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The map label for this gene is mltA [H]

Identifier: 59711194

GI number: 59711194

Start: 645166

End: 646266

Strand: Direct

Name: mltA [H]

Synonym: VF_0587

Alternate gene names: 59711194

Gene position: 645166-646266 (Clockwise)

Preceding gene: 59711193

Following gene: 59711195

Centisome position: 22.27

GC content: 40.96

Gene sequence:

>1101_bases
GTGTTTCGTAAATTATCTTTTGTGTGTGTTCTTCTTGGATTAGCTGGGTGTGCTGATCAACCAACAGATCGTGCTCAGCA
GTATCTGGATGGTGGGTTTAGTAGTAACTTGAATAAAGTTGGCGAAATTAATTCAGATAAGCCTTCAGATTTTAGTGCTT
TCAAAAAACAGAGTGCAGAAGTTTTAGAGCGTTCTGAATCAATGTCATTACGTTATGAAGAACTCTATGTTCAATTACAA
AAATGGATTGATGAAAGTTCAAACCCTGCAGAGTTGTCGAACTACGGTATTCAATTTGCTCAGATGGGGGGGGGGGATAA
AAAAGGTAACGTAATGTTTACCGGTTACTTTTCTCCAGTAATTGAGATGCGTCATACGCCGAACGAAACGTTTAAATACC
CAGTATATGATAAGCCTGATTGTGGTTCAGATTGTCCAACTCGTGCAGAAATTAACGCGGGAGCATTAGCAGGATTAGGA
CTTGAGTTAGGTTATGCTGATAACATGATTGACCCGTTTATCATGGAAGTGCAAGGCAGTGGCTTTGTCCATTTTGGTGA
TGATGACAAACTTGAGTATTTTGCCTATGGTGGGAAAAATAATCATCCTTACGTAAGTATTGGCCGCATTCTGATAGAGC
GTGGTGAAGTTGAGCGTAAAGATATGTCTTTAAAAGCAATCAAAGAATGGGTTGCGAAAAACGATGAAGCAACGGTTCGT
GAATTGTTAGAGACAAACCCTTCTTATGTCTTTTTCTCACCAAAAGAAGCGCATCATGTTTTAGGTACCGCTGGTATACC
ATTGCATGCTGGTGCCGCTGTAGCTGCCGATCGTACTTTATTGCCTATGGGAACCCCAATCCTTGCTGAGGTCCCTCAAT
TAGATAAAGACGGTAAGTGGACGGGGAAACACGTACTTAAAGTGTTGCTTGCTTTAGATACCGGTGGTGCTGTGAAAGAA
AACCATTTAGATCAATATTATGGAATGGGGACAGAAGCAGGTATTGCTGCGGGTCACTTTAAACATTTTGGTCGAGTGTG
GAAATTGGGTTTGCAGGATACTGAAACTGAAAATCCTTGGGAAATGCCTAAATCAGAATAA

Upstream 100 bases:

>100_bases
TCAAAATTATCCTTTTCTTACATTTATTGCACTCTAAATAATTGCCCTCTCTGAATTTGTTTGTCATCCTTGCCGCATTA
TTTCTCAATAAGGCTTTATT

Downstream 100 bases:

>100_bases
TGTGTTGGCCGCTTGTATCGCTTAACACTTGATCTTCTAAAAAAGAGTGCGTATAAATCGTGCTCTTTTTTTGTTTTTGA
GTAAGGTAACCCCATGCGCG

Product: murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MFRKLSFVCVLLGLAGCADQPTDRAQQYLDGGFSSNLNKVGEINSDKPSDFSAFKKQSAEVLERSESMSLRYEELYVQLQ
KWIDESSNPAELSNYGIQFAQMGGGDKKGNVMFTGYFSPVIEMRHTPNETFKYPVYDKPDCGSDCPTRAEINAGALAGLG
LELGYADNMIDPFIMEVQGSGFVHFGDDDKLEYFAYGGKNNHPYVSIGRILIERGEVERKDMSLKAIKEWVAKNDEATVR
ELLETNPSYVFFSPKEAHHVLGTAGIPLHAGAAVAADRTLLPMGTPILAEVPQLDKDGKWTGKHVLKVLLALDTGGAVKE
NHLDQYYGMGTEAGIAAGHFKHFGRVWKLGLQDTETENPWEMPKSE

Sequences:

