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The map label for this gene is guaB [H]

Identifier: 59711244

GI number: 59711244

Start: 694001

End: 695464

Strand: Direct

Name: guaB [H]

Synonym: VF_0637

Alternate gene names: 59711244

Gene position: 694001-695464 (Clockwise)

Preceding gene: 59711242

Following gene: 59711245

Centisome position: 23.95

GC content: 44.19

Gene sequence:

>1464_bases
ATGCTACGAATCGCAAAAGAAGCTCTAACCTTCGATGACGTTTTACTCGTCCCAGCACACTCAACAGTTCTTCCTAACAC
TGCTGATCTTCGCACTCAGTTAACCAAGAACATTTCTCTGAATATTCCAATGATCTCAGCATCTATGGATACGGTAACAG
AAGCGCGCCTTGCTATTGCATTAGCGCAAGAGGGTGGCATCGGTTTTATCCACAAAAACATGTCTATTGAGCAGCAAGCT
GAAGAAGTTCGCCTAGTTAAAATTTTTGAAGCTGGTGTTGTTTCTGCTCCTGTCACTGTTCGTCCAGACGCAACGATTCA
AGATGTTAAAGAACTAACAGAGAAACACGGCTTTGCTGGCTTCCCTGTAGTTACTGAAACTAATGAACTTGTAGGTATTA
TCACAGGTCGTGATGTTCGCTTTGTAACTGATTTATCTAAGAAAGTTGACGTTGTAATGACGCCGAAATCACGTTTGGCT
TCTGTTAAAGAAGGTGCAACTCGTGAAGAAGTTCAAGAGAAAATGCACGAAGCTCGTGTTGAGAAAGTACTAGTAGTGAA
CGATGAGTTCCAACTAACCGGTATGATCACGGCAAAAGATTTCCATAAAGCAGAACGTAAACCAAATGCATGTAAAGACG
AGCGTGGTCGTCTACGTGTAGGTGCTGCAGTAGGTGCAGGTGCAGGTAACGAAGAACGTGTTAAAGCATTAGTTGAAGCT
GGTGTGGATGTTCTACTAATCGACTCTTCACACGGTCACTCTGAAGGTGTTTTAAACCGTATCCGTGAAACACGTGCTGC
ATACCCAGATTTAGATATTATCGGTGGTAATGTTGCAACAGCAGCTGGTGCAAAAGCACTAATCGAAGCTGGTGTAAGCG
CAGTTAAAGTGGGTATCGGCCCAGGTTCAATCTGTACAACTCGTATCGTAACAGGTGTTGGTGTTCCTCAAGTAACAGCT
ATTGCAGATGCAGCATCAGCAGCGGCTGAATACGGTATTCCAGTAATCGCTGATGGCGGTATCCGTTTCTCTGGTGACAT
CTGTAAAGCAATCGTAGCTGGCGCATCATGTGTGATGGTTGGTTCAATGTTTGCTGGTACAGAAGAAGCACCAGGCGAAG
TGATTCTTTACCAAGGTCGTTCATACAAAGCATACCGTGGTATGGGTTCTTTAGGTGCAATGTCTCAAGGGTCTTCAGAC
CGTTACTTCCAATCAGATAACGCAGCAGATAAATTGGTACCAGAAGGTATCGAAGGTCGTATCGCATATAAAGGTCGTCT
AAAAGAGATCGTTCACCAACAAATGGGTGGCTTACGTTCAAGCATGGGCCTAACAGGTTCAGCAACAATTGAAGACATGC
GTACTAAAGCTGAATTTGTTCGTATTTCAGGCGCAGGGATGAAAGAGTCTCACGTACATGATGTTCAAATCACGAAAGAA
GCACCAAACTATCGCCTAGGCTAA

Upstream 100 bases:

>100_bases
CGTATAATCCGTCTGCAATATCAAATCCAAAACACTTTATTATGCGAAACGATAAAGTGGGATTTATTCCTTTAAACACC
TTTGTTGTGAGATATTGCAA

Downstream 100 bases:

>100_bases
TTTTTCTTAATTTTCTTTGCAGAATCTTCCGATTTCGTTGTCAAAGGTACTCATTTACACTTGTAAACTCCGTGCCTTTT
CCTAGAATTCGAATGATTCT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNISLNIPMISASMDTVTEARLAIALAQEGGIGFIHKNMSIEQQA
EEVRLVKIFEAGVVSAPVTVRPDATIQDVKELTEKHGFAGFPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKSRLA
SVKEGATREEVQEKMHEARVEKVLVVNDEFQLTGMITAKDFHKAERKPNACKDERGRLRVGAAVGAGAGNEERVKALVEA
GVDVLLIDSSHGHSEGVLNRIRETRAAYPDLDIIGGNVATAAGAKALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQVTA
IADAASAAAEYGIPVIADGGIRFSGDICKAIVAGASCVMVGSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRIAYKGRLKEIVHQQMGGLRSSMGLTGSATIEDMRTKAEFVRISGAGMKESHVHDVQITKE
APNYRLG

Sequences:

>Translated_487_residues
MLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNISLNIPMISASMDTVTEARLAIALAQEGGIGFIHKNMSIEQQA
EEVRLVKIFEAGVVSAPVTVRPDATIQDVKELTEKHGFAGFPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKSRLA
SVKEGATREEVQEKMHEARVEKVLVVNDEFQLTGMITAKDFHKAERKPNACKDERGRLRVGAAVGAGAGNEERVKALVEA
GVDVLLIDSSHGHSEGVLNRIRETRAAYPDLDIIGGNVATAAGAKALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQVTA
IADAASAAAEYGIPVIADGGIRFSGDICKAIVAGASCVMVGSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRIAYKGRLKEIVHQQMGGLRSSMGLTGSATIEDMRTKAEFVRISGAGMKESHVHDVQITKE
APNYRLG
>Mature_487_residues
MLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNISLNIPMISASMDTVTEARLAIALAQEGGIGFIHKNMSIEQQA
EEVRLVKIFEAGVVSAPVTVRPDATIQDVKELTEKHGFAGFPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKSRLA
SVKEGATREEVQEKMHEARVEKVLVVNDEFQLTGMITAKDFHKAERKPNACKDERGRLRVGAAVGAGAGNEERVKALVEA
GVDVLLIDSSHGHSEGVLNRIRETRAAYPDLDIIGGNVATAAGAKALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQVTA
IADAASAAAEYGIPVIADGGIRFSGDICKAIVAGASCVMVGSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRIAYKGRLKEIVHQQMGGLRSSMGLTGSATIEDMRTKAEFVRISGAGMKESHVHDVQITKE
APNYRLG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=463, Percent_Identity=41.9006479481641, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI66933016, Length=457, Percent_Identity=41.5754923413567, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI34328928, Length=463, Percent_Identity=41.9006479481641, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI156616279, Length=463, Percent_Identity=41.9006479481641, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI34328930, Length=463, Percent_Identity=41.9006479481641, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI217035152, Length=452, Percent_Identity=42.2566371681416, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI217035148, Length=463, Percent_Identity=41.036717062635, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI217035150, Length=463, Percent_Identity=38.4449244060475, Blast_Score=299, Evalue=4e-81,
Organism=Homo sapiens, GI156104880, Length=247, Percent_Identity=35.2226720647773, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=34.412955465587, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=34.412955465587, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=34.412955465587, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=34.412955465587, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=83.1622176591376, Blast_Score=762, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=246, Percent_Identity=32.520325203252, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=500, Percent_Identity=37.2, Blast_Score=281, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=40.2843601895735, Blast_Score=271, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=35.7142857142857, Blast_Score=151, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6323585, Length=460, Percent_Identity=39.7826086956522, Blast_Score=336, Evalue=6e-93,
Organism=Saccharomyces cerevisiae, GI6322012, Length=483, Percent_Identity=38.0952380952381, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=38.9233954451346, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=39.9408284023669, Blast_Score=257, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6319353, Length=101, Percent_Identity=40.5940594059406, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=39.2561983471074, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=39.2561983471074, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=39.8190045248869, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51665; Mature: 51665

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNISLNIPMISASMDTVTEARLAIA
CCEEHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHCCEEEECEEEECCHHHHHHHHEEEE
LAQEGGIGFIHKNMSIEQQAEEVRLVKIFEAGVVSAPVTVRPDATIQDVKELTEKHGFAG
EECCCCEEEEECCCCHHHHHHHHEEEEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCCC
FPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKSRLASVKEGATREEVQEKMHEARV
CCEEECCCCEEEEEECCCEEEEEHHCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHH
EKVLVVNDEFQLTGMITAKDFHKAERKPNACKDERGRLRVGAAVGAGAGNEERVKALVEA
CEEEEECCCEEEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLNRIRETRAAYPDLDIIGGNVATAAGAKALIEAGVSAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQVTAIADAASAAAEYGIPVIADGGIRFSGDICKAIVAGASCVMV
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECHHHHHHHHCCCHHEEH
GSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCE
IAYKGRLKEIVHQQMGGLRSSMGLTGSATIEDMRTKAEFVRISGAGMKESHVHDVQITKE
EEEHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHEEEEECCCCCCCCCEEEEEECC
APNYRLG
CCCCCCC
>Mature Secondary Structure
MLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNISLNIPMISASMDTVTEARLAIA
CCEEHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHCCEEEECEEEECCHHHHHHHHEEEE
LAQEGGIGFIHKNMSIEQQAEEVRLVKIFEAGVVSAPVTVRPDATIQDVKELTEKHGFAG
EECCCCEEEEECCCCHHHHHHHHEEEEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCCC
FPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKSRLASVKEGATREEVQEKMHEARV
CCEEECCCCEEEEEECCCEEEEEHHCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHH
EKVLVVNDEFQLTGMITAKDFHKAERKPNACKDERGRLRVGAAVGAGAGNEERVKALVEA
CEEEEECCCEEEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLNRIRETRAAYPDLDIIGGNVATAAGAKALIEAGVSAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQVTAIADAASAAAEYGIPVIADGGIRFSGDICKAIVAGASCVMV
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECHHHHHHHHCCCHHEEH
GSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCE
IAYKGRLKEIVHQQMGGLRSSMGLTGSATIEDMRTKAEFVRISGAGMKESHVHDVQITKE
EEEHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHEEEEECCCCCCCCCEEEEEECC
APNYRLG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]