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The map label for this gene is bglA [H]

Identifier: 59711212

GI number: 59711212

Start: 664198

End: 665607

Strand: Direct

Name: bglA [H]

Synonym: VF_0605

Alternate gene names: 59711212

Gene position: 664198-665607 (Clockwise)

Preceding gene: 59711211

Following gene: 59711213

Centisome position: 22.92

GC content: 38.65

Gene sequence:

>1410_bases
ATGAAATTTGCACATGATTTTTTATTTGGCGCAGCAACCGCTTCTTATCAAGTGGAAGGCGCGTGGGATCAAGATGGTAA
AGGTCCTACAAACTGGGATGAGTTTACTAAAATACCAGGAAAAACGTTTGAAGGAACTAACGGTGATGTCGCGGTTGATC
ATTACAATCGTTATAAAGAAGACATCGCTTTAATGGCGGAAATGGGGTTAGAGTCATACCGTTTTTCAATTTCTTGGGCT
CGTATTTTCCCAAATGGAACGGGTGAAATTAACCAAAAAGGCATCGATTTTTATAATAATCTGATCGATGAATGTTTGAA
ATATGGCATTGTTCCTTTTGTTACCCTATATCACTGGGATCTGCCATTAGCACTAGAAAAAGAAGGTGCATGGTTAAATA
AAGCAACGGGCGATGCGTATGTCGAGTTCGCTAAATTATGTTTCAACGAATTCGGTGACCGTGTTAAGCATTTTATAACG
TTTAATGAAACGGTTGTGTTCTGTGCTCTAGGATATATGGCAGGCGCACACCCACCAGGCATTCAAAATGACCCGAAAAA
ATACTTCCAAGCAACACATAACGTATTTTACGCTCATGCTAAAGCAGTGATTGAATATAAAAAATTAAATCAATTTGGTG
AGATTGGTTTGAGTCATGTATTTAGCCCTGCATTTGGGGTTGATGATTCTGAAGAGAGTCACTTTGCTGCAATGCATGCG
AATCAATTTAGTATGAACTGGTTCTATGATCCTATTTTGCTTGGTAAATACCCAGAGTATGTAGTTAAGCAATTACAAGA
AGAAGGTAACCTTCCTGATTGGACGGATGAAGAGCTACAAACTATTTTTGAAGCCGCACCTTTGAATGACTTTATGGGAT
TGAATTATTACCAGCCTCAGCGTGTAGAGAAAATTCAAGGGGATGTTGAAGCTCGTACGATTACACGAGAAAACTCAACG
GGCTCACCTGGTAACCCTAGTTACGATAATGTGTACCGTACTGTGAAAATGGCAGATAAAAAGTACACGAAATGGGATTG
GGAAATTTCACCTGAAGGGTTTGTTGGCGGATTAGAAATGCTGAAAGAGCACTATGGTCAAATTAAACTCTACATCACGG
AAAATGGTTTAGGTGATGAAGATCCAATCATTGAAGGTGAAGTGTGCGATATTCCACGTATTAATTTTATTAAAGAGCAC
TTAGGTGCGGTAAAAGAAGCGGTTCGTCGTGGTGTTCATATTAAAGGGTATTACGCTTGGTCTGCCATTGACTTATTAAG
TTGGTTAAATGGTTATAAAAAGCAATATGGTTTTATCTATGTAGATCATCAAAATGGATTGGCTCGTAAGAAAAAAGCAT
CATTCCACTGGTTTAAAGATGTCATAGCCACTCGTGGTGAAGATATTTAA

Upstream 100 bases:

>100_bases
GGATTACGGCATGATGAAAGGCGAGAAGATTCTAAATGATGCATTGGCTCTTTTAGACTAACAATATTCAGTTGGCTACA
GTAATAGACAGGAATTTGAA

Downstream 100 bases:

>100_bases
CTGAAATAAAGAGAGAAGTTCGCATTATGGCAACGTACATTTCGTTTGATATTGGTGGTACAGACATAAAGTTTGGCGTG
TTAAATGAACAAGGAAAAGT

Product: 6-phospho-beta-glucosidase A

Products: NA

Alternate protein names: 6-phospho-beta-glucosidase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MKFAHDFLFGAATASYQVEGAWDQDGKGPTNWDEFTKIPGKTFEGTNGDVAVDHYNRYKEDIALMAEMGLESYRFSISWA
RIFPNGTGEINQKGIDFYNNLIDECLKYGIVPFVTLYHWDLPLALEKEGAWLNKATGDAYVEFAKLCFNEFGDRVKHFIT
FNETVVFCALGYMAGAHPPGIQNDPKKYFQATHNVFYAHAKAVIEYKKLNQFGEIGLSHVFSPAFGVDDSEESHFAAMHA
NQFSMNWFYDPILLGKYPEYVVKQLQEEGNLPDWTDEELQTIFEAAPLNDFMGLNYYQPQRVEKIQGDVEARTITRENST
GSPGNPSYDNVYRTVKMADKKYTKWDWEISPEGFVGGLEMLKEHYGQIKLYITENGLGDEDPIIEGEVCDIPRINFIKEH
LGAVKEAVRRGVHIKGYYAWSAIDLLSWLNGYKKQYGFIYVDHQNGLARKKKASFHWFKDVIATRGEDI

Sequences:

>Translated_469_residues
MKFAHDFLFGAATASYQVEGAWDQDGKGPTNWDEFTKIPGKTFEGTNGDVAVDHYNRYKEDIALMAEMGLESYRFSISWA
RIFPNGTGEINQKGIDFYNNLIDECLKYGIVPFVTLYHWDLPLALEKEGAWLNKATGDAYVEFAKLCFNEFGDRVKHFIT
FNETVVFCALGYMAGAHPPGIQNDPKKYFQATHNVFYAHAKAVIEYKKLNQFGEIGLSHVFSPAFGVDDSEESHFAAMHA
NQFSMNWFYDPILLGKYPEYVVKQLQEEGNLPDWTDEELQTIFEAAPLNDFMGLNYYQPQRVEKIQGDVEARTITRENST
GSPGNPSYDNVYRTVKMADKKYTKWDWEISPEGFVGGLEMLKEHYGQIKLYITENGLGDEDPIIEGEVCDIPRINFIKEH
LGAVKEAVRRGVHIKGYYAWSAIDLLSWLNGYKKQYGFIYVDHQNGLARKKKASFHWFKDVIATRGEDI
>Mature_469_residues
MKFAHDFLFGAATASYQVEGAWDQDGKGPTNWDEFTKIPGKTFEGTNGDVAVDHYNRYKEDIALMAEMGLESYRFSISWA
RIFPNGTGEINQKGIDFYNNLIDECLKYGIVPFVTLYHWDLPLALEKEGAWLNKATGDAYVEFAKLCFNEFGDRVKHFIT
FNETVVFCALGYMAGAHPPGIQNDPKKYFQATHNVFYAHAKAVIEYKKLNQFGEIGLSHVFSPAFGVDDSEESHFAAMHA
NQFSMNWFYDPILLGKYPEYVVKQLQEEGNLPDWTDEELQTIFEAAPLNDFMGLNYYQPQRVEKIQGDVEARTITRENST
GSPGNPSYDNVYRTVKMADKKYTKWDWEISPEGFVGGLEMLKEHYGQIKLYITENGLGDEDPIIEGEVCDIPRINFIKEH
LGAVKEAVRRGVHIKGYYAWSAIDLLSWLNGYKKQYGFIYVDHQNGLARKKKASFHWFKDVIATRGEDI

Specific function: Is able to catalyze the hydrolysis of aryl-phospho-beta- D-glucosides such as 4-methylumbelliferyl-phospho-beta-D- glucopyranoside (MUG-P), phosphoarbutin and phosphosalicin. Is not essential for growth on arbutin and salicin as the sole carbon source [H]

COG id: COG2723

COG function: function code G; Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 1 family [H]

Homologues:

Organism=Homo sapiens, GI110681710, Length=485, Percent_Identity=36.0824742268041, Blast_Score=278, Evalue=6e-75,
Organism=Homo sapiens, GI32481206, Length=488, Percent_Identity=36.8852459016393, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI13273313, Length=466, Percent_Identity=37.1244635193133, Blast_Score=272, Evalue=6e-73,
Organism=Homo sapiens, GI28376633, Length=478, Percent_Identity=30.9623430962343, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI24497614, Length=468, Percent_Identity=29.4871794871795, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI190360571, Length=99, Percent_Identity=50.5050505050505, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI2367174, Length=502, Percent_Identity=34.6613545816733, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1789070, Length=497, Percent_Identity=33.6016096579477, Blast_Score=233, Evalue=3e-62,
Organism=Escherichia coli, GI2367270, Length=483, Percent_Identity=33.9544513457557, Blast_Score=232, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17552856, Length=478, Percent_Identity=32.8451882845188, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17539390, Length=459, Percent_Identity=32.4618736383442, Blast_Score=225, Evalue=5e-59,
Organism=Drosophila melanogaster, GI21356577, Length=489, Percent_Identity=32.5153374233129, Blast_Score=242, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001360
- InterPro:   IPR018120
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00232 Glyco_hydro_1 [H]

EC number: =3.2.1.86 [H]

Molecular weight: Translated: 53658; Mature: 53658

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00572 GLYCOSYL_HYDROL_F1_1 ; PS00653 GLYCOSYL_HYDROL_F1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFAHDFLFGAATASYQVEGAWDQDGKGPTNWDEFTKIPGKTFEGTNGDVAVDHYNRYKE
CCCHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEHHHHHHHH
DIALMAEMGLESYRFSISWARIFPNGTGEINQKGIDFYNNLIDECLKYGIVPFVTLYHWD
HHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCC
LPLALEKEGAWLNKATGDAYVEFAKLCFNEFGDRVKHFITFNETVVFCALGYMAGAHPPG
CCEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCCCCC
IQNDPKKYFQATHNVFYAHAKAVIEYKKLNQFGEIGLSHVFSPAFGVDDSEESHFAAMHA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEC
NQFSMNWFYDPILLGKYPEYVVKQLQEEGNLPDWTDEELQTIFEAAPLNDFMGLNYYQPQ
CEEECCEEECCEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHCCCCCCCHH
RVEKIQGDVEARTITRENSTGSPGNPSYDNVYRTVKMADKKYTKWDWEISPEGFVGGLEM
HHHHHHCCHHHEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHH
LKEHYGQIKLYITENGLGDEDPIIEGEVCDIPRINFIKEHLGAVKEAVRRGVHIKGYYAW
HHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEHH
SAIDLLSWLNGYKKQYGFIYVDHQNGLARKKKASFHWFKDVIATRGEDI
HHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKFAHDFLFGAATASYQVEGAWDQDGKGPTNWDEFTKIPGKTFEGTNGDVAVDHYNRYKE
CCCHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEHHHHHHHH
DIALMAEMGLESYRFSISWARIFPNGTGEINQKGIDFYNNLIDECLKYGIVPFVTLYHWD
HHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCC
LPLALEKEGAWLNKATGDAYVEFAKLCFNEFGDRVKHFITFNETVVFCALGYMAGAHPPG
CCEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCCCCC
IQNDPKKYFQATHNVFYAHAKAVIEYKKLNQFGEIGLSHVFSPAFGVDDSEESHFAAMHA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEC
NQFSMNWFYDPILLGKYPEYVVKQLQEEGNLPDWTDEELQTIFEAAPLNDFMGLNYYQPQ
CEEECCEEECCEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHCCCCCCCHH
RVEKIQGDVEARTITRENSTGSPGNPSYDNVYRTVKMADKKYTKWDWEISPEGFVGGLEM
HHHHHHCCHHHEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHH
LKEHYGQIKLYITENGLGDEDPIIEGEVCDIPRINFIKEHLGAVKEAVRRGVHIKGYYAW
HHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEHH
SAIDLLSWLNGYKKQYGFIYVDHQNGLARKKKASFHWFKDVIATRGEDI
HHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7704255; 8969502; 9384377; 2841296 [H]