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The map label for this gene is glpT [H]

Identifier: 59710679

GI number: 59710679

Start: 83482

End: 84846

Strand: Reverse

Name: glpT [H]

Synonym: VF_0072

Alternate gene names: 59710679

Gene position: 84846-83482 (Counterclockwise)

Preceding gene: 59710682

Following gene: 59710676

Centisome position: 2.93

GC content: 41.1

Gene sequence:

>1365_bases
ATGTTTGGTGTTTTTAAACCTAAAGCACATATCGCACAACTCCCAACAGGAGAAATCAATAGCACTTATAAACGGTTACG
GTGGCAACTTTTTCTCGGCATTTTCTTTGGTTATGCTGGATACTATCTTGTTCGAAAAAACTTCAGTTTAGCAATGCCTT
ACCTTATCGAACAAGGATACAGTCGAGGCGATTTAGGGGTTGCTCTAGCTGCGGTATCTATCGCTTATGGTTTATCTAAA
TTCTTAATGGGAAGTGTTTCTGACCGTTCCAATCCTCGATATTTTCTCAGTGCTGGTTTGGTCATGTCTGCTCTCGTTAT
GTTTTGTTTTGGCTTTATGCCTTGGGCAACAGGCAGCATTACCGCCATGTTTATCTTGTTATTTTTAAATGGTTGGTTTC
AAGGTATGGGATGGCCTGCCTGTGGTAGAACCATGGTGCACTGGTGGTCAAGAAAAGAGCGTGGTGAAATAGTTTCGGTA
TGGAACGTTGCACACAACGTTGGAGGCGGGTTAATTGGCCCAATGTTCCTTCTTGGTTTATGGGCATTTAATGATGATTG
GCGAACTGCGTTTTACGTACCAGCTTTCTTTGCTCTTCTTGTTGCTTTTTTTGTTTGGTTAACAGTAAGAGATACTCCTC
AATCATGCGGTCTTCCGCCAATTGAAGAATTTAAAAACGACTACCCAGATGATTATGATTCCGCATATGAAACAGAAATG
ACGGCGAAAGAAATCTTCTTCAAGTATGTTTTTTCAAATAAATTATTGTGGTCTATTGCGATAGCCAACGCCTTTGTCTA
CCTAATCCGTTATGGCGTTTTAGATTGGGCTCCTGTTTACTTAAAAGAAGCCAAAGAATTCACTGTTGATAAATCTTCTT
GGGCATATTTCCTATATGAGTGGGCTGGTATTCCAGGCACCCTTCTATGTGGTTGGATTTCTGATAAGTTATTTAAAGGG
AAACGAGCGCCTGCTGGGATTCTATTTATGGCATTAGTGACTATTGCAGTATTGGTTTACTGGTTTAACCCTGCAGGAAA
CCCAACCGTTGATATGATCGCATTAGTTGCTATTGGTTTCTTAATCTATGGTCCGGTAATGCTTATTGGTTTATATGCGT
TGGAATTAGCACCTAAAAAGGCGGCGGGTACAGCGGCAGGATTAACTGGATTATTTGGTTACCTTGGTGGAGCCGTTGCA
GCGAACGCACTGCTTGGTTATACCGTTGACCACTTTGGTTGGGATGGTGGCTTTATGATCTTAGTTGCCTCTTGTGTCAT
CTCTATTGTTTGCCTAACTTATGCACTAATTGGTGAGCAAAAGCATCATAAAGAAAAGATTGAGAAAGAAAGTCACATGG
CTTAA

Upstream 100 bases:

>100_bases
ACAGTTTTCTAAATCAATCATTATAATAATAGCCAAAATTTCGAACGAACCTAAAAGCAGGTTCGATAATGAAAATTAAT
AATAAAATAAGAGGTCGGCT

Downstream 100 bases:

>100_bases
TCCAAAAAAAACGGCTGTATATTTACAGCCGTTTTCTTTTAAAAATTAAGCAACTTAAAACAAACCAACAATAAAGCTCA
GTTCGTCTAGCGCTTCTCCT

Product: sn-glycerol-3-phosphate transporter

Products: Proton [Cytoplasm]; glycerol-3-phosphate [Cytoplasm] [C]

Alternate protein names: G-3-P transporter; G-3-P permease [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MFGVFKPKAHIAQLPTGEINSTYKRLRWQLFLGIFFGYAGYYLVRKNFSLAMPYLIEQGYSRGDLGVALAAVSIAYGLSK
FLMGSVSDRSNPRYFLSAGLVMSALVMFCFGFMPWATGSITAMFILLFLNGWFQGMGWPACGRTMVHWWSRKERGEIVSV
WNVAHNVGGGLIGPMFLLGLWAFNDDWRTAFYVPAFFALLVAFFVWLTVRDTPQSCGLPPIEEFKNDYPDDYDSAYETEM
TAKEIFFKYVFSNKLLWSIAIANAFVYLIRYGVLDWAPVYLKEAKEFTVDKSSWAYFLYEWAGIPGTLLCGWISDKLFKG
KRAPAGILFMALVTIAVLVYWFNPAGNPTVDMIALVAIGFLIYGPVMLIGLYALELAPKKAAGTAAGLTGLFGYLGGAVA
ANALLGYTVDHFGWDGGFMILVASCVISIVCLTYALIGEQKHHKEKIEKESHMA

Sequences:

>Translated_454_residues
MFGVFKPKAHIAQLPTGEINSTYKRLRWQLFLGIFFGYAGYYLVRKNFSLAMPYLIEQGYSRGDLGVALAAVSIAYGLSK
FLMGSVSDRSNPRYFLSAGLVMSALVMFCFGFMPWATGSITAMFILLFLNGWFQGMGWPACGRTMVHWWSRKERGEIVSV
WNVAHNVGGGLIGPMFLLGLWAFNDDWRTAFYVPAFFALLVAFFVWLTVRDTPQSCGLPPIEEFKNDYPDDYDSAYETEM
TAKEIFFKYVFSNKLLWSIAIANAFVYLIRYGVLDWAPVYLKEAKEFTVDKSSWAYFLYEWAGIPGTLLCGWISDKLFKG
KRAPAGILFMALVTIAVLVYWFNPAGNPTVDMIALVAIGFLIYGPVMLIGLYALELAPKKAAGTAAGLTGLFGYLGGAVA
ANALLGYTVDHFGWDGGFMILVASCVISIVCLTYALIGEQKHHKEKIEKESHMA
>Mature_454_residues
MFGVFKPKAHIAQLPTGEINSTYKRLRWQLFLGIFFGYAGYYLVRKNFSLAMPYLIEQGYSRGDLGVALAAVSIAYGLSK
FLMGSVSDRSNPRYFLSAGLVMSALVMFCFGFMPWATGSITAMFILLFLNGWFQGMGWPACGRTMVHWWSRKERGEIVSV
WNVAHNVGGGLIGPMFLLGLWAFNDDWRTAFYVPAFFALLVAFFVWLTVRDTPQSCGLPPIEEFKNDYPDDYDSAYETEM
TAKEIFFKYVFSNKLLWSIAIANAFVYLIRYGVLDWAPVYLKEAKEFTVDKSSWAYFLYEWAGIPGTLLCGWISDKLFKG
KRAPAGILFMALVTIAVLVYWFNPAGNPTVDMIALVAIGFLIYGPVMLIGLYALELAPKKAAGTAAGLTGLFGYLGGAVA
ANALLGYTVDHFGWDGGFMILVASCVISIVCLTYALIGEQKHHKEKIEKESHMA

Specific function: Responsible for glycerol-3-phosphate uptake [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=441, Percent_Identity=26.530612244898, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4503847, Length=441, Percent_Identity=26.530612244898, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI256219483, Length=441, Percent_Identity=26.530612244898, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI256219543, Length=463, Percent_Identity=25.0539956803456, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI256219564, Length=372, Percent_Identity=23.9247311827957, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI46361976, Length=407, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38093649, Length=482, Percent_Identity=23.2365145228216, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI223717983, Length=482, Percent_Identity=23.2365145228216, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788573, Length=451, Percent_Identity=69.6230598669623, Blast_Score=676, Evalue=0.0,
Organism=Escherichia coli, GI87082310, Length=416, Percent_Identity=36.7788461538462, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI2367259, Length=458, Percent_Identity=33.1877729257642, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1789515, Length=437, Percent_Identity=24.0274599542334, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789152, Length=345, Percent_Identity=24.0579710144928, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI2367379, Length=329, Percent_Identity=24.0121580547112, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082320, Length=448, Percent_Identity=23.8839285714286, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133930953, Length=477, Percent_Identity=23.4800838574423, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI133901856, Length=456, Percent_Identity=24.1228070175439, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI133901854, Length=456, Percent_Identity=24.1228070175439, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17542316, Length=460, Percent_Identity=24.7826086956522, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17564204, Length=387, Percent_Identity=25.3229974160207, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17564202, Length=456, Percent_Identity=24.3421052631579, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24656861, Length=491, Percent_Identity=23.0142566191446, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24656866, Length=491, Percent_Identity=23.0142566191446, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45550478, Length=491, Percent_Identity=23.0142566191446, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005267
- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50599; Mature: 50599

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; glycerol-3-phosphate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + glycerol-3-phosphate [Periplasm] = Proton [Cytoplasm] + glycerol-3-phosphate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3329281; 9205837; 9278503; 3141744; 12893936 [H]