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The map label for this gene is hutH [H]

Identifier: 59711459

GI number: 59711459

Start: 937616

End: 939151

Strand: Direct

Name: hutH [H]

Synonym: VF_0852

Alternate gene names: 59711459

Gene position: 937616-939151 (Clockwise)

Preceding gene: 59711458

Following gene: 59711460

Centisome position: 32.36

GC content: 40.89

Gene sequence:

>1536_bases
ATGACAACTAATTCAATTACATTTGGTAAAGGACGTCTGACAATTGAAGACGTTGTTGATATTGCAAATGGTGCAAATGC
ACAACTTAATAATTCTGATGAATTCACTGCCAAAATTGACCGTGGTGTTGAGTTTTTAGAACGTTTATTAAAAGAAGAAG
GCGTGATCTATGGTGTAACAACGGGTTATGGTGACTCTTGTACTGTAGCAATCCCAATGGATTTAGTGGATGAATTACCG
CTGCATTTAACTCGTTTTCACGGTTGTGGTTTAGGCGAAAACTTAGATGAACAACAAGCACGTGCTGTATTAGCGACTCG
CTTATGCTCTTTATCACAAGGGGTATCGGGTGTGACTCATGATCTGCTTAATCAAATCGTGACTCTAATTAATCACGGCG
TATCTCCACGTATTCCTCAAGAAGGTTCTGTGGGTGCAAGTGGTGATTTAACGCCATTATCTTATCTTGCTGCTGCCCTT
ATTGGTGAGCGTGAAGTGATTTATAAAGGTGAAATCCGTGCAACTGCAGATGTATTTAAAGAGCTAAATATCACACCAAT
CAAGCTTAAACCAAAAGAAGGTTTGGCTTTAATGAATGGTACATCAGTGATGACAGCGTTAGCGTGTTTAGCATATAAGC
GTGCTGAGTACTTAGCGCAAATGGCAACTAAGATCACCGCAATGGTATCGGTAGGGATGCAAGGTAATGACTTCCACTTT
GATGAAGCGTTATTTGCGGTGAAACCACATCCAGGCCAACAACAAATTGCTGCTTGGTTACGTTCTGATTTACATAACGA
AACACCACCAAGAAACAGTGATCGTCTGCAAGACCGTTACTCACTTCGTTGTGCTCCACATGTGATTGGTGTACTTCAAG
ATAGCCTACCGTTCTTGCGTCAAATGATTGAAAATGAATTAAACAGTGCGAACGATAACCCAATTATCGATGGTGATAAT
GAGCGTGTTCTTCACGGTGGTCATTTCTATGGTGGTCATATTGCAATGGCAATGGACATGCTAAAAACCGCAGTAGCAAA
TATTGCTGATTTATTAGATCGCCAAATGGCACAGCTAATGGATTACAAATTCAATAACGGTTTACCATTTAACCTGACGG
GGTCAACAGGGGCTCGTAAACCAATTAACCATGGCTTTAAAGCGGTTCAGATTGGTATTTCAGCATGGACAGCAGAAGCG
CTTAAAGGAACAATGCCTGCAAGTGTTTTCTCACGTTCAACAGAATGTCATAACCAAGATAAAGTGAGCATGGGTACGAT
TGCCTCTCGTGATTGTTTACGTGTTTTACAGTTAACAGAGCAAGTGACATCAGCTTCATTATTAGCGGCAACTCAAGCGT
TAGTATTGCGTGAAAAGCAAGGTGAGCTTGATGATACTCAGTTAAGTAAAGAGCTTAAAACCATGCGTGATGCGGTATTA
AGTGAATTTGCTTTTGTCGATGAAGACCGACCATTAGAGAACGATTTACGTAACTTTATGGCGAAGATTCAGCAACAGCA
CTGGACACTATACTAA

Upstream 100 bases:

>100_bases
GTCGTACAAAATTATGCTCAACGTCTAGAGCATTTCACATTAAAAGCACCATCACAATGGTATAACTTTTTTAATTTTTG
GCAGTTAACTGGAAAGAAAG

Downstream 100 bases:

>100_bases
GGTTAAATGTTGTGACTAATACAAATGAAGCTAAGCCAGTGAATGTATTAAGCGCAGAAGTGATGATCACAACCGCCTTT
CAGGATGCGGATCCGATGGG

Product: phenylalanine and histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTTNSITFGKGRLTIEDVVDIANGANAQLNNSDEFTAKIDRGVEFLERLLKEEGVIYGVTTGYGDSCTVAIPMDLVDELP
LHLTRFHGCGLGENLDEQQARAVLATRLCSLSQGVSGVTHDLLNQIVTLINHGVSPRIPQEGSVGASGDLTPLSYLAAAL
IGEREVIYKGEIRATADVFKELNITPIKLKPKEGLALMNGTSVMTALACLAYKRAEYLAQMATKITAMVSVGMQGNDFHF
DEALFAVKPHPGQQQIAAWLRSDLHNETPPRNSDRLQDRYSLRCAPHVIGVLQDSLPFLRQMIENELNSANDNPIIDGDN
ERVLHGGHFYGGHIAMAMDMLKTAVANIADLLDRQMAQLMDYKFNNGLPFNLTGSTGARKPINHGFKAVQIGISAWTAEA
LKGTMPASVFSRSTECHNQDKVSMGTIASRDCLRVLQLTEQVTSASLLAATQALVLREKQGELDDTQLSKELKTMRDAVL
SEFAFVDEDRPLENDLRNFMAKIQQQHWTLY

Sequences:

>Translated_511_residues
MTTNSITFGKGRLTIEDVVDIANGANAQLNNSDEFTAKIDRGVEFLERLLKEEGVIYGVTTGYGDSCTVAIPMDLVDELP
LHLTRFHGCGLGENLDEQQARAVLATRLCSLSQGVSGVTHDLLNQIVTLINHGVSPRIPQEGSVGASGDLTPLSYLAAAL
IGEREVIYKGEIRATADVFKELNITPIKLKPKEGLALMNGTSVMTALACLAYKRAEYLAQMATKITAMVSVGMQGNDFHF
DEALFAVKPHPGQQQIAAWLRSDLHNETPPRNSDRLQDRYSLRCAPHVIGVLQDSLPFLRQMIENELNSANDNPIIDGDN
ERVLHGGHFYGGHIAMAMDMLKTAVANIADLLDRQMAQLMDYKFNNGLPFNLTGSTGARKPINHGFKAVQIGISAWTAEA
LKGTMPASVFSRSTECHNQDKVSMGTIASRDCLRVLQLTEQVTSASLLAATQALVLREKQGELDDTQLSKELKTMRDAVL
SEFAFVDEDRPLENDLRNFMAKIQQQHWTLY
>Mature_510_residues
TTNSITFGKGRLTIEDVVDIANGANAQLNNSDEFTAKIDRGVEFLERLLKEEGVIYGVTTGYGDSCTVAIPMDLVDELPL
HLTRFHGCGLGENLDEQQARAVLATRLCSLSQGVSGVTHDLLNQIVTLINHGVSPRIPQEGSVGASGDLTPLSYLAAALI
GEREVIYKGEIRATADVFKELNITPIKLKPKEGLALMNGTSVMTALACLAYKRAEYLAQMATKITAMVSVGMQGNDFHFD
EALFAVKPHPGQQQIAAWLRSDLHNETPPRNSDRLQDRYSLRCAPHVIGVLQDSLPFLRQMIENELNSANDNPIIDGDNE
RVLHGGHFYGGHIAMAMDMLKTAVANIADLLDRQMAQLMDYKFNNGLPFNLTGSTGARKPINHGFKAVQIGISAWTAEAL
KGTMPASVFSRSTECHNQDKVSMGTIASRDCLRVLQLTEQVTSASLLAATQALVLREKQGELDDTQLSKELKTMRDAVLS
EFAFVDEDRPLENDLRNFMAKIQQQHWTLY

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=451, Percent_Identity=35.920177383592, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17567831, Length=450, Percent_Identity=37.7777777777778, Blast_Score=269, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 56098; Mature: 55966

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNSITFGKGRLTIEDVVDIANGANAQLNNSDEFTAKIDRGVEFLERLLKEEGVIYGVT
CCCCCEECCCCCEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEE
TGYGDSCTVAIPMDLVDELPLHLTRFHGCGLGENLDEQQARAVLATRLCSLSQGVSGVTH
CCCCCCEEEEECHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
DLLNQIVTLINHGVSPRIPQEGSVGASGDLTPLSYLAAALIGEREVIYKGEIRATADVFK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHH
ELNITPIKLKPKEGLALMNGTSVMTALACLAYKRAEYLAQMATKITAMVSVGMQGNDFHF
HCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DEALFAVKPHPGQQQIAAWLRSDLHNETPPRNSDRLQDRYSLRCAPHVIGVLQDSLPFLR
CCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMIENELNSANDNPIIDGDNERVLHGGHFYGGHIAMAMDMLKTAVANIADLLDRQMAQLM
HHHHHHHCCCCCCCCCCCCCCEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYKFNNGLPFNLTGSTGARKPINHGFKAVQIGISAWTAEALKGTMPASVFSRSTECHNQD
CCCCCCCCCEEECCCCCCCCCHHCCCEEEEEHHHHHHHHHHHCCCCHHHHHCCHHHCCCC
KVSMGTIASRDCLRVLQLTEQVTSASLLAATQALVLREKQGELDDTQLSKELKTMRDAVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
SEFAFVDEDRPLENDLRNFMAKIQQQHWTLY
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTNSITFGKGRLTIEDVVDIANGANAQLNNSDEFTAKIDRGVEFLERLLKEEGVIYGVT
CCCCEECCCCCEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEE
TGYGDSCTVAIPMDLVDELPLHLTRFHGCGLGENLDEQQARAVLATRLCSLSQGVSGVTH
CCCCCCEEEEECHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
DLLNQIVTLINHGVSPRIPQEGSVGASGDLTPLSYLAAALIGEREVIYKGEIRATADVFK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHH
ELNITPIKLKPKEGLALMNGTSVMTALACLAYKRAEYLAQMATKITAMVSVGMQGNDFHF
HCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DEALFAVKPHPGQQQIAAWLRSDLHNETPPRNSDRLQDRYSLRCAPHVIGVLQDSLPFLR
CCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMIENELNSANDNPIIDGDNERVLHGGHFYGGHIAMAMDMLKTAVANIADLLDRQMAQLM
HHHHHHHCCCCCCCCCCCCCCEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYKFNNGLPFNLTGSTGARKPINHGFKAVQIGISAWTAEALKGTMPASVFSRSTECHNQD
CCCCCCCCCEEECCCCCCCCCHHCCCEEEEEHHHHHHHHHHHCCCCHHHHHCCHHHCCCC
KVSMGTIASRDCLRVLQLTEQVTSASLLAATQALVLREKQGELDDTQLSKELKTMRDAVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
SEFAFVDEDRPLENDLRNFMAKIQQQHWTLY
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA