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The map label for this gene is pcoR [H]

Identifier: 57238514

GI number: 57238514

Start: 1564412

End: 1565092

Strand: Reverse

Name: pcoR [H]

Synonym: CJE1664

Alternate gene names: 57238514

Gene position: 1565092-1564412 (Counterclockwise)

Preceding gene: 57238515

Following gene: 57238513

Centisome position: 88.03

GC content: 29.07

Gene sequence:

>681_bases
ATGTCACAAGAATGTAAAGAATTGATAATATTAGTAGTTGAAGATGAGGTTAAGGCTAGAGAATCAATGATTAATATATT
AAGCGAACGCTTTAGTAAAGTAATCGGAGCTCAAAATGGAGATGAGGGGCTTAAAAAATTTAAAAAATTTAAGCCAGATT
TAGTTATCACAGATATTGCTATGCCTATTATGGATGGACTGGATATGGCAAGAGAGATTAAAGAAATTTCAGATGATGTT
CCAATTGTTGTTCTTAGTGCGTATTCAGAGAAAGAGAGACTTTTGCGTTCTATTGATATTGGTATAGATAAATATTTGAT
TAAACCTGTTGATATAGAAGAGTTGTTTAAAGTTTTAGATTATCTGATAGGTGAAAAAATTGAAGCAAATATGCTTGTAA
AAATTTCTGAAGAATATCAATTTAACAAAACTAAACGAACTTTAATTTACAGTGGTGAAGAAATTGTTTTAACTAAAAAA
GAATTGGCTTTTATTTCTTTGCTTTTAAAGCAACCTGGGGCTTTGGTTTTGCATGAAGATATTAAGAAAAATGTTTGGAT
AGGTGAACATGTGAGCGATACTGCTGTTAGAACTTTTATAAAAAGAGTAAGAGATAAAGTGGGTGAAGATTTTATAAAAA
ATGTGCCAAGTTTAGGTTATAAGATAAATATCAATAAATAA

Upstream 100 bases:

>100_bases
AAATTATCGAAAGTTTCCAAGGAAAAATAAAAGTTAAAAATGGAAAAGACGGGGCTTGTTTTGAGATATTTTTAAAACTA
AAAGAGAGGGTAGAGTAGAA

Downstream 100 bases:

>100_bases
GACTGATTTAACCTTAAAATATAAAGCATAACAAATGATTAACAAAATTGTTGTTTTTAAGAAAAAATGTATAATTAATA
TTCTATAATATTCTCTTGTT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MSQECKELIILVVEDEVKARESMINILSERFSKVIGAQNGDEGLKKFKKFKPDLVITDIAMPIMDGLDMAREIKEISDDV
PIVVLSAYSEKERLLRSIDIGIDKYLIKPVDIEELFKVLDYLIGEKIEANMLVKISEEYQFNKTKRTLIYSGEEIVLTKK
ELAFISLLLKQPGALVLHEDIKKNVWIGEHVSDTAVRTFIKRVRDKVGEDFIKNVPSLGYKININK

Sequences:

>Translated_226_residues
MSQECKELIILVVEDEVKARESMINILSERFSKVIGAQNGDEGLKKFKKFKPDLVITDIAMPIMDGLDMAREIKEISDDV
PIVVLSAYSEKERLLRSIDIGIDKYLIKPVDIEELFKVLDYLIGEKIEANMLVKISEEYQFNKTKRTLIYSGEEIVLTKK
ELAFISLLLKQPGALVLHEDIKKNVWIGEHVSDTAVRTFIKRVRDKVGEDFIKNVPSLGYKININK
>Mature_225_residues
SQECKELIILVVEDEVKARESMINILSERFSKVIGAQNGDEGLKKFKKFKPDLVITDIAMPIMDGLDMAREIKEISDDVP
IVVLSAYSEKERLLRSIDIGIDKYLIKPVDIEELFKVLDYLIGEKIEANMLVKISEEYQFNKTKRTLIYSGEEIVLTKKE
LAFISLLLKQPGALVLHEDIKKNVWIGEHVSDTAVRTFIKRVRDKVGEDFIKNVPSLGYKININK

Specific function: Probable member of a two-component regulatory system pcoS/pcoR. May be involved in the activation of copper resistance gene operon pcoABCD by binding to a specific site on the cop operon promoter (copper box) [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=29.7777777777778, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1789402, Length=216, Percent_Identity=26.8518518518519, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=29.1479820627803, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=27.9279279279279, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=27.3127753303965, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=25.4464285714286, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=26.7281105990783, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790860, Length=201, Percent_Identity=25.3731343283582, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=33.0188679245283, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=34.6534653465347, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=25.5506607929515, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788905, Length=120, Percent_Identity=31.6666666666667, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=111, Percent_Identity=31.5315315315315, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1790299, Length=115, Percent_Identity=29.5652173913043, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787375, Length=216, Percent_Identity=23.6111111111111, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1790863, Length=208, Percent_Identity=27.8846153846154, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25872; Mature: 25741

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQECKELIILVVEDEVKARESMINILSERFSKVIGAQNGDEGLKKFKKFKPDLVITDIA
CCCCHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEHHHH
MPIMDGLDMAREIKEISDDVPIVVLSAYSEKERLLRSIDIGIDKYLIKPVDIEELFKVLD
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHH
YLIGEKIEANMLVKISEEYQFNKTKRTLIYSGEEIVLTKKELAFISLLLKQPGALVLHED
HHHCCCCCCCEEEEECCHHHCCCHHEEEEECCCEEEEEHHHHHHHHHHHHCCCCEEEHHH
IKKNVWIGEHVSDTAVRTFIKRVRDKVGEDFIKNVPSLGYKININK
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure 
SQECKELIILVVEDEVKARESMINILSERFSKVIGAQNGDEGLKKFKKFKPDLVITDIA
CCCHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEHHHH
MPIMDGLDMAREIKEISDDVPIVVLSAYSEKERLLRSIDIGIDKYLIKPVDIEELFKVLD
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHH
YLIGEKIEANMLVKISEEYQFNKTKRTLIYSGEEIVLTKKELAFISLLLKQPGALVLHED
HHHCCCCCCCEEEEECCHHHCCCHHEEEEECCCEEEEEHHHHHHHHHHHHCCCCEEEHHH
IKKNVWIGEHVSDTAVRTFIKRVRDKVGEDFIKNVPSLGYKININK
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8594334; 9141682 [H]