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The map label for this gene is appC [H]

Identifier: 57650188

GI number: 57650188

Start: 1008235

End: 1009116

Strand: Direct

Name: appC [H]

Synonym: SACOL1000

Alternate gene names: 57650188

Gene position: 1008235-1009116 (Clockwise)

Preceding gene: 57650187

Following gene: 57650190

Centisome position: 35.89

GC content: 31.29

Gene sequence:

>882_bases
ATGCAAAATAAGTCAAAATCGCCTTTTAAAATTGCATTTTCTAAATTTATTCATAATAAAATTGCAATGTTATCGGTTAT
TTTTTTATTAATCATAACTATTGTATCAATTATAGCGCCATTAATAGCTCCTTTTCCAGTGAACCAACAAGATTTATTAA
ATATAAAAGGTGAAATGACAGCACAAAACATTCTTGGTACAGACTCTGGTGGTAGGGATAACTTTAGTCGTTTGTTATAT
GCAGGTCGTATTTCATTATCCATTGGAATTACATCTACAATAGGAATGCTTTTGATTGGAATTACAGTTGGAGTGATTTC
TGGTTATTTTGGAGGTATTGTTGATACATTATTAATGAGAATAACCGAATTTGTTATGTTATTTCCATTTTTAATATTTG
CAATTGTATTAAATGCTGCACTTGGAGATAAAATTAAAAATCCTTATGGATCTGCCATAATTCTTGTTCTAGTTATTATC
GTATTAAGTTGGGGAGGTATTGCAAGACTTGTTCGTGGTAAAGTACTTCAAGAAAAAGAAAATGAATACTTTTTGGCAGC
AAAATCAATTGGTACACCCACATATAAAATTATTTTGAAACATCTTTTGCCGAATATATTAAGTGTAGTTATCGTACAAG
CAACATTGTTATTTGCCGGTATGATTGTAGTGGAATCAGGATTGAGCTTTTTAGGATTCGGAATTAGTAAAGCAATACCA
TCTTGGGGTAATATGTTGAGTGATGCTCAAGAAGGGGATGTTATAAGTGGTAAACCGTGGATATGGATGCCACCTGCTAT
AATGATTACATTAACTATATTAAGTATAAACTTTGTAGGGGAAGGGATTAAAGATGCTTTTAATCCTAGAGGTAGACGTT
AA

Upstream 100 bases:

>100_bases
CGTTATTTTTCTCATTTTTAGGTTTACTGGGTAATTTGATTTCTGATATTACTTATGGATTTATAGATCCAAGAATTAGA
AGTAACTAGGGGGGATTAGA

Downstream 100 bases:

>100_bases
ATAATAAAAGAGGCACTAGTTAATTCTAGTACCTCTTTATTTTATCTCTTACGTCCTAAACCCATCGCTTTTTCCATTTT
TTTGACAGTTTTAAATGAAA

Product: oligopeptide ABC transporter permease

Products: ADP; phosphate; oligopeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MQNKSKSPFKIAFSKFIHNKIAMLSVIFLLIITIVSIIAPLIAPFPVNQQDLLNIKGEMTAQNILGTDSGGRDNFSRLLY
AGRISLSIGITSTIGMLLIGITVGVISGYFGGIVDTLLMRITEFVMLFPFLIFAIVLNAALGDKIKNPYGSAIILVLVII
VLSWGGIARLVRGKVLQEKENEYFLAAKSIGTPTYKIILKHLLPNILSVVIVQATLLFAGMIVVESGLSFLGFGISKAIP
SWGNMLSDAQEGDVISGKPWIWMPPAIMITLTILSINFVGEGIKDAFNPRGRR

Sequences:

>Translated_293_residues
MQNKSKSPFKIAFSKFIHNKIAMLSVIFLLIITIVSIIAPLIAPFPVNQQDLLNIKGEMTAQNILGTDSGGRDNFSRLLY
AGRISLSIGITSTIGMLLIGITVGVISGYFGGIVDTLLMRITEFVMLFPFLIFAIVLNAALGDKIKNPYGSAIILVLVII
VLSWGGIARLVRGKVLQEKENEYFLAAKSIGTPTYKIILKHLLPNILSVVIVQATLLFAGMIVVESGLSFLGFGISKAIP
SWGNMLSDAQEGDVISGKPWIWMPPAIMITLTILSINFVGEGIKDAFNPRGRR
>Mature_293_residues
MQNKSKSPFKIAFSKFIHNKIAMLSVIFLLIITIVSIIAPLIAPFPVNQQDLLNIKGEMTAQNILGTDSGGRDNFSRLLY
AGRISLSIGITSTIGMLLIGITVGVISGYFGGIVDTLLMRITEFVMLFPFLIFAIVLNAALGDKIKNPYGSAIILVLVII
VLSWGGIARLVRGKVLQEKENEYFLAAKSIGTPTYKIILKHLLPNILSVVIVQATLLFAGMIVVESGLSFLGFGISKAIP
SWGNMLSDAQEGDVISGKPWIWMPPAIMITLTILSINFVGEGIKDAFNPRGRR

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787498, Length=294, Percent_Identity=36.0544217687075, Blast_Score=174, Evalue=5e-45,
Organism=Escherichia coli, GI1787054, Length=289, Percent_Identity=33.5640138408304, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1789964, Length=292, Percent_Identity=34.2465753424658, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787760, Length=267, Percent_Identity=29.9625468164794, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789889, Length=231, Percent_Identity=32.034632034632, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788505, Length=234, Percent_Identity=30.3418803418803, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787549, Length=293, Percent_Identity=26.6211604095563, Blast_Score=101, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 31821; Mature: 31821

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKSKSPFKIAFSKFIHNKIAMLSVIFLLIITIVSIIAPLIAPFPVNQQDLLNIKGEMT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHH
AQNILGTDSGGRDNFSRLLYAGRISLSIGITSTIGMLLIGITVGVISGYFGGIVDTLLMR
HHHHCCCCCCCCHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITEFVMLFPFLIFAIVLNAALGDKIKNPYGSAIILVLVIIVLSWGGIARLVRGKVLQEKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
NEYFLAAKSIGTPTYKIILKHLLPNILSVVIVQATLLFAGMIVVESGLSFLGFGISKAIP
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCC
SWGNMLSDAQEGDVISGKPWIWMPPAIMITLTILSINFVGEGIKDAFNPRGRR
HHHHHHCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
>Mature Secondary Structure
MQNKSKSPFKIAFSKFIHNKIAMLSVIFLLIITIVSIIAPLIAPFPVNQQDLLNIKGEMT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHH
AQNILGTDSGGRDNFSRLLYAGRISLSIGITSTIGMLLIGITVGVISGYFGGIVDTLLMR
HHHHCCCCCCCCHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITEFVMLFPFLIFAIVLNAALGDKIKNPYGSAIILVLVIIVLSWGGIARLVRGKVLQEKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
NEYFLAAKSIGTPTYKIILKHLLPNILSVVIVQATLLFAGMIVVESGLSFLGFGISKAIP
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCC
SWGNMLSDAQEGDVISGKPWIWMPPAIMITLTILSINFVGEGIKDAFNPRGRR
HHHHHHCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; oligopeptides [Periplasm]; H2O [C]

Specific reaction: ATP + oligopeptides [Periplasm] + H2O = ADP + phosphate + oligopeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]