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The map label for this gene is fcl [H]

Identifier: 57238462

GI number: 57238462

Start: 1514017

End: 1515066

Strand: Reverse

Name: fcl [H]

Synonym: CJE1612

Alternate gene names: 57238462

Gene position: 1515066-1514017 (Counterclockwise)

Preceding gene: 57238463

Following gene: 57238461

Centisome position: 85.22

GC content: 28.1

Gene sequence:

>1050_bases
ATGAAAAAAAATGATAAAATTTATATAGCTGGCCATAGGGGGTTGGTTGGTTCTGCTATTTTGAGAAAATTAAAAGATAA
TGGCTATGAGAATTTAATTTATAAAACGCATTCTGAATTGGATTTAACTGATCAAAGTGCTGTAAAGTTTTTTTTTGAGA
AAGAAAAACCAGATTTTGTTTTTTTGTGTGCAGCGAAACTTGGCGGTATGGATGCGCATAGAAAATTTAGAGCCGAATTT
ATTTATGATAATTTACAAATTCAAAATAACGTAATCCATCAATCGTATATAAATAATGTAAAAAAACTTTTATTTATCAG
CAGTACAAGTGTCTATCCAGAGCATGCTTCACTGCCTATAAAAGAAGAATGTTTATTAAGTGGTAAATTACAATATCTGC
ATGAACCTTATGCTATAGCTAAAATAGCTGGTATGAAGATGTGTGAAGCATATTCTGATAGATATGGTGTAAATTTTATT
TCAGTATGTCCTACAACTTTATATGGACCAAATGATAATTTTGATATTGAAAGTGCTAATGTTGTTTCAGCTTTAATGAG
AAAAATATATTTGGCCAAGTTATTGAAAGAGAAGCGGTATGATCTAGTTTTAAAAGATTTAGAAATTGATGATATTGATA
AAGCCAAAAACTATTTAGATATTTTAGGTGTGAAAGAAAATTCCATAGAAATTTGGGGAAGCGGTAACCCAAAGAGAGAA
TTTTTATATAGTGATGATTTGGCTAACGCTTGTATTCATATAATGCAAAATATTAATATTGAACATATAAATAAAATAGA
TAGAGATAATCCGCATATTAATATTGGTCCTGAAAAAAATTATTCGATTAAAGAACTAGCGTATTTATTAAAAACAGTTA
TTCAATTTGAAGGTGAATTTAGATATAATTTAAGTAAGCCCGATGGCACATATGAAAAATTAACTTGTTGTGATAAAATA
AAGCAAATGAATTGGCAAGCTTATACAAAATTAGAAGATGGGATAAGATCAACATTTCATTGGTATAAAAGTAACAAAGG
ATTGATATGA

Upstream 100 bases:

>100_bases
ATACGGCTCAACCTATATTTTATAGTAAGTCTTTTGATACAAGACCATTGGGCGTGTTTTTAGAAGGTTTATGTTTATAT
GAATTATAATAAGGATGGAT

Downstream 100 bases:

>100_bases
AAAAAACAGCGTTAATTACAGGATTTACAGGGCAAGTTGGTTCTCAAATGGCAGATTTTTTGCTTGCAAATACGGATTAT
GAAGTTATAGGAATGATGCG

Product: GDP-L-fucose synthetase

Products: NA

Alternate protein names: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKKNDKIYIAGHRGLVGSAILRKLKDNGYENLIYKTHSELDLTDQSAVKFFFEKEKPDFVFLCAAKLGGMDAHRKFRAEF
IYDNLQIQNNVIHQSYINNVKKLLFISSTSVYPEHASLPIKEECLLSGKLQYLHEPYAIAKIAGMKMCEAYSDRYGVNFI
SVCPTTLYGPNDNFDIESANVVSALMRKIYLAKLLKEKRYDLVLKDLEIDDIDKAKNYLDILGVKENSIEIWGSGNPKRE
FLYSDDLANACIHIMQNINIEHINKIDRDNPHINIGPEKNYSIKELAYLLKTVIQFEGEFRYNLSKPDGTYEKLTCCDKI
KQMNWQAYTKLEDGIRSTFHWYKSNKGLI

Sequences:

>Translated_349_residues
MKKNDKIYIAGHRGLVGSAILRKLKDNGYENLIYKTHSELDLTDQSAVKFFFEKEKPDFVFLCAAKLGGMDAHRKFRAEF
IYDNLQIQNNVIHQSYINNVKKLLFISSTSVYPEHASLPIKEECLLSGKLQYLHEPYAIAKIAGMKMCEAYSDRYGVNFI
SVCPTTLYGPNDNFDIESANVVSALMRKIYLAKLLKEKRYDLVLKDLEIDDIDKAKNYLDILGVKENSIEIWGSGNPKRE
FLYSDDLANACIHIMQNINIEHINKIDRDNPHINIGPEKNYSIKELAYLLKTVIQFEGEFRYNLSKPDGTYEKLTCCDKI
KQMNWQAYTKLEDGIRSTFHWYKSNKGLI
>Mature_349_residues
MKKNDKIYIAGHRGLVGSAILRKLKDNGYENLIYKTHSELDLTDQSAVKFFFEKEKPDFVFLCAAKLGGMDAHRKFRAEF
IYDNLQIQNNVIHQSYINNVKKLLFISSTSVYPEHASLPIKEECLLSGKLQYLHEPYAIAKIAGMKMCEAYSDRYGVNFI
SVCPTTLYGPNDNFDIESANVVSALMRKIYLAKLLKEKRYDLVLKDLEIDDIDKAKNYLDILGVKENSIEIWGSGNPKRE
FLYSDDLANACIHIMQNINIEHINKIDRDNPHINIGPEKNYSIKELAYLLKTVIQFEGEFRYNLSKPDGTYEKLTCCDKI
KQMNWQAYTKLEDGIRSTFHWYKSNKGLI

Specific function: Two step NADP-dependent conversion of GDP-4-dehydro-6- deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=345, Percent_Identity=27.8260869565217, Blast_Score=158, Evalue=6e-39,
Organism=Escherichia coli, GI1788365, Length=344, Percent_Identity=40.406976744186, Blast_Score=273, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17554428, Length=344, Percent_Identity=25.2906976744186, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI19922778, Length=343, Percent_Identity=27.1137026239067, Blast_Score=131, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.271 [H]

Molecular weight: Translated: 40315; Mature: 40315

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNDKIYIAGHRGLVGSAILRKLKDNGYENLIYKTHSELDLTDQSAVKFFFEKEKPDFV
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEE
FLCAAKLGGMDAHRKFRAEFIYDNLQIQNNVIHQSYINNVKKLLFISSTSVYPEHASLPI
EEEEHHHCCCCHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCC
KEECLLSGKLQYLHEPYAIAKIAGMKMCEAYSDRYGVNFISVCPTTLYGPNDNFDIESAN
HHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCHHH
VVSALMRKIYLAKLLKEKRYDLVLKDLEIDDIDKAKNYLDILGVKENSIEIWGSGNPKRE
HHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHEECCCCCEEEEECCCCCCC
FLYSDDLANACIHIMQNINIEHINKIDRDNPHINIGPEKNYSIKELAYLLKTVIQFEGEF
EEECCHHHHHHHHHHHCCCHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCE
RYNLSKPDGTYEKLTCCDKIKQMNWQAYTKLEDGIRSTFHWYKSNKGLI
EEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKNDKIYIAGHRGLVGSAILRKLKDNGYENLIYKTHSELDLTDQSAVKFFFEKEKPDFV
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEE
FLCAAKLGGMDAHRKFRAEFIYDNLQIQNNVIHQSYINNVKKLLFISSTSVYPEHASLPI
EEEEHHHCCCCHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCC
KEECLLSGKLQYLHEPYAIAKIAGMKMCEAYSDRYGVNFISVCPTTLYGPNDNFDIESAN
HHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCHHH
VVSALMRKIYLAKLLKEKRYDLVLKDLEIDDIDKAKNYLDILGVKENSIEIWGSGNPKRE
HHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHEECCCCCEEEEECCCCCCC
FLYSDDLANACIHIMQNINIEHINKIDRDNPHINIGPEKNYSIKELAYLLKTVIQFEGEF
EEECCHHHHHHHHHHHCCCHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCE
RYNLSKPDGTYEKLTCCDKIKQMNWQAYTKLEDGIRSTFHWYKSNKGLI
EEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7815923; 8759852; 9097040; 9278503; 9473059; 9862812 [H]