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The map label for this gene is iscU [H]

Identifier: 59711225

GI number: 59711225

Start: 675827

End: 676210

Strand: Direct

Name: iscU [H]

Synonym: VF_0618

Alternate gene names: 59711225

Gene position: 675827-676210 (Clockwise)

Preceding gene: 59711224

Following gene: 59711226

Centisome position: 23.32

GC content: 40.62

Gene sequence:

>384_bases
ATGGCTTATAGCGAAAAAGTAATCGACCATTACGAAAACCCTCGTAATGTTGGTTCATTTGAAAAAGACGACCCATCAGT
GGGTAGCGGCATGGTTGGTGCTCCGGCTTGTGGTGATGTTATGAAACTACAAATCAAAGTATCTCCAGAAGGTGTTATCG
AAGATGCAAAATTCAAAACATACGGTTGTGGTTCTGCAATTGCATCAAGCTCATTAGTTACTGAGTGGGTAAAAGGTAAA
ACACTAGACGAAGCTGCAGCACTTAAAAATGCTGAAATTGCAGAAGAGCTTGAGTTACCACCAGTGAAAGTTCACTGTTC
AATTCTTGCAGAAGATGCGATCAAAGCAGCGGTATCTGATTACCGTAATAAACACCAAGATTAA

Upstream 100 bases:

>100_bases
TCACCACTGTGGGACATGTACAAAGAAGGCATCGACTTAAACACGGTTGAGTGGGCACACCACTAAAACACGGACGTTAC
AGAATTTAGAGGTATATATC

Downstream 100 bases:

>100_bases
TTATTTTTGGTTAGATAGAGCACCTTTATTATTTGTTTTATTAATAAAAGGTGCTTTATTATTGAGTAATGTCGTTAATA
ATTAATGACTCCCATGACCA

Product: scaffold protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 127; Mature: 126

Protein sequence:

>127_residues
MAYSEKVIDHYENPRNVGSFEKDDPSVGSGMVGAPACGDVMKLQIKVSPEGVIEDAKFKTYGCGSAIASSSLVTEWVKGK
TLDEAAALKNAEIAEELELPPVKVHCSILAEDAIKAAVSDYRNKHQD

Sequences:

>Translated_127_residues
MAYSEKVIDHYENPRNVGSFEKDDPSVGSGMVGAPACGDVMKLQIKVSPEGVIEDAKFKTYGCGSAIASSSLVTEWVKGK
TLDEAAALKNAEIAEELELPPVKVHCSILAEDAIKAAVSDYRNKHQD
>Mature_126_residues
AYSEKVIDHYENPRNVGSFEKDDPSVGSGMVGAPACGDVMKLQIKVSPEGVIEDAKFKTYGCGSAIASSSLVTEWVKGKT
LDEAAALKNAEIAEELELPPVKVHCSILAEDAIKAAVSDYRNKHQD

Specific function: May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins (Potential) [H]

COG id: COG0822

COG function: function code C; NifU homolog involved in Fe-S cluster formation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nifU family [H]

Homologues:

Organism=Homo sapiens, GI56699456, Length=124, Percent_Identity=70.1612903225807, Blast_Score=189, Evalue=4e-49,
Organism=Homo sapiens, GI24307953, Length=124, Percent_Identity=69.3548387096774, Blast_Score=187, Evalue=3e-48,
Organism=Escherichia coli, GI1788878, Length=126, Percent_Identity=83.3333333333333, Blast_Score=226, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17543474, Length=123, Percent_Identity=72.3577235772358, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6325122, Length=125, Percent_Identity=69.6, Blast_Score=185, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324800, Length=125, Percent_Identity=67.2, Blast_Score=178, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21355597, Length=124, Percent_Identity=73.3870967741936, Blast_Score=197, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011339
- InterPro:   IPR002871 [H]

Pfam domain/function: PF01592 NifU_N [H]

EC number: NA

Molecular weight: Translated: 13611; Mature: 13480

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSEKVIDHYENPRNVGSFEKDDPSVGSGMVGAPACGDVMKLQIKVSPEGVIEDAKFKT
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCC
YGCGSAIASSSLVTEWVKGKTLDEAAALKNAEIAEELELPPVKVHCSILAEDAIKAAVSD
CCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
YRNKHQD
HHHCCCC
>Mature Secondary Structure 
AYSEKVIDHYENPRNVGSFEKDDPSVGSGMVGAPACGDVMKLQIKVSPEGVIEDAKFKT
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCC
YGCGSAIASSSLVTEWVKGKTLDEAAALKNAEIAEELELPPVKVHCSILAEDAIKAAVSD
CCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
YRNKHQD
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]