Click here to switch to the map view.

The map label for this gene is oadA [H]

Identifier: 59711146

GI number: 59711146

Start: 585207

End: 586994

Strand: Direct

Name: oadA [H]

Synonym: VF_0539

Alternate gene names: 59711146

Gene position: 585207-586994 (Clockwise)

Preceding gene: 172087670

Following gene: 59711147

Centisome position: 20.2

GC content: 40.21

Gene sequence:

>1788_bases
ATGTCTAAACCACTTTCTATCACTGATGTGGTACTTCGTGACGCCCATCAATCACTATTTGCAACACGTATGCGTGTTGA
AGATATGTTACCGATTGCAGAACAGTTGGATAAAATTGGTTATTGGTCTCTAGAAACTTGGGGAGGCGCAACATTTGATT
CTTGTATTCGTTATCTAGGAGAAGATCCGTGGGAGCGTTTACGATTATTAAAAAAAGCCATGCCAAATACACCAATGCAA
ATGCTTTTACGTGGTCAAAACTTATTAGGTTATCGTCACTATGCCGATGATGTAGTTGAGAAGTTTGTTGAGCGAGCACA
TGCAAATGGAATGGATGTATTCCGTATTTTTGATGCAATGAACGATGTAAGAAACTTTCAAAAAGCGGTAAAAGCGACAA
TCGACGTAGGCGCTCATGCACAAGGTACGCTTTCATACACAACAAGTCCTGTTCATAATACCGATACTTGGGTCGATTTA
GCCAAACGCCTAGAAGATTTAGGTTGTCACTCTCTATGTATAAAAGACATGTCGGGTTTGCTTAAACCTTATGAAGCTGA
AGAGTTAATCACTCGAATTAAGGCATCCTGTGATGTGCCTTTAGCTCTGCATAGCCATGCAACAACTGGACTTTCTACCG
CAACAGCAATTAAAGCTGTAGAAGCTGGTATTGATATTCTTGATACGGCTATTTCTTCAATGAGTCAAACTTATGGTCAT
ACACCAACAGAAACCGTTGTTGCTATGTTAGAAGAAACTGGACGTGATACTAATCTGAAATTAGATCAATTAGCACCTAT
TGCTAGTTATTTCCGAGAAGTTCGTAAAAAATATGCAAAATTTGAAGGTCAACTAAAAGGGGTTGATTCACGAATTCTTA
TTGCTCAAGTTCCGGGTGGCATGCTGACTAATATGGAAAGCCAACTTAAAGAGCAAGGTGCTGCTGATAAGATGGATGAA
GTTTTAGCAGAGATCCCTAAAGTGCGTAAAGATCTTGGTTATATTCCACTAGTAACGCCAACTTCTCAAATTGTGGGAAC
ACAAGCGGTGATTAATGTTCTTACTGGAGAGCGTTATAAGAGCATAACAAAAGAAACTGCTGGTGTACTGAAAGGGGAAT
ACGGTGCAGCCCCTGCTGAGGTTAATGCTGAGTTACAAGCTCGAGTTCTTGATGGTAAAGAAGCGGTAACTTGTCGTCCT
GCTGATCTTTTAAAAGCGGAACTTCATACATTAACTGATGAGTTACTGGAAAAAGCGAAAGAAGAGAATATTGAACTTGC
TGAGCAACAAGTTGATGATGTTTTAACTTATGCATTATTCCCTCAAGTTGGTTTGAAATTCCTTAAAAACCGTAATAATC
CAGAGGCATTTGAACCCGCTCCAGGTACTGAAAAAGAAGCAGAGAAGGAAGAGGTCAAAGTCTCTGCGGCTAAAGGCAGT
GTTGAAGCCTATAGCGTAAAAGTGGATGGGCAAGTATATAACGTTGAAGTTGGTCCTCAGGGAGTTATCTCTTCTGTTGA
ACAAATTTCAGCGCAAGCTGCTCCAGTTCAATCACCGCAACTTTCTGCAATGGATGCTGAATCTGTTGATGCTCCATTGG
CAGGCAATATCTTTAAGGTATTAGTGCAAGCAGGTGCAGAAGTTGTTGAAGGTGATGTATTACTTATTCTTGAAGCAATG
AAAATGGAAACAGAAATCAAAGCTTCACGTAGTGGTACAGTGCAAGATATTTTAACTAAAGAAGGTGATGCGGTTACTGT
TGGTACACCGTTACTTTCTCTAGCGTAG

Upstream 100 bases:

>100_bases
GCAGCCTCAGATAATTGCTGCAATTTCTGCTGCGATTAAATTACACCGCGAAAAGAATAAATAACTGTTTTAGGAAAATT
ATTACAAGGAGTTTGTAAGC

Downstream 100 bases:

>100_bases
ATGTAGGTATAAAACATGGATGGTTTATTAACATTATGGAATGAAACAGCCATTGCCAATTTTAAGTTTGAGCAACTTAT
TATGATGGCTGTGGGTTGTG

Product: oxaloacetate decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MSKPLSITDVVLRDAHQSLFATRMRVEDMLPIAEQLDKIGYWSLETWGGATFDSCIRYLGEDPWERLRLLKKAMPNTPMQ
MLLRGQNLLGYRHYADDVVEKFVERAHANGMDVFRIFDAMNDVRNFQKAVKATIDVGAHAQGTLSYTTSPVHNTDTWVDL
AKRLEDLGCHSLCIKDMSGLLKPYEAEELITRIKASCDVPLALHSHATTGLSTATAIKAVEAGIDILDTAISSMSQTYGH
TPTETVVAMLEETGRDTNLKLDQLAPIASYFREVRKKYAKFEGQLKGVDSRILIAQVPGGMLTNMESQLKEQGAADKMDE
VLAEIPKVRKDLGYIPLVTPTSQIVGTQAVINVLTGERYKSITKETAGVLKGEYGAAPAEVNAELQARVLDGKEAVTCRP
ADLLKAELHTLTDELLEKAKEENIELAEQQVDDVLTYALFPQVGLKFLKNRNNPEAFEPAPGTEKEAEKEEVKVSAAKGS
VEAYSVKVDGQVYNVEVGPQGVISSVEQISAQAAPVQSPQLSAMDAESVDAPLAGNIFKVLVQAGAEVVEGDVLLILEAM
KMETEIKASRSGTVQDILTKEGDAVTVGTPLLSLA

Sequences:

>Translated_595_residues
MSKPLSITDVVLRDAHQSLFATRMRVEDMLPIAEQLDKIGYWSLETWGGATFDSCIRYLGEDPWERLRLLKKAMPNTPMQ
MLLRGQNLLGYRHYADDVVEKFVERAHANGMDVFRIFDAMNDVRNFQKAVKATIDVGAHAQGTLSYTTSPVHNTDTWVDL
AKRLEDLGCHSLCIKDMSGLLKPYEAEELITRIKASCDVPLALHSHATTGLSTATAIKAVEAGIDILDTAISSMSQTYGH
TPTETVVAMLEETGRDTNLKLDQLAPIASYFREVRKKYAKFEGQLKGVDSRILIAQVPGGMLTNMESQLKEQGAADKMDE
VLAEIPKVRKDLGYIPLVTPTSQIVGTQAVINVLTGERYKSITKETAGVLKGEYGAAPAEVNAELQARVLDGKEAVTCRP
ADLLKAELHTLTDELLEKAKEENIELAEQQVDDVLTYALFPQVGLKFLKNRNNPEAFEPAPGTEKEAEKEEVKVSAAKGS
VEAYSVKVDGQVYNVEVGPQGVISSVEQISAQAAPVQSPQLSAMDAESVDAPLAGNIFKVLVQAGAEVVEGDVLLILEAM
KMETEIKASRSGTVQDILTKEGDAVTVGTPLLSLA
>Mature_594_residues
SKPLSITDVVLRDAHQSLFATRMRVEDMLPIAEQLDKIGYWSLETWGGATFDSCIRYLGEDPWERLRLLKKAMPNTPMQM
LLRGQNLLGYRHYADDVVEKFVERAHANGMDVFRIFDAMNDVRNFQKAVKATIDVGAHAQGTLSYTTSPVHNTDTWVDLA
KRLEDLGCHSLCIKDMSGLLKPYEAEELITRIKASCDVPLALHSHATTGLSTATAIKAVEAGIDILDTAISSMSQTYGHT
PTETVVAMLEETGRDTNLKLDQLAPIASYFREVRKKYAKFEGQLKGVDSRILIAQVPGGMLTNMESQLKEQGAADKMDEV
LAEIPKVRKDLGYIPLVTPTSQIVGTQAVINVLTGERYKSITKETAGVLKGEYGAAPAEVNAELQARVLDGKEAVTCRPA
DLLKAELHTLTDELLEKAKEENIELAEQQVDDVLTYALFPQVGLKFLKNRNNPEAFEPAPGTEKEAEKEEVKVSAAKGSV
EAYSVKVDGQVYNVEVGPQGVISSVEQISAQAAPVQSPQLSAMDAESVDAPLAGNIFKVLVQAGAEVVEGDVLLILEAMK
METEIKASRSGTVQDILTKEGDAVTVGTPLLSLA

Specific function: Lyase and sodium transporter [H]

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=620, Percent_Identity=32.5806451612903, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI106049295, Length=620, Percent_Identity=32.5806451612903, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI106049292, Length=620, Percent_Identity=32.5806451612903, Blast_Score=276, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17562816, Length=616, Percent_Identity=33.7662337662338, Blast_Score=299, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6319695, Length=624, Percent_Identity=31.8910256410256, Blast_Score=295, Evalue=9e-81,
Organism=Saccharomyces cerevisiae, GI6321376, Length=616, Percent_Identity=31.8181818181818, Blast_Score=282, Evalue=8e-77,
Organism=Drosophila melanogaster, GI24652212, Length=621, Percent_Identity=33.8164251207729, Blast_Score=301, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24652210, Length=621, Percent_Identity=33.8164251207729, Blast_Score=301, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24652214, Length=621, Percent_Identity=33.8164251207729, Blast_Score=301, Evalue=1e-81,
Organism=Drosophila melanogaster, GI19921944, Length=621, Percent_Identity=33.8164251207729, Blast_Score=301, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24652216, Length=621, Percent_Identity=33.8164251207729, Blast_Score=301, Evalue=1e-81,
Organism=Drosophila melanogaster, GI281363050, Length=621, Percent_Identity=33.8164251207729, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24652224, Length=621, Percent_Identity=33.8164251207729, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24652222, Length=621, Percent_Identity=33.8164251207729, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24652220, Length=621, Percent_Identity=33.8164251207729, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24652218, Length=621, Percent_Identity=33.8164251207729, Blast_Score=300, Evalue=1e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR003379
- InterPro:   IPR005776
- InterPro:   IPR000891
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =4.1.1.3 [H]

Molecular weight: Translated: 64872; Mature: 64741

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPLSITDVVLRDAHQSLFATRMRVEDMLPIAEQLDKIGYWSLETWGGATFDSCIRYLG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHC
EDPWERLRLLKKAMPNTPMQMLLRGQNLLGYRHYADDVVEKFVERAHANGMDVFRIFDAM
CCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
NDVRNFQKAVKATIDVGAHAQGTLSYTTSPVHNTDTWVDLAKRLEDLGCHSLCIKDMSGL
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
LKPYEAEELITRIKASCDVPLALHSHATTGLSTATAIKAVEAGIDILDTAISSMSQTYGH
CCCCCHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TPTETVVAMLEETGRDTNLKLDQLAPIASYFREVRKKYAKFEGQLKGVDSRILIAQVPGG
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
MLTNMESQLKEQGAADKMDEVLAEIPKVRKDLGYIPLVTPTSQIVGTQAVINVLTGERYK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHH
SITKETAGVLKGEYGAAPAEVNAELQARVLDGKEAVTCRPADLLKAELHTLTDELLEKAK
HHHHHHHHHHCCCCCCCCCCCCCHHHEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHH
EENIELAEQQVDDVLTYALFPQVGLKFLKNRNNPEAFEPAPGTEKEAEKEEVKVSAAKGS
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
VEAYSVKVDGQVYNVEVGPQGVISSVEQISAQAAPVQSPQLSAMDAESVDAPLAGNIFKV
CEEEEEEECCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCHHHHHH
LVQAGAEVVEGDVLLILEAMKMETEIKASRSGTVQDILTKEGDAVTVGTPLLSLA
HHHHCHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCCHHHCC
>Mature Secondary Structure 
SKPLSITDVVLRDAHQSLFATRMRVEDMLPIAEQLDKIGYWSLETWGGATFDSCIRYLG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHC
EDPWERLRLLKKAMPNTPMQMLLRGQNLLGYRHYADDVVEKFVERAHANGMDVFRIFDAM
CCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
NDVRNFQKAVKATIDVGAHAQGTLSYTTSPVHNTDTWVDLAKRLEDLGCHSLCIKDMSGL
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
LKPYEAEELITRIKASCDVPLALHSHATTGLSTATAIKAVEAGIDILDTAISSMSQTYGH
CCCCCHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TPTETVVAMLEETGRDTNLKLDQLAPIASYFREVRKKYAKFEGQLKGVDSRILIAQVPGG
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
MLTNMESQLKEQGAADKMDEVLAEIPKVRKDLGYIPLVTPTSQIVGTQAVINVLTGERYK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHH
SITKETAGVLKGEYGAAPAEVNAELQARVLDGKEAVTCRPADLLKAELHTLTDELLEKAK
HHHHHHHHHHCCCCCCCCCCCCCHHHEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHH
EENIELAEQQVDDVLTYALFPQVGLKFLKNRNNPEAFEPAPGTEKEAEKEEVKVSAAKGS
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
VEAYSVKVDGQVYNVEVGPQGVISSVEQISAQAAPVQSPQLSAMDAESVDAPLAGNIFKV
CEEEEEEECCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCHHHHHH
LVQAGAEVVEGDVLLILEAMKMETEIKASRSGTVQDILTKEGDAVTVGTPLLSLA
HHHHCHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2454915 [H]