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The map label for this gene is uvrA [H]

Identifier: 58617038

GI number: 58617038

Start: 513291

End: 516170

Strand: Reverse

Name: uvrA [H]

Synonym: ERGA_CDS_03110

Alternate gene names: 58617038

Gene position: 516170-513291 (Counterclockwise)

Preceding gene: 58617039

Following gene: 58617037

Centisome position: 34.41

GC content: 29.86

Gene sequence:

>2880_bases
ATGGCTAATTTTATTAGTATACGTAATGCTAAAGAACACAATCTTCGTAATATTTGTATAGATATACCTAAAAATAAACT
AATTGTAATAACTGGAGTAAGTGGATCTGGAAAATCAAGTTTAGCATTCGATACAATATATGCTGAAGGACAACGTAGAT
ATGTAGAAAATCTATCATCTTATGCTCGTCAGTTTCTTGATTCATGTACAAAACCAGATGTTGAATCAATAACAGGACTT
TCACCAGCAATTGCACTTACCCAAAGACCTTTATCAAAAAATTCACGATCAACTGTATCAACTGCTACAGAAATTTATGA
CTATTTAAGGTTGATGTACTCTAAGATAGGTATCCCACATTCTCCTAGTACTGGATTACCAATAACAAAACAATCTACAC
ATCAAATAATAGATCAAGTATTAAAATTACCACTAGGCACAGAAATTCTAATTTTAGGAGCATTAATCAGAAACAAAAAA
GGAGAACATCAAAAAGAAATCCTAGAAATAAAAAAACAAAATTATCAATACCTAAAGATCAACGGTACTATACACGATAT
TAATAATATACCTAAATTAGATAGAAATAAAAAACATAATATCTGTGTTATTATAGAAAAAGCAATACTATCAGAAAGCT
CTCTCAATAGTATAGCTGATAGCATAACAACAGCATTAAAAATAGGAAATGGTATAATTCATGTAGAAATACTAAATTTA
CCAGAAAGCTATAACAATCAAAAATATCATCAAAATCAAATACTAACTTTTTCAGAAAATTTTTCATGTCCTGAAACAGA
TTTTAACATAGAAGAAATAGAACCAAGATTATTTTCGTTTAACACTTCATATGGCTCATGCAAAAGCTGTGAAGGAACAG
GAAAAACTTACAGTATCGATAAAAATCTTATTATAACCAATGACAATTTATCAATATTAGAAGGAGCTATACACCCAATT
GGCCCAATTAATTTACAAGTCCTTCACCATAAAATTAATTCTAATTTTAGCTATCATTATGCAAATATCATTCTATCCTT
AGCAAAATATTATAACTTTGATATAACACAACCATGGAAAGAACTTAACAATAATATACAAGATATTATTTTATTTGGTA
CCAATGGAGTACCAATACCTATATCTTATCACAACGAAGAATATAAATATTCTCAGAACAGACAATTTGATGGCATAATA
AACATATTAAATAATAAAAAAGATATAATAACTGAAAGGATAGCTGAACAATATTTATCTATAAACACATGTAGTACATG
CCAAGGTTTTAGATTGCGACCTGAAGCCCTATCAGTAAAAATCAATAATAAACATATAGGAGAAATTACAAAACTATCTG
TAGTAGAAGCAATATCATGGTGTCAAGCCTTATTATCCCAACTTACTGGTCAACAAAGAGATATTTCACAAAAGTTACTC
GATGAAATAATTAGAAGATTAACATTTCTCAAAAATGTTGGACTAGGTTATTTAACACTTAGCCGTGAGTCAGGAACATT
ATCCGGAGGAGAAGGTCAAAGAATAAAACTAGCATCACAAATTGGATCAGGACTCACAGGAATAATTTATGTATTAGATG
AACCATCAATCGGCCTTCATCAAAAAGACAATGCATTGTTAATTAGTACTTTAAAAAAACTACGCGATCTAGAAAATACA
GTAATCGTTGTCGAACATGATGAAGAAACAATGGAAAATGCAGACTATATAATAGACATGGGCCCAGGAGCAGGACAAAA
TGGAGGACATGTAATAGCAAGTGGAACACTAAAAGATATACTCAACAATACCAATAGCATCACCGGACAATATCTAAGTA
AGAAAAAAGTAATACCATATTTCAAAAAAAATAAAACTTTTGATCAATGGATTAAAATCACCGGAGCACGAGAAAACAAC
TTACGCAATATTGATGCACAGATTCCTCTGAATGCTCTAACATGTATTACTGGAGTTTCAGGTAGCGGAAAATCTAGTTT
AATAAATAATACTTTATATAAATATGCTATTAATAAACTAAATAACATAAACTGGATACATAATAAATGTACATCTATAT
CAGGGTTAGAACATATAGATAAAATACTTCTAATAGATCAATCACCTATTGGAAGAACTCCTTTATCAAACCCTGCAACT
TACATAGGATTATTTACCTATATCAGATCATGGTTTGCTGGATTACCACTATCTAAAACAAGAGGATATAATATAAGCAG
ATTTTCTTTTAACTCAAAAGGAGGAAGATGTGAAACATGTAAAGGTGACGGACAAATAAAAATAGAAATGCATTTCTTAC
CTGATGTACATGTAAAATGCGAACAATGCAAAGGTAAACGTTATAACAAAGAAACACTAGAAATAACATATAAAGGAAAA
TCAATAGCTGATGTATTAAACATGACAGTTGATCAAGCATACGAATTTTTCATAGACTTACCATTAATTAAAGAGAAACT
AGATTCTTTACGTAGCATAGGAATGGGTTATATAAAAATTGGCCAGACATCTAATACGTTATCAGGAGGTGAAGCACAAC
GAATAAAGTTATCTAGAGAATTATCAAAACGAGCTACAGGTAAAACCCTATACATATTAGATGAACCAACTACAGGATTA
CATCTTGCAGATATAAATAACTTACTATATGTTTTACATACACTCTGTGATTTAGGAAATACAATAATAGTAATTGAACA
TAATTTACATGTAATAAAAACAGCAGAATATATAATAGATATGGGCCCAAATGGAGGAGATGAAGGAGGTAGAATTATAG
CAACTGGAACTCCACAGGAAATAATAGAAAACCCTCAAAGTATAACTGGACAATATTTAAAACAATACTTACAAGTATAA

Upstream 100 bases:

>100_bases
ATGTCTTCTTTTATATAAAAATTTAGATGAACAATTACCATTCTTCATATATTATAATATCTTTAATTTTAATCTGACAG
TCATGATGGTAATGTAAAAT

Downstream 100 bases:

>100_bases
AATACAAATTAACTTTTATAATCAATTTTAAATACAATATAATACATAGGATAGTGTTATGTAATAACATAATATTTTTT
AATAATTAAATAATTGTCTA

Product: UvrABC system protein A (UvrA protein)

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 959; Mature: 958

Protein sequence:

>959_residues
MANFISIRNAKEHNLRNICIDIPKNKLIVITGVSGSGKSSLAFDTIYAEGQRRYVENLSSYARQFLDSCTKPDVESITGL
SPAIALTQRPLSKNSRSTVSTATEIYDYLRLMYSKIGIPHSPSTGLPITKQSTHQIIDQVLKLPLGTEILILGALIRNKK
GEHQKEILEIKKQNYQYLKINGTIHDINNIPKLDRNKKHNICVIIEKAILSESSLNSIADSITTALKIGNGIIHVEILNL
PESYNNQKYHQNQILTFSENFSCPETDFNIEEIEPRLFSFNTSYGSCKSCEGTGKTYSIDKNLIITNDNLSILEGAIHPI
GPINLQVLHHKINSNFSYHYANIILSLAKYYNFDITQPWKELNNNIQDIILFGTNGVPIPISYHNEEYKYSQNRQFDGII
NILNNKKDIITERIAEQYLSINTCSTCQGFRLRPEALSVKINNKHIGEITKLSVVEAISWCQALLSQLTGQQRDISQKLL
DEIIRRLTFLKNVGLGYLTLSRESGTLSGGEGQRIKLASQIGSGLTGIIYVLDEPSIGLHQKDNALLISTLKKLRDLENT
VIVVEHDEETMENADYIIDMGPGAGQNGGHVIASGTLKDILNNTNSITGQYLSKKKVIPYFKKNKTFDQWIKITGARENN
LRNIDAQIPLNALTCITGVSGSGKSSLINNTLYKYAINKLNNINWIHNKCTSISGLEHIDKILLIDQSPIGRTPLSNPAT
YIGLFTYIRSWFAGLPLSKTRGYNISRFSFNSKGGRCETCKGDGQIKIEMHFLPDVHVKCEQCKGKRYNKETLEITYKGK
SIADVLNMTVDQAYEFFIDLPLIKEKLDSLRSIGMGYIKIGQTSNTLSGGEAQRIKLSRELSKRATGKTLYILDEPTTGL
HLADINNLLYVLHTLCDLGNTIIVIEHNLHVIKTAEYIIDMGPNGGDEGGRIIATGTPQEIIENPQSITGQYLKQYLQV

Sequences:

>Translated_959_residues
MANFISIRNAKEHNLRNICIDIPKNKLIVITGVSGSGKSSLAFDTIYAEGQRRYVENLSSYARQFLDSCTKPDVESITGL
SPAIALTQRPLSKNSRSTVSTATEIYDYLRLMYSKIGIPHSPSTGLPITKQSTHQIIDQVLKLPLGTEILILGALIRNKK
GEHQKEILEIKKQNYQYLKINGTIHDINNIPKLDRNKKHNICVIIEKAILSESSLNSIADSITTALKIGNGIIHVEILNL
PESYNNQKYHQNQILTFSENFSCPETDFNIEEIEPRLFSFNTSYGSCKSCEGTGKTYSIDKNLIITNDNLSILEGAIHPI
GPINLQVLHHKINSNFSYHYANIILSLAKYYNFDITQPWKELNNNIQDIILFGTNGVPIPISYHNEEYKYSQNRQFDGII
NILNNKKDIITERIAEQYLSINTCSTCQGFRLRPEALSVKINNKHIGEITKLSVVEAISWCQALLSQLTGQQRDISQKLL
DEIIRRLTFLKNVGLGYLTLSRESGTLSGGEGQRIKLASQIGSGLTGIIYVLDEPSIGLHQKDNALLISTLKKLRDLENT
VIVVEHDEETMENADYIIDMGPGAGQNGGHVIASGTLKDILNNTNSITGQYLSKKKVIPYFKKNKTFDQWIKITGARENN
LRNIDAQIPLNALTCITGVSGSGKSSLINNTLYKYAINKLNNINWIHNKCTSISGLEHIDKILLIDQSPIGRTPLSNPAT
YIGLFTYIRSWFAGLPLSKTRGYNISRFSFNSKGGRCETCKGDGQIKIEMHFLPDVHVKCEQCKGKRYNKETLEITYKGK
SIADVLNMTVDQAYEFFIDLPLIKEKLDSLRSIGMGYIKIGQTSNTLSGGEAQRIKLSRELSKRATGKTLYILDEPTTGL
HLADINNLLYVLHTLCDLGNTIIVIEHNLHVIKTAEYIIDMGPNGGDEGGRIIATGTPQEIIENPQSITGQYLKQYLQV
>Mature_958_residues
ANFISIRNAKEHNLRNICIDIPKNKLIVITGVSGSGKSSLAFDTIYAEGQRRYVENLSSYARQFLDSCTKPDVESITGLS
PAIALTQRPLSKNSRSTVSTATEIYDYLRLMYSKIGIPHSPSTGLPITKQSTHQIIDQVLKLPLGTEILILGALIRNKKG
EHQKEILEIKKQNYQYLKINGTIHDINNIPKLDRNKKHNICVIIEKAILSESSLNSIADSITTALKIGNGIIHVEILNLP
ESYNNQKYHQNQILTFSENFSCPETDFNIEEIEPRLFSFNTSYGSCKSCEGTGKTYSIDKNLIITNDNLSILEGAIHPIG
PINLQVLHHKINSNFSYHYANIILSLAKYYNFDITQPWKELNNNIQDIILFGTNGVPIPISYHNEEYKYSQNRQFDGIIN
ILNNKKDIITERIAEQYLSINTCSTCQGFRLRPEALSVKINNKHIGEITKLSVVEAISWCQALLSQLTGQQRDISQKLLD
EIIRRLTFLKNVGLGYLTLSRESGTLSGGEGQRIKLASQIGSGLTGIIYVLDEPSIGLHQKDNALLISTLKKLRDLENTV
IVVEHDEETMENADYIIDMGPGAGQNGGHVIASGTLKDILNNTNSITGQYLSKKKVIPYFKKNKTFDQWIKITGARENNL
RNIDAQIPLNALTCITGVSGSGKSSLINNTLYKYAINKLNNINWIHNKCTSISGLEHIDKILLIDQSPIGRTPLSNPATY
IGLFTYIRSWFAGLPLSKTRGYNISRFSFNSKGGRCETCKGDGQIKIEMHFLPDVHVKCEQCKGKRYNKETLEITYKGKS
IADVLNMTVDQAYEFFIDLPLIKEKLDSLRSIGMGYIKIGQTSNTLSGGEAQRIKLSRELSKRATGKTLYILDEPTTGLH
LADINNLLYVLHTLCDLGNTIIVIEHNLHVIKTAEYIIDMGPNGGDEGGRIIATGTPQEIIENPQSITGQYLKQYLQV

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=961, Percent_Identity=49.531737773153, Blast_Score=935, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 107185; Mature: 107054

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANFISIRNAKEHNLRNICIDIPKNKLIVITGVSGSGKSSLAFDTIYAEGQRRYVENLSS
CCCEEECCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHH
YARQFLDSCTKPDVESITGLSPAIALTQRPLSKNSRSTVSTATEIYDYLRLMYSKIGIPH
HHHHHHHHCCCCCHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
SPSTGLPITKQSTHQIIDQVLKLPLGTEILILGALIRNKKGEHQKEILEIKKQNYQYLKI
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEE
NGTIHDINNIPKLDRNKKHNICVIIEKAILSESSLNSIADSITTALKIGNGIIHVEILNL
CCEEECCCCCCCCCCCCCCCEEEEEEHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEEEEC
PESYNNQKYHQNQILTFSENFSCPETDFNIEEIEPRLFSFNTSYGSCKSCEGTGKTYSID
CCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHCCCEEEEEECCCCCCCCCCCCCCEEEEC
KNLIITNDNLSILEGAIHPIGPINLQVLHHKINSNFSYHYANIILSLAKYYNFDITQPWK
CCEEEECCCHHHHHCCCCCCCCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHCCCCCCCHH
ELNNNIQDIILFGTNGVPIPISYHNEEYKYSQNRQFDGIINILNNKKDIITERIAEQYLS
HHCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHC
INTCSTCQGFRLRPEALSVKINNKHIGEITKLSVVEAISWCQALLSQLTGQQRDISQKLL
CCCCCCCCCCEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DEIIRRLTFLKNVGLGYLTLSRESGTLSGGEGQRIKLASQIGSGLTGIIYVLDEPSIGLH
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEHHHHCCCCEEEEEEEECCCCCCC
QKDNALLISTLKKLRDLENTVIVVEHDEETMENADYIIDMGPGAGQNGGHVIASGTLKDI
CCCCCHHHHHHHHHHCCCCEEEEEECCHHHHCCCCEEEECCCCCCCCCCEEEECCHHHHH
LNNTNSITGQYLSKKKVIPYFKKNKTFDQWIKITGARENNLRNIDAQIPLNALTCITGVS
HCCCCCCCHHHHCCCCCCCHHHCCCCHHHHEEEECCCCCCCCCCCCCCCCHHHHHEECCC
GSGKSSLINNTLYKYAINKLNNINWIHNKCTSISGLEHIDKILLIDQSPIGRTPLSNPAT
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHCEEEEEECCCCCCCCCCCCHH
YIGLFTYIRSWFAGLPLSKTRGYNISRFSFNSKGGRCETCKGDGQIKIEMHFLPDVHVKC
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEECCCCCEEEEEEEECCCCCEEH
EQCKGKRYNKETLEITYKGKSIADVLNMTVDQAYEFFIDLPLIKEKLDSLRSIGMGYIKI
HHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEE
GQTSNTLSGGEAQRIKLSRELSKRATGKTLYILDEPTTGLHLADINNLLYVLHTLCDLGN
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCC
TIIVIEHNLHVIKTAEYIIDMGPNGGDEGGRIIATGTPQEIIENPQSITGQYLKQYLQV
EEEEEECCCEEEEEEEEEEECCCCCCCCCCEEEECCCCHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ANFISIRNAKEHNLRNICIDIPKNKLIVITGVSGSGKSSLAFDTIYAEGQRRYVENLSS
CCEEECCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHH
YARQFLDSCTKPDVESITGLSPAIALTQRPLSKNSRSTVSTATEIYDYLRLMYSKIGIPH
HHHHHHHHCCCCCHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
SPSTGLPITKQSTHQIIDQVLKLPLGTEILILGALIRNKKGEHQKEILEIKKQNYQYLKI
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEE
NGTIHDINNIPKLDRNKKHNICVIIEKAILSESSLNSIADSITTALKIGNGIIHVEILNL
CCEEECCCCCCCCCCCCCCCEEEEEEHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEEEEC
PESYNNQKYHQNQILTFSENFSCPETDFNIEEIEPRLFSFNTSYGSCKSCEGTGKTYSID
CCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHCCCEEEEEECCCCCCCCCCCCCCEEEEC
KNLIITNDNLSILEGAIHPIGPINLQVLHHKINSNFSYHYANIILSLAKYYNFDITQPWK
CCEEEECCCHHHHHCCCCCCCCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHCCCCCCCHH
ELNNNIQDIILFGTNGVPIPISYHNEEYKYSQNRQFDGIINILNNKKDIITERIAEQYLS
HHCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHC
INTCSTCQGFRLRPEALSVKINNKHIGEITKLSVVEAISWCQALLSQLTGQQRDISQKLL
CCCCCCCCCCEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DEIIRRLTFLKNVGLGYLTLSRESGTLSGGEGQRIKLASQIGSGLTGIIYVLDEPSIGLH
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEHHHHCCCCEEEEEEEECCCCCCC
QKDNALLISTLKKLRDLENTVIVVEHDEETMENADYIIDMGPGAGQNGGHVIASGTLKDI
CCCCCHHHHHHHHHHCCCCEEEEEECCHHHHCCCCEEEECCCCCCCCCCEEEECCHHHHH
LNNTNSITGQYLSKKKVIPYFKKNKTFDQWIKITGARENNLRNIDAQIPLNALTCITGVS
HCCCCCCCHHHHCCCCCCCHHHCCCCHHHHEEEECCCCCCCCCCCCCCCCHHHHHEECCC
GSGKSSLINNTLYKYAINKLNNINWIHNKCTSISGLEHIDKILLIDQSPIGRTPLSNPAT
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHCEEEEEECCCCCCCCCCCCHH
YIGLFTYIRSWFAGLPLSKTRGYNISRFSFNSKGGRCETCKGDGQIKIEMHFLPDVHVKC
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEECCCCCEEEEEEEECCCCCEEH
EQCKGKRYNKETLEITYKGKSIADVLNMTVDQAYEFFIDLPLIKEKLDSLRSIGMGYIKI
HHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEE
GQTSNTLSGGEAQRIKLSRELSKRATGKTLYILDEPTTGLHLADINNLLYVLHTLCDLGN
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCC
TIIVIEHNLHVIKTAEYIIDMGPNGGDEGGRIIATGTPQEIIENPQSITGQYLKQYLQV
EEEEEECCCEEEEEEEEEEECCCCCCCCCCEEEECCCCHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]