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The map label for this gene is tmk [H]

Identifier: 57237611

GI number: 57237611

Start: 796288

End: 796866

Strand: Reverse

Name: tmk [H]

Synonym: CJE0857

Alternate gene names: 57237611

Gene position: 796866-796288 (Counterclockwise)

Preceding gene: 57237612

Following gene: 57237610

Centisome position: 44.82

GC content: 29.53

Gene sequence:

>579_bases
TTGTATGTAGTTTTTGAAGGTATTGACTGCGTAGGAAAAAGTACGCAAATTTCACTTTTAAAAGAAATTTATAAAGACGC
CATTTTCACACTCGAACCTGGCGGAACAGAACTTGGAAAACATTTAAGAGAAATTTTACTTAATAAAACTCATCCTATTA
ACAAAAGAGCTGAACTCTTGCTTTTTTTAGCTGATCGTGCTCAACATTTTGAAGAAATCTTAAAAACCAATCAAAACAAA
CTCATTATTAGCGATAGAAGTTTTATTTCAGGCATGGCTTATGCCAAAGATTTTGAAAACGATTTGCTTTTTGCTTTAAA
TAGTTTTGCTTTAGAAAATTTTTTTCCACAAAAAATTATCTTTTTAAAAGGAGATGCAAACCTTATCCAAGAACGCCTCA
GTCAAAAAGAACTAGATAGTATAGAAAAACGTGGCATTGAGTATTTTTTAAGCGTGCAAGATAAACTCGAAAAAGTGCTT
CATTTTTTAAAAGAAAAAATTTCTGTAGAAATTTTAACACTTGACGCAAAAGAAAGTAAAGAAAAATTACACCAACAAAT
AAAGGAATTTTTACAATGA

Upstream 100 bases:

>100_bases
CTTTTATTTCAAGTTCTATTGTGCGTTCTATAGTAGCACATGGGGGTGATGTAAGTTCTCTTGTTCCAAAAGAAATTCTA
CCTTTTTTAAAGGATCAATC

Downstream 100 bases:

>100_bases
TTAACGCTTTAAAAGGAATGAAAGATTTATTAGATAAAGATGCATATTATTATGAAAAAGTGATTAAAATCTGCGAAGAA
GTAGCTAAAAACTATGGCTT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MYVVFEGIDCVGKSTQISLLKEIYKDAIFTLEPGGTELGKHLREILLNKTHPINKRAELLLFLADRAQHFEEILKTNQNK
LIISDRSFISGMAYAKDFENDLLFALNSFALENFFPQKIIFLKGDANLIQERLSQKELDSIEKRGIEYFLSVQDKLEKVL
HFLKEKISVEILTLDAKESKEKLHQQIKEFLQ

Sequences:

>Translated_192_residues
MYVVFEGIDCVGKSTQISLLKEIYKDAIFTLEPGGTELGKHLREILLNKTHPINKRAELLLFLADRAQHFEEILKTNQNK
LIISDRSFISGMAYAKDFENDLLFALNSFALENFFPQKIIFLKGDANLIQERLSQKELDSIEKRGIEYFLSVQDKLEKVL
HFLKEKISVEILTLDAKESKEKLHQQIKEFLQ
>Mature_192_residues
MYVVFEGIDCVGKSTQISLLKEIYKDAIFTLEPGGTELGKHLREILLNKTHPINKRAELLLFLADRAQHFEEILKTNQNK
LIISDRSFISGMAYAKDFENDLLFALNSFALENFFPQKIIFLKGDANLIQERLSQKELDSIEKRGIEYFLSVQDKLEKVL
HFLKEKISVEILTLDAKESKEKLHQQIKEFLQ

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=209, Percent_Identity=28.2296650717703, Blast_Score=76, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22275; Mature: 22275

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVVFEGIDCVGKSTQISLLKEIYKDAIFTLEPGGTELGKHLREILLNKTHPINKRAELL
CEEEEECCCCCCCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHH
LFLADRAQHFEEILKTNQNKLIISDRSFISGMAYAKDFENDLLFALNSFALENFFPQKII
HHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEE
FLKGDANLIQERLSQKELDSIEKRGIEYFLSVQDKLEKVLHFLKEKISVEILTLDAKESK
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHH
EKLHQQIKEFLQ
HHHHHHHHHHHC
>Mature Secondary Structure
MYVVFEGIDCVGKSTQISLLKEIYKDAIFTLEPGGTELGKHLREILLNKTHPINKRAELL
CEEEEECCCCCCCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHH
LFLADRAQHFEEILKTNQNKLIISDRSFISGMAYAKDFENDLLFALNSFALENFFPQKII
HHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEE
FLKGDANLIQERLSQKELDSIEKRGIEYFLSVQDKLEKVLHFLKEKISVEILTLDAKESK
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHH
EKLHQQIKEFLQ
HHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA