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The map label for this gene is livM [H]

Identifier: 57237903

GI number: 57237903

Start: 1077052

End: 1078104

Strand: Reverse

Name: livM [H]

Synonym: CJE1160

Alternate gene names: 57237903

Gene position: 1078104-1077052 (Counterclockwise)

Preceding gene: 57237904

Following gene: 57237902

Centisome position: 60.64

GC content: 32.19

Gene sequence:

>1053_bases
ATGATGGTTAGAATTAAGGTTTCACATTTAATCTTTTTAATTGCTTCAATTATTTTTATTTTCATTTCTCCTTATATTTT
TGGGGACTATGGATTAAACATTGTTAATCAAATTGCTATTTTTATTATTTTGGCTGTGAGTTACAACCTTATTAATGGTG
TAACTGGACAATTTTCACTAGAACCCAATGGATTTGTTGCGATTGGAGCTTATGTGGCTGCTTTAGTTCTTTTAAGTGCT
GATGCAAAAAATGATCAGTTTTTTTTAGATGGTCCTAGTTCTTTTATTTTAGCTATCCATTCAAATTCCTTTATTCTAGC
TTTAATTATGGCTGGAATTTGTTCATCTTTACTTGCCCTGATTTTGGCTTTTGCTGTATTTCGCGTGAGAGGGGATTATT
TGGCTATTGTAACTTTAGGCTTTGGAATAATTATTAAAATAGCTGCTATTAATTTTCCTTCTATTACTAATGGCTCAAGA
GGGCTGGTAGATATTCCACAATTTTCCACGATCTATTGGACAGGTGGTATTGCTATTGTAGCGGTTATTTTAATTTTAAA
TATAGTTTATTCTAAATATGGTCGTGCAATGAAGGCTATAAGAGATGATGAAGATGCTGCAAGCGCTATGGGAATAAATA
CTTTTTGGATAAAAACTTTAGCTTTTAGCACTTCAGCATTTTTAGAAGGTGTAGGTGGCGGACTTTTAGCTTGTCTGTTG
ACTACCGTATCTCCAACTCAATTTGATTTTTTACTTACTTTTCAGCTTTTGATTATTATTGTTTTAGGTGGACTTGGTTC
TACTACAGGTGCTATTATAGGTGCGATATTGGTTATTGGTGGAAGTGAGTGGCTTAGATTTTTAGATGAGTTAAATATAA
AAATAGATTCTTTAAATCTTTATATCCAATCAACGCCAGGGCTTAGAATGGTTGTTTTTTCTATTGTTCTGATTTTAGTA
ATGCTTTTTGCAAGAAAAGGCATAATGGGTTATTATGAGTTGAGTGATGTGATTAGAGGGATTAAAAAGCGTTTTAAAAG
GAGCAAAAAATGA

Upstream 100 bases:

>100_bases
CAGGCTTTAAAGATGCATTTGCTTTTATTTTTTTGGTGTTTATATTGTTATTTAGGCCTACGGGAATTTTAGGTATAAAT
TTTGAAAAGAGTAGGTTTTA

Downstream 100 bases:

>100_bases
TTTTGGAATTAAAACAAATTTCAAAAAGTTTTGGTAGTGTTAAGGCTATTAATGAAACTTCTTTTAAAATCAATGAGGGT
GAAATTTTTGCTTTAATTGG

Product: high affinity branched-chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MMVRIKVSHLIFLIASIIFIFISPYIFGDYGLNIVNQIAIFIILAVSYNLINGVTGQFSLEPNGFVAIGAYVAALVLLSA
DAKNDQFFLDGPSSFILAIHSNSFILALIMAGICSSLLALILAFAVFRVRGDYLAIVTLGFGIIIKIAAINFPSITNGSR
GLVDIPQFSTIYWTGGIAIVAVILILNIVYSKYGRAMKAIRDDEDAASAMGINTFWIKTLAFSTSAFLEGVGGGLLACLL
TTVSPTQFDFLLTFQLLIIIVLGGLGSTTGAIIGAILVIGGSEWLRFLDELNIKIDSLNLYIQSTPGLRMVVFSIVLILV
MLFARKGIMGYYELSDVIRGIKKRFKRSKK

Sequences:

>Translated_350_residues
MMVRIKVSHLIFLIASIIFIFISPYIFGDYGLNIVNQIAIFIILAVSYNLINGVTGQFSLEPNGFVAIGAYVAALVLLSA
DAKNDQFFLDGPSSFILAIHSNSFILALIMAGICSSLLALILAFAVFRVRGDYLAIVTLGFGIIIKIAAINFPSITNGSR
GLVDIPQFSTIYWTGGIAIVAVILILNIVYSKYGRAMKAIRDDEDAASAMGINTFWIKTLAFSTSAFLEGVGGGLLACLL
TTVSPTQFDFLLTFQLLIIIVLGGLGSTTGAIIGAILVIGGSEWLRFLDELNIKIDSLNLYIQSTPGLRMVVFSIVLILV
MLFARKGIMGYYELSDVIRGIKKRFKRSKK
>Mature_350_residues
MMVRIKVSHLIFLIASIIFIFISPYIFGDYGLNIVNQIAIFIILAVSYNLINGVTGQFSLEPNGFVAIGAYVAALVLLSA
DAKNDQFFLDGPSSFILAIHSNSFILALIMAGICSSLLALILAFAVFRVRGDYLAIVTLGFGIIIKIAAINFPSITNGSR
GLVDIPQFSTIYWTGGIAIVAVILILNIVYSKYGRAMKAIRDDEDAASAMGINTFWIKTLAFSTSAFLEGVGGGLLACLL
TTVSPTQFDFLLTFQLLIIIVLGGLGSTTGAIIGAILVIGGSEWLRFLDELNIKIDSLNLYIQSTPGLRMVVFSIVLILV
MLFARKGIMGYYELSDVIRGIKKRFKRSKK

Specific function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=304, Percent_Identity=31.25, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 37966; Mature: 37966

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVRIKVSHLIFLIASIIFIFISPYIFGDYGLNIVNQIAIFIILAVSYNLINGVTGQFSL
CEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
EPNGFVAIGAYVAALVLLSADAKNDQFFLDGPSSFILAIHSNSFILALIMAGICSSLLAL
CCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHH
ILAFAVFRVRGDYLAIVTLGFGIIIKIAAINFPSITNGSRGLVDIPQFSTIYWTGGIAIV
HHHHHHHHHCCCEEEEHHHHHHHHHHHHEECCCCCCCCCCCCEECCCCCEEEEECHHHHH
AVILILNIVYSKYGRAMKAIRDDEDAASAMGINTFWIKTLAFSTSAFLEGVGGGLLACLL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TTVSPTQFDFLLTFQLLIIIVLGGLGSTTGAIIGAILVIGGSEWLRFLDELNIKIDSLNL
HHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEE
YIQSTPGLRMVVFSIVLILVMLFARKGIMGYYELSDVIRGIKKRFKRSKK
EEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMVRIKVSHLIFLIASIIFIFISPYIFGDYGLNIVNQIAIFIILAVSYNLINGVTGQFSL
CEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
EPNGFVAIGAYVAALVLLSADAKNDQFFLDGPSSFILAIHSNSFILALIMAGICSSLLAL
CCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHH
ILAFAVFRVRGDYLAIVTLGFGIIIKIAAINFPSITNGSRGLVDIPQFSTIYWTGGIAIV
HHHHHHHHHCCCEEEEHHHHHHHHHHHHEECCCCCCCCCCCCEECCCCCEEEEECHHHHH
AVILILNIVYSKYGRAMKAIRDDEDAASAMGINTFWIKTLAFSTSAFLEGVGGGLLACLL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TTVSPTQFDFLLTFQLLIIIVLGGLGSTTGAIIGAILVIGGSEWLRFLDELNIKIDSLNL
HHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEE
YIQSTPGLRMVVFSIVLILVMLFARKGIMGYYELSDVIRGIKKRFKRSKK
EEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2120183; 10984043 [H]