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The map label for this gene is yhdH [H]

Identifier: 59710630

GI number: 59710630

Start: 23656

End: 24636

Strand: Reverse

Name: yhdH [H]

Synonym: VF_0023

Alternate gene names: 59710630

Gene position: 24636-23656 (Counterclockwise)

Preceding gene: 172087631

Following gene: 59710626

Centisome position: 0.85

GC content: 42.61

Gene sequence:

>981_bases
ATGTTTAAAGCATTAGTTCTAAATCAAGAAGATAGAAATACAATTGCAGCAGTTACTGAGATCGATGAATCTCAACTACC
TGAAGGTAATGTTAAAATCGACGTAAACTACTCTTCTCTTAACTACAAAGACGGCTTAGCGATCACTGGTAAAGGACGCA
TTGTTCGTAACTTCCCAATGGTTCCTGGTATCGACTTATCAGGTGTGGTTTCTCAATCAGATGATCCTCGCTATAAAGCG
GGTGATGAAGTTGTTCTTACTGGTTGGGGTGTTGGTGAAGGTCACTGGGGTGGTATGGCTGAGAAAGCAAGCCTAAACGG
TGACTGGTTAGTACCTATGCCAAAAGGCCTAGATGCTAAAAAAGTAATGGCAATCGGTACAGCTGGTTTCACAGCAATGC
TATGTGTACAAGCCATTGTTGATGCCGATATTAAACCTGAAGACGGTGAAATCCTAGTAACGGGTTCAAGCGGCGGTGTG
GGCAGTGTTGCAATTACACTTCTAAACCAATTGGGTTATAAAGTTGCAGCAGTAACAGGCCGAGCTTCTGAAAATGGCGA
ATTACTAAAATCTCTAGGTGCGACTCGTATTGTTGAGCGTAGCGAATTAGAAGAACCAGCAAAACCATTAGAAAAACAGC
TATGGGCTGGCGCTATCGATACTGTTGGTAGCAAAGTATTGGCAAAAGTATTAGCACAAGTAGATTACAACGGCGCAGTA
GCGGCATGTGGTCTTGCTGGTGGTTTTGATTTACCAACAACGGTAATGCCATTCATTCTACGCAACGTTCGTCTACAAGG
TATTGACTCTGTAATGTGCCCTCGCGAAAAACGCATTAAAGCATGGGAACAATTAGCTGAGCTACTACCAGCATCATTCT
TTGACCAAGCAACAAAAGAAGTGTCTCTTGATGATGCAATCCAAGCTGCTGAAGACATTACCAATGGTCAAATCACAGGT
CGCGTTGTAATTAAAATCTAA

Upstream 100 bases:

>100_bases
TTTAAGTATCATTTTTTTTCTTTTCAAAACTCACCTACACTTACTCTCATTGGTCAAACAGACCGTTTGATGTTCGTTAT
TATCCTTATTGGAGTTCGTT

Downstream 100 bases:

>100_bases
GTAGTTATTAAAATCTAAAAGGTTTAAAACTAAGTCCTACCTAACTTAGTTTTAGATAACATCAGTAATTCAAGGCAGCA
TTATCGCTGCCTTTTTTTAT

Product: oxidoreductase, Zn-dependent and NAD(P)-binding

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MFKALVLNQEDRNTIAAVTEIDESQLPEGNVKIDVNYSSLNYKDGLAITGKGRIVRNFPMVPGIDLSGVVSQSDDPRYKA
GDEVVLTGWGVGEGHWGGMAEKASLNGDWLVPMPKGLDAKKVMAIGTAGFTAMLCVQAIVDADIKPEDGEILVTGSSGGV
GSVAITLLNQLGYKVAAVTGRASENGELLKSLGATRIVERSELEEPAKPLEKQLWAGAIDTVGSKVLAKVLAQVDYNGAV
AACGLAGGFDLPTTVMPFILRNVRLQGIDSVMCPREKRIKAWEQLAELLPASFFDQATKEVSLDDAIQAAEDITNGQITG
RVVIKI

Sequences:

>Translated_326_residues
MFKALVLNQEDRNTIAAVTEIDESQLPEGNVKIDVNYSSLNYKDGLAITGKGRIVRNFPMVPGIDLSGVVSQSDDPRYKA
GDEVVLTGWGVGEGHWGGMAEKASLNGDWLVPMPKGLDAKKVMAIGTAGFTAMLCVQAIVDADIKPEDGEILVTGSSGGV
GSVAITLLNQLGYKVAAVTGRASENGELLKSLGATRIVERSELEEPAKPLEKQLWAGAIDTVGSKVLAKVLAQVDYNGAV
AACGLAGGFDLPTTVMPFILRNVRLQGIDSVMCPREKRIKAWEQLAELLPASFFDQATKEVSLDDAIQAAEDITNGQITG
RVVIKI
>Mature_326_residues
MFKALVLNQEDRNTIAAVTEIDESQLPEGNVKIDVNYSSLNYKDGLAITGKGRIVRNFPMVPGIDLSGVVSQSDDPRYKA
GDEVVLTGWGVGEGHWGGMAEKASLNGDWLVPMPKGLDAKKVMAIGTAGFTAMLCVQAIVDADIKPEDGEILVTGSSGGV
GSVAITLLNQLGYKVAAVTGRASENGELLKSLGATRIVERSELEEPAKPLEKQLWAGAIDTVGSKVLAKVLAQVDYNGAV
AACGLAGGFDLPTTVMPFILRNVRLQGIDSVMCPREKRIKAWEQLAELLPASFFDQATKEVSLDDAIQAAEDITNGQITG
RVVIKI

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789651, Length=325, Percent_Identity=65.8461538461538, Blast_Score=452, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR014188 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 34595; Mature: 34595

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKALVLNQEDRNTIAAVTEIDESQLPEGNVKIDVNYSSLNYKDGLAITGKGRIVRNFPM
CCEEEEECCCCCCEEEEEEECCHHHCCCCCEEEEEEECCCCCCCCEEEECCCEEEEECCC
VPGIDLSGVVSQSDDPRYKAGDEVVLTGWGVGEGHWGGMAEKASLNGDWLVPMPKGLDAK
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
KVMAIGTAGFTAMLCVQAIVDADIKPEDGEILVTGSSGGVGSVAITLLNQLGYKVAAVTG
CEEEEECCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEEC
RASENGELLKSLGATRIVERSELEEPAKPLEKQLWAGAIDTVGSKVLAKVLAQVDYNGAV
CCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
AACGLAGGFDLPTTVMPFILRNVRLQGIDSVMCPREKRIKAWEQLAELLPASFFDQATKE
EEEECCCCCCCHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
VSLDDAIQAAEDITNGQITGRVVIKI
CCHHHHHHHHHHCCCCEEEEEEEEEC
>Mature Secondary Structure
MFKALVLNQEDRNTIAAVTEIDESQLPEGNVKIDVNYSSLNYKDGLAITGKGRIVRNFPM
CCEEEEECCCCCCEEEEEEECCHHHCCCCCEEEEEEECCCCCCCCEEEECCCEEEEECCC
VPGIDLSGVVSQSDDPRYKAGDEVVLTGWGVGEGHWGGMAEKASLNGDWLVPMPKGLDAK
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
KVMAIGTAGFTAMLCVQAIVDADIKPEDGEILVTGSSGGVGSVAITLLNQLGYKVAAVTG
CEEEEECCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEEC
RASENGELLKSLGATRIVERSELEEPAKPLEKQLWAGAIDTVGSKVLAKVLAQVDYNGAV
CCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
AACGLAGGFDLPTTVMPFILRNVRLQGIDSVMCPREKRIKAWEQLAELLPASFFDQATKE
EEEECCCCCCCHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
VSLDDAIQAAEDITNGQITGRVVIKI
CCHHHHHHHHHHCCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1370469; 9278503 [H]