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The map label for this gene is rmlA1 [C]

Identifier: 57238458

GI number: 57238458

Start: 1510712

End: 1511392

Strand: Reverse

Name: rmlA1 [C]

Synonym: CJE1608

Alternate gene names: 57238458

Gene position: 1511392-1510712 (Counterclockwise)

Preceding gene: 57238459

Following gene: 57238457

Centisome position: 85.01

GC content: 26.14

Gene sequence:

>681_bases
TTGCAAGCAATAATACTTTGTGGCGGCTTAGGAACAAGGCTTAAAAGTGTTATAAAAGACATTCCAAAGCCTATGGCACC
GATAAATGATAAGCCTTTTTTAGAATTTATTTTTGAGTATCTTAAAAAGCAAGGCATAAAAGAAGTTATCTTAGCAGTAT
CATACAAGTATGAGGTGATACAAGAATATTTTAAAGATGAGTTTTTAGGTATAAAAATAAAATACAGTATAGAAAAAGAA
CCTCTAGGAACAGGCGGAGCCATAAAAGAGGCTTTGAAATTTATAAAAAATGAAGCTTATGTTTTAAATGGTGATACGAT
TTTTGATATTGATTTAAAAAAGCTTATTTTAAATAATAGTAAAATCTGTCTTGCTTTAAAACAAATGAATGATTTTGATA
GATATGGTACAGTAGAGCTTGATAGTAAAAATTATATTAAGCTTTTTAAAGAAAAAGAATTTAAAAAGCAAGGGTTGATA
AATGGCGGAATTTACTTTTTAAATAAAGATATCTTTAATGATTTTACTTTACAAGAAAAATTTTCTTTTGAAGAATTTTT
ACAAGAAAATTATGAAAAACTAAAAGCTAAAGCTCATATTTTTGATAATTATTTTATAGATATTGGCGTACCTGGGGATT
ATGGGAGATTTATGAATGATATTTTTACATCGTCAAAATAA

Upstream 100 bases:

>100_bases
TACCTTCAACTTGCACACCAAGAATTCAAGAAGCACATATTTTAATAGGACATATTATTTGTGCTATCGTTGAAGAAGAG
CTTTTTGGCAAAGGTTTTTC

Downstream 100 bases:

>100_bases
TTTAGACTTATCTATTGAAGGTTATGGTATAGAAATTGATTTAAGGTATAATCAAAAATTAGTATTAAACCATGATCTAT
TAGAAAAAAATTCTCTATAT

Product: capsular biosynthesis nucleotidyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MQAIILCGGLGTRLKSVIKDIPKPMAPINDKPFLEFIFEYLKKQGIKEVILAVSYKYEVIQEYFKDEFLGIKIKYSIEKE
PLGTGGAIKEALKFIKNEAYVLNGDTIFDIDLKKLILNNSKICLALKQMNDFDRYGTVELDSKNYIKLFKEKEFKKQGLI
NGGIYFLNKDIFNDFTLQEKFSFEEFLQENYEKLKAKAHIFDNYFIDIGVPGDYGRFMNDIFTSSK

Sequences:

>Translated_226_residues
MQAIILCGGLGTRLKSVIKDIPKPMAPINDKPFLEFIFEYLKKQGIKEVILAVSYKYEVIQEYFKDEFLGIKIKYSIEKE
PLGTGGAIKEALKFIKNEAYVLNGDTIFDIDLKKLILNNSKICLALKQMNDFDRYGTVELDSKNYIKLFKEKEFKKQGLI
NGGIYFLNKDIFNDFTLQEKFSFEEFLQENYEKLKAKAHIFDNYFIDIGVPGDYGRFMNDIFTSSK
>Mature_226_residues
MQAIILCGGLGTRLKSVIKDIPKPMAPINDKPFLEFIFEYLKKQGIKEVILAVSYKYEVIQEYFKDEFLGIKIKYSIEKE
PLGTGGAIKEALKFIKNEAYVLNGDTIFDIDLKKLILNNSKICLALKQMNDFDRYGTVELDSKNYIKLFKEKEFKKQGLI
NGGIYFLNKDIFNDFTLQEKFSFEEFLQENYEKLKAKAHIFDNYFIDIGVPGDYGRFMNDIFTSSK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=225, Percent_Identity=29.7777777777778, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI11761619, Length=225, Percent_Identity=29.7777777777778, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI1788351, Length=179, Percent_Identity=29.0502793296089, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=238, Percent_Identity=30.672268907563, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320148, Length=232, Percent_Identity=29.7413793103448, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355443, Length=224, Percent_Identity=33.0357142857143, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24644084, Length=224, Percent_Identity=33.0357142857143, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 26225; Mature: 26225

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIILCGGLGTRLKSVIKDIPKPMAPINDKPFLEFIFEYLKKQGIKEVILAVSYKYEVI
CCEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QEYFKDEFLGIKIKYSIEKEPLGTGGAIKEALKFIKNEAYVLNGDTIFDIDLKKLILNNS
HHHHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECCCEEEEHHHHHHHHCCC
KICLALKQMNDFDRYGTVELDSKNYIKLFKEKEFKKQGLINGGIYFLNKDIFNDFTLQEK
CEEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCHHHH
FSFEEFLQENYEKLKAKAHIFDNYFIDIGVPGDYGRFMNDIFTSSK
CCHHHHHHHHHHHHHHHHEEECCEEEEEECCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MQAIILCGGLGTRLKSVIKDIPKPMAPINDKPFLEFIFEYLKKQGIKEVILAVSYKYEVI
CCEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QEYFKDEFLGIKIKYSIEKEPLGTGGAIKEALKFIKNEAYVLNGDTIFDIDLKKLILNNS
HHHHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECCCEEEEHHHHHHHHCCC
KICLALKQMNDFDRYGTVELDSKNYIKLFKEKEFKKQGLINGGIYFLNKDIFNDFTLQEK
CEEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCHHHH
FSFEEFLQENYEKLKAKAHIFDNYFIDIGVPGDYGRFMNDIFTSSK
CCHHHHHHHHHHHHHHHHEEECCEEEEEECCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA