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The map label for this gene is tolC [H]

Identifier: 58617542

GI number: 58617542

Start: 1302592

End: 1303839

Strand: Reverse

Name: tolC [H]

Synonym: ERGA_CDS_08150

Alternate gene names: 58617542

Gene position: 1303839-1302592 (Counterclockwise)

Preceding gene: 58617551

Following gene: 58617541

Centisome position: 86.93

GC content: 32.05

Gene sequence:

>1248_bases
ATGTATAAAACCTGTTACATCCTAATATTGATTATGGTATTAATTATGCTGCCTCATGGTAGTTATTGTACTGACCTGAA
TCAAGCATTGCATGCAGCATTGAAAAATAATCCTAGTATAAAAGCAAAGTTCTATGGTTCTTTAGAAAATAGACAAAGAC
TCAAACTGAATAGTATATCAAAATTTTTACCATCGATTGTATATTCATATAACTCACGTTTTCCTGGTCTGACTTCAGAT
CATAACATAAAAAACATGAGTATTAGTGTAACGCAACAGGTATTCAATGGTGGAGCTGATGCTGCTGCTTTTCAGCAAGC
TAAATATTTAACGAATATTGAGGAAATCAATTTCTTATTAGAAAAACAAAACGTTCTCCTTAATGCAGTAAAAGCGTATA
TGAAAGTTTTAACAACATCTGAAGTTTATAAGCTGACTCAACATACAGAAAAGGTTTTAACTGAGCATTTATTGGCTACA
GAAAAAAGATTTGCTTTAGCAGAAGTGACAAAAACAGATGTATCACAAGCAACTGCTAGGTTATCTGCTGCTAAATCAGA
ATCCATTAAGGCGTATGGTAATATGAAAGCTGCAGAAGCTAGTTATGTTCATACAATAGGAGAATTGCCAATTGATTTAC
AAGATCCTGTTACACCTGTGTTACCAAGCTCAGTGGAAGAGGCTTTAGAGATTGCACAACGGAATAATCTTTCTTTACAG
ATATCTAACAATGGACATAAAGCAGCTAAACAAGGTGTTTTAATTGCACTTGGGCATTTATTGCCTTCTATTAGTGTATC
AGCTGTTACCTCGTATACAGAAACTGATATTTTTAAAAAGGATATTCAAAAAACTGAAGATGTTTTTGAGATTAAAATGT
CATTACCTATATTTCAGCAAGGACTTAATCTTGGAGCAGTGACACAGTCTGAACTTGCTGTAAAACAAAAAATGTATGCA
TATTATGAAGCATTGAATTCGATCAAAGAATCTATTGTTTCAAATTGGGAGAGCATTTCTACAGCTAATTCTATGCTACA
AGCTGCGCAAGATCATGTAAAGTATACAGAAGTTGTATTATTTGGAGTTAAGAAAGAAGTTGAATTAAACTTAAGGACGA
TTCTAGATGTGTTAGATGCAGAAGAAGAGTTATTGAAGGCAAAAGTAAATTTAGTTAATGTACAGAGTAATGTTATTATT
AGTATATATAATTTACTTGCTTTGATTGGACAATTGAATATTAATTAA

Upstream 100 bases:

>100_bases
TTACACTTAATGCTTGCTAATGAAAATTAATTACAGTTTAATCGTTGTCAGTATAATTTTTTTGCATAATACTAGAAATA
TTTAATTTATTAGATTTTGT

Downstream 100 bases:

>100_bases
TTATTTAATATGATAAATTTATGAGTGATACTAATAATTTTCAGTCTATTAAAGACGTAATTGCTAACATTAGGAAAGTT
ATGTCTAGCAATGATACGGC

Product: Outer membrane protein tolC precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MYKTCYILILIMVLIMLPHGSYCTDLNQALHAALKNNPSIKAKFYGSLENRQRLKLNSISKFLPSIVYSYNSRFPGLTSD
HNIKNMSISVTQQVFNGGADAAAFQQAKYLTNIEEINFLLEKQNVLLNAVKAYMKVLTTSEVYKLTQHTEKVLTEHLLAT
EKRFALAEVTKTDVSQATARLSAAKSESIKAYGNMKAAEASYVHTIGELPIDLQDPVTPVLPSSVEEALEIAQRNNLSLQ
ISNNGHKAAKQGVLIALGHLLPSISVSAVTSYTETDIFKKDIQKTEDVFEIKMSLPIFQQGLNLGAVTQSELAVKQKMYA
YYEALNSIKESIVSNWESISTANSMLQAAQDHVKYTEVVLFGVKKEVELNLRTILDVLDAEEELLKAKVNLVNVQSNVII
SIYNLLALIGQLNIN

Sequences:

>Translated_415_residues
MYKTCYILILIMVLIMLPHGSYCTDLNQALHAALKNNPSIKAKFYGSLENRQRLKLNSISKFLPSIVYSYNSRFPGLTSD
HNIKNMSISVTQQVFNGGADAAAFQQAKYLTNIEEINFLLEKQNVLLNAVKAYMKVLTTSEVYKLTQHTEKVLTEHLLAT
EKRFALAEVTKTDVSQATARLSAAKSESIKAYGNMKAAEASYVHTIGELPIDLQDPVTPVLPSSVEEALEIAQRNNLSLQ
ISNNGHKAAKQGVLIALGHLLPSISVSAVTSYTETDIFKKDIQKTEDVFEIKMSLPIFQQGLNLGAVTQSELAVKQKMYA
YYEALNSIKESIVSNWESISTANSMLQAAQDHVKYTEVVLFGVKKEVELNLRTILDVLDAEEELLKAKVNLVNVQSNVII
SIYNLLALIGQLNIN
>Mature_415_residues
MYKTCYILILIMVLIMLPHGSYCTDLNQALHAALKNNPSIKAKFYGSLENRQRLKLNSISKFLPSIVYSYNSRFPGLTSD
HNIKNMSISVTQQVFNGGADAAAFQQAKYLTNIEEINFLLEKQNVLLNAVKAYMKVLTTSEVYKLTQHTEKVLTEHLLAT
EKRFALAEVTKTDVSQATARLSAAKSESIKAYGNMKAAEASYVHTIGELPIDLQDPVTPVLPSSVEEALEIAQRNNLSLQ
ISNNGHKAAKQGVLIALGHLLPSISVSAVTSYTETDIFKKDIQKTEDVFEIKMSLPIFQQGLNLGAVTQSELAVKQKMYA
YYEALNSIKESIVSNWESISTANSMLQAAQDHVKYTEVVLFGVKKEVELNLRTILDVLDAEEELLKAKVNLVNVQSNVII
SIYNLLALIGQLNIN

Specific function: Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI87082199, Length=374, Percent_Identity=24.0641711229947, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 46048; Mature: 46048

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKTCYILILIMVLIMLPHGSYCTDLNQALHAALKNNPSIKAKFYGSLENRQRLKLNSIS
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHH
KFLPSIVYSYNSRFPGLTSDHNIKNMSISVTQQVFNGGADAAAFQQAKYLTNIEEINFLL
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EKQNVLLNAVKAYMKVLTTSEVYKLTQHTEKVLTEHLLATEKRFALAEVTKTDVSQATAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSAAKSESIKAYGNMKAAEASYVHTIGELPIDLQDPVTPVLPSSVEEALEIAQRNNLSLQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEE
ISNNGHKAAKQGVLIALGHLLPSISVSAVTSYTETDIFKKDIQKTEDVFEIKMSLPIFQQ
ECCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHC
GLNLGAVTQSELAVKQKMYAYYEALNSIKESIVSNWESISTANSMLQAAQDHVKYTEVVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
FGVKKEVELNLRTILDVLDAEEELLKAKVNLVNVQSNVIISIYNLLALIGQLNIN
EECCHHHHHHHHHHHHHHCCHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYKTCYILILIMVLIMLPHGSYCTDLNQALHAALKNNPSIKAKFYGSLENRQRLKLNSIS
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHH
KFLPSIVYSYNSRFPGLTSDHNIKNMSISVTQQVFNGGADAAAFQQAKYLTNIEEINFLL
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EKQNVLLNAVKAYMKVLTTSEVYKLTQHTEKVLTEHLLATEKRFALAEVTKTDVSQATAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSAAKSESIKAYGNMKAAEASYVHTIGELPIDLQDPVTPVLPSSVEEALEIAQRNNLSLQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEE
ISNNGHKAAKQGVLIALGHLLPSISVSAVTSYTETDIFKKDIQKTEDVFEIKMSLPIFQQ
ECCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHC
GLNLGAVTQSELAVKQKMYAYYEALNSIKESIVSNWESISTANSMLQAAQDHVKYTEVVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
FGVKKEVELNLRTILDVLDAEEELLKAKVNLVNVQSNVIISIYNLLALIGQLNIN
EECCHHHHHHHHHHHHHHCCHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]