Click here to switch to the map view.

The map label for this gene is crtM

Identifier: 57652299

GI number: 57652299

Start: 2640354

End: 2641217

Strand: Reverse

Name: crtM

Synonym: SACOL2577

Alternate gene names: 57652299

Gene position: 2641217-2640354 (Counterclockwise)

Preceding gene: 57652300

Following gene: 57652298

Centisome position: 94.01

GC content: 31.37

Gene sequence:

>864_bases
ATGACAATGATGGATATGAATTTTAAATATTGTCATAAAATCATGAAGAAACATTCAAAAAGCTTTTCTTACGCTTTTGA
CTTGTTACCAGAAGATCAAAGAAAAGCGGTTTGGGCAATTTATGCTGTGTGTCGTAAAATTGATGACAGTATAGATGTTT
ATGGCGATATTCAATTTTTAAATCAAATAAAAGAAGATATACAATCTATTGAAAAATACCCATATGAACATCATCACTTT
CAAAGTGATCGTAGAATCATGATGGCGCTTCAGCATGTTGCACAACATAAAAATATCGCCTTTCAATCTTTTTATAATCT
CATTGATACTGTATATAAAGATCAACATTTTACAATGTTTGAAACGGACGCTGAATTATTCGGATATTGTTATGGTGTTG
CTGGTACAGTAGGTGAAGTATTGACGCCGATTTTAAGTGATCATGAAACACATCAGACATACGATGTCGCAAGAAGACTT
GGTGAATCGTTGCAATTGATTAATATATTAAGAGATGTCGGTGAAGATTTTGACAATGAACGGATATATTTTAGTAAGCA
ACGATTAAAGCAATATGAAGTTGATATTGCTGAAGTGTACCAAAATGGTGTTAATAATCATTATATTGACTTATGGGAAT
ATTATGCAGCTATCGCAGAAAAAGATTTTCAAGATGTTATGGATCAAATCAAAGTATTTAGTATTGAAGCACAACCAATC
ATAGAATTAGCAGCACGTATATATATTGAAATACTGGACGAAGTGAGACAGGCTAACTATACATTACATGAACGTGTTTT
TGTGGATAAGAGGAAAAAGGCAAAGTTGTTTCATGAAATAAATAGTAAATATCATAGAATATAG

Upstream 100 bases:

>100_bases
AACGCATCGTTATGGTGTAGTTGAATGGAAAGGTCGTCAATATTCTATATCTAAAGAACAATAAATCAAGGTAATGGCAT
TTCAATATAGGAGGACTAGT

Downstream 100 bases:

>100_bases
GTGGTTGAATAATGAAGATTGCAGTAATTGGTGCAGGTGTCACAGGATTAGCAGCGGCAGCCCGTATTGCTTCTCAAGGT
CATGAAGTGACGATATTTGA

Product: dehydrosqualene synthase

Products: NA

Alternate protein names: 4,4'-diapophytoene synthase; DAP synthase; Diapophytoene synthase

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MTMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDSIDVYGDIQFLNQIKEDIQSIEKYPYEHHHF
QSDRRIMMALQHVAQHKNIAFQSFYNLIDTVYKDQHFTMFETDAELFGYCYGVAGTVGEVLTPILSDHETHQTYDVARRL
GESLQLINILRDVGEDFDNERIYFSKQRLKQYEVDIAEVYQNGVNNHYIDLWEYYAAIAEKDFQDVMDQIKVFSIEAQPI
IELAARIYIEILDEVRQANYTLHERVFVDKRKKAKLFHEINSKYHRI

Sequences:

>Translated_287_residues
MTMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDSIDVYGDIQFLNQIKEDIQSIEKYPYEHHHF
QSDRRIMMALQHVAQHKNIAFQSFYNLIDTVYKDQHFTMFETDAELFGYCYGVAGTVGEVLTPILSDHETHQTYDVARRL
GESLQLINILRDVGEDFDNERIYFSKQRLKQYEVDIAEVYQNGVNNHYIDLWEYYAAIAEKDFQDVMDQIKVFSIEAQPI
IELAARIYIEILDEVRQANYTLHERVFVDKRKKAKLFHEINSKYHRI
>Mature_286_residues
TMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDSIDVYGDIQFLNQIKEDIQSIEKYPYEHHHFQ
SDRRIMMALQHVAQHKNIAFQSFYNLIDTVYKDQHFTMFETDAELFGYCYGVAGTVGEVLTPILSDHETHQTYDVARRLG
ESLQLINILRDVGEDFDNERIYFSKQRLKQYEVDIAEVYQNGVNNHYIDLWEYYAAIAEKDFQDVMDQIKVFSIEAQPII
ELAARIYIEILDEVRQANYTLHERVFVDKRKKAKLFHEINSKYHRI

Specific function: Catalyzes the head-to-head condensation of two molecules of farnesyl diphosphate (FPP) into the colorless C(30) carotenoid dehydrosqualene (4,4'-diapophytoene). This is the initial step in the biosynthesis of staphyloxanthin, an orange carotenoid present

COG id: COG1562

COG function: function code I; Phytoene/squalene synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phytoene/squalene synthase family. CrtM subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CRTM_STAA3 (Q2FDU5)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_495133.1
- ProteinModelPortal:   Q2FDU5
- SMR:   Q2FDU5
- STRING:   Q2FDU5
- EnsemblBacteria:   EBSTAT00000037196
- GeneID:   3914346
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_2499
- eggNOG:   COG1562
- GeneTree:   EBGT00050000025455
- HOGENOM:   HBG693191
- OMA:   RFGYSEA
- ProtClustDB:   CLSK886072
- InterPro:   IPR002060
- InterPro:   IPR019845
- InterPro:   IPR008949
- Gene3D:   G3DSA:1.10.600.10

Pfam domain/function: PF00494 SQS_PSY; SSF48576 Terpenoid_synth

EC number: NA

Molecular weight: Translated: 34231; Mature: 34100

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS01044 SQUALEN_PHYTOEN_SYN_1; PS01045 SQUALEN_PHYTOEN_SYN_2

Important sites: BINDING 41-41 BINDING 168-168 BINDING 171-171 BINDING 172-172 BINDING 248-248

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDSIDVYGDIQFL
CCEECCCHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
NQIKEDIQSIEKYPYEHHHFQSDRRIMMALQHVAQHKNIAFQSFYNLIDTVYKDQHFTMF
HHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEE
ETDAELFGYCYGVAGTVGEVLTPILSDHETHQTYDVARRLGESLQLINILRDVGEDFDNE
ECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RIYFSKQRLKQYEVDIAEVYQNGVNNHYIDLWEYYAAIAEKDFQDVMDQIKVFSIEAQPI
CEEEEHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IELAARIYIEILDEVRQANYTLHERVFVDKRKKAKLFHEINSKYHRI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDSIDVYGDIQFL
CEECCCHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
NQIKEDIQSIEKYPYEHHHFQSDRRIMMALQHVAQHKNIAFQSFYNLIDTVYKDQHFTMF
HHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEE
ETDAELFGYCYGVAGTVGEVLTPILSDHETHQTYDVARRLGESLQLINILRDVGEDFDNE
ECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RIYFSKQRLKQYEVDIAEVYQNGVNNHYIDLWEYYAAIAEKDFQDVMDQIKVFSIEAQPI
CEEEEHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IELAARIYIEILDEVRQANYTLHERVFVDKRKKAKLFHEINSKYHRI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA