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The map label for this gene is lysC [H]

Identifier: 59711144

GI number: 59711144

Start: 581256

End: 582425

Strand: Direct

Name: lysC [H]

Synonym: VF_0537

Alternate gene names: 59711144

Gene position: 581256-582425 (Clockwise)

Preceding gene: 59711143

Following gene: 59711145

Centisome position: 20.06

GC content: 39.57

Gene sequence:

>1170_bases
GTGGCATTAATCGTACAAAAGTATGGTGGTACATCAGTTGGATCCGTTGAACGGATCCAATCTGTTTCCGAACGTATCAT
ATCAACACTGCAGCAAGGGCATGATGTCGTTGTTGCGGTTTCTGCCATGGCAGGAGAAACAAACCGACTATTGCATTTAG
CAAATCAAATAAGTGAGGTACCTGAACCTCGTGAATTAGATATGTTACTTTCAGCTGGTGAACAAGTTTCTATTGCGTTA
TTGGCAATGTCTTTAAATCAAAAGGGCATAAAAGCAATATCACTAACCGCTGACCAAGCGGGCATTCATACGAATAACTC
ATTCAATGATGCGACAATTAAGCATATTGAAACGGATCTTATCACTCAGTGGGTAGATAAAGGGTATGTCGTTATTGTAG
CTGGGTTCCAAGGTCGAGATGACCAAGGTAACATTACTACATTAGGTCGAGGTGGTTCCGATACCACAGCAGTAGCGCTT
GCCGCTGCACTAGATGCTGATGAGTGCCAGATTTTTACTGATGTTGATGGGGTATATACCTCTGATCCTCGTTTTGTATC
TAATACCCGCCGTTTAGAAGAAGTTTCTTTTTCTGATATGCATGCACTAGCAAAATCTGGAGCCAAAGTTCTTCAAGAGC
ATTCTGTCGCTCATGCTTGGAATTCATCGGTAGCATTGAGGGTACTATCCTCATTTGAAGATGGCGAAGGAACGTTAATT
TGTGAGAATCCTAAACAACCTTTAGCGGTTACTGGATTAGCACTCAAACAAGATTTATCTTTGGTTGAATGTGAGAATAT
TTCAAGCGAAGAGCAAGCAGAACTCTATAAACAGTATAGAGTGTTAAATGAAAGATGTGATTGTTTTCAAATTGTTGTAC
CTAAAGCGACTTTTTTACAATTGAAGCTGGCATTTGATACTAAAATACGCAATATTAGTAGCTTATCAATTCTGACGTTA
GTCGGAGATAATGTTGAAGGGATGGCAGAGTCTGCTTGCAATCAACTATTGGCAAATGATATTGATGTTCATCAATATGA
TATTGAGCCAAAAAGTGTGTCGGTTATCGTAAATCAAGCTGATTTACACCGAGCGGCCGAAATTTTACATAAAACGTTTG
TTATTACAGAGCAATCGCAAGATAATGATCTTTTGGTCGCTGTTTCTTGA

Upstream 100 bases:

>100_bases
AGATATGGCTCAAGCTGGCGGTACTGATGCTGAAGCATTACCAAATGCACTTGCTTCTGTTGAAGCTTGGCTAACTGAGC
GTCTATAATAGGTCGTATCA

Downstream 100 bases:

>100_bases
GCAAAGACGTTTATGAAAATAAGCGATAACGGACGATACATACATTTATTATAATACTGAGATAACTCAAGGAGCATTCG
AATGCTAATTTTGACTCGCC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MALIVQKYGGTSVGSVERIQSVSERIISTLQQGHDVVVAVSAMAGETNRLLHLANQISEVPEPRELDMLLSAGEQVSIAL
LAMSLNQKGIKAISLTADQAGIHTNNSFNDATIKHIETDLITQWVDKGYVVIVAGFQGRDDQGNITTLGRGGSDTTAVAL
AAALDADECQIFTDVDGVYTSDPRFVSNTRRLEEVSFSDMHALAKSGAKVLQEHSVAHAWNSSVALRVLSSFEDGEGTLI
CENPKQPLAVTGLALKQDLSLVECENISSEEQAELYKQYRVLNERCDCFQIVVPKATFLQLKLAFDTKIRNISSLSILTL
VGDNVEGMAESACNQLLANDIDVHQYDIEPKSVSVIVNQADLHRAAEILHKTFVITEQSQDNDLLVAVS

Sequences:

>Translated_389_residues
MALIVQKYGGTSVGSVERIQSVSERIISTLQQGHDVVVAVSAMAGETNRLLHLANQISEVPEPRELDMLLSAGEQVSIAL
LAMSLNQKGIKAISLTADQAGIHTNNSFNDATIKHIETDLITQWVDKGYVVIVAGFQGRDDQGNITTLGRGGSDTTAVAL
AAALDADECQIFTDVDGVYTSDPRFVSNTRRLEEVSFSDMHALAKSGAKVLQEHSVAHAWNSSVALRVLSSFEDGEGTLI
CENPKQPLAVTGLALKQDLSLVECENISSEEQAELYKQYRVLNERCDCFQIVVPKATFLQLKLAFDTKIRNISSLSILTL
VGDNVEGMAESACNQLLANDIDVHQYDIEPKSVSVIVNQADLHRAAEILHKTFVITEQSQDNDLLVAVS
>Mature_388_residues
ALIVQKYGGTSVGSVERIQSVSERIISTLQQGHDVVVAVSAMAGETNRLLHLANQISEVPEPRELDMLLSAGEQVSIALL
AMSLNQKGIKAISLTADQAGIHTNNSFNDATIKHIETDLITQWVDKGYVVIVAGFQGRDDQGNITTLGRGGSDTTAVALA
AALDADECQIFTDVDGVYTSDPRFVSNTRRLEEVSFSDMHALAKSGAKVLQEHSVAHAWNSSVALRVLSSFEDGEGTLIC
ENPKQPLAVTGLALKQDLSLVECENISSEEQAELYKQYRVLNERCDCFQIVVPKATFLQLKLAFDTKIRNISSLSILTLV
GDNVEGMAESACNQLLANDIDVHQYDIEPKSVSVIVNQADLHRAAEILHKTFVITEQSQDNDLLVAVS

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=321, Percent_Identity=29.595015576324, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1786183, Length=345, Percent_Identity=24.0579710144928, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790376, Length=173, Percent_Identity=27.7456647398844, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=185, Percent_Identity=27.5675675675676, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 42206; Mature: 42075

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVQKYGGTSVGSVERIQSVSERIISTLQQGHDVVVAVSAMAGETNRLLHLANQISEV
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHC
PEPRELDMLLSAGEQVSIALLAMSLNQKGIKAISLTADQAGIHTNNSFNDATIKHIETDL
CCCHHHHHHHCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
ITQWVDKGYVVIVAGFQGRDDQGNITTLGRGGSDTTAVALAAALDADECQIFTDVDGVYT
HHHHHCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCEEEECCCCEEC
SDPRFVSNTRRLEEVSFSDMHALAKSGAKVLQEHSVAHAWNSSVALRVLSSFEDGEGTLI
CCCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEE
CENPKQPLAVTGLALKQDLSLVECENISSEEQAELYKQYRVLNERCDCFQIVVPKATFLQ
ECCCCCCEEEECHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEE
LKLAFDTKIRNISSLSILTLVGDNVEGMAESACNQLLANDIDVHQYDIEPKSVSVIVNQA
EEEEECHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEHH
DLHRAAEILHKTFVITEQSQDNDLLVAVS
HHHHHHHHHHHHEEEEECCCCCCEEEEEC
>Mature Secondary Structure 
ALIVQKYGGTSVGSVERIQSVSERIISTLQQGHDVVVAVSAMAGETNRLLHLANQISEV
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHC
PEPRELDMLLSAGEQVSIALLAMSLNQKGIKAISLTADQAGIHTNNSFNDATIKHIETDL
CCCHHHHHHHCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
ITQWVDKGYVVIVAGFQGRDDQGNITTLGRGGSDTTAVALAAALDADECQIFTDVDGVYT
HHHHHCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCEEEECCCCEEC
SDPRFVSNTRRLEEVSFSDMHALAKSGAKVLQEHSVAHAWNSSVALRVLSSFEDGEGTLI
CCCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEE
CENPKQPLAVTGLALKQDLSLVECENISSEEQAELYKQYRVLNERCDCFQIVVPKATFLQ
ECCCCCCEEEECHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEE
LKLAFDTKIRNISSLSILTLVGDNVEGMAESACNQLLANDIDVHQYDIEPKSVSVIVNQA
EEEEECHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEHH
DLHRAAEILHKTFVITEQSQDNDLLVAVS
HHHHHHHHHHHHEEEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]