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The map label for this gene is clpA [H]

Identifier: 57237990

GI number: 57237990

Start: 1166798

End: 1168927

Strand: Direct

Name: clpA [H]

Synonym: CJE1251

Alternate gene names: 57237990

Gene position: 1166798-1168927 (Clockwise)

Preceding gene: 57237989

Following gene: 57237991

Centisome position: 65.63

GC content: 28.4

Gene sequence:

>2130_bases
ATGAAATACCAAGAAAATTTACAAAAATATCTTGATAATGCCAAAAATCTAAGCTTAATAAATCACCATGAATTTGTTAC
CTGTGAGCATGTACTGTTTGCATTACTAAAACTAAGCACTGATTTTAAGGATATATTTGAAGAATTTTCAGATGGAGATC
TTGAACTTCTAGAAACTGAATTAAAAAATTACATTTCTCAAAACAATCAAGTTATTAAACAAGAAATAGAACCTACAATA
TCTGTTGTTTTAGATGAAATCTTACTTTCATCTAAAAATAAAAATAATGAAATTAAAATTATAGATTTTTTAGAAAAGCT
CATACAGGATTCAAGAAGTTATTCTAGCTATCTCTTAAAAAAACACAACATAAATCTTAACAAAATTCAAGAACTTCAAA
ATCATGAAAATATACAAAATTTAAACAACCACACAAGTGATTTAACACTTTTGGCTCAAAATGGCAAGATTGATCCTTTA
ATAGGAAGAAAATTTGAACTTGAAAGAATGATGCAAATTCTTTCACGTCGCAAGAAAAATAATCCTATTTTAGTAGGAGA
GGCAGGAGTTGGCAAAACGGCCATTGTAGAAGGATTAGCATTAGCTATTGCGGAAAAAAAGGTGCCTAAAAACTTACAAA
ATGCAAAAATTTTTAGTCTTGATATGGCTAGTATACTTGCGGGAACAAAATACCGTGGAGATTTTGAGAAAAGAATTAAA
GAAATTTTAAATGAACTTGAGAAAATACCCAATGCTATTTTATTTATTGATGAAATTCACACTATAGTAGGAGCTGGAAG
CACAGGAGAATCTCATACTGATTTTTCCAATCTTTTAAAACCAGCTCTAAGTAATGGAACTTTAAAATGCATAGGTGCAA
CAACTTTTATGGAATATAAAAATACTTTTGATAAAAATAAACCCCTAAGTCGCCGTTTTGCTAAAATAAATGTAGATGAA
CCAAGCCAAGAAGAAAGCTTGCAAATTCTTAAAGGATTAAAAAACAAATATGAAGAATTTCATCATATAAAATTAAACGA
TGAAATTCTTCAATATGCTGTAATTTGGGGTAAAAAATTTTTTAATGATAAATTTTTACCTGATTGTGCTATAGATCTGA
TCGATGAACTTGGCGCTTCTTTTGCTTTAAATCCAAAAGCTAAAAAAAATGCCAATTTAAAAGATTTAGAAAATGTTTTA
GCAAAAATGACTCACCATCACAAAATATTTGAATTCGATCAAAATAAAGCTTTAATGAATTTAAAAACAAATTTAAAAGC
AAAAATTTTTGGCCAAGATGAAGTTATAGATAGCCTTGTTTCATCACTTAAGCAAAGTTTCGCGGGGTTTAAAAATTCCA
ATACACCACGCGGAGTGTTTTTGTTTACTGGATCAAGTGGAGTTGGAAAAACAGAACTTTGCAAAGCTTTAGCTGAATTT
TTAGGTTTAAATTTAGAACGCTTTGATATGAGTGAATATGCAGAAAAACATACTATAAGTAAACTAATAGGATCTCCAGC
TGGATATATAGGTTTTGAAGAGGGTGGACTTTTAAGTAATGCTATTCGCAAAAATCCTTTCAGTCTTGTTCTTTTTGATG
AAATAGAAAAGGCTCATCCTGATTTAAGCAATACCTTTTTACAGATTTTTGACAATGCTGAACTCACCGACAATAGCGGT
CTTAAAGTAGATTTTAAAAATACAATCATTATTATGACATCTAATCTAGGACTTAAAGAAAGCAATGAGCTTGGTTTTTT
AAGTAAAAATGAAGAAAAAAGTAATCGTGCTATCAAAGATTTTTTTGCTCCAGAATTTATTAATCGCATTGATAAAATTT
TACATTTTAATGATTTAAACGATGCTATACTTGTTAAAATTATCGAAAAAGAACTTGATGAAATTTCTAAAAATTTAAAT
AATATAAAATTATCAGTGGATGATAAAGCCAAAATTTATTTAGCTAAAAAAGCCTATAATAAAGAATTTGGAGTAAGGCT
TTTAAAACGCATAATTTCTGAGGAAATAGGAGAAAAAATCAGTGATGAAATTTTATTCGGAAAGCTTAAAAAAGGCGGTA
TAGCTAAAATCAAACTTGGTAAAAATGGAAAGCTCGAATTTATATTCTAA

Upstream 100 bases:

>100_bases
GTGGCATTTACACCCAGGAAATAGCTCTTTCAAAACAAAAAAAAGTTATGGATGCGGCTAAACTTGCTAATTTTCCACTA
CAAGCAAAGGTGGAAGAAGA

Downstream 100 bases:

>100_bases
ATTACTCAATGCACCTAAAAATGCTCCTGTATTTTTAAGTCAAAATTTAGAAGCTGATTTTATTGTAAAAGCTTATACTT
TTGGTCTATTCCCATGGACA

Product: ATP-dependent Clp protease ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 709; Mature: 709

Protein sequence:

>709_residues
MKYQENLQKYLDNAKNLSLINHHEFVTCEHVLFALLKLSTDFKDIFEEFSDGDLELLETELKNYISQNNQVIKQEIEPTI
SVVLDEILLSSKNKNNEIKIIDFLEKLIQDSRSYSSYLLKKHNINLNKIQELQNHENIQNLNNHTSDLTLLAQNGKIDPL
IGRKFELERMMQILSRRKKNNPILVGEAGVGKTAIVEGLALAIAEKKVPKNLQNAKIFSLDMASILAGTKYRGDFEKRIK
EILNELEKIPNAILFIDEIHTIVGAGSTGESHTDFSNLLKPALSNGTLKCIGATTFMEYKNTFDKNKPLSRRFAKINVDE
PSQEESLQILKGLKNKYEEFHHIKLNDEILQYAVIWGKKFFNDKFLPDCAIDLIDELGASFALNPKAKKNANLKDLENVL
AKMTHHHKIFEFDQNKALMNLKTNLKAKIFGQDEVIDSLVSSLKQSFAGFKNSNTPRGVFLFTGSSGVGKTELCKALAEF
LGLNLERFDMSEYAEKHTISKLIGSPAGYIGFEEGGLLSNAIRKNPFSLVLFDEIEKAHPDLSNTFLQIFDNAELTDNSG
LKVDFKNTIIIMTSNLGLKESNELGFLSKNEEKSNRAIKDFFAPEFINRIDKILHFNDLNDAILVKIIEKELDEISKNLN
NIKLSVDDKAKIYLAKKAYNKEFGVRLLKRIISEEIGEKISDEILFGKLKKGGIAKIKLGKNGKLEFIF

Sequences:

>Translated_709_residues
MKYQENLQKYLDNAKNLSLINHHEFVTCEHVLFALLKLSTDFKDIFEEFSDGDLELLETELKNYISQNNQVIKQEIEPTI
SVVLDEILLSSKNKNNEIKIIDFLEKLIQDSRSYSSYLLKKHNINLNKIQELQNHENIQNLNNHTSDLTLLAQNGKIDPL
IGRKFELERMMQILSRRKKNNPILVGEAGVGKTAIVEGLALAIAEKKVPKNLQNAKIFSLDMASILAGTKYRGDFEKRIK
EILNELEKIPNAILFIDEIHTIVGAGSTGESHTDFSNLLKPALSNGTLKCIGATTFMEYKNTFDKNKPLSRRFAKINVDE
PSQEESLQILKGLKNKYEEFHHIKLNDEILQYAVIWGKKFFNDKFLPDCAIDLIDELGASFALNPKAKKNANLKDLENVL
AKMTHHHKIFEFDQNKALMNLKTNLKAKIFGQDEVIDSLVSSLKQSFAGFKNSNTPRGVFLFTGSSGVGKTELCKALAEF
LGLNLERFDMSEYAEKHTISKLIGSPAGYIGFEEGGLLSNAIRKNPFSLVLFDEIEKAHPDLSNTFLQIFDNAELTDNSG
LKVDFKNTIIIMTSNLGLKESNELGFLSKNEEKSNRAIKDFFAPEFINRIDKILHFNDLNDAILVKIIEKELDEISKNLN
NIKLSVDDKAKIYLAKKAYNKEFGVRLLKRIISEEIGEKISDEILFGKLKKGGIAKIKLGKNGKLEFIF
>Mature_709_residues
MKYQENLQKYLDNAKNLSLINHHEFVTCEHVLFALLKLSTDFKDIFEEFSDGDLELLETELKNYISQNNQVIKQEIEPTI
SVVLDEILLSSKNKNNEIKIIDFLEKLIQDSRSYSSYLLKKHNINLNKIQELQNHENIQNLNNHTSDLTLLAQNGKIDPL
IGRKFELERMMQILSRRKKNNPILVGEAGVGKTAIVEGLALAIAEKKVPKNLQNAKIFSLDMASILAGTKYRGDFEKRIK
EILNELEKIPNAILFIDEIHTIVGAGSTGESHTDFSNLLKPALSNGTLKCIGATTFMEYKNTFDKNKPLSRRFAKINVDE
PSQEESLQILKGLKNKYEEFHHIKLNDEILQYAVIWGKKFFNDKFLPDCAIDLIDELGASFALNPKAKKNANLKDLENVL
AKMTHHHKIFEFDQNKALMNLKTNLKAKIFGQDEVIDSLVSSLKQSFAGFKNSNTPRGVFLFTGSSGVGKTELCKALAEF
LGLNLERFDMSEYAEKHTISKLIGSPAGYIGFEEGGLLSNAIRKNPFSLVLFDEIEKAHPDLSNTFLQIFDNAELTDNSG
LKVDFKNTIIIMTSNLGLKESNELGFLSKNEEKSNRAIKDFFAPEFINRIDKILHFNDLNDAILVKIIEKELDEISKNLN
NIKLSVDDKAKIYLAKKAYNKEFGVRLLKRIISEEIGEKISDEILFGKLKKGGIAKIKLGKNGKLEFIF

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=294, Percent_Identity=34.6938775510204, Blast_Score=159, Evalue=1e-38,
Organism=Escherichia coli, GI1787109, Length=721, Percent_Identity=41.6088765603329, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1788943, Length=251, Percent_Identity=49.402390438247, Blast_Score=258, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6320464, Length=319, Percent_Identity=40.7523510971787, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6323002, Length=252, Percent_Identity=45.6349206349206, Blast_Score=223, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 80371; Mature: 80371

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYQENLQKYLDNAKNLSLINHHEFVTCEHVLFALLKLSTDFKDIFEEFSDGDLELLETE
CCHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHH
LKNYISQNNQVIKQEIEPTISVVLDEILLSSKNKNNEIKIIDFLEKLIQDSRSYSSYLLK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCHHHHHHHHH
KHNINLNKIQELQNHENIQNLNNHTSDLTLLAQNGKIDPLIGRKFELERMMQILSRRKKN
HCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCC
NPILVGEAGVGKTAIVEGLALAIAEKKVPKNLQNAKIFSLDMASILAGTKYRGDFEKRIK
CCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHCCCCCCCCHHHHHH
EILNELEKIPNAILFIDEIHTIVGAGSTGESHTDFSNLLKPALSNGTLKCIGATTFMEYK
HHHHHHHHCCCCEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHH
NTFDKNKPLSRRFAKINVDEPSQEESLQILKGLKNKYEEFHHIKLNDEILQYAVIWGKKF
HHCCCCCCHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHH
FNDKFLPDCAIDLIDELGASFALNPKAKKNANLKDLENVLAKMTHHHKIFEFDQNKALMN
CCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCHHEEECCCCEEEE
LKTNLKAKIFGQDEVIDSLVSSLKQSFAGFKNSNTPRGVFLFTGSSGVGKTELCKALAEF
ECCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
LGLNLERFDMSEYAEKHTISKLIGSPAGYIGFEEGGLLSNAIRKNPFSLVLFDEIEKAHP
HCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHCC
DLSNTFLQIFDNAELTDNSGLKVDFKNTIIIMTSNLGLKESNELGFLSKNEEKSNRAIKD
CHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
FFAPEFINRIDKILHFNDLNDAILVKIIEKELDEISKNLNNIKLSVDDKAKIYLAKKAYN
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEEHHHHC
KEFGVRLLKRIISEEIGEKISDEILFGKLKKGGIAKIKLGKNGKLEFIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEC
>Mature Secondary Structure
MKYQENLQKYLDNAKNLSLINHHEFVTCEHVLFALLKLSTDFKDIFEEFSDGDLELLETE
CCHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHH
LKNYISQNNQVIKQEIEPTISVVLDEILLSSKNKNNEIKIIDFLEKLIQDSRSYSSYLLK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCHHHHHHHHH
KHNINLNKIQELQNHENIQNLNNHTSDLTLLAQNGKIDPLIGRKFELERMMQILSRRKKN
HCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCC
NPILVGEAGVGKTAIVEGLALAIAEKKVPKNLQNAKIFSLDMASILAGTKYRGDFEKRIK
CCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHCCCCCCCCHHHHHH
EILNELEKIPNAILFIDEIHTIVGAGSTGESHTDFSNLLKPALSNGTLKCIGATTFMEYK
HHHHHHHHCCCCEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHH
NTFDKNKPLSRRFAKINVDEPSQEESLQILKGLKNKYEEFHHIKLNDEILQYAVIWGKKF
HHCCCCCCHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHH
FNDKFLPDCAIDLIDELGASFALNPKAKKNANLKDLENVLAKMTHHHKIFEFDQNKALMN
CCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCHHEEECCCCEEEE
LKTNLKAKIFGQDEVIDSLVSSLKQSFAGFKNSNTPRGVFLFTGSSGVGKTELCKALAEF
ECCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
LGLNLERFDMSEYAEKHTISKLIGSPAGYIGFEEGGLLSNAIRKNPFSLVLFDEIEKAHP
HCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHCC
DLSNTFLQIFDNAELTDNSGLKVDFKNTIIIMTSNLGLKESNELGFLSKNEEKSNRAIKD
CHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
FFAPEFINRIDKILHFNDLNDAILVKIIEKELDEISKNLNNIKLSVDDKAKIYLAKKAYN
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEEHHHHC
KEFGVRLLKRIISEEIGEKISDEILFGKLKKGGIAKIKLGKNGKLEFIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]