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The map label for this gene is folP [H]

Identifier: 57238219

GI number: 57238219

Start: 620531

End: 621673

Strand: Direct

Name: folP [H]

Synonym: CJE0688

Alternate gene names: 57238219

Gene position: 620531-621673 (Clockwise)

Preceding gene: 57238220

Following gene: 57238218

Centisome position: 34.9

GC content: 29.75

Gene sequence:

>1143_bases
ATGAAATTTTTTAAAATCAATCCAAATACCGATTTTAATTTGCTTTGTTCTTTCATAAATCCCCATAAAATGGGACAAAA
AATTATGAGTGAAAAAACAAAAATTCATTTTATTTTTATCAAAGATATTTCCACTCCTGCGGCAAATATTTTAAAACAAG
ATGCTTTAAGAGTAGGAGCTGAACTTATTACTCATAAAGAAGTAATTACTGCAAAAATCACTCATTCAAATGCGCTTTTA
ATGGCAAGTAAAGAGCAAATTCAAAAGCTTGTTGTCAAAGAAAAACTTCAAGATTTTGGACTTAAAAATTTGGCTCTTTT
TTTGCAAAAAGATTTTTTAAAACAGAAAAAAGCCGAGCTTATGGCAGTGATTAATGTCAATGAAGACAGTTTTAATGCAA
AAAGTCGTGTGAGTGAAGAAGACTTTGAAAAAAGGCTTAATGACTTTCTTGCTTTAAAGCCTGAATATATCGATATAGGT
GCGGTAAGTTCAAGACCTGGGAGTGAGTATTGTGGCAAGGAAGAGGAATTTAAAAGACTGAAAAAAGTACTTGACTTAAT
TTATGAGAAAAATTATTACGAACAAGCAATTTTTAGTTTAGATAGTTTTGATGAATATTGTCTAGAATATGCTTTAAATA
AGGGTTTTAAACTCATTAATGATATTACAAGTTTAAGAAATCTTAATCTAGCCAAACTTGCAAGTAAATATGGGGCAAAA
TATTGCTTAATGCACATGCAAAACAATCCAAATAACATGCAAGATAATCCTTTTTATGAAGATTTGCTTGATGAGATGAC
TTTGTTTTTTAAAGAAAAACTTGAGCTTTTAGAAAGTTTTGGAGTAAAAGAAAGTATTTTAGATGTAGGTATTGGTTTTG
GAAAGAGTGCGGGGCATAATATGATTTTAATCAAACACTTAGAACATTTTTTGCAATTTAATAAACCTTTACTTATAGGT
GCGAGTCGTAAAAGTGTGATTAATGCGTATTTTCAAAGCGAGATTAAAGATCGTTTAGCGGGAACTTTATATTTGCATTT
AAAGGCTTTTGAAAATGGTGCTAGTATTATAAGAGTGCATGATTTATATGAGCATAAACAACTTTTTGCTTTAGCGCAGG
CAATGGATAATATAGGAGTTTAG

Upstream 100 bases:

>100_bases
TTAGAGTTTTTTTATGAAGGCTATGAGCTTGCAAAATTAAATTCTAAAAGCGGGGTGCTTTTAGCTACTCTTTTGTTAAA
TTACTATACAAAGAAATAAA

Downstream 100 bases:

>100_bases
ATGAAAAAAGAAGAGTATTTAGAAAAAGTTGCTTTAGCTAATTTGTGGATGAGGGCATATTATGAAAAAGATGAACCCTT
GGCTAGCGATGAAGAATACG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKFFKINPNTDFNLLCSFINPHKMGQKIMSEKTKIHFIFIKDISTPAANILKQDALRVGAELITHKEVITAKITHSNALL
MASKEQIQKLVVKEKLQDFGLKNLALFLQKDFLKQKKAELMAVINVNEDSFNAKSRVSEEDFEKRLNDFLALKPEYIDIG
AVSSRPGSEYCGKEEEFKRLKKVLDLIYEKNYYEQAIFSLDSFDEYCLEYALNKGFKLINDITSLRNLNLAKLASKYGAK
YCLMHMQNNPNNMQDNPFYEDLLDEMTLFFKEKLELLESFGVKESILDVGIGFGKSAGHNMILIKHLEHFLQFNKPLLIG
ASRKSVINAYFQSEIKDRLAGTLYLHLKAFENGASIIRVHDLYEHKQLFALAQAMDNIGV

Sequences:

>Translated_380_residues
MKFFKINPNTDFNLLCSFINPHKMGQKIMSEKTKIHFIFIKDISTPAANILKQDALRVGAELITHKEVITAKITHSNALL
MASKEQIQKLVVKEKLQDFGLKNLALFLQKDFLKQKKAELMAVINVNEDSFNAKSRVSEEDFEKRLNDFLALKPEYIDIG
AVSSRPGSEYCGKEEEFKRLKKVLDLIYEKNYYEQAIFSLDSFDEYCLEYALNKGFKLINDITSLRNLNLAKLASKYGAK
YCLMHMQNNPNNMQDNPFYEDLLDEMTLFFKEKLELLESFGVKESILDVGIGFGKSAGHNMILIKHLEHFLQFNKPLLIG
ASRKSVINAYFQSEIKDRLAGTLYLHLKAFENGASIIRVHDLYEHKQLFALAQAMDNIGV
>Mature_380_residues
MKFFKINPNTDFNLLCSFINPHKMGQKIMSEKTKIHFIFIKDISTPAANILKQDALRVGAELITHKEVITAKITHSNALL
MASKEQIQKLVVKEKLQDFGLKNLALFLQKDFLKQKKAELMAVINVNEDSFNAKSRVSEEDFEKRLNDFLALKPEYIDIG
AVSSRPGSEYCGKEEEFKRLKKVLDLIYEKNYYEQAIFSLDSFDEYCLEYALNKGFKLINDITSLRNLNLAKLASKYGAK
YCLMHMQNNPNNMQDNPFYEDLLDEMTLFFKEKLELLESFGVKESILDVGIGFGKSAGHNMILIKHLEHFLQFNKPLLIG
ASRKSVINAYFQSEIKDRLAGTLYLHLKAFENGASIIRVHDLYEHKQLFALAQAMDNIGV

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=274, Percent_Identity=35.036496350365, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324073, Length=317, Percent_Identity=25.5520504731861, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 43632; Mature: 43632

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFFKINPNTDFNLLCSFINPHKMGQKIMSEKTKIHFIFIKDISTPAANILKQDALRVGA
CCEEEECCCCCHHHHHHHCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHH
ELITHKEVITAKITHSNALLMASKEQIQKLVVKEKLQDFGLKNLALFLQKDFLKQKKAEL
HHHHHHHHHEEEEECCCEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHE
MAVINVNEDSFNAKSRVSEEDFEKRLNDFLALKPEYIDIGAVSSRPGSEYCGKEEEFKRL
EEEEECCCCCCCHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHCCCHHHHHHH
KKVLDLIYEKNYYEQAIFSLDSFDEYCLEYALNKGFKLINDITSLRNLNLAKLASKYGAK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCC
YCLMHMQNNPNNMQDNPFYEDLLDEMTLFFKEKLELLESFGVKESILDVGIGFGKSAGHN
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCC
MILIKHLEHFLQFNKPLLIGASRKSVINAYFQSEIKDRLAGTLYLHLKAFENGASIIRVH
EEEHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCEEEEH
DLYEHKQLFALAQAMDNIGV
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKFFKINPNTDFNLLCSFINPHKMGQKIMSEKTKIHFIFIKDISTPAANILKQDALRVGA
CCEEEECCCCCHHHHHHHCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHH
ELITHKEVITAKITHSNALLMASKEQIQKLVVKEKLQDFGLKNLALFLQKDFLKQKKAEL
HHHHHHHHHEEEEECCCEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHE
MAVINVNEDSFNAKSRVSEEDFEKRLNDFLALKPEYIDIGAVSSRPGSEYCGKEEEFKRL
EEEEECCCCCCCHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHCCCHHHHHHH
KKVLDLIYEKNYYEQAIFSLDSFDEYCLEYALNKGFKLINDITSLRNLNLAKLASKYGAK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCC
YCLMHMQNNPNNMQDNPFYEDLLDEMTLFFKEKLELLESFGVKESILDVGIGFGKSAGHN
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCC
MILIKHLEHFLQFNKPLLIGASRKSVINAYFQSEIKDRLAGTLYLHLKAFENGASIIRVH
EEEHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCEEEEH
DLYEHKQLFALAQAMDNIGV
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]