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The map label for this gene is fucP [H]

Identifier: 57237539

GI number: 57237539

Start: 491288

End: 492544

Strand: Direct

Name: fucP [H]

Synonym: CJE0536

Alternate gene names: 57237539

Gene position: 491288-492544 (Clockwise)

Preceding gene: 57237538

Following gene: 57237540

Centisome position: 27.63

GC content: 32.78

Gene sequence:

>1257_bases
ATGACTGATTCTAAAAATATAAAAATAGCTATTGTTTTGGTAACTTCTCTTTTCTTTTTATGGGGAGTAAGCTATGGACT
TATTGATGTGATGAATAAAAATTTTCAAAATCATCTTCATATTAGCCAGCATGAAAGTGGCTTTTTACAGTTTGCTTATT
TTGGTGCTTATTTTATCATAGCCTTACCCGCAGGTTATATAGCCAATAGATTTTCTTATAAAATGGGAATCATTTTTGGC
TTAGCTCTTTATGCCATAGGAGCTTTGCTTATTATACCTGCTACAAATTTGGCTTCTTTTCATTTGTTTTTGTTTGCGTT
TTTTATTTTAGCTTGTGGTATTGGTTCTTTAGAAACTAGTGCAAATCCCTACATGACAAAGCTTGGTGATGAAAAAAATG
CGAGTTTTAGAATCAATGCTGCGCAAAGTTTTAATGGTTTGGGGCAATTTGTAGGACCTATTATAGGCGGAGTTTTATTT
TTATCTATTACTAAACAAGAAGAGGGTGCGAGTAAAGAGCAAATCGAGGCTGCATTGGTAGCTAATATGGGAAATGTCCA
GCTTGTTTATATAGGAATTGCTGTCATTGTTATTTTGATTTTAATTGCTTTTGTTGCAAATAAGCTTCCAGAAGGAAGTG
CGGTAAGTGATGATTATAAGCAAAAAGATGATTCTAAGCCCATATATGTTTTTAAACACAGACATTTTAACTTAGGGCTT
TTAGCGCAGTTTTTGTATATAGCCAATCAAGTTGCAGCAGGAGCTTTTTTTATCAATTATGTTGTAGAACATAATGAAGG
TTTAAAAGATGCGCAAGGTGCTTATTATTTTTCTATAGCTTTGGTTGCATTTATGCTAGGGCGCATTGTTTCTACTCCTT
TGATGAAGATAATCAAAGGTGAAAAAATTTTAGGATTTTATTCTCTAATCAATGTGCTTATATGCTTTAGCTTGTATTTT
GCTAGCGGGTTTTTTAGCATAGTGCTTTTAATAGCTTTATTTTTCTTTATGTCTATTTCTTTTCCTACTATTTTTGCGGT
AGCAACAAAAAATTTACCTTTAAATCAAGTAAAACTAGGCGGTTCTTTGCTTGTGATGAGCATAGTAGGTGGAGCAATTA
TGCCTATAATTATAGGTTTTATTAATGATCATTATGGTACAGGCGCTGGGTATTTAGCAATGGCACCTTTGTTTTTATAT
GTGGCTTGGTATGGCTTTATAGGCTCAAAAGTGAGAAAAAATGCAAAAGATTTTTGA

Upstream 100 bases:

>100_bases
CCCCTTGCTTCACATACTACAGGGCAAATTTTAATGCCAGATGGAGGTTATGTGCATTTAGATAGAGCATTAAATTGGGA
TGAAAACTAAGGAGTAAAAA

Downstream 100 bases:

>100_bases
TGCTCATCTACACCTTTGGGATTTGGAAAAAATACCTATTTCATGGATAAAAGACGATGAAAAATTAGAGCAAAATTATG
ATTTTTTTAGGATGAAACAA

Product: L-fucose permease

Products: Proton [Cytoplasm]; L-fucose [Cytoplasm] [C]

Alternate protein names: 6-deoxy-L-galactose permease; L-fucose permease [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTDSKNIKIAIVLVTSLFFLWGVSYGLIDVMNKNFQNHLHISQHESGFLQFAYFGAYFIIALPAGYIANRFSYKMGIIFG
LALYAIGALLIIPATNLASFHLFLFAFFILACGIGSLETSANPYMTKLGDEKNASFRINAAQSFNGLGQFVGPIIGGVLF
LSITKQEEGASKEQIEAALVANMGNVQLVYIGIAVIVILILIAFVANKLPEGSAVSDDYKQKDDSKPIYVFKHRHFNLGL
LAQFLYIANQVAAGAFFINYVVEHNEGLKDAQGAYYFSIALVAFMLGRIVSTPLMKIIKGEKILGFYSLINVLICFSLYF
ASGFFSIVLLIALFFFMSISFPTIFAVATKNLPLNQVKLGGSLLVMSIVGGAIMPIIIGFINDHYGTGAGYLAMAPLFLY
VAWYGFIGSKVRKNAKDF

Sequences:

>Translated_418_residues
MTDSKNIKIAIVLVTSLFFLWGVSYGLIDVMNKNFQNHLHISQHESGFLQFAYFGAYFIIALPAGYIANRFSYKMGIIFG
LALYAIGALLIIPATNLASFHLFLFAFFILACGIGSLETSANPYMTKLGDEKNASFRINAAQSFNGLGQFVGPIIGGVLF
LSITKQEEGASKEQIEAALVANMGNVQLVYIGIAVIVILILIAFVANKLPEGSAVSDDYKQKDDSKPIYVFKHRHFNLGL
LAQFLYIANQVAAGAFFINYVVEHNEGLKDAQGAYYFSIALVAFMLGRIVSTPLMKIIKGEKILGFYSLINVLICFSLYF
ASGFFSIVLLIALFFFMSISFPTIFAVATKNLPLNQVKLGGSLLVMSIVGGAIMPIIIGFINDHYGTGAGYLAMAPLFLY
VAWYGFIGSKVRKNAKDF
>Mature_417_residues
TDSKNIKIAIVLVTSLFFLWGVSYGLIDVMNKNFQNHLHISQHESGFLQFAYFGAYFIIALPAGYIANRFSYKMGIIFGL
ALYAIGALLIIPATNLASFHLFLFAFFILACGIGSLETSANPYMTKLGDEKNASFRINAAQSFNGLGQFVGPIIGGVLFL
SITKQEEGASKEQIEAALVANMGNVQLVYIGIAVIVILILIAFVANKLPEGSAVSDDYKQKDDSKPIYVFKHRHFNLGLL
AQFLYIANQVAAGAFFINYVVEHNEGLKDAQGAYYFSIALVAFMLGRIVSTPLMKIIKGEKILGFYSLINVLICFSLYFA
SGFFSIVLLIALFFFMSISFPTIFAVATKNLPLNQVKLGGSLLVMSIVGGAIMPIIIGFINDHYGTGAGYLAMAPLFLYV
AWYGFIGSKVRKNAKDF

Specific function: Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-

COG id: COG0738

COG function: function code G; Fucose permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family [H]

Homologues:

Organism=Escherichia coli, GI1789166, Length=391, Percent_Identity=36.8286445012788, Blast_Score=241, Evalue=9e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005275
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45789; Mature: 45657

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSKNIKIAIVLVTSLFFLWGVSYGLIDVMNKNFQNHLHISQHESGFLQFAYFGAYFII
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHH
ALPAGYIANRFSYKMGIIFGLALYAIGALLIIPATNLASFHLFLFAFFILACGIGSLETS
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
ANPYMTKLGDEKNASFRINAAQSFNGLGQFVGPIIGGVLFLSITKQEEGASKEQIEAALV
CCCHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHH
ANMGNVQLVYIGIAVIVILILIAFVANKLPEGSAVSDDYKQKDDSKPIYVFKHRHFNLGL
HCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCEEEEEECCCCHHH
LAQFLYIANQVAAGAFFINYVVEHNEGLKDAQGAYYFSIALVAFMLGRIVSTPLMKIIKG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
EKILGFYSLINVLICFSLYFASGFFSIVLLIALFFFMSISFPTIFAVATKNLPLNQVKLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHCCCCCCHHEECC
GSLLVMSIVGGAIMPIIIGFINDHYGTGAGYLAMAPLFLYVAWYGFIGSKVRKNAKDF
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDSKNIKIAIVLVTSLFFLWGVSYGLIDVMNKNFQNHLHISQHESGFLQFAYFGAYFII
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHH
ALPAGYIANRFSYKMGIIFGLALYAIGALLIIPATNLASFHLFLFAFFILACGIGSLETS
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
ANPYMTKLGDEKNASFRINAAQSFNGLGQFVGPIIGGVLFLSITKQEEGASKEQIEAALV
CCCHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHH
ANMGNVQLVYIGIAVIVILILIAFVANKLPEGSAVSDDYKQKDDSKPIYVFKHRHFNLGL
HCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCEEEEEECCCCHHH
LAQFLYIANQVAAGAFFINYVVEHNEGLKDAQGAYYFSIALVAFMLGRIVSTPLMKIIKG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
EKILGFYSLINVLICFSLYFASGFFSIVLLIALFFFMSISFPTIFAVATKNLPLNQVKLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHCCCCCCHHEECC
GSLLVMSIVGGAIMPIIIGFINDHYGTGAGYLAMAPLFLYVAWYGFIGSKVRKNAKDF
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-fucose [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-fucose [Periplasm] = Proton [Cytoplasm] + L-fucose [Cytoplasm] [C]

General reaction: Permease [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2664711; 9278503; 2553671; 8052131; 2829831; 7783647 [H]