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The map label for this gene is cbf2

Identifier: 57238208

GI number: 57238208

Start: 629574

End: 630395

Strand: Direct

Name: cbf2

Synonym: CJE0699

Alternate gene names: 57238208

Gene position: 629574-630395 (Clockwise)

Preceding gene: 57238214

Following gene: 57238207

Centisome position: 35.41

GC content: 30.78

Gene sequence:

>822_bases
ATGAAAAAATTTTCTTTAGTCGCAGCAACTTTGATTGCAGGTGTAGTTTTAAATGTAAATGCAGCTACAGTAGCTACTGT
TAATGGCAAGAGCATTAGCGATACAGAAGTAAGTGAATTTTTTGCCCCTATGCTTAGAGGACAGGATTTTAAAACTTTGC
CAGATAATCAAAAAAAAGCTCTTATTCAGCAATATATTATGCAAGATTTAATTTTGCAAGATGCTAAAAAACAAAATTTA
GAAAAAGACCCTTTATACACAAAAGAACTTGATCGTGCAAAAGATGCAATACTTGTTAATGTTTATCAAGAGAAAATTTT
AAATACTATTAAAATTGATGCGGCTAAAGTTAAAGCTTTTTATGATCAAAATAAAGACAAATATGTAAAACCTGCAAGAG
TGCAAGCAAAACATATCTTAGTAGCGACAGAAAAAGAAGCTAAGGATATTATTAACGAACTTAAAGGTTTAAAAGGTAAA
GAACTAGATGCTAAATTTAGCGAGCTTGCTAAAGAGAAATCAATTGATCCAGGTTCAAAAAACCAAGGTGGTGAGCTTGG
TTGGTTTGATCAATCAACTATGGTAAAGCCTTTTACAGATGCTGCTTTCGCGCTTAAAAATGGTACTATTACTACAACTC
CGGTAAAAACGAATTTTGGTTATCATGTAATCTTAAAAGAAAATTCGCAAGCTAAAGGTCAAATCAAATTTGATGAAGTA
AAACAAGGTATTGAAAACGGACTTAAATTTGAAGAATTTAAAAAAGTTATCAATCAAAAAGGCCAAGATCTCTTAAATAG
TGCTAAAGTGGAATATAAATAA

Upstream 100 bases:

>100_bases
ATTTCTAAATTTCTTTTCATTTTTTAATTTTAGTTAATTAGCTTTAAACCAAGTTTAGATATAATTGATTTTATATACAT
TTTATTAAAAAGGAAACCTA

Downstream 100 bases:

>100_bases
TGGGTGTTTTAGACATTGTAAAAGCAGGGGTGATTAGCGGAGATGAGCTTAATAAAATTTATGACTATGCTAAAGCAGAG
GGTTTTGCTATCCCTGCTGT

Product: major antigenic peptide PEB4

Products: peptidylproline (omega=0) [C]

Alternate protein names: Major antigen peb4A

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MKKFSLVAATLIAGVVLNVNAATVATVNGKSISDTEVSEFFAPMLRGQDFKTLPDNQKKALIQQYIMQDLILQDAKKQNL
EKDPLYTKELDRAKDAILVNVYQEKILNTIKIDAAKVKAFYDQNKDKYVKPARVQAKHILVATEKEAKDIINELKGLKGK
ELDAKFSELAKEKSIDPGSKNQGGELGWFDQSTMVKPFTDAAFALKNGTITTTPVKTNFGYHVILKENSQAKGQIKFDEV
KQGIENGLKFEEFKKVINQKGQDLLNSAKVEYK

Sequences:

>Translated_273_residues
MKKFSLVAATLIAGVVLNVNAATVATVNGKSISDTEVSEFFAPMLRGQDFKTLPDNQKKALIQQYIMQDLILQDAKKQNL
EKDPLYTKELDRAKDAILVNVYQEKILNTIKIDAAKVKAFYDQNKDKYVKPARVQAKHILVATEKEAKDIINELKGLKGK
ELDAKFSELAKEKSIDPGSKNQGGELGWFDQSTMVKPFTDAAFALKNGTITTTPVKTNFGYHVILKENSQAKGQIKFDEV
KQGIENGLKFEEFKKVINQKGQDLLNSAKVEYK
>Mature_273_residues
MKKFSLVAATLIAGVVLNVNAATVATVNGKSISDTEVSEFFAPMLRGQDFKTLPDNQKKALIQQYIMQDLILQDAKKQNL
EKDPLYTKELDRAKDAILVNVYQEKILNTIKIDAAKVKAFYDQNKDKYVKPARVQAKHILVATEKEAKDIINELKGLKGK
ELDAKFSELAKEKSIDPGSKNQGGELGWFDQSTMVKPFTDAAFALKNGTITTTPVKTNFGYHVILKENSQAKGQIKFDEV
KQGIENGLKFEEFKKVINQKGQDLLNSAKVEYK

Specific function: Ppiases Accelerate The Folding Of Proteins. Seems To Be Involved In The Folding Of Outer Membrane Proteins. Its Preference At The P1 Position Of The Peptide Substrate Is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Type II Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain

Homologues:

Organism=Escherichia coli, GI1786645, Length=154, Percent_Identity=30.5194805194805, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17537235, Length=101, Percent_Identity=43.5643564356436, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CBF2_CAMJE (Q0PAS1)

Other databases:

- EMBL:   AL111168
- PIR:   S52412
- RefSeq:   YP_002344026.1
- ProteinModelPortal:   Q0PAS1
- SMR:   Q0PAS1
- MINT:   MINT-6484412
- GeneID:   904921
- GenomeReviews:   AL111168_GR
- KEGG:   cje:Cj0596
- HOGENOM:   HBG712792
- OMA:   KGAGGNR
- PhylomeDB:   Q0PAS1
- ProtClustDB:   CLSK878849
- BioCyc:   CJEJ192222:CJ0596-MONOMER
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880

Pfam domain/function: PF00639 Rotamase; SSF109998 Trigger_fac_C_bac

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 30518; Mature: 30518

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS01096 PPIC_PPIASE_1; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFSLVAATLIAGVVLNVNAATVATVNGKSISDTEVSEFFAPMLRGQDFKTLPDNQKKA
CCHHHHHHHHHHHHHHEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHH
LIQQYIMQDLILQDAKKQNLEKDPLYTKELDRAKDAILVNVYQEKILNTIKIDAAKVKAF
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDQNKDKYVKPARVQAKHILVATEKEAKDIINELKGLKGKELDAKFSELAKEKSIDPGSK
HHCCCCCCCCCHHHCEEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
NQGGELGWFDQSTMVKPFTDAAFALKNGTITTTPVKTNFGYHVILKENSQAKGQIKFDEV
CCCCCCCCCCCCCCCCCCCCHHHEEECCEEEECEEECCCCEEEEEECCCCCCCCEEHHHH
KQGIENGLKFEEFKKVINQKGQDLLNSAKVEYK
HHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCCC
>Mature Secondary Structure
MKKFSLVAATLIAGVVLNVNAATVATVNGKSISDTEVSEFFAPMLRGQDFKTLPDNQKKA
CCHHHHHHHHHHHHHHEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHH
LIQQYIMQDLILQDAKKQNLEKDPLYTKELDRAKDAILVNVYQEKILNTIKIDAAKVKAF
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDQNKDKYVKPARVQAKHILVATEKEAKDIINELKGLKGKELDAKFSELAKEKSIDPGSK
HHCCCCCCCCCHHHCEEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
NQGGELGWFDQSTMVKPFTDAAFALKNGTITTTPVKTNFGYHVILKENSQAKGQIKFDEV
CCCCCCCCCCCCCCCCCCCCHHHEEECCEEEECEEECCCCEEEEEECCCCCCCCEEHHHH
KQGIENGLKFEEFKKVINQKGQDLLNSAKVEYK
HHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10688204