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The map label for this gene is fabF [H]

Identifier: 58616940

GI number: 58616940

Start: 347382

End: 348653

Strand: Reverse

Name: fabF [H]

Synonym: ERGA_CDS_02130

Alternate gene names: 58616940

Gene position: 348653-347382 (Counterclockwise)

Preceding gene: 58616941

Following gene: 58616939

Centisome position: 23.24

GC content: 35.46

Gene sequence:

>1272_bases
ATGGCAGGAAAAAGGGTCGTTATTACTGGGTTAGGGTTAGTAACTCCACTAGGAAATGATATAAAAACAGTATGGGATCT
TTTATGTAAAGGAACTTCAGGAATAAAGAAAATTAATAGGTTTGATGCGTCTGACCTTGATTGTAAGATCGGTGGTCAAA
TAATAATGAAGTCAGATTCCGAAATACACACATTTGATCCTGCAAACTGGATAGAAGAAAAAGAACTTAAAAAAATGGAC
ATTTTCATTCATTTTGGTATAGCAGCTGCCATTCAAGCAGTTAATGACTCAAACCTGTTAGCTTATAGTAATCTTGATTA
TAATAGAGTAGGAGTAATAGTTGGATCTGGCATAGGTGGATTAGCGTTTATAGAGAAAACATCTATTTGTTTACAGGATC
GTGGACCAAAGAGAATTAGCCCATTTTTTATTCCTGCAAGTTTGATTAATTTATTACCTGGACACATATCTATAAAATAT
GGGTTCGCAGGGGTTAACGATGGAGGAGTAACTGCATGTGCAACAAGTGCACAAACCATAGGTAATGCAGCAAGAATAAT
CAAATCTGGAGAAGCAGATGTTATAATAGCAGGTGGAGCTGAAAGTGCAATATGTCGTATGGGTGTTGCAGGATTTGCTG
CATTAAAGGCTTTATCAACAAAGTTCAATGATACTCCAGAATTAGCATCACGCCCTTGGGATAAACAACGTGACGGTTTT
GTTATGGGAGAAGGTTCAGGAATAATTGTACTTGAAGATTACGAACATGCTAAAAAGCGTAATGCAAAAATATACGCAGA
GTTAATAGGGTATGGTATGACGGCAGATGCATATCATATAACAGCACCTCATCCAGAAGGGAAAGGTGGAAAAAAATCTA
TGGAATTAGCATTAAGTAGTGCTCAATTAAGTCCAGATTCTATAAACTACATAAATGCACATGGTACTTCTACTCCAATT
GGAGACAGTACTGAAATTCACGCAATAAAAGAAGTATTCAAAGATAGTACATATAAGATTCCAATATCTTCAACAAAATC
TTCCATAGGACATTTACTTGGAGCTGCTGGAAGTGTTGAGGCTATATTTTGTATACTTGCTATTAATACAGGAATTGTTC
CACCTACTCTCAATTTATATGATTCATCTGAGGATCCAAAACTAAATCTTGTTCCATTAACTGCACAAGAGCATACAATA
AATTATGCGTTATCCAACTCTTTTGGTTTTGGTGGAACAAATGTATCACTAGTATTTAGTAAGCTATATTAA

Upstream 100 bases:

>100_bases
AATCTCTGATGAAGAAGCACAAGAACTTGAAACTATAGATAAAATAGAGGAGTACATACGTAATAAATTATCAGACAAAA
CTAACTAAGGTTATTTATCT

Downstream 100 bases:

>100_bases
TATCAAAATGTTATAATCTTTGGTATAGCAAATCAGTAGTTCCTAAGTGTTTTTCTACAATGTGTTTATTAATTGTTTGA
TTGTTTTTAATTAATATTTT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MAGKRVVITGLGLVTPLGNDIKTVWDLLCKGTSGIKKINRFDASDLDCKIGGQIIMKSDSEIHTFDPANWIEEKELKKMD
IFIHFGIAAAIQAVNDSNLLAYSNLDYNRVGVIVGSGIGGLAFIEKTSICLQDRGPKRISPFFIPASLINLLPGHISIKY
GFAGVNDGGVTACATSAQTIGNAARIIKSGEADVIIAGGAESAICRMGVAGFAALKALSTKFNDTPELASRPWDKQRDGF
VMGEGSGIIVLEDYEHAKKRNAKIYAELIGYGMTADAYHITAPHPEGKGGKKSMELALSSAQLSPDSINYINAHGTSTPI
GDSTEIHAIKEVFKDSTYKIPISSTKSSIGHLLGAAGSVEAIFCILAINTGIVPPTLNLYDSSEDPKLNLVPLTAQEHTI
NYALSNSFGFGGTNVSLVFSKLY

Sequences:

>Translated_423_residues
MAGKRVVITGLGLVTPLGNDIKTVWDLLCKGTSGIKKINRFDASDLDCKIGGQIIMKSDSEIHTFDPANWIEEKELKKMD
IFIHFGIAAAIQAVNDSNLLAYSNLDYNRVGVIVGSGIGGLAFIEKTSICLQDRGPKRISPFFIPASLINLLPGHISIKY
GFAGVNDGGVTACATSAQTIGNAARIIKSGEADVIIAGGAESAICRMGVAGFAALKALSTKFNDTPELASRPWDKQRDGF
VMGEGSGIIVLEDYEHAKKRNAKIYAELIGYGMTADAYHITAPHPEGKGGKKSMELALSSAQLSPDSINYINAHGTSTPI
GDSTEIHAIKEVFKDSTYKIPISSTKSSIGHLLGAAGSVEAIFCILAINTGIVPPTLNLYDSSEDPKLNLVPLTAQEHTI
NYALSNSFGFGGTNVSLVFSKLY
>Mature_422_residues
AGKRVVITGLGLVTPLGNDIKTVWDLLCKGTSGIKKINRFDASDLDCKIGGQIIMKSDSEIHTFDPANWIEEKELKKMDI
FIHFGIAAAIQAVNDSNLLAYSNLDYNRVGVIVGSGIGGLAFIEKTSICLQDRGPKRISPFFIPASLINLLPGHISIKYG
FAGVNDGGVTACATSAQTIGNAARIIKSGEADVIIAGGAESAICRMGVAGFAALKALSTKFNDTPELASRPWDKQRDGFV
MGEGSGIIVLEDYEHAKKRNAKIYAELIGYGMTADAYHITAPHPEGKGGKKSMELALSSAQLSPDSINYINAHGTSTPIG
DSTEIHAIKEVFKDSTYKIPISSTKSSIGHLLGAAGSVEAIFCILAINTGIVPPTLNLYDSSEDPKLNLVPLTAQEHTIN
YALSNSFGFGGTNVSLVFSKLY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=45.7345971563981, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI223972627, Length=150, Percent_Identity=54, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI41872631, Length=430, Percent_Identity=25.1162790697674, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1787337, Length=423, Percent_Identity=48.936170212766, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1788663, Length=422, Percent_Identity=38.8625592417062, Blast_Score=262, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71983541, Length=425, Percent_Identity=36.7058823529412, Blast_Score=264, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=257, Percent_Identity=43.9688715953307, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI212642053, Length=434, Percent_Identity=25.3456221198157, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=254, Percent_Identity=29.5275590551181, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=37.5, Blast_Score=284, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=41.4691943127962, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI19920632, Length=371, Percent_Identity=24.5283018867925, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI221330659, Length=371, Percent_Identity=24.5283018867925, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24581345, Length=373, Percent_Identity=23.3243967828418, Blast_Score=95, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44928; Mature: 44797

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGKRVVITGLGLVTPLGNDIKTVWDLLCKGTSGIKKINRFDASDLDCKIGGQIIMKSDS
CCCCEEEEEECEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEECCEEEEECCC
EIHTFDPANWIEEKELKKMDIFIHFGIAAAIQAVNDSNLLAYSNLDYNRVGVIVGSGIGG
CEEECCCHHHHCHHHHCEEEEEEEECHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCC
LAFIEKTSICLQDRGPKRISPFFIPASLINLLPGHISIKYGFAGVNDGGVTACATSAQTI
EEEEECCEEEEECCCCCCCCCEEEHHHHHHHCCCEEEEEEEEEECCCCCCEEEECCHHHH
GNAARIIKSGEADVIIAGGAESAICRMGVAGFAALKALSTKFNDTPELASRPWDKQRDGF
HHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCE
VMGEGSGIIVLEDYEHAKKRNAKIYAELIGYGMTADAYHITAPHPEGKGGKKSMELALSS
EEECCCCEEEECCCHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCCCCHHHHEEEEC
AQLSPDSINYINAHGTSTPIGDSTEIHAIKEVFKDSTYKIPISSTKSSIGHLLGAAGSVE
CCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCHH
AIFCILAINTGIVPPTLNLYDSSEDPKLNLVPLTAQEHTINYALSNSFGFGGTNVSLVFS
HEEEEEEECCCCCCCCCEECCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCEEEEE
KLY
ECC
>Mature Secondary Structure 
AGKRVVITGLGLVTPLGNDIKTVWDLLCKGTSGIKKINRFDASDLDCKIGGQIIMKSDS
CCCEEEEEECEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEECCEEEEECCC
EIHTFDPANWIEEKELKKMDIFIHFGIAAAIQAVNDSNLLAYSNLDYNRVGVIVGSGIGG
CEEECCCHHHHCHHHHCEEEEEEEECHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCC
LAFIEKTSICLQDRGPKRISPFFIPASLINLLPGHISIKYGFAGVNDGGVTACATSAQTI
EEEEECCEEEEECCCCCCCCCEEEHHHHHHHCCCEEEEEEEEEECCCCCCEEEECCHHHH
GNAARIIKSGEADVIIAGGAESAICRMGVAGFAALKALSTKFNDTPELASRPWDKQRDGF
HHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCE
VMGEGSGIIVLEDYEHAKKRNAKIYAELIGYGMTADAYHITAPHPEGKGGKKSMELALSS
EEECCCCEEEECCCHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCCCCHHHHEEEEC
AQLSPDSINYINAHGTSTPIGDSTEIHAIKEVFKDSTYKIPISSTKSSIGHLLGAAGSVE
CCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCHH
AIFCILAINTGIVPPTLNLYDSSEDPKLNLVPLTAQEHTINYALSNSFGFGGTNVSLVFS
HEEEEEEECCCCCCCCCEECCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCEEEEE
KLY
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]