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The map label for this gene is serA [H]

Identifier: 57237720

GI number: 57237720

Start: 908321

End: 909904

Strand: Reverse

Name: serA [H]

Synonym: CJE0970

Alternate gene names: 57237720

Gene position: 909904-908321 (Counterclockwise)

Preceding gene: 57237721

Following gene: 57237719

Centisome position: 51.18

GC content: 32.83

Gene sequence:

>1584_bases
ATGAAAAAAAAGATTATAGTGTGTGATGCTATTTTGGATAAAGGTGTCGATATTCTAAGAAAAGCTGAAGATATTGAGCT
TATAGAAGCTGCAAAATTTCCAAAAGATGAACTTATGCAAATGCTAAGCGATATTGAAGTTGCAATTACTAGAAGTTCTA
CGGATGTAGATGTAAATTTTTTAAATCATGCCAAAAAATTAAAAGCGCTTGTGCGTGCTGGGGTGGGCGTAGATAATGTT
GATATTCCAGAGTGTTCTAAACGAGGAGTGATTGTGATGAATGTCCCAACTGCAAATACTATTGCCGCAGTTGAACTAAC
AATGGCACATCTTTTAACATCAGCTAGAAGCTTTGTCAATGCTCATAATTTTTTAAAAATTGAAAGAAAATGGGAAAGAG
AAAAATGGTATGGCATTGAATTGATGAATAAAACGCTAGGGGTTATAGGTTTTGGAAATATAGGTTCAAGAGTAGCTATC
CGTGCTAAAGCATTTGGTATGAAAATTTTAGCCTATGATCCGTATATTTCTGCTTCTAAGATTACAGATTTAGATATGGA
ACAAGCAAAAAATTTGGATGAAATTTTAGAAAAAAGTGATTTTATTACCATTCACACACCAAAAACCAAAGAAACCAATG
GTATGATAGGAAAGCAAGAAATTGCAAAAATGAAAGATGGAATAAGATTAATAAATTGTGCTCGCGGAGGATTATACACA
GAAGAGGCTTTATATGAAGGTTTAAAAAGTGGTAAAATAGCATGGCTTGGTATAGATGTGTTCGATAAAGAACCCGCAAC
CAATCATCCTCTTTTAGACTTTGAAAATATTTCAGTTACTTCTCACCTAGGAGCAAATACTTTAGAAAGTCAAGACAATA
TCGCAAGAGAAGCTTGTGAGCAAGCATTAAGTGCAGCACGAGGCGTGGCTTATCCTAATGCCTTAAATTTACCAATTAAA
ACTGAAGACTTACCACCTTTTGTAGCTCCTTATATAGAACTTGTTTCTAAAATGGCTTTTTTAGCTGTTCAAATTGATAA
AAATCCTATAAAAAGTATTAAATTAGAGGCTGAAGGAATTATTGGTGAGTATGCAAATTCTATGCTAACTTTTGCAGCTG
TTGGTGCTTTGGGTGGAATTTTAGGAGAGAAAATTAATTATGTTAATGCAGAATTTGTTGCCAAAGAAAAAGGAGTTGAA
TTATCTTGCGAAACTCTTCCAAATAGTGGTTATAATAATAAACTTAGCGTTAAAATTATCACCGAAAATTCAAATATCAG
TGTTTCAGGAACAGTGTTTAATGAAAATGAACAACGCATAGTTGGATTAAATGGCTTTAAAACTGATTTTAAGCCAAAGG
GAAAAATGATTATTTTTAAAAACAAAGACATACCAGGAGTTATAGCTAAAATCAGTTCCGTTTTGGCAGCTAAAAATATC
AACATAGCTGATTTTAGGCTTGGTAGAGATGGTTTTGGGTATGCTTTGGCTGTTGTTTTGATTGATGAAAAAGTTCAAAA
AGAAGTATTAGATGAACTAAAACAATTAGAGGCGTGTGTATTTGTCCAATATGTTGAAATTTAA

Upstream 100 bases:

>100_bases
CAGAAATCTTTTTGGATACAGGCAATGAAAAACTTATAGATGATATTATCAAAGAATTAAAAAAATATAAAATAAATACA
GAAGTAAAGGAAATTTGGTT

Downstream 100 bases:

>100_bases
AATTTTAATTATAGAAGATGATATAGATTTAAACGAACTGCTTGTTTTAAAGTTAAAATCTAGTGGTTATGAAGTTATAT
CTTTAGCGGATTTTTTTGGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MKKKIIVCDAILDKGVDILRKAEDIELIEAAKFPKDELMQMLSDIEVAITRSSTDVDVNFLNHAKKLKALVRAGVGVDNV
DIPECSKRGVIVMNVPTANTIAAVELTMAHLLTSARSFVNAHNFLKIERKWEREKWYGIELMNKTLGVIGFGNIGSRVAI
RAKAFGMKILAYDPYISASKITDLDMEQAKNLDEILEKSDFITIHTPKTKETNGMIGKQEIAKMKDGIRLINCARGGLYT
EEALYEGLKSGKIAWLGIDVFDKEPATNHPLLDFENISVTSHLGANTLESQDNIAREACEQALSAARGVAYPNALNLPIK
TEDLPPFVAPYIELVSKMAFLAVQIDKNPIKSIKLEAEGIIGEYANSMLTFAAVGALGGILGEKINYVNAEFVAKEKGVE
LSCETLPNSGYNNKLSVKIITENSNISVSGTVFNENEQRIVGLNGFKTDFKPKGKMIIFKNKDIPGVIAKISSVLAAKNI
NIADFRLGRDGFGYALAVVLIDEKVQKEVLDELKQLEACVFVQYVEI

Sequences:

>Translated_527_residues
MKKKIIVCDAILDKGVDILRKAEDIELIEAAKFPKDELMQMLSDIEVAITRSSTDVDVNFLNHAKKLKALVRAGVGVDNV
DIPECSKRGVIVMNVPTANTIAAVELTMAHLLTSARSFVNAHNFLKIERKWEREKWYGIELMNKTLGVIGFGNIGSRVAI
RAKAFGMKILAYDPYISASKITDLDMEQAKNLDEILEKSDFITIHTPKTKETNGMIGKQEIAKMKDGIRLINCARGGLYT
EEALYEGLKSGKIAWLGIDVFDKEPATNHPLLDFENISVTSHLGANTLESQDNIAREACEQALSAARGVAYPNALNLPIK
TEDLPPFVAPYIELVSKMAFLAVQIDKNPIKSIKLEAEGIIGEYANSMLTFAAVGALGGILGEKINYVNAEFVAKEKGVE
LSCETLPNSGYNNKLSVKIITENSNISVSGTVFNENEQRIVGLNGFKTDFKPKGKMIIFKNKDIPGVIAKISSVLAAKNI
NIADFRLGRDGFGYALAVVLIDEKVQKEVLDELKQLEACVFVQYVEI
>Mature_527_residues
MKKKIIVCDAILDKGVDILRKAEDIELIEAAKFPKDELMQMLSDIEVAITRSSTDVDVNFLNHAKKLKALVRAGVGVDNV
DIPECSKRGVIVMNVPTANTIAAVELTMAHLLTSARSFVNAHNFLKIERKWEREKWYGIELMNKTLGVIGFGNIGSRVAI
RAKAFGMKILAYDPYISASKITDLDMEQAKNLDEILEKSDFITIHTPKTKETNGMIGKQEIAKMKDGIRLINCARGGLYT
EEALYEGLKSGKIAWLGIDVFDKEPATNHPLLDFENISVTSHLGANTLESQDNIAREACEQALSAARGVAYPNALNLPIK
TEDLPPFVAPYIELVSKMAFLAVQIDKNPIKSIKLEAEGIIGEYANSMLTFAAVGALGGILGEKINYVNAEFVAKEKGVE
LSCETLPNSGYNNKLSVKIITENSNISVSGTVFNENEQRIVGLNGFKTDFKPKGKMIIFKNKDIPGVIAKISSVLAAKNI
NIADFRLGRDGFGYALAVVLIDEKVQKEVLDELKQLEACVFVQYVEI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=410, Percent_Identity=35.1219512195122, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI61743967, Length=245, Percent_Identity=34.2857142857143, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4557497, Length=245, Percent_Identity=34.2857142857143, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI145580578, Length=226, Percent_Identity=34.5132743362832, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI4557499, Length=226, Percent_Identity=34.5132743362832, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI6912396, Length=322, Percent_Identity=31.055900621118, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI145580575, Length=226, Percent_Identity=34.5132743362832, Blast_Score=129, Evalue=7e-30,
Organism=Escherichia coli, GI1789279, Length=325, Percent_Identity=32.3076923076923, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=30.4615384615385, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1787645, Length=267, Percent_Identity=29.9625468164794, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788660, Length=290, Percent_Identity=28.6206896551724, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87081824, Length=231, Percent_Identity=26.4069264069264, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=306, Percent_Identity=38.2352941176471, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI25147481, Length=252, Percent_Identity=27.7777777777778, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=280, Percent_Identity=33.5714285714286, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6322116, Length=280, Percent_Identity=32.5, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324964, Length=289, Percent_Identity=31.1418685121107, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324055, Length=328, Percent_Identity=27.7439024390244, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324980, Length=177, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=32.2147651006711, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=168, Percent_Identity=29.7619047619048, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=303, Percent_Identity=38.6138613861386, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI28574286, Length=317, Percent_Identity=31.2302839116719, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI28574284, Length=314, Percent_Identity=27.3885350318471, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45551003, Length=314, Percent_Identity=27.3885350318471, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24585514, Length=314, Percent_Identity=27.3885350318471, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574282, Length=314, Percent_Identity=27.3885350318471, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45552429, Length=314, Percent_Identity=27.3885350318471, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646446, Length=226, Percent_Identity=33.1858407079646, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646448, Length=226, Percent_Identity=33.1858407079646, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646452, Length=226, Percent_Identity=33.1858407079646, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646450, Length=226, Percent_Identity=33.1858407079646, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI62472511, Length=226, Percent_Identity=33.1858407079646, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28571528, Length=301, Percent_Identity=30.5647840531561, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585516, Length=295, Percent_Identity=27.1186440677966, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 57930; Mature: 57930

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKIIVCDAILDKGVDILRKAEDIELIEAAKFPKDELMQMLSDIEVAITRSSTDVDVNF
CCCEEEEEHHHHHCCHHHHHCCCCHHHHHHCCCCHHHHHHHHCCCEEEEEECCCCEEHHH
LNHAKKLKALVRAGVGVDNVDIPECSKRGVIVMNVPTANTIAAVELTMAHLLTSARSFVN
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
AHNFLKIERKWEREKWYGIELMNKTLGVIGFGNIGSRVAIRAKAFGMKILAYDPYISASK
HHHEEEEEEHHCCCCCCCCEECCCCCCEEEECCCCCEEEEEEHHHCEEEEEECCCCCCCC
ITDLDMEQAKNLDEILEKSDFITIHTPKTKETNGMIGKQEIAKMKDGIRLINCARGGLYT
CCCCCHHHHCCHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCH
EEALYEGLKSGKIAWLGIDVFDKEPATNHPLLDFENISVTSHLGANTLESQDNIAREACE
HHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEECCCEEECCCCCCCCCCHHHHHHHHHH
QALSAARGVAYPNALNLPIKTEDLPPFVAPYIELVSKMAFLAVQIDKNPIKSIKLEAEGI
HHHHHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHEEEEEEECCCCCCEEEEECCHH
IGEYANSMLTFAAVGALGGILGEKINYVNAEFVAKEKGVELSCETLPNSGYNNKLSVKII
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCCEEEEEECCCCCCCCEEEEEEE
TENSNISVSGTVFNENEQRIVGLNGFKTDFKPKGKMIIFKNKDIPGVIAKISSVLAAKNI
EECCCEEEEEEEECCCCCEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
NIADFRLGRDGFGYALAVVLIDEKVQKEVLDELKQLEACVFVQYVEI
CEEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MKKKIIVCDAILDKGVDILRKAEDIELIEAAKFPKDELMQMLSDIEVAITRSSTDVDVNF
CCCEEEEEHHHHHCCHHHHHCCCCHHHHHHCCCCHHHHHHHHCCCEEEEEECCCCEEHHH
LNHAKKLKALVRAGVGVDNVDIPECSKRGVIVMNVPTANTIAAVELTMAHLLTSARSFVN
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
AHNFLKIERKWEREKWYGIELMNKTLGVIGFGNIGSRVAIRAKAFGMKILAYDPYISASK
HHHEEEEEEHHCCCCCCCCEECCCCCCEEEECCCCCEEEEEEHHHCEEEEEECCCCCCCC
ITDLDMEQAKNLDEILEKSDFITIHTPKTKETNGMIGKQEIAKMKDGIRLINCARGGLYT
CCCCCHHHHCCHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCH
EEALYEGLKSGKIAWLGIDVFDKEPATNHPLLDFENISVTSHLGANTLESQDNIAREACE
HHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEECCCEEECCCCCCCCCCHHHHHHHHHH
QALSAARGVAYPNALNLPIKTEDLPPFVAPYIELVSKMAFLAVQIDKNPIKSIKLEAEGI
HHHHHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHEEEEEEECCCCCCEEEEECCHH
IGEYANSMLTFAAVGALGGILGEKINYVNAEFVAKEKGVELSCETLPNSGYNNKLSVKII
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCCEEEEEECCCCCCCCEEEEEEE
TENSNISVSGTVFNENEQRIVGLNGFKTDFKPKGKMIIFKNKDIPGVIAKISSVLAAKNI
EECCCEEEEEEEECCCCCEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
NIADFRLGRDGFGYALAVVLIDEKVQKEVLDELKQLEACVFVQYVEI
CEEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]