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The map label for this gene is sdhA [H]

Identifier: 58617435

GI number: 58617435

Start: 1124554

End: 1126350

Strand: Reverse

Name: sdhA [H]

Synonym: ERGA_CDS_07080

Alternate gene names: 58617435

Gene position: 1126350-1124554 (Counterclockwise)

Preceding gene: 58617436

Following gene: 58617434

Centisome position: 75.09

GC content: 38.56

Gene sequence:

>1797_bases
ATGTCTAGTTCTACGTACAGTATTATAGACCATGAGTATGATGTTGTAATAATAGGTGCTGGGGGAGCTGGCTTGAGGGC
AACTTTTGGGATGACTTCTGTTGGCTTGTCTGTTGCATGCATATCTAAGGTTTTTCCAACGAGAAGTCATACAGTAGCTG
CTCAAGGTGGTATTAGTGCTGCTCTAGGTAATGTTACTGAGGATGACTGGAGATGGCATATGTTTGATACAGTCAAAGGT
TCTGACTGGCTTGGTGATCAAGATGCTATTGAATATATGTGTAAAAATGCAGCAGAAGCTGTTATTGAACTTGAGCGTTA
TGGAGTACCTTTCTCACGTACTAGTGATGGTAAAATATATCAGCGTCCTTTTGGTGGTATGACTACAGAATTTGGTAAAG
GTAAACCAGCAATTCGTACTTGTGCTGCATCTGATAAAACAGGTCATGCTATACTTCATACTCTATATCAGCAATCTTTA
AAGCACAATGCTGAATTTTTTGTGGAGTATTTTGCTATTGATTTAATTATGAATGAAGTTGGTCAGTGTCAAGGTGTAAT
TGCATGGTCATTATGTGATGGGACGTTACATAGGTTCCGTTCTCATGCTGTTGTTCTTGCTACAGGTGGGTATGGTAGGA
TATATTTTTCTGCAACTAGTGCTCATACTTGTACTGGTGATGGTGGTGGAATGGTATCTCGTATTAATTTGCCTTTAGAA
GATATGGAATTTGTACAATTTCATCCAACAGGGATATATGGTTCTGGGTGTTTGATGACCGAAGGATGTAGAGGAGAAGG
TGGTTATTTAATTAATTCTGAAGGTGAAAGATTTATGGAGCGTTATGCTCCAAAAGCTAAAGATTTAGCATCTCGTGATG
TTGTGAGTAGGGCCATGACTTTGGAAATAAGAGAAGGTCGTGGTGTAGGGCCTAACAAGGATCATGTATATTTATCTATA
TCTCATTTAGGAGCAGAAGTTATACATGATAAATTACCAGGTATTAGTGAAACTGCTCGTACTTTTGCTGGAGTGGATGT
TACGAAAGAACCTATACCTGTATTACCAACTGTTCATTATAATATGGGTGGTATTCCCACAAATTATTATGGTCAAGTGA
TTACGTTAACAGATAGTGGAGAAAAGATCGTACCTGGGCTTTTTGCGATAGGAGAGGCAGCATGTGTTTCTGTGCATGGA
GCAAATCGTTTGGGTTCTAATTCATTACTTGATTTAGTTGTATTTGGTAGGGCTGCAGCTATTAAAGCAAAGGAATTGAT
AAAGCCTGGTATGTTACATGCTCCTATAAACAAAGCTAGTGAAGAAAAAATAATTGCTCGTTTTGATGGAATTAGGTTTT
CTAAGGGGAGTTTACGTGTTGCGGAAGTGCGTGGTAAAATGCAGCATGTTATGCAAAATCATGCAGCTGTTTTTCGTACA
GCAGAAGTGTTAGATGAAGGAAAAGTCAAGATTAAAGATGTAGCTAAGCTAATGCCTGAGATTGTAGTGCAGGATAAGAG
CATGATATGGAATAGTGATCTAGTTGAAGCATTGGAGTTGACTAACATGATGCCGCAAGCAGTTGTAACTATGGAATGTG
CAGCAAACCGTCAGGAAAGTAGAGGAGCTCATGCACGGGAAGATTTTCCTGAACGTGATGATGAAAATTGGATGAAACAT
ACTTTAGCTTGGTATGATGCTGCTAATTGTTCTGTAGAAATTAAGTATAAGGATGTTGCTAAGACGACTTTAACAAATGA
TGTTCAATATTTTCCCCCACAGAAAAGAGTATATTAG

Upstream 100 bases:

>100_bases
TATTATTAAACTGTTTTAATATAGAAATTATGTTGACTCATTGTGTTATTATGGTAGCCTAGTTATGTTTTCTGTTGTTT
TGTAATATTATTTTTTTGTA

Downstream 100 bases:

>100_bases
TTATCCGTATAGGAATTGTGTAAAAGGTTTGTTATGGTTCAGTTTTTTTTACCTAAGAATTCTAAGATTAATAAAAATGG
GGAAGTATATAATGCTCCTG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MSSSTYSIIDHEYDVVIIGAGGAGLRATFGMTSVGLSVACISKVFPTRSHTVAAQGGISAALGNVTEDDWRWHMFDTVKG
SDWLGDQDAIEYMCKNAAEAVIELERYGVPFSRTSDGKIYQRPFGGMTTEFGKGKPAIRTCAASDKTGHAILHTLYQQSL
KHNAEFFVEYFAIDLIMNEVGQCQGVIAWSLCDGTLHRFRSHAVVLATGGYGRIYFSATSAHTCTGDGGGMVSRINLPLE
DMEFVQFHPTGIYGSGCLMTEGCRGEGGYLINSEGERFMERYAPKAKDLASRDVVSRAMTLEIREGRGVGPNKDHVYLSI
SHLGAEVIHDKLPGISETARTFAGVDVTKEPIPVLPTVHYNMGGIPTNYYGQVITLTDSGEKIVPGLFAIGEAACVSVHG
ANRLGSNSLLDLVVFGRAAAIKAKELIKPGMLHAPINKASEEKIIARFDGIRFSKGSLRVAEVRGKMQHVMQNHAAVFRT
AEVLDEGKVKIKDVAKLMPEIVVQDKSMIWNSDLVEALELTNMMPQAVVTMECAANRQESRGAHAREDFPERDDENWMKH
TLAWYDAANCSVEIKYKDVAKTTLTNDVQYFPPQKRVY

Sequences:

>Translated_598_residues
MSSSTYSIIDHEYDVVIIGAGGAGLRATFGMTSVGLSVACISKVFPTRSHTVAAQGGISAALGNVTEDDWRWHMFDTVKG
SDWLGDQDAIEYMCKNAAEAVIELERYGVPFSRTSDGKIYQRPFGGMTTEFGKGKPAIRTCAASDKTGHAILHTLYQQSL
KHNAEFFVEYFAIDLIMNEVGQCQGVIAWSLCDGTLHRFRSHAVVLATGGYGRIYFSATSAHTCTGDGGGMVSRINLPLE
DMEFVQFHPTGIYGSGCLMTEGCRGEGGYLINSEGERFMERYAPKAKDLASRDVVSRAMTLEIREGRGVGPNKDHVYLSI
SHLGAEVIHDKLPGISETARTFAGVDVTKEPIPVLPTVHYNMGGIPTNYYGQVITLTDSGEKIVPGLFAIGEAACVSVHG
ANRLGSNSLLDLVVFGRAAAIKAKELIKPGMLHAPINKASEEKIIARFDGIRFSKGSLRVAEVRGKMQHVMQNHAAVFRT
AEVLDEGKVKIKDVAKLMPEIVVQDKSMIWNSDLVEALELTNMMPQAVVTMECAANRQESRGAHAREDFPERDDENWMKH
TLAWYDAANCSVEIKYKDVAKTTLTNDVQYFPPQKRVY
>Mature_597_residues
SSSTYSIIDHEYDVVIIGAGGAGLRATFGMTSVGLSVACISKVFPTRSHTVAAQGGISAALGNVTEDDWRWHMFDTVKGS
DWLGDQDAIEYMCKNAAEAVIELERYGVPFSRTSDGKIYQRPFGGMTTEFGKGKPAIRTCAASDKTGHAILHTLYQQSLK
HNAEFFVEYFAIDLIMNEVGQCQGVIAWSLCDGTLHRFRSHAVVLATGGYGRIYFSATSAHTCTGDGGGMVSRINLPLED
MEFVQFHPTGIYGSGCLMTEGCRGEGGYLINSEGERFMERYAPKAKDLASRDVVSRAMTLEIREGRGVGPNKDHVYLSIS
HLGAEVIHDKLPGISETARTFAGVDVTKEPIPVLPTVHYNMGGIPTNYYGQVITLTDSGEKIVPGLFAIGEAACVSVHGA
NRLGSNSLLDLVVFGRAAAIKAKELIKPGMLHAPINKASEEKIIARFDGIRFSKGSLRVAEVRGKMQHVMQNHAAVFRTA
EVLDEGKVKIKDVAKLMPEIVVQDKSMIWNSDLVEALELTNMMPQAVVTMECAANRQESRGAHAREDFPERDDENWMKHT
LAWYDAANCSVEIKYKDVAKTTLTNDVQYFPPQKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=614, Percent_Identity=60.4234527687296, Blast_Score=740, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=598, Percent_Identity=53.1772575250836, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI1790597, Length=577, Percent_Identity=42.1143847487002, Blast_Score=414, Evalue=1e-116,
Organism=Escherichia coli, GI1788928, Length=559, Percent_Identity=31.3059033989267, Blast_Score=218, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17550100, Length=614, Percent_Identity=59.1205211726384, Blast_Score=721, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=619, Percent_Identity=57.3505654281099, Blast_Score=705, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71986328, Length=462, Percent_Identity=25.5411255411255, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322701, Length=596, Percent_Identity=63.4228187919463, Blast_Score=776, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=596, Percent_Identity=63.758389261745, Blast_Score=775, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=483, Percent_Identity=27.9503105590062, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137288, Length=614, Percent_Identity=61.400651465798, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=614, Percent_Identity=61.400651465798, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=614, Percent_Identity=61.400651465798, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=613, Percent_Identity=55.4649265905383, Blast_Score=689, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65485; Mature: 65354

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSTYSIIDHEYDVVIIGAGGAGLRATFGMTSVGLSVACISKVFPTRSHTVAAQGGISA
CCCCEEEEECCCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCHH
ALGNVTEDDWRWHMFDTVKGSDWLGDQDAIEYMCKNAAEAVIELERYGVPFSRTSDGKIY
HHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
QRPFGGMTTEFGKGKPAIRTCAASDKTGHAILHTLYQQSLKHNAEFFVEYFAIDLIMNEV
ECCCCCCCCCCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GQCQGVIAWSLCDGTLHRFRSHAVVLATGGYGRIYFSATSAHTCTGDGGGMVSRINLPLE
HCCCCEEEEEEHHHHHHHHHCCEEEEEECCCEEEEEEECCCCEEECCCCCEEEEECCCCC
DMEFVQFHPTGIYGSGCLMTEGCRGEGGYLINSEGERFMERYAPKAKDLASRDVVSRAMT
CCCEEEEECCCEECCCCEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHEEE
LEIREGRGVGPNKDHVYLSISHLGAEVIHDKLPGISETARTFAGVDVTKEPIPVLPTVHY
EEEECCCCCCCCCCEEEEEHHHCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCEEEC
NMGGIPTNYYGQVITLTDSGEKIVPGLFAIGEAACVSVHGANRLGSNSLLDLVVFGRAAA
CCCCCCCCCCCEEEEEECCCCCCCCHHHHHCCEEEEEEECCCCCCCCCHHHHHHHCCHHH
IKAKELIKPGMLHAPINKASEEKIIARFDGIRFSKGSLRVAEVRGKMQHVMQNHAAVFRT
HHHHHHCCCCCEECCCCCCCHHHHHHHHCCEEECCCCEEHHHHHHHHHHHHHHHHHHHHH
AEVLDEGKVKIKDVAKLMPEIVVQDKSMIWNSDLVEALELTNMMPQAVVTMECAANRQES
HHHHHCCCEEHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHCCHHHHEEHHHHCCCHHH
RGAHAREDFPERDDENWMKHTLAWYDAANCSVEIKYKDVAKTTLTNDVQYFPPQKRVY
CCCCCCCCCCCCCCHHHHHHHHHEEECCCCEEEEEEHHHHHHHHCCCCEECCCCCCCC
>Mature Secondary Structure 
SSSTYSIIDHEYDVVIIGAGGAGLRATFGMTSVGLSVACISKVFPTRSHTVAAQGGISA
CCCEEEEECCCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCHH
ALGNVTEDDWRWHMFDTVKGSDWLGDQDAIEYMCKNAAEAVIELERYGVPFSRTSDGKIY
HHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
QRPFGGMTTEFGKGKPAIRTCAASDKTGHAILHTLYQQSLKHNAEFFVEYFAIDLIMNEV
ECCCCCCCCCCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GQCQGVIAWSLCDGTLHRFRSHAVVLATGGYGRIYFSATSAHTCTGDGGGMVSRINLPLE
HCCCCEEEEEEHHHHHHHHHCCEEEEEECCCEEEEEEECCCCEEECCCCCEEEEECCCCC
DMEFVQFHPTGIYGSGCLMTEGCRGEGGYLINSEGERFMERYAPKAKDLASRDVVSRAMT
CCCEEEEECCCEECCCCEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHEEE
LEIREGRGVGPNKDHVYLSISHLGAEVIHDKLPGISETARTFAGVDVTKEPIPVLPTVHY
EEEECCCCCCCCCCEEEEEHHHCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCEEEC
NMGGIPTNYYGQVITLTDSGEKIVPGLFAIGEAACVSVHGANRLGSNSLLDLVVFGRAAA
CCCCCCCCCCCEEEEEECCCCCCCCHHHHHCCEEEEEEECCCCCCCCCHHHHHHHCCHHH
IKAKELIKPGMLHAPINKASEEKIIARFDGIRFSKGSLRVAEVRGKMQHVMQNHAAVFRT
HHHHHHCCCCCEECCCCCCCHHHHHHHHCCEEECCCCEEHHHHHHHHHHHHHHHHHHHHH
AEVLDEGKVKIKDVAKLMPEIVVQDKSMIWNSDLVEALELTNMMPQAVVTMECAANRQES
HHHHHCCCEEHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHCCHHHHEEHHHHCCCHHH
RGAHAREDFPERDDENWMKHTLAWYDAANCSVEIKYKDVAKTTLTNDVQYFPPQKRVY
CCCCCCCCCCCCCCHHHHHHHHHEEECCCCEEEEEEHHHHHHHHCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA