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The map label for this gene is hisD [H]

Identifier: 57238611

GI number: 57238611

Start: 1667513

End: 1668799

Strand: Direct

Name: hisD [H]

Synonym: CJE1770

Alternate gene names: 57238611

Gene position: 1667513-1668799 (Clockwise)

Preceding gene: 57238610

Following gene: 57238612

Centisome position: 93.79

GC content: 35.35

Gene sequence:

>1287_bases
ATGCAAATTTTAGTATATGATAATTTGGATGAAAAACAAAAAGAAGAAGCGTTAAAACGCCCTGCTATAAGTGCGAAAGA
TGAAATTTCAAAAATAGTAAGTTCTATCATTAAAGAAGTGCAAGAAAAAGGCGATGAAGCTTTGATAGAACAAGCTTTGA
AATTTGATAAGGCTGAAATTTCAAAGATTAAAATCACTCAAGAAGAAATCACTCAAGCAAGCAAGCGTTTAGATAAAGAT
TTACAAGAAGCTATTTTAGTGGCTTATGAAAATATCAAAAAATTTCACGAAGCCCAAATCCCACATGAAATCGCTCTTGA
AACTACAAAAGGCGTTAAATGTGAAGTTTTAACACGCCCTATAGAAAAAGTAGGACTTTACATACCAGGGGGTTTGGCAC
CTTTGTTTTCAACGGTTTTAATGCTAGCTATTCCTGCAAAAATTGCAGGTTGTGAAAAAATCGTTTTAGCAAGTCCTGCA
AAAATCAATGATGCTGTGCTTTTTTGTGCTAAGCTTTGTGGCGTGGATGAAATTTATCAAATGGGCGGTGCAGGAGCTAT
AGCAGCTTTGGCTTACGGTACCCAGAGTGTTTTAAAGGTGGATAAAATTTTTGGCCCAGGAAATGCCTTTGTAACCGAAG
CAAAACGCCAAGTAAGTAGTGATATAAACGGAGCAGCTATTGATATGCAAGCAGGACCTAGTGAAGTTTTAGTCATAGCT
GATGATTTAGCTAATGAAAAATTTGTAGCTAGTGATTTGCTTTCACAAGCTGAACATGGTGCAGATTCTCAAGTGATTTT
AGTGTGTTTAAGTCAAGATTTTGCTAAAAAAGCAAGTGATGAAGTCCAAAGTCAATTAGAACTTTTGCCTCGCAAAGAAC
TTGCAAGCAAAAGCATTGCTAATTCACGCATTATCATAGCTAAAGATTTAAATCAAGCCTTAGAAATTTCAAATCTTTAC
GCCCCTGAACATTTGATCATACAAACTCAAAATCCACGAGAACTTTTAAAAGGTGTAAAACACGCAGGATCAGTATTTTT
AGGAGCTTATTCCCCAGAGTCTATGGGTGATTATGCAAGTGGGACAAATCATGTTTTACCTACTTATGGACTTACTAAAA
CGCATTCTAGTTTAGGTTTGGCAGATTTTAGCAAAAGAATGACCGTTCAAGAGTTAAGTAAAGAAGGTTTTTTAGCTTTA
GGTAAAAGTGTTGAAATTTTAGCACAAAATGAGCATTTAGACGCGCACAAAAATGCAGTAACTTTTCGTTTAGAAAGCTT
AAAATGA

Upstream 100 bases:

>100_bases
AAAGAAAATCTTTTTTGGGAAACCATGGAGGCTTTAAAAGAAGAAGGTGCGAGTTCGATTTTAGTTCTGCCTATAGAAAA
AATGTTAAAGTGAGTAAAAA

Downstream 100 bases:

>100_bases
GTCAAAAAATCCTTTTTATAGATAGAGATGGCACTTTAATAGAGGAGCCAAAAAGCGATTTTCAAATCGATACTCTTGAA
AAATTGCGTTTTGAAAAAGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MQILVYDNLDEKQKEEALKRPAISAKDEISKIVSSIIKEVQEKGDEALIEQALKFDKAEISKIKITQEEITQASKRLDKD
LQEAILVAYENIKKFHEAQIPHEIALETTKGVKCEVLTRPIEKVGLYIPGGLAPLFSTVLMLAIPAKIAGCEKIVLASPA
KINDAVLFCAKLCGVDEIYQMGGAGAIAALAYGTQSVLKVDKIFGPGNAFVTEAKRQVSSDINGAAIDMQAGPSEVLVIA
DDLANEKFVASDLLSQAEHGADSQVILVCLSQDFAKKASDEVQSQLELLPRKELASKSIANSRIIIAKDLNQALEISNLY
APEHLIIQTQNPRELLKGVKHAGSVFLGAYSPESMGDYASGTNHVLPTYGLTKTHSSLGLADFSKRMTVQELSKEGFLAL
GKSVEILAQNEHLDAHKNAVTFRLESLK

Sequences:

>Translated_428_residues
MQILVYDNLDEKQKEEALKRPAISAKDEISKIVSSIIKEVQEKGDEALIEQALKFDKAEISKIKITQEEITQASKRLDKD
LQEAILVAYENIKKFHEAQIPHEIALETTKGVKCEVLTRPIEKVGLYIPGGLAPLFSTVLMLAIPAKIAGCEKIVLASPA
KINDAVLFCAKLCGVDEIYQMGGAGAIAALAYGTQSVLKVDKIFGPGNAFVTEAKRQVSSDINGAAIDMQAGPSEVLVIA
DDLANEKFVASDLLSQAEHGADSQVILVCLSQDFAKKASDEVQSQLELLPRKELASKSIANSRIIIAKDLNQALEISNLY
APEHLIIQTQNPRELLKGVKHAGSVFLGAYSPESMGDYASGTNHVLPTYGLTKTHSSLGLADFSKRMTVQELSKEGFLAL
GKSVEILAQNEHLDAHKNAVTFRLESLK
>Mature_428_residues
MQILVYDNLDEKQKEEALKRPAISAKDEISKIVSSIIKEVQEKGDEALIEQALKFDKAEISKIKITQEEITQASKRLDKD
LQEAILVAYENIKKFHEAQIPHEIALETTKGVKCEVLTRPIEKVGLYIPGGLAPLFSTVLMLAIPAKIAGCEKIVLASPA
KINDAVLFCAKLCGVDEIYQMGGAGAIAALAYGTQSVLKVDKIFGPGNAFVTEAKRQVSSDINGAAIDMQAGPSEVLVIA
DDLANEKFVASDLLSQAEHGADSQVILVCLSQDFAKKASDEVQSQLELLPRKELASKSIANSRIIIAKDLNQALEISNLY
APEHLIIQTQNPRELLKGVKHAGSVFLGAYSPESMGDYASGTNHVLPTYGLTKTHSSLGLADFSKRMTVQELSKEGFLAL
GKSVEILAQNEHLDAHKNAVTFRLESLK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=426, Percent_Identity=60.5633802816901, Blast_Score=531, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6319819, Length=422, Percent_Identity=48.5781990521327, Blast_Score=380, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46431; Mature: 46431

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQILVYDNLDEKQKEEALKRPAISAKDEISKIVSSIIKEVQEKGDEALIEQALKFDKAEI
CEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHH
SKIKITQEEITQASKRLDKDLQEAILVAYENIKKFHEAQIPHEIALETTKGVKCEVLTRP
HHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCCEEHHHHCC
IEKVGLYIPGGLAPLFSTVLMLAIPAKIAGCEKIVLASPAKINDAVLFCAKLCGVDEIYQ
HHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCHHHHHH
MGGAGAIAALAYGTQSVLKVDKIFGPGNAFVTEAKRQVSSDINGAAIDMQAGPSEVLVIA
CCCCHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEE
DDLANEKFVASDLLSQAEHGADSQVILVCLSQDFAKKASDEVQSQLELLPRKELASKSIA
CCCCCCHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
NSRIIIAKDLNQALEISNLYAPEHLIIQTQNPRELLKGVKHAGSVFLGAYSPESMGDYAS
CCEEEEEECHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCEEEECCCCCCCCCCCC
GTNHVLPTYGLTKTHSSLGLADFSKRMTVQELSKEGFLALGKSVEILAQNEHLDAHKNAV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCEEEEECCCCCCCCCCEE
TFRLESLK
EEEEECCC
>Mature Secondary Structure
MQILVYDNLDEKQKEEALKRPAISAKDEISKIVSSIIKEVQEKGDEALIEQALKFDKAEI
CEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHH
SKIKITQEEITQASKRLDKDLQEAILVAYENIKKFHEAQIPHEIALETTKGVKCEVLTRP
HHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCCEEHHHHCC
IEKVGLYIPGGLAPLFSTVLMLAIPAKIAGCEKIVLASPAKINDAVLFCAKLCGVDEIYQ
HHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCHHHHHH
MGGAGAIAALAYGTQSVLKVDKIFGPGNAFVTEAKRQVSSDINGAAIDMQAGPSEVLVIA
CCCCHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEE
DDLANEKFVASDLLSQAEHGADSQVILVCLSQDFAKKASDEVQSQLELLPRKELASKSIA
CCCCCCHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
NSRIIIAKDLNQALEISNLYAPEHLIIQTQNPRELLKGVKHAGSVFLGAYSPESMGDYAS
CCEEEEEECHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCEEEECCCCCCCCCCCC
GTNHVLPTYGLTKTHSSLGLADFSKRMTVQELSKEGFLALGKSVEILAQNEHLDAHKNAV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCEEEEECCCCCCCCCCEE
TFRLESLK
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]