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The map label for this gene is csrD [H]

Identifier: 59710962

GI number: 59710962

Start: 386002

End: 387981

Strand: Direct

Name: csrD [H]

Synonym: VF_0355

Alternate gene names: 59710962

Gene position: 386002-387981 (Clockwise)

Preceding gene: 59710960

Following gene: 59710963

Centisome position: 13.32

GC content: 36.97

Gene sequence:

>1980_bases
ATGAGAAAAACGCCTAGTTTACGTTTAAGTAACCGCTTAATTTCGTTTGTTACTTTGATGGTTTCTGCCGCAATATTTAT
ATTATTTATTGGTGGTACTATCTCAGTTAAGCAAATTGGTACAGAGTATCTCGATCATTATTTAACAGGGGTTGTTACCG
TTGTTGATGAAGAGTTAGTCAATCCTGAGAAAGCGAAATCCATGGAAACGTGGCTACCAAAACTGCTGAAAGCCAGTAAT
GTGGTTAGCATGGACCTGTCTTCTTCTACTGGGCCTATATACTCTTTTCAAAGCTTAGCTATTATTCCTGATGATAGTTT
GTTGTACCATAAAACACTTCCACTACAAATTAATAAAGGATATGAAATTTCCTTTAAGTCAGTACCTCCTTACAGTGCTT
TTACTTATTCGTTGGGAGCTCTATTTTCTATTACTGCTGCCATTGCTGTTATCGTTGTTTCACTCTTATGGGGTGTTGTT
TGGCTGAGAAAACAATTACATGGTTCTGAGTTATTAGAAGAAAGAGGTCGGATGCTATTGGCTGGGAAACTTGACGATTA
CTCTACCGGTAGCGAAGAAGAATGGCCAGCCACAGCAAGTTTAGCATTAGATAATATTATTGCGGAATTAAAAGATGCAA
GAAAAGAACGCAGCCGTTTTGATACCTTTATTCGAACTCATACTTTTTTAGATCAATTAACGGGCTCAGCGAATAGAGTG
CTATTTGATAGTAAATTAGAGTCTATTTTGCAGGAATCTCAAAGCCAAGGGGTTTTATTATTACTACGCATTAATGGCTG
GGAAGAATTAGTTGAAGAGCAAGGAAGTGCTGTTGGGGATGAATTAATTGTTGAGGTAGGAAAGCAATTAAATAATATCA
TGCAACGTTACAGTGATAGTGTTCTTTCTCGTTATTATCAATCAGACTTTGCTTTATTGGTTCCCCAACAATCATTGAAA
GAGGCGAAATCACTAGCTGCTCAATGTCTAAAGTTAATAGAAAAAATTAATCCACCTCGTAGCTTGGACCGTGATAACTG
GTGTCATATTGGGGTGAGTATGTTTGTAAGCGGCGAACGACGTGGTCGTTTGATGGAAGAGCTTGATATGGCTCATCGTA
GCGCCTTACTTCAAAACAACAACACTTGGTCGTTATTTAAAAAGCAGCAGCAATTAGCAGAGAGTTTAGGAAGTGTTCGA
TGGAGAACCTTATTTGATGCTATTTTTCAGCAAGATAAATTAATTATTTATAAGCAGCCAACTTTTTTATTTGATGGTAA
TGAACTTGTACCTCTCCATTTAGAGTTATTTTCACGTATAAAAGATGAAAATGGTGTTCAAATTAAGGCTTCACGTTTCT
TACCTGCAATTAAACAAGTAGGGTATCAAGTCAAACTTGATAGTGCGGTCTTAAAACAAGTGTTCCCTTTATTAAGTGAC
CCTGAATTAAATCACAATTCGTTTTCAGTTCATTTACAGGTTAAGAGCATTACTAATGCGGCATTTATCCGTCAATTAAG
AAATCGTTTATTGCAAACGCCAAGAGCACAGCTTCAACGACTAAGTTTTGAGTTAATTGAAGGTCAGGTTGTTACCTATT
TAGATGCTGTAAGACCCGTCGCAAAAATGTTAAAAAGTTTTGGTTGTCAATTGGTCGTAGAGCAAGCGGGAAGAACTATT
GTAAGTACTCATTATATTAAAGATTTGAATGTTGATTTTGTAAAACTCCATCGTAGTTTAATGAAGGACATTCATCAGAG
ATATGAGAATCAATTATTCGTTCGTAGTCTGTTGGGTGCATGTGAAACCACGGGAGCTCAAGTGATTGCTGTTGGTATAG
AAAAAGAAAAGGAATTTAGATTATTAAAAGATCTTGGCGTTGAAGGTGGACAAGGGCGATTTTTTGAATCAGAAACGGCT
CTGCATCATCGCCAAGAAAAGGTATCTATACCTAAGCGAAGAAGCCGTTGGGGTAAATAA

Upstream 100 bases:

>100_bases
ATTTGTATTATATCTAATACGTATTTAGAGAATGTTCTAAATTTATCAATGAATTTGTGTATATATTCACAATCTATTTT
CTTCAAGGAAGAAGAGCTTA

Downstream 100 bases:

>100_bases
AATTCTCTTATTTTGTTAATAACGGTCGTATCCTAAAAGAATAGAATGTTGTATGATTGCGCGTCACTTGTGTTCTTTAT
GAGAACGTTGTAAGTAAAGT

Product: regulatory protein CsrD

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MRKTPSLRLSNRLISFVTLMVSAAIFILFIGGTISVKQIGTEYLDHYLTGVVTVVDEELVNPEKAKSMETWLPKLLKASN
VVSMDLSSSTGPIYSFQSLAIIPDDSLLYHKTLPLQINKGYEISFKSVPPYSAFTYSLGALFSITAAIAVIVVSLLWGVV
WLRKQLHGSELLEERGRMLLAGKLDDYSTGSEEEWPATASLALDNIIAELKDARKERSRFDTFIRTHTFLDQLTGSANRV
LFDSKLESILQESQSQGVLLLLRINGWEELVEEQGSAVGDELIVEVGKQLNNIMQRYSDSVLSRYYQSDFALLVPQQSLK
EAKSLAAQCLKLIEKINPPRSLDRDNWCHIGVSMFVSGERRGRLMEELDMAHRSALLQNNNTWSLFKKQQQLAESLGSVR
WRTLFDAIFQQDKLIIYKQPTFLFDGNELVPLHLELFSRIKDENGVQIKASRFLPAIKQVGYQVKLDSAVLKQVFPLLSD
PELNHNSFSVHLQVKSITNAAFIRQLRNRLLQTPRAQLQRLSFELIEGQVVTYLDAVRPVAKMLKSFGCQLVVEQAGRTI
VSTHYIKDLNVDFVKLHRSLMKDIHQRYENQLFVRSLLGACETTGAQVIAVGIEKEKEFRLLKDLGVEGGQGRFFESETA
LHHRQEKVSIPKRRSRWGK

Sequences:

>Translated_659_residues
MRKTPSLRLSNRLISFVTLMVSAAIFILFIGGTISVKQIGTEYLDHYLTGVVTVVDEELVNPEKAKSMETWLPKLLKASN
VVSMDLSSSTGPIYSFQSLAIIPDDSLLYHKTLPLQINKGYEISFKSVPPYSAFTYSLGALFSITAAIAVIVVSLLWGVV
WLRKQLHGSELLEERGRMLLAGKLDDYSTGSEEEWPATASLALDNIIAELKDARKERSRFDTFIRTHTFLDQLTGSANRV
LFDSKLESILQESQSQGVLLLLRINGWEELVEEQGSAVGDELIVEVGKQLNNIMQRYSDSVLSRYYQSDFALLVPQQSLK
EAKSLAAQCLKLIEKINPPRSLDRDNWCHIGVSMFVSGERRGRLMEELDMAHRSALLQNNNTWSLFKKQQQLAESLGSVR
WRTLFDAIFQQDKLIIYKQPTFLFDGNELVPLHLELFSRIKDENGVQIKASRFLPAIKQVGYQVKLDSAVLKQVFPLLSD
PELNHNSFSVHLQVKSITNAAFIRQLRNRLLQTPRAQLQRLSFELIEGQVVTYLDAVRPVAKMLKSFGCQLVVEQAGRTI
VSTHYIKDLNVDFVKLHRSLMKDIHQRYENQLFVRSLLGACETTGAQVIAVGIEKEKEFRLLKDLGVEGGQGRFFESETA
LHHRQEKVSIPKRRSRWGK
>Mature_659_residues
MRKTPSLRLSNRLISFVTLMVSAAIFILFIGGTISVKQIGTEYLDHYLTGVVTVVDEELVNPEKAKSMETWLPKLLKASN
VVSMDLSSSTGPIYSFQSLAIIPDDSLLYHKTLPLQINKGYEISFKSVPPYSAFTYSLGALFSITAAIAVIVVSLLWGVV
WLRKQLHGSELLEERGRMLLAGKLDDYSTGSEEEWPATASLALDNIIAELKDARKERSRFDTFIRTHTFLDQLTGSANRV
LFDSKLESILQESQSQGVLLLLRINGWEELVEEQGSAVGDELIVEVGKQLNNIMQRYSDSVLSRYYQSDFALLVPQQSLK
EAKSLAAQCLKLIEKINPPRSLDRDNWCHIGVSMFVSGERRGRLMEELDMAHRSALLQNNNTWSLFKKQQQLAESLGSVR
WRTLFDAIFQQDKLIIYKQPTFLFDGNELVPLHLELFSRIKDENGVQIKASRFLPAIKQVGYQVKLDSAVLKQVFPLLSD
PELNHNSFSVHLQVKSITNAAFIRQLRNRLLQTPRAQLQRLSFELIEGQVVTYLDAVRPVAKMLKSFGCQLVVEQAGRTI
VSTHYIKDLNVDFVKLHRSLMKDIHQRYENQLFVRSLLGACETTGAQVIAVGIEKEKEFRLLKDLGVEGGQGRFFESETA
LHHRQEKVSIPKRRSRWGK

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=651, Percent_Identity=32.4116743471582, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1790496, Length=228, Percent_Identity=22.8070175438596, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1787541, Length=438, Percent_Identity=20.7762557077626, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788849, Length=200, Percent_Identity=23, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 74702; Mature: 74702

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTPSLRLSNRLISFVTLMVSAAIFILFIGGTISVKQIGTEYLDHYLTGVVTVVDEELV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHC
NPEKAKSMETWLPKLLKASNVVSMDLSSSTGPIYSFQSLAIIPDDSLLYHKTLPLQINKG
CCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEECCEEEECCCCCEEEEEECCEEECCC
YEISFKSVPPYSAFTYSLGALFSITAAIAVIVVSLLWGVVWLRKQLHGSELLEERGRMLL
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AGKLDDYSTGSEEEWPATASLALDNIIAELKDARKERSRFDTFIRTHTFLDQLTGSANRV
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
LFDSKLESILQESQSQGVLLLLRINGWEELVEEQGSAVGDELIVEVGKQLNNIMQRYSDS
EEHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLSRYYQSDFALLVPQQSLKEAKSLAAQCLKLIEKINPPRSLDRDNWCHIGVSMFVSGER
HHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHEEECCCH
RGRLMEELDMAHRSALLQNNNTWSLFKKQQQLAESLGSVRWRTLFDAIFQQDKLIIYKQP
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
TFLFDGNELVPLHLELFSRIKDENGVQIKASRFLPAIKQVGYQVKLDSAVLKQVFPLLSD
EEEECCCCEEEHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCC
PELNHNSFSVHLQVKSITNAAFIRQLRNRLLQTPRAQLQRLSFELIEGQVVTYLDAVRPV
CCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHH
AKMLKSFGCQLVVEQAGRTIVSTHYIKDLNVDFVKLHRSLMKDIHQRYENQLFVRSLLGA
HHHHHHCCHHHHHHHCCCEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CETTGAQVIAVGIEKEKEFRLLKDLGVEGGQGRFFESETALHHRQEKVSIPKRRSRWGK
HHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHCCCCHHHCCCCC
>Mature Secondary Structure
MRKTPSLRLSNRLISFVTLMVSAAIFILFIGGTISVKQIGTEYLDHYLTGVVTVVDEELV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHC
NPEKAKSMETWLPKLLKASNVVSMDLSSSTGPIYSFQSLAIIPDDSLLYHKTLPLQINKG
CCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEECCEEEECCCCCEEEEEECCEEECCC
YEISFKSVPPYSAFTYSLGALFSITAAIAVIVVSLLWGVVWLRKQLHGSELLEERGRMLL
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AGKLDDYSTGSEEEWPATASLALDNIIAELKDARKERSRFDTFIRTHTFLDQLTGSANRV
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
LFDSKLESILQESQSQGVLLLLRINGWEELVEEQGSAVGDELIVEVGKQLNNIMQRYSDS
EEHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLSRYYQSDFALLVPQQSLKEAKSLAAQCLKLIEKINPPRSLDRDNWCHIGVSMFVSGER
HHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHEEECCCH
RGRLMEELDMAHRSALLQNNNTWSLFKKQQQLAESLGSVRWRTLFDAIFQQDKLIIYKQP
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
TFLFDGNELVPLHLELFSRIKDENGVQIKASRFLPAIKQVGYQVKLDSAVLKQVFPLLSD
EEEECCCCEEEHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCC
PELNHNSFSVHLQVKSITNAAFIRQLRNRLLQTPRAQLQRLSFELIEGQVVTYLDAVRPV
CCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHH
AKMLKSFGCQLVVEQAGRTIVSTHYIKDLNVDFVKLHRSLMKDIHQRYENQLFVRSLLGA
HHHHHHCCHHHHHHHCCCEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CETTGAQVIAVGIEKEKEFRLLKDLGVEGGQGRFFESETALHHRQEKVSIPKRRSRWGK
HHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]