Click here to switch to the map view.

The map label for this gene is ribA [H]

Identifier: 58616745

GI number: 58616745

Start: 18637

End: 19752

Strand: Reverse

Name: ribA [H]

Synonym: ERGA_CDS_00180

Alternate gene names: 58616745

Gene position: 19752-18637 (Counterclockwise)

Preceding gene: 58616746

Following gene: 58616744

Centisome position: 1.32

GC content: 28.32

Gene sequence:

>1116_bases
ATGGAAAATTTACTTAATAGCTTTAATTCCAATAAACATATTATAAAAAAATCCATAGCAGAATTAAGGACTGGCATACC
AGTACTATTATACAATCACAAAAGTAACCTGCTTGTCTTTCCAAGTGAAATGATAGATAATCAAATATTACATAAAATCC
AAAAATACTCGGATAATGCTTACATATTGATCACAGGAAATAGATTGAATTTTATACTTCAATCTCCAGGAAATCAGCTT
TCTAGAATTACTTTAAAAGAATCTTACAGTATAGACTATATCTCATATCTACTAACAGGTAAGAAACCACACAGTTCATT
TGATCATATTGATACAAATCATATAACTACAAGTACAAATCCTTTAGATATAACATCTATTTCTTTAATCAAGTTAACAA
AATTATTACCATCAGCAATTGTTACTGAAATAAAACATCCCGATATATTACAGTGGTGTAATAAGTATAATATTACTCCT
ATAAAACAAGAAATTATCGATAATCACAATCAAGAATATGAATTACATGAAGTATGTAGCTCTCCTTTATTTTTAAAAAA
TTGCTGTAATGCCAATGTAAACTCAAGCATAAATATTTACCGATCAGATATAGGAGAACCTGAACATTATGCACTTATTA
TAGGAGAACCAGATTATAGTAACCCACTTGTTAGAATTCATTCTTCATGCTACACAGGAGATCTATTAGATAGTCTATCC
TGTGATTGCCGTTCCCAATTACATCTTTCTATAAAACTAATGGTAGAAAATAAGGGTGGAATAATTTTATACCTAGCACA
AGATGGCCGTGGTATTGGACTAACAAATAAAATAAGAACTTACCAATTACAAATAAAGTACAACTTTGATACTGTAGATG
CTAATAGATTTTTTGGGTTTGAAGACGATGAAAGAGCATTTATTGCAGCCATAAAAATATTAGAAAAACTAGGAATCTCA
AAATTACAGTTACTAACTAACAATCCCAATAAAGCTGAAGAAATTAAAAAATATGGAATAAATATTACAAAAATATTACC
TATTTTTGTTGACATAAACCAACATAATATTAATTATATCAATACCAAAGCTAAAAGACTGGGTCACGTAAGTTAG

Upstream 100 bases:

>100_bases
GTGGAATTGGTAGACACGCAGCGTTGAGGTCGCTGTGGTTTAAAAAAGACCTTGGAAGTTCGAGTCTTCTCAACCGCACC
ATGTAATATTTGAGCACAAT

Downstream 100 bases:

>100_bases
GAAAATGCTTTTTTATGCTATTTTTACATATCAATGTTAATCTGATGTAAATAAATAGGGTATATATACGCTTTAGTGAC
CTACCATGATAGAGTAGTAA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MENLLNSFNSNKHIIKKSIAELRTGIPVLLYNHKSNLLVFPSEMIDNQILHKIQKYSDNAYILITGNRLNFILQSPGNQL
SRITLKESYSIDYISYLLTGKKPHSSFDHIDTNHITTSTNPLDITSISLIKLTKLLPSAIVTEIKHPDILQWCNKYNITP
IKQEIIDNHNQEYELHEVCSSPLFLKNCCNANVNSSINIYRSDIGEPEHYALIIGEPDYSNPLVRIHSSCYTGDLLDSLS
CDCRSQLHLSIKLMVENKGGIILYLAQDGRGIGLTNKIRTYQLQIKYNFDTVDANRFFGFEDDERAFIAAIKILEKLGIS
KLQLLTNNPNKAEEIKKYGINITKILPIFVDINQHNINYINTKAKRLGHVS

Sequences:

>Translated_371_residues
MENLLNSFNSNKHIIKKSIAELRTGIPVLLYNHKSNLLVFPSEMIDNQILHKIQKYSDNAYILITGNRLNFILQSPGNQL
SRITLKESYSIDYISYLLTGKKPHSSFDHIDTNHITTSTNPLDITSISLIKLTKLLPSAIVTEIKHPDILQWCNKYNITP
IKQEIIDNHNQEYELHEVCSSPLFLKNCCNANVNSSINIYRSDIGEPEHYALIIGEPDYSNPLVRIHSSCYTGDLLDSLS
CDCRSQLHLSIKLMVENKGGIILYLAQDGRGIGLTNKIRTYQLQIKYNFDTVDANRFFGFEDDERAFIAAIKILEKLGIS
KLQLLTNNPNKAEEIKKYGINITKILPIFVDINQHNINYINTKAKRLGHVS
>Mature_371_residues
MENLLNSFNSNKHIIKKSIAELRTGIPVLLYNHKSNLLVFPSEMIDNQILHKIQKYSDNAYILITGNRLNFILQSPGNQL
SRITLKESYSIDYISYLLTGKKPHSSFDHIDTNHITTSTNPLDITSISLIKLTKLLPSAIVTEIKHPDILQWCNKYNITP
IKQEIIDNHNQEYELHEVCSSPLFLKNCCNANVNSSINIYRSDIGEPEHYALIIGEPDYSNPLVRIHSSCYTGDLLDSLS
CDCRSQLHLSIKLMVENKGGIILYLAQDGRGIGLTNKIRTYQLQIKYNFDTVDANRFFGFEDDERAFIAAIKILEKLGIS
KLQLLTNNPNKAEEIKKYGINITKILPIFVDINQHNINYINTKAKRLGHVS

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=164, Percent_Identity=45.1219512195122, Blast_Score=144, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6319438, Length=173, Percent_Identity=35.2601156069364, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 42258; Mature: 42258

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENLLNSFNSNKHIIKKSIAELRTGIPVLLYNHKSNLLVFPSEMIDNQILHKIQKYSDNA
CCHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEECHHHHHHHHHHHHHHCCCCE
YILITGNRLNFILQSPGNQLSRITLKESYSIDYISYLLTGKKPHSSFDHIDTNHITTSTN
EEEEECCCEEEEEECCCCCEEEEEEECCCCHHEEEHEEECCCCCCCCCCCCCCCEECCCC
PLDITSISLIKLTKLLPSAIVTEIKHPDILQWCNKYNITPIKQEIIDNHNQEYELHEVCS
CCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHC
SPLFLKNCCNANVNSSINIYRSDIGEPEHYALIIGEPDYSNPLVRIHSSCYTGDLLDSLS
CCHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCCHHHHHCC
CDCRSQLHLSIKLMVENKGGIILYLAQDGRGIGLTNKIRTYQLQIKYNFDTVDANRFFGF
CCCCCEEEEEEEEEEECCCCEEEEEECCCCCCCCCCCEEEEEEEEEEECEEECCCCCCCC
EDDERAFIAAIKILEKLGISKLQLLTNNPNKAEEIKKYGINITKILPIFVDINQHNINYI
CCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCEEEEEEEEEEECCCCCEEE
NTKAKRLGHVS
EHHHHHCCCCC
>Mature Secondary Structure
MENLLNSFNSNKHIIKKSIAELRTGIPVLLYNHKSNLLVFPSEMIDNQILHKIQKYSDNA
CCHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEECHHHHHHHHHHHHHHCCCCE
YILITGNRLNFILQSPGNQLSRITLKESYSIDYISYLLTGKKPHSSFDHIDTNHITTSTN
EEEEECCCEEEEEECCCCCEEEEEEECCCCHHEEEHEEECCCCCCCCCCCCCCCEECCCC
PLDITSISLIKLTKLLPSAIVTEIKHPDILQWCNKYNITPIKQEIIDNHNQEYELHEVCS
CCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHC
SPLFLKNCCNANVNSSINIYRSDIGEPEHYALIIGEPDYSNPLVRIHSSCYTGDLLDSLS
CCHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCCHHHHHCC
CDCRSQLHLSIKLMVENKGGIILYLAQDGRGIGLTNKIRTYQLQIKYNFDTVDANRFFGF
CCCCCEEEEEEEEEEECCCCEEEEEECCCCCCCCCCCEEEEEEEEEEECEEECCCCCCCC
EDDERAFIAAIKILEKLGISKLQLLTNNPNKAEEIKKYGINITKILPIFVDINQHNINYI
CCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCEEEEEEEEEEECCCCCEEE
NTKAKRLGHVS
EHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7883178 [H]