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The map label for this gene is nadC [H]

Identifier: 58616728

GI number: 58616728

Start: 16

End: 849

Strand: Reverse

Name: nadC [H]

Synonym: ERGA_CDS_00010

Alternate gene names: 58616728

Gene position: 849-16 (Counterclockwise)

Preceding gene: 58616730

Following gene: NA

Centisome position: 0.06

GC content: 32.13

Gene sequence:

>834_bases
ATGAATGGTTTATTCTCAGAAATTATACACAATGCTTTAAAAGAAGATCTAGGTAAAATTGGTGATATAACAACCAATAA
TACACTAACTAATGAACAAGTTGATTTCACTATTAGTGCAAGAGAAGATCTAGTGGTGTGTGGAATGCCAATATTGGAAG
AGATATTTGGTATGAATAAAGGTTCTATTTGTTATAAAATACACAGAAGTGATGGGGAATTTATAGGAGAAAATAGTATA
TTAGTTAGTGGTAAAGGACTAGCAAAGTGCTTATTGCCAATTGAAAGAGTAATGCTGAATCTCATTCAGCATGCTTCTGG
TATAGCATCTATTACTAAGCAATTTGTCGATGAGATAACTGGAACAAAAGCAAAAATTCGTAGTACCAGAAAGACTACTC
CTGGATTGAGAATACTAGACAAATACTCAGTACACATAGGGGGTGGAGAAAATTATAGAAATAGTCTATATGATGGTATC
CTTATAAAGGATAATCATATAGCTAGTTGTGGTAGCATAACTTTAGCTATACAACGGATTAAGGAAAATTTAAAAGATGA
GTACATTGCTGTTGAATGTGATAATATTTCTCAAGTTGAGGAGTCGTTACTTAATAATGTAAACATGATTCTACTAGATA
ATATGAGTATAGCAGAAATAGAACAAGCAGTATCTATAGTGAATGGAAAATCAATCTTAGAAGCTTCTGGTTGTATAGAT
ATAAGAAATGTGAGGAGTATCGCAATGACAGGTGTGGACTACATTTCTATTGGATGCATAACCCATTCATTTAAAAACAA
AGACATAGGCCTAGATATTGTGCATAATGTTTAA

Upstream 100 bases:

>100_bases
CATCTAAATAAATTTACACTTAAATGATAAATGATATAAGATTTTTATATTACTTCAACATCCGTTATAATATTTTACAA
TATGTAAAAAAGTATCAAAT

Downstream 100 bases:

>100_bases
TACACTTAGCTTTCATTATTATAAAAACTTCTAACTTGATCTAATATCATTCCAGAAACTCTTTACTTTTTGAAAAAACC
CTGTAGATTGCGGGTTACAT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNGLFSEIIHNALKEDLGKIGDITTNNTLTNEQVDFTISAREDLVVCGMPILEEIFGMNKGSICYKIHRSDGEFIGENSI
LVSGKGLAKCLLPIERVMLNLIQHASGIASITKQFVDEITGTKAKIRSTRKTTPGLRILDKYSVHIGGGENYRNSLYDGI
LIKDNHIASCGSITLAIQRIKENLKDEYIAVECDNISQVEESLLNNVNMILLDNMSIAEIEQAVSIVNGKSILEASGCID
IRNVRSIAMTGVDYISIGCITHSFKNKDIGLDIVHNV

Sequences:

>Translated_277_residues
MNGLFSEIIHNALKEDLGKIGDITTNNTLTNEQVDFTISAREDLVVCGMPILEEIFGMNKGSICYKIHRSDGEFIGENSI
LVSGKGLAKCLLPIERVMLNLIQHASGIASITKQFVDEITGTKAKIRSTRKTTPGLRILDKYSVHIGGGENYRNSLYDGI
LIKDNHIASCGSITLAIQRIKENLKDEYIAVECDNISQVEESLLNNVNMILLDNMSIAEIEQAVSIVNGKSILEASGCID
IRNVRSIAMTGVDYISIGCITHSFKNKDIGLDIVHNV
>Mature_277_residues
MNGLFSEIIHNALKEDLGKIGDITTNNTLTNEQVDFTISAREDLVVCGMPILEEIFGMNKGSICYKIHRSDGEFIGENSI
LVSGKGLAKCLLPIERVMLNLIQHASGIASITKQFVDEITGTKAKIRSTRKTTPGLRILDKYSVHIGGGENYRNSLYDGI
LIKDNHIASCGSITLAIQRIKENLKDEYIAVECDNISQVEESLLNNVNMILLDNMSIAEIEQAVSIVNGKSILEASGCID
IRNVRSIAMTGVDYISIGCITHSFKNKDIGLDIVHNV

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=252, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=36.6666666666667, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321162, Length=293, Percent_Identity=30.0341296928328, Blast_Score=109, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30368; Mature: 30368

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLFSEIIHNALKEDLGKIGDITTNNTLTNEQVDFTISAREDLVVCGMPILEEIFGMNK
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEECHHHHHHHHCCCC
GSICYKIHRSDGEFIGENSILVSGKGLAKCLLPIERVMLNLIQHASGIASITKQFVDEIT
CCEEEEEECCCCCEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GTKAKIRSTRKTTPGLRILDKYSVHIGGGENYRNSLYDGILIKDNHIASCGSITLAIQRI
CCHHHHHHCCCCCCCCEEEEEEEEEECCCCHHHHHHHCCEEEECCCCCCCHHHHHHHHHH
KENLKDEYIAVECDNISQVEESLLNNVNMILLDNMSIAEIEQAVSIVNGKSILEASGCID
HHHHCCCEEEEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCHHHHCCCCEE
IRNVRSIAMTGVDYISIGCITHSFKNKDIGLDIVHNV
HHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEEECCC
>Mature Secondary Structure
MNGLFSEIIHNALKEDLGKIGDITTNNTLTNEQVDFTISAREDLVVCGMPILEEIFGMNK
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEECHHHHHHHHCCCC
GSICYKIHRSDGEFIGENSILVSGKGLAKCLLPIERVMLNLIQHASGIASITKQFVDEIT
CCEEEEEECCCCCEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GTKAKIRSTRKTTPGLRILDKYSVHIGGGENYRNSLYDGILIKDNHIASCGSITLAIQRI
CCHHHHHHCCCCCCCCEEEEEEEEEECCCCHHHHHHHCCEEEECCCCCCCHHHHHHHHHH
KENLKDEYIAVECDNISQVEESLLNNVNMILLDNMSIAEIEQAVSIVNGKSILEASGCID
HHHHCCCEEEEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCHHHHCCCCEE
IRNVRSIAMTGVDYISIGCITHSFKNKDIGLDIVHNV
HHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]