFGFVAYP
LMVGLFTKTSAKQFLVAMKKPQAVALSTASSMATLPVTMETVEKDLGVRNSTASFVLPLGATINMSGNAIYYGLVAIFFA
QLFNIDLSIGAYIAIIVTSTLGAVGQAGVPGPSFLVVAVLLAAGIPIEGLPLLFALDRIFDMIRTALNITGDAACAVIVD
AMVEEEHKKTVRTENQNA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=417, Percent_Identity=30.6954436450839, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI169790839, Length=464, Percent_Identity=27.801724137931, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI66773030, Length=466, Percent_Identity=28.755364806867, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4827012, Length=450, Percent_Identity=27.5555555555556, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI223468566, Length=304, Percent_Identity=32.2368421052632, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI5032093, Length=399, Percent_Identity=31.328320802005, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI223468564, Length=269, Percent_Identity=33.457249070632, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI194239697, Length=490, Percent_Identity=27.3469387755102, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI40254478, Length=457, Percent_Identity=25.8205689277899, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI301601644, Length=184, Percent_Identity=36.9565217391304, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI262359914, Length=390, Percent_Identity=26.6666666666667, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1790514, Length=428, Percent_Identity=35.981308411215, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1789947, Length=423, Percent_Identity=30.2600472813239, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1788024, Length=407, Percent_Identity=27.027027027027, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789473, Length=384, Percent_Identity=26.5625, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI193206505, Length=410, Percent_Identity=30, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71983106, Length=410, Percent_Identity=30.4878048780488, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71983099, Length=410, Percent_Identity=30.4878048780488, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17537407, Length=414, Percent_Identity=29.4685990338164, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17541374, Length=410, Percent_Identity=31.219512195122, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI193206654, Length=411, Percent_Identity=29.9270072992701, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71996953, Length=417, Percent_Identity=27.3381294964029, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24583025, Length=447, Percent_Identity=24.3847874720358, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17137668, Length=447, Percent_Identity=24.3847874720358, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24583023, Length=447, Percent_Identity=24.3847874720358, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI281360483, Length=430, Percent_Identity=28.3720930232558, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17137666, Length=430, Percent_Identity=28.3720930232558, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI281360481, Length=430, Percent_Identity=28.3720930232558, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43889; Mature: 43889

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKKGFMNNIGVQVVIAMIIGTMVGATMGESASMFAPLGTIFINLIKMLVIPLVAVALI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGAAGLGNSSNAGKVGLSTLGYFGITSALAVALALFMGEIFEPGKGIDVSGVEGMFSSAY
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
ASKGELPTFWATITGMIPTNVFQSLNEANILQILVFCLFFGIGLSKLEKTRREPMLNAVN
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AIVDVMVWMINKVMIIAPIGVFGLMAEAVGTFGFGALMVVFKLFVVYVAAIVIFGFVAYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMVGLFTKTSAKQFLVAMKKPQAVALSTASSMATLPVTMETVEKDLGVRNSTASFVLPLG
HHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECC
ATINMSGNAIYYGLVAIFFAQLFNIDLSIGAYIAIIVTSTLGAVGQAGVPGPSFLVVAVL
CEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LAAGIPIEGLPLLFALDRIFDMIRTALNITGDAACAVIVDAMVEEEHKKTVRTENQNA
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLNKKGFMNNIGVQVVIAMIIGTMVGATMGESASMFAPLGTIFINLIKMLVIPLVAVALI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGAAGLGNSSNAGKVGLSTLGYFGITSALAVALALFMGEIFEPGKGIDVSGVEGMFSSAY
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
ASKGELPTFWATITGMIPTNVFQSLNEANILQILVFCLFFGIGLSKLEKTRREPMLNAVN
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AIVDVMVWMINKVMIIAPIGVFGLMAEAVGTFGFGALMVVFKLFVVYVAAIVIFGFVAYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMVGLFTKTSAKQFLVAMKKPQAVALSTASSMATLPVTMETVEKDLGVRNSTASFVLPLG
HHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECC
ATINMSGNAIYYGLVAIFFAQLFNIDLSIGAYIAIIVTSTLGAVGQAGVPGPSFLVVAVL
CEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LAAGIPIEGLPLLFALDRIFDMIRTALNITGDAACAVIVDAMVEEEHKKTVRTENQNA
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]