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The map label for this gene is hisG [H]

Identifier: 57238610

GI number: 57238610

Start: 1666606

End: 1667505

Strand: Direct

Name: hisG [H]

Synonym: CJE1769

Alternate gene names: 57238610

Gene position: 1666606-1667505 (Clockwise)

Preceding gene: 57238609

Following gene: 57238611

Centisome position: 93.74

GC content: 34.33

Gene sequence:

>900_bases
ATGCAAGAAAACACTCGTTTACGCATTGCGATACAAAAATCAGGTAGACTTTCAAAAGAATCCATAGAGCTTCTTTCAGA
ATGTGGTGTTAAAATGCATATCCATGAACAAAGCTTGATCGCTTTTTCTACAAATTTACCCATAGATATTTTACGCGTTA
GAGATGATGATATCCCTGGGCTTATTTTTGATGGGGTTGTAGATTTAGGCATTATAGGGGAAAATGTTTTAGAAGAAAAT
GAACTTGAACGCCAGTCTTTAGGAGAAAATCCAAGCTATAAGCTTTTAAAAAAGCTAGATTTTGGATATTGCCGTCTTTC
TCTTGCCTTACCTCAAGAAAATAAATTTCAAAATTTGAAAGATTTTGAAGGCTTAAGGATAGCTACTTCTTATCCACAAC
TTTTAAAGCGTTTTATGAAAGAAAATGGGATTAATTATAAAAATTGTACGCTTACAGGTTCTGTTGAAGTAGCCCCTAGG
GCAAATTTAGCCGATGCGATTTGCGATCTTGTTTCAAGCGGGGCAACTTTACAAGCAAACAATCTTAAAGAAGTTAAAGT
CATTTATGAATCTCGTGCTTGTTTGATTCAAAAAGAAAATGCTTTAAGTAAAGAAAAACAAGCCTTAGTGGATAAAATTA
TGTTGCGTGTAGCAGGAGTAATGCAAGCAAGAGAATCTAAATACATTATGCTTCATGCTCCAAAAGAAAAGCTTGATAAA
ATTCAAGCCCTACTTCCAGGAGTTGAAAGACCGACTATCTTACCTTTAGCACACGATGAAAAAAATGTAGCTTTACATAT
GGTAAGTAAAGAAAATCTTTTTTGGGAAACCATGGAGGCTTTAAAAGAAGAAGGTGCGAGTTCGATTTTAGTTCTGCCTA
TAGAAAAAATGTTAAAGTGA

Upstream 100 bases:

>100_bases
TTTAAATAAAATTAAATTTATTTATTTTCTAAAACCCTTGCTAAAAATTCAACTACTTATGCTAATATAAGTTTTTAATT
TTTAATTTCAAGGATATGTT

Downstream 100 bases:

>100_bases
GTAAAAAATGCAAATTTTAGTATATGATAATTTGGATGAAAAACAAAAAGAAGAAGCGTTAAAACGCCCTGCTATAAGTG
CGAAAGATGAAATTTCAAAA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MQENTRLRIAIQKSGRLSKESIELLSECGVKMHIHEQSLIAFSTNLPIDILRVRDDDIPGLIFDGVVDLGIIGENVLEEN
ELERQSLGENPSYKLLKKLDFGYCRLSLALPQENKFQNLKDFEGLRIATSYPQLLKRFMKENGINYKNCTLTGSVEVAPR
ANLADAICDLVSSGATLQANNLKEVKVIYESRACLIQKENALSKEKQALVDKIMLRVAGVMQARESKYIMLHAPKEKLDK
IQALLPGVERPTILPLAHDEKNVALHMVSKENLFWETMEALKEEGASSILVLPIEKMLK

Sequences:

>Translated_299_residues
MQENTRLRIAIQKSGRLSKESIELLSECGVKMHIHEQSLIAFSTNLPIDILRVRDDDIPGLIFDGVVDLGIIGENVLEEN
ELERQSLGENPSYKLLKKLDFGYCRLSLALPQENKFQNLKDFEGLRIATSYPQLLKRFMKENGINYKNCTLTGSVEVAPR
ANLADAICDLVSSGATLQANNLKEVKVIYESRACLIQKENALSKEKQALVDKIMLRVAGVMQARESKYIMLHAPKEKLDK
IQALLPGVERPTILPLAHDEKNVALHMVSKENLFWETMEALKEEGASSILVLPIEKMLK
>Mature_299_residues
MQENTRLRIAIQKSGRLSKESIELLSECGVKMHIHEQSLIAFSTNLPIDILRVRDDDIPGLIFDGVVDLGIIGENVLEEN
ELERQSLGENPSYKLLKKLDFGYCRLSLALPQENKFQNLKDFEGLRIATSYPQLLKRFMKENGINYKNCTLTGSVEVAPR
ANLADAICDLVSSGATLQANNLKEVKVIYESRACLIQKENALSKEKQALVDKIMLRVAGVMQARESKYIMLHAPKEKLDK
IQALLPGVERPTILPLAHDEKNVALHMVSKENLFWETMEALKEEGASSILVLPIEKMLK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=299, Percent_Identity=66.2207357859532, Blast_Score=421, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6320896, Length=295, Percent_Identity=30.5084745762712, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 33640; Mature: 33640

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQENTRLRIAIQKSGRLSKESIELLSECGVKMHIHEQSLIAFSTNLPIDILRVRDDDIPG
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCEEEEEECCCCEEEEEECCCCCCC
LIFDGVVDLGIIGENVLEENELERQSLGENPSYKLLKKLDFGYCRLSLALPQENKFQNLK
CHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCH
DFEGLRIATSYPQLLKRFMKENGINYKNCTLTGSVEVAPRANLADAICDLVSSGATLQAN
HCCCEEEECHHHHHHHHHHHHCCCCCCEEEEECCEEECCCCCHHHHHHHHHHCCCEEEEC
NLKEVKVIYESRACLIQKENALSKEKQALVDKIMLRVAGVMQARESKYIMLHAPKEKLDK
CCCEEEEEECCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
IQALLPGVERPTILPLAHDEKNVALHMVSKENLFWETMEALKEEGASSILVLPIEKMLK
HHHHHCCCCCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEHHHHCC
>Mature Secondary Structure
MQENTRLRIAIQKSGRLSKESIELLSECGVKMHIHEQSLIAFSTNLPIDILRVRDDDIPG
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCEEEEEECCCCEEEEEECCCCCCC
LIFDGVVDLGIIGENVLEENELERQSLGENPSYKLLKKLDFGYCRLSLALPQENKFQNLK
CHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCH
DFEGLRIATSYPQLLKRFMKENGINYKNCTLTGSVEVAPRANLADAICDLVSSGATLQAN
HCCCEEEECHHHHHHHHHHHHCCCCCCEEEEECCEEECCCCCHHHHHHHHHHCCCEEEEC
NLKEVKVIYESRACLIQKENALSKEKQALVDKIMLRVAGVMQARESKYIMLHAPKEKLDK
CCCEEEEEECCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
IQALLPGVERPTILPLAHDEKNVALHMVSKENLFWETMEALKEEGASSILVLPIEKMLK
HHHHHCCCCCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA