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The map label for this gene is gpp

Identifier: 59710661

GI number: 59710661

Start: 61453

End: 62946

Strand: Reverse

Name: gpp

Synonym: VF_0054

Alternate gene names: 59710661

Gene position: 62946-61453 (Counterclockwise)

Preceding gene: 172087635

Following gene: 59710659

Centisome position: 2.17

GC content: 43.04

Gene sequence:

>1494_bases
ATGAAAAGTTCAACAATGTCACCAATGTATGCCGCCATCGATTTAGGCTCCAATAGCTTCCATATGCTTGTTGTGCGTCA
TATAAATGGTAGTGTGCAAACCATGGCTAAAATTAAACGTAAAGTTCGTTTAGCTGCGGGATTAAATGAAAATAACACAC
TCAGCCATGAAGCTATGCAACGTGGGTGGGATTGTTTGAGCTTATTTGCAGAACGTCTGCAAGACATCCCTGTAGAAAAT
ATTCGCATTGTCGGTACAGCAACGCTGCGTGTCGCTAGCAATGTGGATATCTTCTTAGAAAAAGCCAATCAAATCTTAGG
TCACAACATTAACGTGATCGAAGGCGAAGAAGAAGCTCGTATGATTTACCAAGGAGTTGCGCACACTTCAGGTGGTAATG
GCCGTCGTTTAGTCGTTGATATCGGCGGAGCAAGTACAGAGCTAATTATTGGTGAAGGCTTTGAAGCACAAGCACTCACA
AGCTTAAAAATGGGTTGTGTAACTTGGCTAGAAGGCTACTTTAAAGATCGTGCCCTAACCCAAAAGAACTTTAATGCAGC
AATTGCCGGCGCTAAAGAGACGTTAGCTCCAATTTTACAGCAATATACTGACCTAGGTTGGCAGACCTGTGTTGGAGCCA
GTGGTACGGTACAAGCATTGCAAGAAATTATGTTGGCGCAAGGCATGGATGAGGTCATCACCTTAGCCAAGCTAAAGCGC
CTTCAAAAGCAAGCAATGCAATATGAACACTTAGAAGAGTTAGATATTGATGGGTTAACACTTGAGCGAGCATTAGTGTT
CCCAAGCGGTTTATCCATCCTTATTGCTATTTTTGAATTATTGAACATCGATTCTATGACTCTAGCTGGCGGCGCGTTAC
GTGAAGGCCTATGCTACGGAATGATCGATGAACTGCAACACGATGAAGTGTGTCAACGCACAATAAAGAGCACCCAACAA
CGTTATCAATTAGACGTTGACTACGCTCAACAGGTCACTGACCTCTCAATTCAACTTGTGCAGCAATGTGGTAACGACTG
GCTTATTGAGCCACAAGCATTGCCATTGCTTACTGCGGCAACTCAGCTTCATGAAATTGGTATGTGTATTGATTATAAAA
AAGGTGGAGAGCACTCAGCCTATTTAATTAACGCACTGGATTTACCAGGTTTCACTCGTGCTCAAAAACACTTACTTGGT
GAGTTATTACGCCGTTACCGCGAATATTTCTCAGCCATGCCAACTCAACATGCCGTTTCTGATATCTCGGCTCAACGCAT
GCTACGTATTTTACGTTTAGCGATTATTCTCACTCATCGTCGTGATGTGAATTTAGCACCTACTGTAACGCTATCAGAAA
AAAATGATGTTTTGTCATTGTCGATTGATGGAGCTTGGTTGGCGGCAAATCCTCTAACGAGATCTGAGTTAGAGATCGAG
GCGGATAAACAGACGAATATTGGTTGGGAGTTGGTTATAGATGCTAGGGACTAG

Upstream 100 bases:

>100_bases
TGGTCAACGTCAAGGCGGCAACCGTAAGCATACTCGCCCACGTCAACCACGTAATACTCAGTCGTAAATTGAGCGCTCAG
TAAAAAAGTAAAAGGATGTT

Downstream 100 bases:

>100_bases
GGACTAGAACGCTTCGCTTCTATAAGAGCAAAAGCAAGAGCCTTACCGGTACTAATTTCAGGGTTCAGGATTCAGGATTC
AGGATTCAGGAAAAATAAAA

Product: guanosine pentaphosphate phosphohydrolase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MKSSTMSPMYAAIDLGSNSFHMLVVRHINGSVQTMAKIKRKVRLAAGLNENNTLSHEAMQRGWDCLSLFAERLQDIPVEN
IRIVGTATLRVASNVDIFLEKANQILGHNINVIEGEEEARMIYQGVAHTSGGNGRRLVVDIGGASTELIIGEGFEAQALT
SLKMGCVTWLEGYFKDRALTQKNFNAAIAGAKETLAPILQQYTDLGWQTCVGASGTVQALQEIMLAQGMDEVITLAKLKR
LQKQAMQYEHLEELDIDGLTLERALVFPSGLSILIAIFELLNIDSMTLAGGALREGLCYGMIDELQHDEVCQRTIKSTQQ
RYQLDVDYAQQVTDLSIQLVQQCGNDWLIEPQALPLLTAATQLHEIGMCIDYKKGGEHSAYLINALDLPGFTRAQKHLLG
ELLRRYREYFSAMPTQHAVSDISAQRMLRILRLAIILTHRRDVNLAPTVTLSEKNDVLSLSIDGAWLAANPLTRSELEIE
ADKQTNIGWELVIDARD

Sequences:

>Translated_497_residues
MKSSTMSPMYAAIDLGSNSFHMLVVRHINGSVQTMAKIKRKVRLAAGLNENNTLSHEAMQRGWDCLSLFAERLQDIPVEN
IRIVGTATLRVASNVDIFLEKANQILGHNINVIEGEEEARMIYQGVAHTSGGNGRRLVVDIGGASTELIIGEGFEAQALT
SLKMGCVTWLEGYFKDRALTQKNFNAAIAGAKETLAPILQQYTDLGWQTCVGASGTVQALQEIMLAQGMDEVITLAKLKR
LQKQAMQYEHLEELDIDGLTLERALVFPSGLSILIAIFELLNIDSMTLAGGALREGLCYGMIDELQHDEVCQRTIKSTQQ
RYQLDVDYAQQVTDLSIQLVQQCGNDWLIEPQALPLLTAATQLHEIGMCIDYKKGGEHSAYLINALDLPGFTRAQKHLLG
ELLRRYREYFSAMPTQHAVSDISAQRMLRILRLAIILTHRRDVNLAPTVTLSEKNDVLSLSIDGAWLAANPLTRSELEIE
ADKQTNIGWELVIDARD
>Mature_497_residues
MKSSTMSPMYAAIDLGSNSFHMLVVRHINGSVQTMAKIKRKVRLAAGLNENNTLSHEAMQRGWDCLSLFAERLQDIPVEN
IRIVGTATLRVASNVDIFLEKANQILGHNINVIEGEEEARMIYQGVAHTSGGNGRRLVVDIGGASTELIIGEGFEAQALT
SLKMGCVTWLEGYFKDRALTQKNFNAAIAGAKETLAPILQQYTDLGWQTCVGASGTVQALQEIMLAQGMDEVITLAKLKR
LQKQAMQYEHLEELDIDGLTLERALVFPSGLSILIAIFELLNIDSMTLAGGALREGLCYGMIDELQHDEVCQRTIKSTQQ
RYQLDVDYAQQVTDLSIQLVQQCGNDWLIEPQALPLLTAATQLHEIGMCIDYKKGGEHSAYLINALDLPGFTRAQKHLLG
ELLRRYREYFSAMPTQHAVSDISAQRMLRILRLAIILTHRRDVNLAPTVTLSEKNDVLSLSIDGAWLAANPLTRSELEIE
ADKQTNIGWELVIDARD

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily

Homologues:

Organism=Escherichia coli, GI48994966, Length=491, Percent_Identity=55.6008146639511, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1788848, Length=492, Percent_Identity=37.8048780487805, Blast_Score=337, Evalue=9e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPPA_VIBF1 (Q5E8U7)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_203437.1
- ProteinModelPortal:   Q5E8U7
- SMR:   Q5E8U7
- STRING:   Q5E8U7
- GeneID:   3277951
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_0054
- NMPDR:   fig|312309.3.peg.54
- eggNOG:   COG0248
- HOGENOM:   HBG451789
- OMA:   AMQRGWQ
- PhylomeDB:   Q5E8U7
- ProtClustDB:   PRK11031
- BioCyc:   VFIS312309:VF0054-MONOMER
- HAMAP:   MF_01550
- InterPro:   IPR003695

Pfam domain/function: PF02541 Ppx-GppA

EC number: =3.6.1.40

Molecular weight: Translated: 55116; Mature: 55116

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSTMSPMYAAIDLGSNSFHMLVVRHINGSVQTMAKIKRKVRLAAGLNENNTLSHEAMQ
CCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
RGWDCLSLFAERLQDIPVENIRIVGTATLRVASNVDIFLEKANQILGHNINVIEGEEEAR
CCHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHCCCCEEEECCHHHH
MIYQGVAHTSGGNGRRLVVDIGGASTELIIGEGFEAQALTSLKMGCVTWLEGYFKDRALT
HHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QKNFNAAIAGAKETLAPILQQYTDLGWQTCVGASGTVQALQEIMLAQGMDEVITLAKLKR
HCCCCHHCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
LQKQAMQYEHLEELDIDGLTLERALVFPSGLSILIAIFELLNIDSMTLAGGALREGLCYG
HHHHHHHHHHHHHCCCCCEEEHHHEECCCHHHHHHHHHHHHCCCCCEECCHHHHHCHHHH
MIDELQHDEVCQRTIKSTQQRYQLDVDYAQQVTDLSIQLVQQCGNDWLIEPQALPLLTAA
HHHHCCHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHH
TQLHEIGMCIDYKKGGEHSAYLINALDLPGFTRAQKHLLGELLRRYREYFSAMPTQHAVS
HHHHHCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
DISAQRMLRILRLAIILTHRRDVNLAPTVTLSEKNDVLSLSIDGAWLAANPLTRSELEIE
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEEECCEEEECCCCCCCCEEEE
ADKQTNIGWELVIDARD
CCCCCCCCEEEEEECCC
>Mature Secondary Structure
MKSSTMSPMYAAIDLGSNSFHMLVVRHINGSVQTMAKIKRKVRLAAGLNENNTLSHEAMQ
CCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
RGWDCLSLFAERLQDIPVENIRIVGTATLRVASNVDIFLEKANQILGHNINVIEGEEEAR
CCHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHCCCCEEEECCHHHH
MIYQGVAHTSGGNGRRLVVDIGGASTELIIGEGFEAQALTSLKMGCVTWLEGYFKDRALT
HHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QKNFNAAIAGAKETLAPILQQYTDLGWQTCVGASGTVQALQEIMLAQGMDEVITLAKLKR
HCCCCHHCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
LQKQAMQYEHLEELDIDGLTLERALVFPSGLSILIAIFELLNIDSMTLAGGALREGLCYG
HHHHHHHHHHHHHCCCCCEEEHHHEECCCHHHHHHHHHHHHCCCCCEECCHHHHHCHHHH
MIDELQHDEVCQRTIKSTQQRYQLDVDYAQQVTDLSIQLVQQCGNDWLIEPQALPLLTAA
HHHHCCHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHH
TQLHEIGMCIDYKKGGEHSAYLINALDLPGFTRAQKHLLGELLRRYREYFSAMPTQHAVS
HHHHHCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
DISAQRMLRILRLAIILTHRRDVNLAPTVTLSEKNDVLSLSIDGAWLAANPLTRSELEIE
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEEECCEEEECCCCCCCCEEEE
ADKQTNIGWELVIDARD
CCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA