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The map label for this gene is hisS [H]

Identifier: 57237610

GI number: 57237610

Start: 795065

End: 796291

Strand: Reverse

Name: hisS [H]

Synonym: CJE0856

Alternate gene names: 57237610

Gene position: 796291-795065 (Counterclockwise)

Preceding gene: 57237611

Following gene: 57237609

Centisome position: 44.79

GC content: 31.7

Gene sequence:

>1227_bases
ATGATTAACGCTTTAAAAGGAATGAAAGATTTATTAGATAAAGATGCATATTATTATGAAAAAGTGATTAAAATCTGCGA
AGAAGTAGCTAAAAACTATGGCTTTACTTTTATCAATACACCGCATTTAGAACTTTGCACCCTTTTTAAAAGAAGCGTAG
GAGAAAGTTCTGATATAGTAGGTAAAGAAATGTATGAATTTATCGATAAAGGCGAAAATCATGTTTGCATGCGTCCTGAA
GGAACTGCTGGGGTGGTGCGTGCCTATATAGAAAAAAAACTCGATAAAAACACTAGTGTGAAAAGATGGTTTTATTATGG
TTCTATGTTTCGTTATGAAAGACCTCAAAAGGGTCGCTTAAGAGAATTTCATCAATTTGGAGTTGAAAGCCTTGGCATAC
CTAATGTTTATGAAGATGCAAGCATTATTTTAATGCTAGTAGAAATTTTCTCACGCCTTGGTATTGATTTTAAACTTCAA
CTTAATTCTTTAGGCTGCTCACAATGCTTGCCAAAATACCGCGATAGGCTCGTTGAATTCTTAGATTCCAAAGAAGGTTT
TTGTGAAGATTGTTTGCGTAGAAAAAATTTAAATCCTATTCGTGTCTTAGATTGTAAAAATGAGCATTGTCAAAATTTGC
TTGAAAATGCTCCGCTTTTGATCAATAATTTATGCACCTCTTGCCAAAAAGACTTTGAAACACTGCAACAAATTTTAAAG
GATAATGGAGTTAAATTTGAGTTAGATTCAAAACTTGTGAGGGGTTTGGATTATTATTCTAAAACGGCTTTTGAATTTAT
AAGCGATGAAATAGGAGCAAAGGCTGCTATCGCAGGTGGAGGACGCTACGATAGACTTATAGAGTATTTAGGTGGAAAAA
GTGGCTATGGTATAGGTTTTGCCATGGGTATAGAAAGAATTATAACTATTTTAGAACAAAAAGAAGAAAAGATTCAAAGA
GAAGGAATTTATCTTTGTGCTATGGATGAAATTTATATCCAAAAACTTTTGCATATCGCTACAAATTTAAGAAAAGAATA
TAAAGTACTTTTAAGCTATGAAGCAAGAAAACTAGCCAAACATCTTGAAAACGCGGATAAAAATAATACTGAAATTTTTC
TTTGCATGGGAGAAAATGAAGCACAAAATGAAAGTTTGTTTTATAAAAATTTAGCAAAAAAAGAAGAAAAAATGATTAAA
ATTTCAGACTTAAAGAAGGTTTTATGA

Upstream 100 bases:

>100_bases
TGCTTCATTTTTTAAAAGAAAAAATTTCTGTAGAAATTTTAACACTTGACGCAAAAGAAAGTAAAGAAAAATTACACCAA
CAAATAAAGGAATTTTTACA

Downstream 100 bases:

>100_bases
TGGATTATGGTATTGATATTTGGGGAAATGAAAATTTCATTATCAAAAATGGTAAAGTTTGTATCAATTACGAGAAAAAA
CCTGCTATTATTGATATAGT

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MINALKGMKDLLDKDAYYYEKVIKICEEVAKNYGFTFINTPHLELCTLFKRSVGESSDIVGKEMYEFIDKGENHVCMRPE
GTAGVVRAYIEKKLDKNTSVKRWFYYGSMFRYERPQKGRLREFHQFGVESLGIPNVYEDASIILMLVEIFSRLGIDFKLQ
LNSLGCSQCLPKYRDRLVEFLDSKEGFCEDCLRRKNLNPIRVLDCKNEHCQNLLENAPLLINNLCTSCQKDFETLQQILK
DNGVKFELDSKLVRGLDYYSKTAFEFISDEIGAKAAIAGGGRYDRLIEYLGGKSGYGIGFAMGIERIITILEQKEEKIQR
EGIYLCAMDEIYIQKLLHIATNLRKEYKVLLSYEARKLAKHLENADKNNTEIFLCMGENEAQNESLFYKNLAKKEEKMIK
ISDLKKVL

Sequences:

>Translated_408_residues
MINALKGMKDLLDKDAYYYEKVIKICEEVAKNYGFTFINTPHLELCTLFKRSVGESSDIVGKEMYEFIDKGENHVCMRPE
GTAGVVRAYIEKKLDKNTSVKRWFYYGSMFRYERPQKGRLREFHQFGVESLGIPNVYEDASIILMLVEIFSRLGIDFKLQ
LNSLGCSQCLPKYRDRLVEFLDSKEGFCEDCLRRKNLNPIRVLDCKNEHCQNLLENAPLLINNLCTSCQKDFETLQQILK
DNGVKFELDSKLVRGLDYYSKTAFEFISDEIGAKAAIAGGGRYDRLIEYLGGKSGYGIGFAMGIERIITILEQKEEKIQR
EGIYLCAMDEIYIQKLLHIATNLRKEYKVLLSYEARKLAKHLENADKNNTEIFLCMGENEAQNESLFYKNLAKKEEKMIK
ISDLKKVL
>Mature_408_residues
MINALKGMKDLLDKDAYYYEKVIKICEEVAKNYGFTFINTPHLELCTLFKRSVGESSDIVGKEMYEFIDKGENHVCMRPE
GTAGVVRAYIEKKLDKNTSVKRWFYYGSMFRYERPQKGRLREFHQFGVESLGIPNVYEDASIILMLVEIFSRLGIDFKLQ
LNSLGCSQCLPKYRDRLVEFLDSKEGFCEDCLRRKNLNPIRVLDCKNEHCQNLLENAPLLINNLCTSCQKDFETLQQILK
DNGVKFELDSKLVRGLDYYSKTAFEFISDEIGAKAAIAGGGRYDRLIEYLGGKSGYGIGFAMGIERIITILEQKEEKIQR
EGIYLCAMDEIYIQKLLHIATNLRKEYKVLLSYEARKLAKHLENADKNNTEIFLCMGENEAQNESLFYKNLAKKEEKMIK
ISDLKKVL

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=448, Percent_Identity=25.6696428571429, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1788861, Length=407, Percent_Identity=37.5921375921376, Blast_Score=287, Evalue=7e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 47158; Mature: 47158

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINALKGMKDLLDKDAYYYEKVIKICEEVAKNYGFTFINTPHLELCTLFKRSVGESSDIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCCHH
GKEMYEFIDKGENHVCMRPEGTAGVVRAYIEKKLDKNTSVKRWFYYGSMFRYERPQKGRL
HHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHH
REFHQFGVESLGIPNVYEDASIILMLVEIFSRLGIDFKLQLNSLGCSQCLPKYRDRLVEF
HHHHHHCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
LDSKEGFCEDCLRRKNLNPIRVLDCKNEHCQNLLENAPLLINNLCTSCQKDFETLQQILK
HHCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
DNGVKFELDSKLVRGLDYYSKTAFEFISDEIGAKAAIAGGGRYDRLIEYLGGKSGYGIGF
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCHHH
AMGIERIITILEQKEEKIQREGIYLCAMDEIYIQKLLHIATNLRKEYKVLLSYEARKLAK
HHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLENADKNNTEIFLCMGENEAQNESLFYKNLAKKEEKMIKISDLKKVL
HHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MINALKGMKDLLDKDAYYYEKVIKICEEVAKNYGFTFINTPHLELCTLFKRSVGESSDIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCCHH
GKEMYEFIDKGENHVCMRPEGTAGVVRAYIEKKLDKNTSVKRWFYYGSMFRYERPQKGRL
HHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHH
REFHQFGVESLGIPNVYEDASIILMLVEIFSRLGIDFKLQLNSLGCSQCLPKYRDRLVEF
HHHHHHCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
LDSKEGFCEDCLRRKNLNPIRVLDCKNEHCQNLLENAPLLINNLCTSCQKDFETLQQILK
HHCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
DNGVKFELDSKLVRGLDYYSKTAFEFISDEIGAKAAIAGGGRYDRLIEYLGGKSGYGIGF
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCHHH
AMGIERIITILEQKEEKIQREGIYLCAMDEIYIQKLLHIATNLRKEYKVLLSYEARKLAK
HHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLENADKNNTEIFLCMGENEAQNESLFYKNLAKKEEKMIKISDLKKVL
HHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA