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The map label for this gene is yicE [H]

Identifier: 59710723

GI number: 59710723

Start: 134406

End: 135797

Strand: Reverse

Name: yicE [H]

Synonym: VF_0116

Alternate gene names: 59710723

Gene position: 135797-134406 (Counterclockwise)

Preceding gene: 59710724

Following gene: 59710720

Centisome position: 4.69

GC content: 43.53

Gene sequence:

>1392_bases
ATGACCGTTAAAAACAGCACCACAAAACCATCTGAATTGATCTACCAATTAGATGATCGTCCACCGCTACCGCACACTTT
ATTTGCTGCTTTTCAGCACTTACTGGCAATGTTTGTTGCTATTATTACGCCTTCTCTGATCATCTGTCAGACACTTGGTG
TTCCAGCGGCTGAAACCAATACCATCATCAGCATGTCTTTATTTGCTTCGGGCATTTCTTCTTTTATTCAAATTAAAACC
TTTGGCCCTATCGGTTCTGGCTTACTTTCAGTTCAAGGCACCAGTTTTAATTTCTTAGGCCCAATCATTGGTGCTGGCCT
TGCACTAAAAGCCGGTGGTGCTGATGTTCCTACAATGATGGCAGCCATTTTCGGTACCATTCTTGTTGCTTCAACCGCTG
AAATTTTCCTGTCTCGTGTTCTTGAATACGCTCAAAAAATCATTACTCCATTAGTCTCTGGCATTGTTGTTACCCTAATT
GGCCTTACTCTTATTCAAGTCGGTTTAGTGTCTATGGGGGGCGGGTATTCAGCTATGGGCGAAGGCACATTTGGTAGCCT
TGATAAACTCGCTCTTGCTGGCACGGTATTACTAATTATTGTGGTATTAAACCGAGCAACTAACCCTTACCTACGTATGG
CGTCTATCGTTATCGCAATGACGGTAGGTACGCTAGTGGCGTGGGCGATGGGAATGCTTAATACAGAGATGTCTCATGAT
GCAGCTCTCATTGCCCTACCTATTCCTATGCAATATGGCTTAGGTTTTGACTGGTCTCTGTTTATTCCTTTGGTGCTTAT
CTTCTTAATCACGGCACTAGAAGCCATTGGTGATATTACTGCGACATCAGAAGTATCAGGCCAACCAGTGAAAGGACCGG
TTTATATGAAGCGCATTAAAGGCGGTGTATTAGCTGATGGTATTAACTCGGCAATCGCTGCAGCATTTAACAGCTTCCCT
AACTCAACGTTTAGCCAAAACAATGGCGTAATTCTATTAACGGGTGTAGCAAGCCGTTATGTGGGTTATTTCATCGCAGG
TATGCTAGTTCTTCTTGGTTTATTCCCAGGGGTAGCAAGCATGGTGCAGATCATTCCTGAGCCTGTGCTTGGTGGTGCGA
CTATTGTGATGTTCGGTACGATTGCGGCTGCTGGTGTGCGTATTATCTCTCGTGTTGAACTAGATCGTCGCGCGATCCTA
ATCATGGCTATGTCTTTCTCCATGGGTCTTGGTTTAGCTCAAAAACCTGAAATTCTTCAGTTCATGCCTGAGATGATTAA
AAACATTTTCTCATCAGGTGTAACTGCTGGTGGTGTAACTGCGATTATCTTAAATATCGTATTGCCGTATGCAGAAGTGA
AAGAAGAAGCAAAACAAGATGTGATTGCTTAA

Upstream 100 bases:

>100_bases
AAGGTTCTGATTAACAGCAATCACAGATTGACGCCTTCTCACTTCAAACTCCCATTCAGCGAGATTTGAAGACAACGTTA
CACAACTAGGAATATCGGCC

Downstream 100 bases:

>100_bases
AGGGACTAGAAACAAGTTCTCTTCGCTCTAAGGACGAGTAAAAACGAAAAAGACCGCAGGTGATTATCATCTGCGGTCTT
TTTTATTTTTTACTAGGAAC

Product: transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTVKNSTTKPSELIYQLDDRPPLPHTLFAAFQHLLAMFVAIITPSLIICQTLGVPAAETNTIISMSLFASGISSFIQIKT
FGPIGSGLLSVQGTSFNFLGPIIGAGLALKAGGADVPTMMAAIFGTILVASTAEIFLSRVLEYAQKIITPLVSGIVVTLI
GLTLIQVGLVSMGGGYSAMGEGTFGSLDKLALAGTVLLIIVVLNRATNPYLRMASIVIAMTVGTLVAWAMGMLNTEMSHD
AALIALPIPMQYGLGFDWSLFIPLVLIFLITALEAIGDITATSEVSGQPVKGPVYMKRIKGGVLADGINSAIAAAFNSFP
NSTFSQNNGVILLTGVASRYVGYFIAGMLVLLGLFPGVASMVQIIPEPVLGGATIVMFGTIAAAGVRIISRVELDRRAIL
IMAMSFSMGLGLAQKPEILQFMPEMIKNIFSSGVTAGGVTAIILNIVLPYAEVKEEAKQDVIA

Sequences:

>Translated_463_residues
MTVKNSTTKPSELIYQLDDRPPLPHTLFAAFQHLLAMFVAIITPSLIICQTLGVPAAETNTIISMSLFASGISSFIQIKT
FGPIGSGLLSVQGTSFNFLGPIIGAGLALKAGGADVPTMMAAIFGTILVASTAEIFLSRVLEYAQKIITPLVSGIVVTLI
GLTLIQVGLVSMGGGYSAMGEGTFGSLDKLALAGTVLLIIVVLNRATNPYLRMASIVIAMTVGTLVAWAMGMLNTEMSHD
AALIALPIPMQYGLGFDWSLFIPLVLIFLITALEAIGDITATSEVSGQPVKGPVYMKRIKGGVLADGINSAIAAAFNSFP
NSTFSQNNGVILLTGVASRYVGYFIAGMLVLLGLFPGVASMVQIIPEPVLGGATIVMFGTIAAAGVRIISRVELDRRAIL
IMAMSFSMGLGLAQKPEILQFMPEMIKNIFSSGVTAGGVTAIILNIVLPYAEVKEEAKQDVIA
>Mature_462_residues
TVKNSTTKPSELIYQLDDRPPLPHTLFAAFQHLLAMFVAIITPSLIICQTLGVPAAETNTIISMSLFASGISSFIQIKTF
GPIGSGLLSVQGTSFNFLGPIIGAGLALKAGGADVPTMMAAIFGTILVASTAEIFLSRVLEYAQKIITPLVSGIVVTLIG
LTLIQVGLVSMGGGYSAMGEGTFGSLDKLALAGTVLLIIVVLNRATNPYLRMASIVIAMTVGTLVAWAMGMLNTEMSHDA
ALIALPIPMQYGLGFDWSLFIPLVLIFLITALEAIGDITATSEVSGQPVKGPVYMKRIKGGVLADGINSAIAAAFNSFPN
STFSQNNGVILLTGVASRYVGYFIAGMLVLLGLFPGVASMVQIIPEPVLGGATIVMFGTIAAAGVRIISRVELDRRAILI
MAMSFSMGLGLAQKPEILQFMPEMIKNIFSSGVTAGGVTAIILNIVLPYAEVKEEAKQDVIA

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=517, Percent_Identity=23.9845261121857, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI40316845, Length=517, Percent_Identity=23.9845261121857, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI44680145, Length=525, Percent_Identity=24.1904761904762, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI44680143, Length=529, Percent_Identity=24.007561436673, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790087, Length=447, Percent_Identity=66.2192393736018, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI87082178, Length=446, Percent_Identity=44.1704035874439, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI87082181, Length=437, Percent_Identity=29.0617848970252, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1788843, Length=389, Percent_Identity=27.2493573264781, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87081818, Length=419, Percent_Identity=25.7756563245823, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17541904, Length=499, Percent_Identity=23.0460921843687, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 48477; Mature: 48346

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00879 ODR_DC_2_2 ; PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKNSTTKPSELIYQLDDRPPLPHTLFAAFQHLLAMFVAIITPSLIICQTLGVPAAETN
CCCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
TIISMSLFASGISSFIQIKTFGPIGSGLLSVQGTSFNFLGPIIGAGLALKAGGADVPTMM
HHHHHHHHHHHHHHHEEEEECCCCCCCEEEECCCCCHHHHHHHHCCCEEECCCCCHHHHH
AAIFGTILVASTAEIFLSRVLEYAQKIITPLVSGIVVTLIGLTLIQVGLVSMGGGYSAMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EGTFGSLDKLALAGTVLLIIVVLNRATNPYLRMASIVIAMTVGTLVAWAMGMLNTEMSHD
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AALIALPIPMQYGLGFDWSLFIPLVLIFLITALEAIGDITATSEVSGQPVKGPVYMKRIK
CEEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHC
GGVLADGINSAIAAAFNSFPNSTFSQNNGVILLTGVASRYVGYFIAGMLVLLGLFPGVAS
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
MVQIIPEPVLGGATIVMFGTIAAAGVRIISRVELDRRAILIMAMSFSMGLGLAQKPEILQ
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
FMPEMIKNIFSSGVTAGGVTAIILNIVLPYAEVKEEAKQDVIA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TVKNSTTKPSELIYQLDDRPPLPHTLFAAFQHLLAMFVAIITPSLIICQTLGVPAAETN
CCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
TIISMSLFASGISSFIQIKTFGPIGSGLLSVQGTSFNFLGPIIGAGLALKAGGADVPTMM
HHHHHHHHHHHHHHHEEEEECCCCCCCEEEECCCCCHHHHHHHHCCCEEECCCCCHHHHH
AAIFGTILVASTAEIFLSRVLEYAQKIITPLVSGIVVTLIGLTLIQVGLVSMGGGYSAMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EGTFGSLDKLALAGTVLLIIVVLNRATNPYLRMASIVIAMTVGTLVAWAMGMLNTEMSHD
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AALIALPIPMQYGLGFDWSLFIPLVLIFLITALEAIGDITATSEVSGQPVKGPVYMKRIK
CEEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHC
GGVLADGINSAIAAAFNSFPNSTFSQNNGVILLTGVASRYVGYFIAGMLVLLGLFPGVAS
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
MVQIIPEPVLGGATIVMFGTIAAAGVRIISRVELDRRAILIMAMSFSMGLGLAQKPEILQ
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
FMPEMIKNIFSSGVTAGGVTAIILNIVLPYAEVKEEAKQDVIA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]