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The map label for this gene is gyrA [H]

Identifier: 57237914

GI number: 57237914

Start: 1085894

End: 1088482

Strand: Reverse

Name: gyrA [H]

Synonym: CJE1171

Alternate gene names: 57237914

Gene position: 1088482-1085894 (Counterclockwise)

Preceding gene: 57237915

Following gene: 57237913

Centisome position: 61.23

GC content: 33.37

Gene sequence:

>2589_bases
ATGGAGAATATTTTTAGCAAAGATTCTGATATTGAACTTGTAGATATAGAAAATTCTATAAAAGGTAGTTACTTAGACTA
TTCTATGAGTGTTATTATAGGTCGTGCTTTGCCTGACGCAAGAGATGGTTTAAAGCCTGTTCATAGAAGAATTTTATATG
CTATGCAAAATGATGAGGCAAAAAGTAGAACAGATTTTGTCAAATCAGCCCGTATAGTGGGTGCTGTTATAGGTCGTTAT
CATCCACATGGAGATACAGCAGTTTATGATGCTTTGGTTAGAATGGCTCAAGATTTTTCTATGAGATATCCAAGTATTAC
AGGACAAGGCAACTTTGGATCTATAGATGGTGATAGCGCTGCTGCGATGCGTTATACTGAAGCAAAAATGAGTAAACTTT
CTCATGAGCTTTTAAAAGATATAGATAAAGATACGGTCGATTTTGTTCCAAATTATGATGGTTCAGAAAGTGAACCTGAT
GTCTTACCTTCTAGGGTTCCAAATTTATTATTAAATGGTTCAAGTGGTATAGCTGTAGGTATGGCGACAAACATCCCACC
TCATAGTTTAAATGAGTTGATAGATGGACTTTTATATTTGCTTGATAGTAAAGATGTAAGCTTAGAAGAGATTATGCAGT
TTATCAAAGGTCCAGATTTTCCAACAGGTGGAATAATTTATGGTAAAAAAGGTATTATAGAAGCTTATCGCACAGGGCGT
GGTCGCGTGAAAGTGCGCGCTAAAACTCATATTGAAAAAAAGACAAATAAAGATGTTATTGTTATAGATGAGCTTCCTTA
TCAAACCAATAAAGCTAGGCTTATAGAGCAGATTGCAGAGCTTGTTAAAGAAAAGCAAATTGAAGGAATATCTGAAGTAA
GAGATGAGAGCAATAAAGAAGGAATCCGCGTTGTTATAGAGCTTAAACGTGAGGCTATGAGTGAAATTGTTTTAAACAAT
CTATTTAAATCTACTACTATGGAAAGTACTTTTGGTGTGATTATGTTGGCAATTCACAATAAAGAACCTAAAATTTTCTC
TTTGTTAGAACTTTTAAATCTTTTCTTAACCCATAGAAAAACAGTTATTATTAGAAGAACGATTTTTGAACTTCAAAAGG
CAAGAGCAAGAGCTCATATTTTAGAAGGTCTTAAAATTGCACTTGATAATATAGATGAAGTGATTGCTTTAATTAAAAAT
AGTTCTGATAATAATACCGCAAGAGATTCTTTGGTAGCTAAATTTGGTCTTAGTGAGCTTCAAGCGAATGCTATTTTAGA
TATGAAACTTGGTCGTTTAACAGGACTTGAAAGAGAAAAAATCGAAAATGAACTTGCAGAATTAATGAAAGAAATTGCAA
GACTTGAAGAAATTTTAAAAAGTGAAACCTTGCTTGAAAATTTAATTCGCGATGAATTAAAAGAAATTAGAAGTAAATTT
GATGTGCCACGTATTACTCAAATTGAAGATGATTATGATGATATTGATATTGAAGATTTGATTCCTAATGAAAATATGGT
TGTAACTATTACGCATCGTGGTTATATTAAGCGTGTGCCTAGTAAACAATATGAAAAGCAAAAACGAGGCGGAAAAGGAA
AATTAGCCGTTACGACTTATGATGATGATTTTATAGAAAGTTTCTTTACGGCAAATACACATGATACACTTATGTTTGTA
ACAGATCGTGGACAGCTTTATTGGCTTAAAGTTTATAAAATTCCTGAAGGCTCAAGAACGGCCAAAGGAAAAGCAGTGGT
AAATCTTATTAATTTACAAGCTGAAGAAAAAATCATGGCTATTATTCCAACCACGGATTTTGATGAGAGTAAATCTTTAT
GTTTCTTTACTAAAAATGGTATTGTAAAGCGTACAAATTTGAGTGAATATCAAAATATCAGAAGTGTAGGAGTTAGAGCG
ATCAACTTGGATGAAAATGATGAGTTGGTAACTGCTATTATTGTTCAAAGAGATGAAGATGAAATTTTTGCCACTGGTGG
TGAAGAAAATTTAGAAAATCAAGAAATTGAAAATTTAGATGATGAAAATCTTGAAAATGAAGAAAGTGTAAGCACACAAG
GTAAAATGCTCTTTGCAGTAACCAAAAAAGGTATGTGTATCAAATTCCCACTTGCTAAAGTGCGTGAAATCGGCCGTGTA
AGTCGTGGGGTGACGGCTATTAAGTTTAAAGAGAAAAATGACGAATTAGTAGGTGCAGTTGTTATAGAAAATGATGAGCA
AGAAATTTTAAGCATAAGTGCAAAAGGTATAGGAAAACGCACAAATGCTGGAGAATATAGATTACAAAGTAGAGGTGGTA
AGGGTGTAATTTGTATGAAACTTACAGAAAAAACCAAAGATCTTATTAGCGTAGTTATAGTAGATGAAACTATGGATTTG
ATGGCTCTTACAAGTTCAGGCAAGATGATACGTGTTGATATGCAAAGCATTAGAAAAGCAGGGCGTAATACGAGTGGTGT
CATTGTAGTTAATGTGGAAAATGACGAGGTGGTTAGCATCGCTAAGTGTCCTAAAGAGGAAAATGATGAGGATGAGTTAA
GCGATGAAAACTTTGGTTTAGATTTGTAA

Upstream 100 bases:

>100_bases
TTAGAAGAAAATAAAATTTCTGTACTTTTTGCTCTTGTTTTAGCTGATGCAAAAGTTTAATATGCTATAATCAAAACTTT
GAACTAATAGAAGGATTTTT

Downstream 100 bases:

>100_bases
TAAGTTTAAAGTTGGAACGCTTATTGCTTTTTATTTTACTAATTACAATATTTTGAAGGTGTAAAAATGAAAAAAATTTA
TTTTATGCTAGCAATAGCAG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 862; Mature: 862

Protein sequence:

>862_residues
MENIFSKDSDIELVDIENSIKGSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMQNDEAKSRTDFVKSARIVGAVIGRY
HPHGDTAVYDALVRMAQDFSMRYPSITGQGNFGSIDGDSAAAMRYTEAKMSKLSHELLKDIDKDTVDFVPNYDGSESEPD
VLPSRVPNLLLNGSSGIAVGMATNIPPHSLNELIDGLLYLLDSKDVSLEEIMQFIKGPDFPTGGIIYGKKGIIEAYRTGR
GRVKVRAKTHIEKKTNKDVIVIDELPYQTNKARLIEQIAELVKEKQIEGISEVRDESNKEGIRVVIELKREAMSEIVLNN
LFKSTTMESTFGVIMLAIHNKEPKIFSLLELLNLFLTHRKTVIIRRTIFELQKARARAHILEGLKIALDNIDEVIALIKN
SSDNNTARDSLVAKFGLSELQANAILDMKLGRLTGLEREKIENELAELMKEIARLEEILKSETLLENLIRDELKEIRSKF
DVPRITQIEDDYDDIDIEDLIPNENMVVTITHRGYIKRVPSKQYEKQKRGGKGKLAVTTYDDDFIESFFTANTHDTLMFV
TDRGQLYWLKVYKIPEGSRTAKGKAVVNLINLQAEEKIMAIIPTTDFDESKSLCFFTKNGIVKRTNLSEYQNIRSVGVRA
INLDENDELVTAIIVQRDEDEIFATGGEENLENQEIENLDDENLENEESVSTQGKMLFAVTKKGMCIKFPLAKVREIGRV
SRGVTAIKFKEKNDELVGAVVIENDEQEILSISAKGIGKRTNAGEYRLQSRGGKGVICMKLTEKTKDLISVVIVDETMDL
MALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVENDEVVSIAKCPKEENDEDELSDENFGLDL

Sequences:

>Translated_862_residues
MENIFSKDSDIELVDIENSIKGSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMQNDEAKSRTDFVKSARIVGAVIGRY
HPHGDTAVYDALVRMAQDFSMRYPSITGQGNFGSIDGDSAAAMRYTEAKMSKLSHELLKDIDKDTVDFVPNYDGSESEPD
VLPSRVPNLLLNGSSGIAVGMATNIPPHSLNELIDGLLYLLDSKDVSLEEIMQFIKGPDFPTGGIIYGKKGIIEAYRTGR
GRVKVRAKTHIEKKTNKDVIVIDELPYQTNKARLIEQIAELVKEKQIEGISEVRDESNKEGIRVVIELKREAMSEIVLNN
LFKSTTMESTFGVIMLAIHNKEPKIFSLLELLNLFLTHRKTVIIRRTIFELQKARARAHILEGLKIALDNIDEVIALIKN
SSDNNTARDSLVAKFGLSELQANAILDMKLGRLTGLEREKIENELAELMKEIARLEEILKSETLLENLIRDELKEIRSKF
DVPRITQIEDDYDDIDIEDLIPNENMVVTITHRGYIKRVPSKQYEKQKRGGKGKLAVTTYDDDFIESFFTANTHDTLMFV
TDRGQLYWLKVYKIPEGSRTAKGKAVVNLINLQAEEKIMAIIPTTDFDESKSLCFFTKNGIVKRTNLSEYQNIRSVGVRA
INLDENDELVTAIIVQRDEDEIFATGGEENLENQEIENLDDENLENEESVSTQGKMLFAVTKKGMCIKFPLAKVREIGRV
SRGVTAIKFKEKNDELVGAVVIENDEQEILSISAKGIGKRTNAGEYRLQSRGGKGVICMKLTEKTKDLISVVIVDETMDL
MALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVENDEVVSIAKCPKEENDEDELSDENFGLDL
>Mature_862_residues
MENIFSKDSDIELVDIENSIKGSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMQNDEAKSRTDFVKSARIVGAVIGRY
HPHGDTAVYDALVRMAQDFSMRYPSITGQGNFGSIDGDSAAAMRYTEAKMSKLSHELLKDIDKDTVDFVPNYDGSESEPD
VLPSRVPNLLLNGSSGIAVGMATNIPPHSLNELIDGLLYLLDSKDVSLEEIMQFIKGPDFPTGGIIYGKKGIIEAYRTGR
GRVKVRAKTHIEKKTNKDVIVIDELPYQTNKARLIEQIAELVKEKQIEGISEVRDESNKEGIRVVIELKREAMSEIVLNN
LFKSTTMESTFGVIMLAIHNKEPKIFSLLELLNLFLTHRKTVIIRRTIFELQKARARAHILEGLKIALDNIDEVIALIKN
SSDNNTARDSLVAKFGLSELQANAILDMKLGRLTGLEREKIENELAELMKEIARLEEILKSETLLENLIRDELKEIRSKF
DVPRITQIEDDYDDIDIEDLIPNENMVVTITHRGYIKRVPSKQYEKQKRGGKGKLAVTTYDDDFIESFFTANTHDTLMFV
TDRGQLYWLKVYKIPEGSRTAKGKAVVNLINLQAEEKIMAIIPTTDFDESKSLCFFTKNGIVKRTNLSEYQNIRSVGVRA
INLDENDELVTAIIVQRDEDEIFATGGEENLENQEIENLDDENLENEESVSTQGKMLFAVTKKGMCIKFPLAKVREIGRV
SRGVTAIKFKEKNDELVGAVVIENDEQEILSISAKGIGKRTNAGEYRLQSRGGKGVICMKLTEKTKDLISVVIVDETMDL
MALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVENDEVVSIAKCPKEENDEDELSDENFGLDL

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=344, Percent_Identity=26.1627906976744, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI19913408, Length=309, Percent_Identity=25.2427184466019, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788562, Length=882, Percent_Identity=47.0521541950113, Blast_Score=797, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=659, Percent_Identity=36.4188163884674, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI212645845, Length=197, Percent_Identity=30.4568527918782, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=274, Percent_Identity=27.7372262773723, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=275, Percent_Identity=27.6363636363636, Blast_Score=79, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=333, Percent_Identity=26.1261261261261, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136538, Length=364, Percent_Identity=24.7252747252747, Blast_Score=77, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96790; Mature: 96790

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENIFSKDSDIELVDIENSIKGSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMQNDEA
CCCCCCCCCCEEEEECCCCCCCCCHHEEEEHEEECCCCCHHCCHHHHHHHHHHHHCCCCH
KSRTDFVKSARIVGAVIGRYHPHGDTAVYDALVRMAQDFSMRYPSITGQGNFGSIDGDSA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
AAMRYTEAKMSKLSHELLKDIDKDTVDFVPNYDGSESEPDVLPSRVPNLLLNGSSGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEE
MATNIPPHSLNELIDGLLYLLDSKDVSLEEIMQFIKGPDFPTGGIIYGKKGIIEAYRTGR
EECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCHHHHHHHCCC
GRVKVRAKTHIEKKTNKDVIVIDELPYQTNKARLIEQIAELVKEKQIEGISEVRDESNKE
CEEEEEEEHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCC
GIRVVIELKREAMSEIVLNNLFKSTTMESTFGVIMLAIHNKEPKIFSLLELLNLFLTHRK
CEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCH
TVIIRRTIFELQKARARAHILEGLKIALDNIDEVIALIKNSSDNNTARDSLVAKFGLSEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHH
QANAILDMKLGRLTGLEREKIENELAELMKEIARLEEILKSETLLENLIRDELKEIRSKF
HHHHEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DVPRITQIEDDYDDIDIEDLIPNENMVVTITHRGYIKRVPSKQYEKQKRGGKGKLAVTTY
CCCCEEECCCCCCCCCHHHCCCCCCEEEEEECCCHHHCCCCHHHHHHHCCCCCCEEEEEC
DDDFIESFFTANTHDTLMFVTDRGQLYWLKVYKIPEGSRTAKGKAVVNLINLQAEEKIMA
CHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCHHEEEEEECCCCCCEEE
IIPTTDFDESKSLCFFTKNGIVKRTNLSEYQNIRSVGVRAINLDENDELVTAIIVQRDED
EECCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHCEEEEECCCCCCEEEEEEEECCCC
EIFATGGEENLENQEIENLDDENLENEESVSTQGKMLFAVTKKGMCIKFPLAKVREIGRV
CEEECCCCCCCCCCHHHCCCCCCCCCCHHHCCCCCEEEEEECCCCEEECCHHHHHHHHHH
SRGVTAIKFKEKNDELVGAVVIENDEQEILSISAKGIGKRTNAGEYRLQSRGGKGVICMK
HCCEEEEEEECCCCCEEEEEEEECCCHHHHEEHHCCCCCCCCCCCEEEECCCCCEEEEEE
LTEKTKDLISVVIVDETMDLMALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVENDEVVSI
ECHHHHHHEEEEEECCCCCEEEEECCCCEEEEEHHHHHHCCCCCCCEEEEEECCCCEEEH
AKCPKEENDEDELSDENFGLDL
HHCCCCCCCHHHCCCCCCCCCC
>Mature Secondary Structure
MENIFSKDSDIELVDIENSIKGSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMQNDEA
CCCCCCCCCCEEEEECCCCCCCCCHHEEEEHEEECCCCCHHCCHHHHHHHHHHHHCCCCH
KSRTDFVKSARIVGAVIGRYHPHGDTAVYDALVRMAQDFSMRYPSITGQGNFGSIDGDSA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
AAMRYTEAKMSKLSHELLKDIDKDTVDFVPNYDGSESEPDVLPSRVPNLLLNGSSGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEE
MATNIPPHSLNELIDGLLYLLDSKDVSLEEIMQFIKGPDFPTGGIIYGKKGIIEAYRTGR
EECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCHHHHHHHCCC
GRVKVRAKTHIEKKTNKDVIVIDELPYQTNKARLIEQIAELVKEKQIEGISEVRDESNKE
CEEEEEEEHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCC
GIRVVIELKREAMSEIVLNNLFKSTTMESTFGVIMLAIHNKEPKIFSLLELLNLFLTHRK
CEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCH
TVIIRRTIFELQKARARAHILEGLKIALDNIDEVIALIKNSSDNNTARDSLVAKFGLSEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHH
QANAILDMKLGRLTGLEREKIENELAELMKEIARLEEILKSETLLENLIRDELKEIRSKF
HHHHEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DVPRITQIEDDYDDIDIEDLIPNENMVVTITHRGYIKRVPSKQYEKQKRGGKGKLAVTTY
CCCCEEECCCCCCCCCHHHCCCCCCEEEEEECCCHHHCCCCHHHHHHHCCCCCCEEEEEC
DDDFIESFFTANTHDTLMFVTDRGQLYWLKVYKIPEGSRTAKGKAVVNLINLQAEEKIMA
CHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCHHEEEEEECCCCCCEEE
IIPTTDFDESKSLCFFTKNGIVKRTNLSEYQNIRSVGVRAINLDENDELVTAIIVQRDED
EECCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHCEEEEECCCCCCEEEEEEEECCCC
EIFATGGEENLENQEIENLDDENLENEESVSTQGKMLFAVTKKGMCIKFPLAKVREIGRV
CEEECCCCCCCCCCHHHCCCCCCCCCCHHHCCCCCEEEEEECCCCEEECCHHHHHHHHHH
SRGVTAIKFKEKNDELVGAVVIENDEQEILSISAKGIGKRTNAGEYRLQSRGGKGVICMK
HCCEEEEEEECCCCCEEEEEEEECCCHHHHEEHHCCCCCCCCCCCEEEECCCCCEEEEEE
LTEKTKDLISVVIVDETMDLMALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVENDEVVSI
ECHHHHHHEEEEEECCCCCEEEEECCCCEEEEEHHHHHHCCCCCCCEEEEEECCCCEEEH
AKCPKEENDEDELSDENFGLDL
HHCCCCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8384814; 10688204 [H]