>Translated_366_residues
MFRKLSFVCVLLGLAGCADQPTDRAQQYLDGGFSSNLNKVGEINSDKPSDFSAFKKQSAEVLERSESMSLRYEELYVQLQ
KWIDESSNPAELSNYGIQFAQMGGGDKKGNVMFTGYFSPVIEMRHTPNETFKYPVYDKPDCGSDCPTRAEINAGALAGLG
LELGYADNMIDPFIMEVQGSGFVHFGDDDKLEYFAYGGKNNHPYVSIGRILIERGEVERKDMSLKAIKEWVAKNDEATVR
ELLETNPSYVFFSPKEAHHVLGTAGIPLHAGAAVAADRTLLPMGTPILAEVPQLDKDGKWTGKHVLKVLLALDTGGAVKE
NHLDQYYGMGTEAGIAAGHFKHFGRVWKLGLQDTETENPWEMPKSE
>Mature_366_residues
MFRKLSFVCVLLGLAGCADQPTDRAQQYLDGGFSSNLNKVGEINSDKPSDFSAFKKQSAEVLERSESMSLRYEELYVQLQ
KWIDESSNPAELSNYGIQFAQMGGGDKKGNVMFTGYFSPVIEMRHTPNETFKYPVYDKPDCGSDCPTRAEINAGALAGLG
LELGYADNMIDPFIMEVQGSGFVHFGDDDKLEYFAYGGKNNHPYVSIGRILIERGEVERKDMSLKAIKEWVAKNDEATVR
ELLETNPSYVFFSPKEAHHVLGTAGIPLHAGAAVAADRTLLPMGTPILAEVPQLDKDGKWTGKHVLKVLLALDTGGAVKE
NHLDQYYGMGTEAGIAAGHFKHFGRVWKLGLQDTETENPWEMPKSE

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=342, Percent_Identity=44.7368421052632, Blast_Score=312, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40447; Mature: 40447

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRKLSFVCVLLGLAGCADQPTDRAQQYLDGGFSSNLNKVGEINSDKPSDFSAFKKQSAE
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHH
VLERSESMSLRYEELYVQLQKWIDESSNPAELSNYGIQFAQMGGGDKKGNVMFTGYFSPV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCEEEEECCCCCCCCCEEEEECCCHH
IEMRHTPNETFKYPVYDKPDCGSDCPTRAEINAGALAGLGLELGYADNMIDPFIMEVQGS
HHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEECCCEEECCCCCCCCCEEEEECCC
GFVHFGDDDKLEYFAYGGKNNHPYVSIGRILIERGEVERKDMSLKAIKEWVAKNDEATVR
CEEEECCCCCEEEEEECCCCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHH
ELLETNPSYVFFSPKEAHHVLGTAGIPLHAGAAVAADRTLLPMGTPILAEVPQLDKDGKW
HHHHCCCCEEEECCCHHHHHHCCCCCCCCCCCHHHCCCEECCCCCHHHHHCCCCCCCCCC
TGKHVLKVLLALDTGGAVKENHLDQYYGMGTEAGIAAGHFKHFGRVWKLGLQDTETENPW
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
EMPKSE
CCCCCC
>Mature Secondary Structure
MFRKLSFVCVLLGLAGCADQPTDRAQQYLDGGFSSNLNKVGEINSDKPSDFSAFKKQSAE
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHH
VLERSESMSLRYEELYVQLQKWIDESSNPAELSNYGIQFAQMGGGDKKGNVMFTGYFSPV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCEEEEECCCCCCCCCEEEEECCCHH
IEMRHTPNETFKYPVYDKPDCGSDCPTRAEINAGALAGLGLELGYADNMIDPFIMEVQGS
HHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEECCCEEECCCCCCCCCEEEEECCC
GFVHFGDDDKLEYFAYGGKNNHPYVSIGRILIERGEVERKDMSLKAIKEWVAKNDEATVR
CEEEECCCCCEEEEEECCCCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHH
ELLETNPSYVFFSPKEAHHVLGTAGIPLHAGAAVAADRTLLPMGTPILAEVPQLDKDGKW
HHHHCCCCEEEECCCHHHHHHCCCCCCCCCCCHHHCCCEECCCCCHHHHHCCCCCCCCCC
TGKHVLKVLLALDTGGAVKENHLDQYYGMGTEAGIAAGHFKHFGRVWKLGLQDTETENPW
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
EMPKSE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]