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The map label for this gene is obgE [H]

Identifier: 59710887

GI number: 59710887

Start: 286199

End: 287371

Strand: Direct

Name: obgE [H]

Synonym: VF_0280

Alternate gene names: 59710887

Gene position: 286199-287371 (Clockwise)

Preceding gene: 59710886

Following gene: 172087652

Centisome position: 9.88

GC content: 42.28

Gene sequence:

>1173_bases
ATGAAATTCGTTGATGAAGCGACAATTAAAGTAGATGCAGGCGACGGCGGTAACGGCGTTGTTAGTTTTTGGCGTGAAAA
ATTCGTAGCCAAAGGTGGCCCTGATGGCGGTGATGGCGGTGATGGCGGCGACGTTTATCTAGAAGCTGATGAAAACCTTA
ACACACTAATCGATTACCGTTTTAATCGTTTTTATAACGCTGAGCGTGGTAAAAATGGTAGTGGTGGTAACTGTACAGGT
AAACGTGGCGAAGACATTACGCTTAAAGTACCTGTAGGCACACGTGCGATTGATATTGATACCGGTGAGAAAGTTGCAGA
ACTAATGACTCACGGTATGAAGCAAATGGTAGCAAAAGGTGGTTGGCACGGTCTAGGTAACACGCGTTTTAAATCATCTG
TAAACCGTGCTCCACGTCAAAAGACATTAGGAACAAAAGGTGAGGTTCGTGAACTTCGTCTAGAGCTTCTTCTTCTTGCT
GATGTTGGTATGCTTGGTCTACCAAATGCGGGTAAATCTACATTTATTCGTGCGGTATCTGCTGCAAAACCAAAAGTAGC
GGATTACCCATTCACAACGTTAATTCCTAGTCTAGGTGTTGTGCGTGCTCGTGGTAATAAGAGTTTCGTTGTTGCGGATA
TCCCAGGTCTAATTGAAGGTGCTGCTGATGGTGCTGGTCTGGGTGTTCGTTTCTTAAAACACCTTGAGCGTTGTCGTGTA
TTGCTTCATGTAATTGATATTCTTCCAATTGATGGAAGTGATCCTGTACAAAATGCATTAACTATCATTGATGAGTTAGA
GCAGTACAGTGAGAAAGTAGCAAGCAAACCACGCTGGTTATTATTCAATAAAACAGACCTTCTATTAGAAGAAGAAGCTG
ACGAGAAGATCAATGAGATCCTAGAAGCATTAGCTTGGGAAGATCGTTACTTTAAGATTGCTGCTGTAAGTCGCACTGGT
ACTCAAGAATTGTGTGATGAATTAGCTGATTTCATGGATACATTACCAAAAGAAATCCAAACAGAAGAAGAAAAAGCAGC
GAACAAAGTTGACTTCATGTGGGATGATTACCACAAAGATGCAATGTCTGGTAAAGACGTTGTTACTGAAGACGACTGGG
ATGATTGGGACGATGAAGAAGATGATGGCCACGTTATCTACGTTCGTGACTAA

Upstream 100 bases:

>100_bases
TCATTGACGATCCAATCTTAAGGTCTCATTCTGGTCTACAGTAAATGAAGCCGTACTTAAATTATAAAATAAGTACCAAC
GCTACAGCTCGGAGAAGAAA

Downstream 100 bases:

>100_bases
CTTGTTCTGTGCTTATTACAGATAATCATTATAAAAAAACCGCACTTGTTGCGGTTTTTTTTATTTAAATCATTAAACAC
TGAGTTGAAAAGATTAGAAT

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKFVDEATIKVDAGDGGNGVVSFWREKFVAKGGPDGGDGGDGGDVYLEADENLNTLIDYRFNRFYNAERGKNGSGGNCTG
KRGEDITLKVPVGTRAIDIDTGEKVAELMTHGMKQMVAKGGWHGLGNTRFKSSVNRAPRQKTLGTKGEVRELRLELLLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVRARGNKSFVVADIPGLIEGAADGAGLGVRFLKHLERCRV
LLHVIDILPIDGSDPVQNALTIIDELEQYSEKVASKPRWLLFNKTDLLLEEEADEKINEILEALAWEDRYFKIAAVSRTG
TQELCDELADFMDTLPKEIQTEEEKAANKVDFMWDDYHKDAMSGKDVVTEDDWDDWDDEEDDGHVIYVRD

Sequences:

>Translated_390_residues
MKFVDEATIKVDAGDGGNGVVSFWREKFVAKGGPDGGDGGDGGDVYLEADENLNTLIDYRFNRFYNAERGKNGSGGNCTG
KRGEDITLKVPVGTRAIDIDTGEKVAELMTHGMKQMVAKGGWHGLGNTRFKSSVNRAPRQKTLGTKGEVRELRLELLLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVRARGNKSFVVADIPGLIEGAADGAGLGVRFLKHLERCRV
LLHVIDILPIDGSDPVQNALTIIDELEQYSEKVASKPRWLLFNKTDLLLEEEADEKINEILEALAWEDRYFKIAAVSRTG
TQELCDELADFMDTLPKEIQTEEEKAANKVDFMWDDYHKDAMSGKDVVTEDDWDDWDDEEDDGHVIYVRD
>Mature_390_residues
MKFVDEATIKVDAGDGGNGVVSFWREKFVAKGGPDGGDGGDGGDVYLEADENLNTLIDYRFNRFYNAERGKNGSGGNCTG
KRGEDITLKVPVGTRAIDIDTGEKVAELMTHGMKQMVAKGGWHGLGNTRFKSSVNRAPRQKTLGTKGEVRELRLELLLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVRARGNKSFVVADIPGLIEGAADGAGLGVRFLKHLERCRV
LLHVIDILPIDGSDPVQNALTIIDELEQYSEKVASKPRWLLFNKTDLLLEEEADEKINEILEALAWEDRYFKIAAVSRTG
TQELCDELADFMDTLPKEIQTEEEKAANKVDFMWDDYHKDAMSGKDVVTEDDWDDWDDEEDDGHVIYVRD

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=305, Percent_Identity=41.3114754098361, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI111955139, Length=288, Percent_Identity=37.8472222222222, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI111955063, Length=144, Percent_Identity=44.4444444444444, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=37.007874015748, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI58761500, Length=135, Percent_Identity=31.8518518518519, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789574, Length=362, Percent_Identity=70.4419889502762, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI1787454, Length=129, Percent_Identity=29.4573643410853, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=334, Percent_Identity=37.7245508982036, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17552324, Length=326, Percent_Identity=29.4478527607362, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17509631, Length=128, Percent_Identity=33.59375, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=34.7457627118644, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=162, Percent_Identity=38.8888888888889, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6319281, Length=128, Percent_Identity=32.03125, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585318, Length=311, Percent_Identity=36.6559485530547, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI20129375, Length=305, Percent_Identity=38.3606557377049, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17981711, Length=127, Percent_Identity=32.2834645669291, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640873, Length=128, Percent_Identity=32.03125, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640877, Length=128, Percent_Identity=32.03125, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640875, Length=128, Percent_Identity=32.03125, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 43014; Mature: 43014

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVDEATIKVDAGDGGNGVVSFWREKFVAKGGPDGGDGGDGGDVYLEADENLNTLIDYR
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHH
FNRFYNAERGKNGSGGNCTGKRGEDITLKVPVGTRAIDIDTGEKVAELMTHGMKQMVAKG
HHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCC
GWHGLGNTRFKSSVNRAPRQKTLGTKGEVRELRLELLLLADVGMLGLPNAGKSTFIRAVS
CCCCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLIPSLGVVRARGNKSFVVADIPGLIEGAADGAGLGVRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHH
LLHVIDILPIDGSDPVQNALTIIDELEQYSEKVASKPRWLLFNKTDLLLEEEADEKINEI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHEEHHHHHHHHHHH
LEALAWEDRYFKIAAVSRTGTQELCDELADFMDTLPKEIQTEEEKAANKVDFMWDDYHKD
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHH
AMSGKDVVTEDDWDDWDDEEDDGHVIYVRD
HCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MKFVDEATIKVDAGDGGNGVVSFWREKFVAKGGPDGGDGGDGGDVYLEADENLNTLIDYR
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHH
FNRFYNAERGKNGSGGNCTGKRGEDITLKVPVGTRAIDIDTGEKVAELMTHGMKQMVAKG
HHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCC
GWHGLGNTRFKSSVNRAPRQKTLGTKGEVRELRLELLLLADVGMLGLPNAGKSTFIRAVS
CCCCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLIPSLGVVRARGNKSFVVADIPGLIEGAADGAGLGVRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHH
LLHVIDILPIDGSDPVQNALTIIDELEQYSEKVASKPRWLLFNKTDLLLEEEADEKINEI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHEEHHHHHHHHHHH
LEALAWEDRYFKIAAVSRTGTQELCDELADFMDTLPKEIQTEEEKAANKVDFMWDDYHKD
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHH
AMSGKDVVTEDDWDDWDDEEDDGHVIYVRD
HCCCCCCCCCCCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA