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The map label for this gene is dxr [H]

Identifier: 57238389

GI number: 57238389

Start: 1431576

End: 1432646

Strand: Reverse

Name: dxr [H]

Synonym: CJE1535

Alternate gene names: 57238389

Gene position: 1432646-1431576 (Counterclockwise)

Preceding gene: 57238390

Following gene: 57238388

Centisome position: 80.58

GC content: 31.28

Gene sequence:

>1071_bases
ATGATACTTTTTGGAAGTACGGGCAGTATAGGAGTAAATGCTCTTAAACTTGCTGCTTTAAAAAACATTCCCATTTCTGC
TTTAGCTTGTGGGGATAACATCGCTCTTTTAAATGAGCAAATCGCAAGGTTTAAACCTAAATTTGTTGCCATAAAAGATT
CAAAAAATAAGCATTTAGTTAAACACGATAGAGTTTTTATAGGGCAAGAAGGTTTAGAGCAAATTTTAACAGAATGTCAA
GATAAGCTTTTACTCAATGCCATTGTAGGTTTTGCAGGACTTAAAAGCACTTTAAAGGCTAAAGAGCTTGGCAAAAACAT
AGCTTTAGCTAACAAAGAAAGTCTTGTAGTAGCTGGGAGTTTTTTGAAAGGCGCTAAATTTTTACCCGTTGATAGTGAGC
ATGCAGCTTTAAAATTTTTACTCGAAGGTAAAAAAAATATAGCAAAACTTTATATCACAGCAAGCGGCGGAGCTTTTTAT
AAGTATAAAATCAAAGATTTAAATCAAGTCAGTCTCAAAGATGCTTTAAAACATCCTAATTGGAACATGGGAGCAAAGAT
CACTATAGATAGTGCGACTATGGCAAATAAGCTTTTTGAGATTATAGAGGCTTATCATTTATATGATTTTAAAGAAATTG
ATGCTTTAATAGAACCAAGATCTTTAGTGCATGCAATGTGTGAATTTAAAAATGGAGCTAGCACGGCGTATTTTTCAAAA
GCAGATATGAAACTAGCTATTTCAGATGCTATATTTGAAAAACAAGATACGCCTATTTTAGAGGCTGTTGATTTTAGTAA
AATGCCTGCTTTAAAATTTCATCCAATCAGCACAAAAAAATATCCTATTTTTAAGCTTAAAAATACATTTTTAAAAGAGC
CAAATTTAGGTGTTATCATCAATGCTGCTAATGAAGTTGGTGTTTATAATTTTTTAGAAAATAAAAGTGGATTTTTAGAC
ATTGCTAAATGCATTTTTAAAGCCCTTGATCATTTTGGAGTACCTAAAATTTCAAGCATAGAAGAAGTTTTTGAGTATGA
TTTTAAAACAAGAGAGTATTTAAGGAGTTAA

Upstream 100 bases:

>100_bases
CAGGTGTAAAAGATAGTGGAGATCTTATCCCTGGTCATGGGGGCATGCTCGATAGGATCGATGCGGTGATCATTGCTGCT
TTTGTGATGGTTGCTCTTTT

Downstream 100 bases:

>100_bases
AATGAAATTTTTTTTAACAATTTTATTTTTTATAACAAGCATTTTTGCTTTAGAGCTAGACTTTAGCGTAGGAGAAAATG
GAAAAAGTCTAGATGATAAT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MILFGSTGSIGVNALKLAALKNIPISALACGDNIALLNEQIARFKPKFVAIKDSKNKHLVKHDRVFIGQEGLEQILTECQ
DKLLLNAIVGFAGLKSTLKAKELGKNIALANKESLVVAGSFLKGAKFLPVDSEHAALKFLLEGKKNIAKLYITASGGAFY
KYKIKDLNQVSLKDALKHPNWNMGAKITIDSATMANKLFEIIEAYHLYDFKEIDALIEPRSLVHAMCEFKNGASTAYFSK
ADMKLAISDAIFEKQDTPILEAVDFSKMPALKFHPISTKKYPIFKLKNTFLKEPNLGVIINAANEVGVYNFLENKSGFLD
IAKCIFKALDHFGVPKISSIEEVFEYDFKTREYLRS

Sequences:

>Translated_356_residues
MILFGSTGSIGVNALKLAALKNIPISALACGDNIALLNEQIARFKPKFVAIKDSKNKHLVKHDRVFIGQEGLEQILTECQ
DKLLLNAIVGFAGLKSTLKAKELGKNIALANKESLVVAGSFLKGAKFLPVDSEHAALKFLLEGKKNIAKLYITASGGAFY
KYKIKDLNQVSLKDALKHPNWNMGAKITIDSATMANKLFEIIEAYHLYDFKEIDALIEPRSLVHAMCEFKNGASTAYFSK
ADMKLAISDAIFEKQDTPILEAVDFSKMPALKFHPISTKKYPIFKLKNTFLKEPNLGVIINAANEVGVYNFLENKSGFLD
IAKCIFKALDHFGVPKISSIEEVFEYDFKTREYLRS
>Mature_356_residues
MILFGSTGSIGVNALKLAALKNIPISALACGDNIALLNEQIARFKPKFVAIKDSKNKHLVKHDRVFIGQEGLEQILTECQ
DKLLLNAIVGFAGLKSTLKAKELGKNIALANKESLVVAGSFLKGAKFLPVDSEHAALKFLLEGKKNIAKLYITASGGAFY
KYKIKDLNQVSLKDALKHPNWNMGAKITIDSATMANKLFEIIEAYHLYDFKEIDALIEPRSLVHAMCEFKNGASTAYFSK
ADMKLAISDAIFEKQDTPILEAVDFSKMPALKFHPISTKKYPIFKLKNTFLKEPNLGVIINAANEVGVYNFLENKSGFLD
IAKCIFKALDHFGVPKISSIEEVFEYDFKTREYLRS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=389, Percent_Identity=31.6195372750643, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 39519; Mature: 39519

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILFGSTGSIGVNALKLAALKNIPISALACGDNIALLNEQIARFKPKFVAIKDSKNKHLV
CEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCEE
KHDRVFIGQEGLEQILTECQDKLLLNAIVGFAGLKSTLKAKELGKNIALANKESLVVAGS
ECCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEH
FLKGAKFLPVDSEHAALKFLLEGKKNIAKLYITASGGAFYKYKIKDLNQVSLKDALKHPN
HHCCCEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCCCHHHHHHHHCCCC
WNMGAKITIDSATMANKLFEIIEAYHLYDFKEIDALIEPRSLVHAMCEFKNGASTAYFSK
CCCCEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEC
ADMKLAISDAIFEKQDTPILEAVDFSKMPALKFHPISTKKYPIFKLKNTFLKEPNLGVII
CCCEEEEHHHHHCCCCCCHHHHCCCCCCCCEEEECCCCCCCEEEEEHHHHHCCCCCEEEE
NAANEVGVYNFLENKSGFLDIAKCIFKALDHFGVPKISSIEEVFEYDFKTREYLRS
ECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCC
>Mature Secondary Structure
MILFGSTGSIGVNALKLAALKNIPISALACGDNIALLNEQIARFKPKFVAIKDSKNKHLV
CEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCEE
KHDRVFIGQEGLEQILTECQDKLLLNAIVGFAGLKSTLKAKELGKNIALANKESLVVAGS
ECCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEH
FLKGAKFLPVDSEHAALKFLLEGKKNIAKLYITASGGAFYKYKIKDLNQVSLKDALKHPN
HHCCCEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCCCHHHHHHHHCCCC
WNMGAKITIDSATMANKLFEIIEAYHLYDFKEIDALIEPRSLVHAMCEFKNGASTAYFSK
CCCCEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEC
ADMKLAISDAIFEKQDTPILEAVDFSKMPALKFHPISTKKYPIFKLKNTFLKEPNLGVII
CCCEEEEHHHHHCCCCCCHHHHCCCCCCCCEEEECCCCCCCEEEEEHHHHHCCCCCEEEE
NAANEVGVYNFLENKSGFLDIAKCIFKALDHFGVPKISSIEEVFEYDFKTREYLRS
ECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA