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The map label for this gene is cobB [H]

Identifier: 57237936

GI number: 57237936

Start: 1110507

End: 1111208

Strand: Reverse

Name: cobB [H]

Synonym: CJE1194

Alternate gene names: 57237936

Gene position: 1111208-1110507 (Counterclockwise)

Preceding gene: 57237937

Following gene: 57237935

Centisome position: 62.5

GC content: 33.9

Gene sequence:

>702_bases
ATGAAAAACATTATGATATTAAGCGGAGCGGGTTTGTCTGCTCCAAGTGGGCTTAAAACTTTTAGAGATAATGATGGACT
TTGGGAAGAATACGATGTTATGGAGGTTTGCTCTGCAACAGGTTTTAGAAAAAATCCTAAAAAAGTACTTGATTTTTACG
ATGCAAGAAGGGTACAACTTCAAAATGTAAAGCCAAATCATGCTCATGAAAAAATCGCACAATTAAAAGAAAAATGGGGT
AAAAATCTTTTTGTCATCACGCAAAATGTAGATGATTTGCTAGAGCGTGCAGGGTGTAAAGATGTAGTACATTTGCATGG
CTTTTTACCCGAACTTCGTTGCCTAAAATGTGAAGGAATTTTTAATATAGGCTATGAAAAAATCATAGATAAACAATGTC
CAAAATGCAAAAGTAAGGATTTAAGACACAATATAGTCATGTTTGAAGAGCAAGCCCCTGCTTATGCTACGCTTTATTCT
TTGCTAAATCAAACTTCGCTTTTTATCAGCATAGGCACAAGTGGGGCGGTTTTGCCTGTAGGGCGTTATGCTTCAATGTG
CGAAAAAAGTATTTTAAATATCTACGAAAAAGATGCGAATTTAGAGCGGTATTTTGATAAAATCTATATAGAAGATATTA
TAAACGCTATTGATAAAATCGCACTTGATATAGAAAATTTTATGAAAGATGGTAATGTTTGA

Upstream 100 bases:

>100_bases
ATTAGAATTTTTAGAAAAAGAAAAAGAAAAAATCTTGCAAAAATATTTATTTTCTTAAAGCATTTTTCGCTAAACTTTGT
AAATTTTATAAGGTTTAGCG

Downstream 100 bases:

>100_bases
TTCTTTTTTAAGTGGAGTTTTTTTGGGCTTTGGAGTGAGTGTTCCTTTTGGACCTGTAAATATTTTGATTTTAACTTATG
CACTAAAAGCTTTTAAAAAT

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKNIMILSGAGLSAPSGLKTFRDNDGLWEEYDVMEVCSATGFRKNPKKVLDFYDARRVQLQNVKPNHAHEKIAQLKEKWG
KNLFVITQNVDDLLERAGCKDVVHLHGFLPELRCLKCEGIFNIGYEKIIDKQCPKCKSKDLRHNIVMFEEQAPAYATLYS
LLNQTSLFISIGTSGAVLPVGRYASMCEKSILNIYEKDANLERYFDKIYIEDIINAIDKIALDIENFMKDGNV

Sequences:

>Translated_233_residues
MKNIMILSGAGLSAPSGLKTFRDNDGLWEEYDVMEVCSATGFRKNPKKVLDFYDARRVQLQNVKPNHAHEKIAQLKEKWG
KNLFVITQNVDDLLERAGCKDVVHLHGFLPELRCLKCEGIFNIGYEKIIDKQCPKCKSKDLRHNIVMFEEQAPAYATLYS
LLNQTSLFISIGTSGAVLPVGRYASMCEKSILNIYEKDANLERYFDKIYIEDIINAIDKIALDIENFMKDGNV
>Mature_233_residues
MKNIMILSGAGLSAPSGLKTFRDNDGLWEEYDVMEVCSATGFRKNPKKVLDFYDARRVQLQNVKPNHAHEKIAQLKEKWG
KNLFVITQNVDDLLERAGCKDVVHLHGFLPELRCLKCEGIFNIGYEKIIDKQCPKCKSKDLRHNIVMFEEQAPAYATLYS
LLNQTSLFISIGTSGAVLPVGRYASMCEKSILNIYEKDANLERYFDKIYIEDIINAIDKIALDIENFMKDGNV

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=197, Percent_Identity=34.5177664974619, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI13787215, Length=212, Percent_Identity=32.0754716981132, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI6912664, Length=212, Percent_Identity=32.0754716981132, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI7657575, Length=213, Percent_Identity=27.6995305164319, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI308199517, Length=202, Percent_Identity=37.6237623762376, Blast_Score=147, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17541892, Length=234, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26531; Mature: 26531

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIMILSGAGLSAPSGLKTFRDNDGLWEEYDVMEVCSATGFRKNPKKVLDFYDARRVQL
CCCEEEEECCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEE
QNVKPNHAHEKIAQLKEKWGKNLFVITQNVDDLLERAGCKDVVHLHGFLPELRCLKCEGI
CCCCCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHCCCHHHHHHHHCCCHHHEEEECCC
FNIGYEKIIDKQCPKCKSKDLRHNIVMFEEQAPAYATLYSLLNQTSLFISIGTSGAVLPV
HHCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCEEEC
GRYASMCEKSILNIYEKDANLERYFDKIYIEDIINAIDKIALDIENFMKDGNV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKNIMILSGAGLSAPSGLKTFRDNDGLWEEYDVMEVCSATGFRKNPKKVLDFYDARRVQL
CCCEEEEECCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEE
QNVKPNHAHEKIAQLKEKWGKNLFVITQNVDDLLERAGCKDVVHLHGFLPELRCLKCEGI
CCCCCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHCCCHHHHHHHHCCCHHHEEEECCC
FNIGYEKIIDKQCPKCKSKDLRHNIVMFEEQAPAYATLYSLLNQTSLFISIGTSGAVLPV
HHCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCEEEC
GRYASMCEKSILNIYEKDANLERYFDKIYIEDIINAIDKIALDIENFMKDGNV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204; 7607469 [H]